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    Evaluation of Serum Selenium Levels in Children with Recurrent Febal Convulsions
    (Galenos Yayincilik, 2011) Berk, Erhan; Kaya, Ali; Deveci, Koksal; Guven, Ahmet Sami; Demir, Mevlut; Gunes, Hatice; Gultekin, Asim
    Introduction: The febrile convulsion (FC) occurs in neurologically normal children aged between six months and five years and it is defined as convulsions occurred during fever and in the absence of central nervous system (CNS) infection, electrolyte imbalance, diseases affecting directly CNS, and history of afebrile convulsion. The aims of this study were to determine the serum levels of selenium in patients with recurrent FC and to compare them with those of healthy children. Materials and Methods: The study included 61 pediatric patients diagnosed with recurrent FC. At the same session, 54 healthy children who admitted to our pediatric clinic for routine controls without history of fever and convulsion, are assigned as control group. The serum level of selenium was measured by atomic absorption spectrometric method (hydride technique). Results: Mean level of selenium was determined as 67.10 +/- 8.87 mu g/L in patients and 81.99 +/- 13.13 mu g/L in control group; the difference was statistically significant (p< 0.05). Discussion: The lower serum levels of selenium in patients with recurrent FC may be the cause of triggering of convulsion or may contribute to its recurrence. Further studies are necessary to clarify this relationship.
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    Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases
    (TURKISH J PEDIATRICS, 2012) Kaya, Ali; Deveci, Koksal; Uysal, Ismail Onder; Guven, Ahmet Sami; Demir, Mevlut; Uysal, Elif Bilge; Gultekin, Asim; Icagasioglu, Fusun Dilara
    Kaya A, Deveci K, Uysal IO, Guven AS, Demir M, Uysal EB, Gultekin A, Icagasioglu FD. Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases. Mirk J Pediatr 2012; 54: 105-112. Tularemia is a zoonotic disease caused by Francisella tularensis. We aimed to explicate the clinical and laboratory findings of 27 consecutive tularemia patients who were included into the study. The average duration between onset of symptoms and diagnosis was 19.1 +/- 7.3 days. Sore throat (100%), fever (93%) and myalgia (100%) were the most frequently observed symptoms, while lymphadenopathy (100%), pharyngeal hyperemia (85%), tonsillitis (74%), and rash (7%) were the most frequently observed physical findings. Treatment failed in 6 patients: 1/13 streptomycin- (changed to doxycycline + streptomycin), 1/7 ciprofloxacin- (changed to streptomycin), and 4/7 gentamicin- (changed to streptomycin) receiving patients who had longer duration to treatment (26.5 +/- 2.9 days) than the 21 successfully treated cases (17.0 +/- 6.8 days). Tularemia should to be taken into account in the differential diagnosis in cases having tonsillopharyngitis and cervical lymphadenopathy without response to beta lactam/macrolide-group antibiotics in rural areas. We believe that streptomycin should be the first-line antibiotic in the treatment of pediatric tularemia cases, but it should be supported by comprehensive studies with larger patient series.