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Öğe Asymptomatic total anomalous pulmonary venous connection with double drainage in a young adult: A case report(FORUM MULTIMEDIA PUBLISHING, LLC, 2007) Yalta, Kenan; Turgut, Okan Onur; Yilmaz, Ahmet; Yilmaz, Mehmet Birhan; Manduz, Sinasi; Karadas, Filiz; Dogan, Kasim; Tandogan, IzzetTotal anomalous pulmonary venous connection is an uncommon congenital anomaly in which all pulmonary venous return drains to the right atrium or one of its tributaries. Survival beyond infancy without surgical palliation is unlikely, so this anomaly is not encountered in the adult population with congenital heart disease. The patient presented here was 22 years old on admission and had no total anomalous pulmonary venous connection-associated symptoms. He underwent transthoracic echocardiographic examination for atypical chest pain. Transthoracic echocardiography along with cardiac catheterization favored the presence of a total anomalous pulmonary venous connection. Surgical correction of pulmonary venous confluence ( draining to both the coronary sinus and right atrium) was performed successfully. This is a rare case of total anomalous pulmonary venous connection with no reported symptoms in contrast to the majority of patients who are symptomatic during the first year of life.Öğe A cardiac hydatid cyst case seen after operation on pulmonary hydatid cyst(GALENOS YAYINCILIK, 2007) Manduz, Sinasi; Katrancioglu, Nurkay; Dogan, Kasim…Öğe The effect of collateral circulation on left ventricular systolic function(LIPPINCOTT WILLIAMS & WILKINS, 2007) Karadas, Filiz; Yalta, Kenan; Turgut, Okan Onur; Yilmaz, Mehmet Birhan; Yilmaz, Ahmet; Dogan, Kasim; Tandogan, IzzetBackground Conflicting reports exist on the influence of coronary collateral circulation on preservation of left ventricular systolic function. The aim of this study was to assess the effect of coronary collateral circulation on left ventricular systolic function in coronary artery disease. Methods Seventy-one consecutive patients having left anterior descending arteries with proximal or near-proximal stenosis of at least 95% (excluding 100%) were included in the study. The coronary collateral circulation to left anterior descending artery was evaluated with regard to its effects on left ventricular systolic function. Results Among the 71 patients, 46 patients were found to have a coronary collateral circulation grade of >= 1 (group 1), whereas the remaining 25 patients had coronary collateral circulation grade of 0 (group 2). The mean value of left ventricular function score in group 1 was higher than that of group 2 (3.69 +/- 2.34 vs. 2.00 +/- 1.55, P= 0.002), whereas the mean value of left ventricular ejection fraction in group 1 was lower than that of group 2 (44.67 +/- 12.05 vs. 54.32 +/- 10.22, P=0.001). The value of coronary collateral circulation grade was found to be positively correlated with the value of left ventricular function score (P= 0.01, r= 0.3), and negatively correlated with the value of left ventricular ejection fraction (P= 0.01, r= - 0.3). Conclusion Coronary collateral circulation to the severely stenotic left anterior descending artery was not found to have an improving effect on left ventricular systolic function. In contrast with the previous studies demonstrating the coronary collateral circulation-associated preservation of left ventricular systolic function, presence of coronary collateral circulation was found to accompany or be associated with impairment of left ventricular systolic function. The grade of coronary collateral circulation was also found to be positively correlated with the severity of left ventricular systolic dysfunction. Further research on larger patient populations based on a long-term follow-up is warranted to investigate this issue. Coron Artery Dis 18:169-173 (C) 2007 Lippincott Williams & Wilkins.Öğe eNOS G894T Polymorphism and Abdominal Aortic Aneurysms(SAGE PUBLICATIONS INC, 2010) Atli, Fahri Hayri; Manduz, Sinasi; Katrancioglu, Nurkay; Ozum, Unal; Disli, Olcay Murat; Atahan, Erhan; Ozdemir, Ozturk; Dogan, Kasim; Berkan, OcalBackground: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism with AAA. Methods: eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique. Results: eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P=.01, P=.03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs. Conclusion: The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.Öğe The heterodox nature of "Turban Pins" in foreign body aspiration; the central anatolian experience(ELSEVIER IRELAND LTD, 2007) Kaptanoglu, Melih; Nadir, Aydin; Dogan, Kasim; Sahin, EkberObjective: The aim of this study is to determine the age and sex distribution and the nature of aspirated foreign bodies (FBs). We also compared Turban Pins (TP) with other FBs and discussed the extracting techniques. Methods: From 1987 through 2006, 414 patients were managed and the records of the patients were retrospectively reviewed. Results: Girls (56%) were influenced much more than the boys (44%). The median age was 4, however median age for girls and boys were 11 and 2, respectively. The 50% of the foreign body aspiration (FBA) were observed in the first years of life. There was also a great tendency to occur in the adolescent age group (32%), especially for girls. The most commonly aspirated foreign body was Turban pin (TP) (n = 121) among 332 foreign bodies. FBs were successfully removed by rigid bronchoscopy in 94% of the patients. In patients who had a negative history (n = 49), bronchoscopy was performed according to clinical suspicion, and it revealed foreign bodies in 41%. Thoracotomy was performed in eight (2.4%) patients. We had no mortality. Conclusions: These cases showed us that the type and age groups of FBA varies according to cultural conditions. We found that TP aspiration has different characteristics and it deserves a special attention. Suspicion is an important indication for bronchoscopy. We prefer rigid bronchoscopy because success rate is satisfactory. (c) 2006 Elsevier Ireland Ltd. All rights reserved.Öğe Hypothermia Evaluation, Diagnosis and Treatment(Aves, 2009) Eren, Sevki Hakan; Korkmaz, Ilhan; Dogan, Kasim; Guven, Fatma Mutlu KukulBody temperature below 35 degrees C is defined as hypothermia. It is classified as mild, moderate and severe. While the standard thermometers can not measure the core temperature below 35 degrees C, thermometers with intravezical, rectal or esophageal probes must be used to determine the core temperature in hypothermic patients. Although hypothermia is seen in cold climates; it can be seen because of environmental conditions, like drowning, too. Also inadequate clothing and hypothermia background can facilitate hypothermia in patients. The common causes for hypothermia are dermatological disease, drug adverse effects, iatrogenic causes, neurological disease, neuromuscular insufficiency, sepsis and metabolic condition of the patient. Resistance to cold in the peoples is not well developed while they are warm-blooded. Especially homeless, psychiatric and lonely elderly people can be affected by hypothermia easily. Although the main heat loss of the body is by radiation; conduction, convection and evaporation take place too. Coordination and consciousness deficiencies are the main symptoms. Nevertheless clinical signs vary according to the hypothermia state. The basic treatment principles resemble each other in mild, moderate and severe hypothermia. These are; reducing of the heat loss, warming of the body with internal and external ways, supplying the main energy and fluid demands for patient metabolism. The defibrillation techniques, resuscitation time and the drugs which are used are different in hypothermic cardiopulmonary resuscitation than normal cardiopulmonary resuscitation. The main systems which are damaged from hypothermia are cardiovascular and central nervous system. That's why early and true diagnosis and aggressive treatment has a great importance for surviving.Öğe Influence of albumin concentration in priming solution on blood viscosity under hypothermic conditions(CLINICS CARDIVE PUBL PTY LTD, 2009) Sapmaz, Ismail; Manduz, Sinasi; Sanri, Umut S.; Karahan, Oguz; Dogan, KasimObjective: Albumin is used routinely as a plasma volume expander in cardiopulmonary bypass operations. The effect of two different concentrations of albumin in Ringer's lactate on blood viscosity was explored in this study. Methods: Ten healthy volunteers (all male) were included in the study, based on their haematocrit levels (42.6 +/- 0.96). Using a heparinised 50-ml syringe, 40 cm(3) of blood were drawn from the antecubital veins of fasting volunteers. Six ml of blood were haemodiluted with 2 ml of albumin (20%), 2 ml of Ringer's lactate containing albumin (1.3%), and 2 ml of Ringer's lactate, in order to simulate cardiopulmonary bypass conditions. Test tubes with the solutions were placed in a 15 degrees C water bath for 25 minutes. Viscosity was measured in the haemodiluted blood samples using an Ostwald viscometer. Relative viscosities of samples were assessed with SPSS software and the ANOVA test. Results: The mean relative viscosity of Ringer's lactate was 4.19 (+/- 0.49), that of Ringer's lactate with 1.3% albumin was 4.30 (+/- 0.31), and of 20% albumin was 7.32 (+/- 0.71). The relative viscosity of Ringer's lactate and Ringer's lactate with 1.3% albumin were statistically similar, but that of 20% albumin was higher than the Ringer's lactate and Ringer's lactate with 1.3% albumin. Conclusion: Albumin is used as a plasma volume expander in priming solutions for cardiopulmonary bypass operations, but its effect on blood viscosity depends on the concentration of albumin used.Öğe The influence of priming solutions used in cardiopulmonary bypass on blood viscosity in hypothermic conditions(LIPPINCOTT WILLIAMS & WILKINS, 2008) Manduz, Sinasi; Sapmaz, Ismail; Sanri, Umut Serhat; Karahan, Oguz; Bascil, Hasan; Dogan, KasimVessel diameter, flow velocity, temperature, and viscosity are among the factors determining blood flow in vessels. To assess the influence of arterial blood flow on veins in a cardiac operation, the viscosity of blood diluted with priming solutions must be known. This study aimed to demonstrate the alteration of blood viscosity following dilution with priming solutions: hydroxyethyl starch (HES), gelatin, albumin, and Ringer's lactated solution (RL). Sixty volunteers were (15 female, 45 male) included in the study. Using a 50-ml syringe containing heparin, 40-ml fasting blood was drawn from antecubital veins. Six milliliters of blood was added to glass tubes previously filled with 2 ml of HES 6%, gelatin 4%, albumin, and RL solutions. Relative viscosity values of these mixtures were measured with an Ostwald viscometer device while the temperature was kept constant at 15 degrees C and 30 degrees C by means of a water bath. Measured viscosity values were compared with the calculated viscosity values and corrected values were obtained. All mixtures demonstrated decreased viscosity; however, it was evident that the mixtures containing HES and gelatin presented a lesser degree of decrease in viscosity when compared with the mixtures containing albumin and RL solution. Viscosity of all mixtures except RL decreased significantly at deep hypothermia (15 degrees C).Öğe Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft(NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2007) Berkan, Ocal; Bagcivan, Ihsan; Kaya, Tijen; Yildirim, Kemal; Yildirim, Sahin; Dogan, KasimThe radial artery (RA) is used as a spastic coronary bypass graft. This study was designed to investigate the mechanism of vasorelaxant effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), a nitric oxide (NO)-independent soluble guanylate cyclase (sGC activator, and DEA/NO (diethylamine/nitric oxide), a NO-nucleophile adduct, on the human RA. RA segments (n = 25) were obtained from coronary artery bypass grafting patients and were divided into 3-4 turn vascular rings. Using the isolated tissue bath technique, the endothelium-independent vasodilatation function was tested in vitro by the addition of cumulative concentrations of YC-1 (10(-10) to 3 x 10(-7) mol/L) and DEA/NO (10(-8) to 3 x 10(-5) mol/L) following vasocontraction by phenylephrine in the presence or absence of 10-5 mol/L ODQ (1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1-one), the selective sGC inhibitor, 10(-7) mol/L iberiotoxin, a blocker of Ca2+- activated K+ channels, or 10(-5) mol/L ODQ plus 10(-7) mol/L iberiotoxin. We also evaluated the effect of YC-1 and DEA/NO on the cGMP levels in vascular rings obtained from human radial artery (n = 6 for each drug). YC-1 (10(-10) to 3 x 10(-7) mol/L) and DEA/NO (10(-8) to 3 x 10(-5) mol/L) caused the concentration-dependent vasorelaxation in RA rings precontracted with phenylephrine (10(-5) mol/L) (n = 20 for each drug). Pre-incubation of RA rings with ODQ, iberiotoxin, or ODQ plus iberiotoxin significantly inhibited the vasorelaxant effect of YC-1, but the inhibitor effect of ODQ plus iberiotoxin was significantly more than that of ODQ and iberiotoxin alone p < 0.05). The vasorelaxant effect of DEA/NO almost completely abolished in the presence of ODQ and iberiotoxin plus ODQ, but did not significantly change in the presence of iberiotoxin alone (P > 0.05). The pEC(50) value of DEA/NO was significantly lower than those for YC-1 (p < 0.01), with no change E. x values in RA rings. In addition, YC- I -stimulated RA rings showed more elevation in cGMP than that of DEA/NO (p < 0.05). These findings indicate that YC-1 is a more potent relaxant than DEA/NO in the human RA. The relaxant effects of YC-1 could be due to the stimulation of the sGC and Ca2+- sensitive K(+)channels, whereas the relaxant effects of DEA/NO could be completely due to the stimulation of the sGC. YC-1 and DEA/NO may be effective as vasodilator for the short-term treatment of perioperative spasm of coronary bypass grafts.Öğe Vascular graft infection by Staphylococcus aureus: efficacy of linezolid, teicoplanin and vancomycin systemic prophylaxis protocols in a rat model(CLINICS CARDIVE PUBL PTY LTD, 2009) Atahan, Erhan; Katrancioglu, Nurkay; Oztop, Yasemin; Tuncer, Ersin; Ozer, Hatice; Manduz, Sinasi; Engin, Aynur; Yalta, Tulin Deniz; Berkan, Ocal; Dogan, KasimObjective: We investigated experimentally the in vivo prophylactic efficacies of linezolid, teicoplanin and vancomycin in subcutaneously implanted dacron graft infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Materials and methods: Dacron grafts (1 cm(2)) were aseptically implanted into subcutaneous pockets that were surgically prepared in the backs of 50 rats. Ten of these rats were used as the control group (group I). Grafts in the remaining 40 rats were infected by inoculation of MRSA at the concentration of 2 x 10(7) colony-forming units (CFU)/ml. Ten of these rats constituted the contaminated, untreated group II. The other three study groups comprising 10 rats each were contaminated and then treated with linezolid (group III), teicoplanin (group IV) and vancomycin (group V), respectively. All rats were sacrificed and the grafts were removed after seven days and evaluated. Results: The bacterial count decreased in the rats from the groups treated with linezolid, teicoplanin and vancomycin. The linezolid and teicoplanin groups, however, showed a significantly lower bacterial number than the vancomycin group (p = 0.009 and p = 0.01). The intensity of inflammation was highest in the contaminated, untreated group, as expected. Conclusions: Single-dose linezolid, teicoplanin and vancomycin for peri-operative prophylaxis may prevent bacterial growth in vascular graft infections. The effect of linezolid and teicoplanin seemed similar and their effect was greater than that of vancomycin.
