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Öğe Assessment of Mitochondrial Functions and Occurrence of Oxidative Stress at Fibromyalgia Patients(CLINICAL & EXPER RHEUMATOLOGY, 2014) Peksen, Halil; Elden, Hasan; Dogan, Sevil Ceyhan; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Salihoglu, Salih…Öğe Body Composition in Patients with Ankylosing Spondylitis on Anti-Tumor Necrosis Factor Alpha Treatment(KUWAIT MEDICAL ASSOC, 2017) Sahin, Ozlem; Kaptanoglu, Ece; Dinler, Mustafa; Dogan, Sevil Ceyhan; Kurt, Kibar GultekinObjectives: To examine the body composition (BC) of the Ankylosing spondylitis (AS) patients on anti-TNF therapy and to evaluate the clinical parameters in obese AS patients Design: Cross-sectional case-control study Setting: Department of Physical Medicine and Rehabilitation, Cumhuriyet University, Medical Faculty, Sivas, Turkey Subjects: Thirty-four AS patients and 34 healthy subjects as controls were included in the study between November 2014 and May 2015 Main outcome measures: Waist circumference (WC), body mass index (BMI), percent body fat (PBF), fat mass (FM) and fat free mass (FFM) were measured in patients and control group. In AS group, disease activity, functional status, spinal mobility and life quality were examined by standard AS questionnaires. Results: WC, BMI, PBF, FM, and FFM were comparable in AS patients and controls. There was a positive correlation between the duration of the anti-TNF treatment and BMI (p = 0.02, r = 0.409). In obese AS patients, the duration of the anti-TNF treatment was significantly longer than the normal weight AS patients (for BMI p = 0.02, for PBF p = 0.03). Obese and normal weight AS patients were comparable regarding disease duration, disease activity, functional status, spinal mobility and life quality. Conclusions: The BC of AS patients on anti-TNF treatment was similar to healthy controls. Anti-TNF treatment has comparable effects on disease parameters in both the normal weight and obese AS patients. Long-term treatment with anti-TNF drugs may lead to obesity. Prospective controlled studies with more patients to clarify this probable effect of anti-TNF drugs are required.Öğe Diffuse Alveolar Hemorrhage: A Life-Threatening Complication of Systemic Lupus Erythematosus(CLINICAL & EXPER RHEUMATOLOGY, 2014) Cengiz, Ahmet Kivanc; Durmaz, Yunus; Dinler, Mustafa; Dogan, Sevil Ceyhan; Hayta, Emrullah; Akin, Recep; Gumus, Cesur; Kaptanoglu, Ece; Hizmetli, Sami…Öğe Disease Activity, Fatigue and Quality of Life in Patients with Coexisting Ankylosing Spondylitis and Familial Mediterranean Fever(CLINICAL & EXPER RHEUMATOLOGY, 2014) Kaptanoglu, Ece; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Hayta, Emrullah; Dogan, Sevil Ceyhan; Hizmetli, Sami…Öğe Does Mean Platelet Volume Really Reflect Disease Activity in Rheumatoid Arthritis?(CLINICAL & EXPER RHEUMATOLOGY, 2014) Hizmetli, Sami; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Hayta, Emrullah; Dogan, Sevil Ceyhan; Kaptanoglu, Ece…Öğe Effects of childhood psychological trauma on rheumatic diseases(Aves, 2019) Salihoglu, Salih; Dogan, Sevil Ceyhan; Kavakci, OnderObjective: The etiology of rheumatic diseases is unclear, but it is thought that environmental factors added to immunogenetic mechanisms in chronic inflammatory diseases play a role. Many inflammatory disorders, autoimmune diseases, and painful conditions have been shown to be associated with the psychological trauma of childhood. The aim of the present study was to investigate childhood psychological trauma that is considered to be one of the environmental factors that initiate inflammation on patients with rheumatic diseases. Methods: In our study, a total of 440 patients (220 patients who have rheumatic diseases as the case group and 220 patients who have no rheumatic disease as the control group) were examined. The Childhood Trauma Questionnaire-28 (CTQ-28) was administered and was completed by the patients. This was a cross-sectional study design. Results: No statistically significant differences were found between the case and control groups with respect to age, gender, marital status, and educational level. The CTQ-28 scale was found to be significantly higher in patients with rheumatic diseases (ankylosing spondylitis, rheumatoid arthritis, and connective tissue disease) in our study. Conclusion: We think that childhood psychiatric traumas are effective in the etiopathogenesis of rheumatic diseases. To make this relationship more understandable, multidisciplinary research and long-term follow-up studies are needed to examine neuroendocrine, genetic, and epidemiological factors.Öğe Effects of neuromuscular blocking drugs on viability of human umbilical vein endothelial cells (HUVECs)(Sage Publications Ltd, 2020) Dogan, Sevil Ceyhan; Polat, Zubeyde Akin; Deren, Serpil; Yayci, Saliha Feyza; Cetin, AliObjective This study aimed to investigate the effects of neuromuscular blocking drugs on the viability of human umbilical vein endothelial cells (HUVECs) and to investigate whether they cause vascular complications due to cell proliferation. Methods HUVECs were cultivated with 5% CO(2)at 37 degrees C in a predefined supplemented medium over 7 days until confluence of cell monolayers. Assays were conducted during the exponential growth phase. Suxamethonium chloride, vecuronium bromide, atracurium besylate, and rocuronium bromide were used at concentrations of 10(-5), 10(-6), and 10(-7)M in proliferation assays in which cells were incubated with these drugs for 24, 48, and 72 hours. All experiments were performed in four replicates. Results The neuromuscular blocking drugs used had comparable effects on the survivability of HUVECs. Overall, no significant difference was observed in the survivability of HUVECs in a dose-dependent manner after exposure to the study drugs. However, some significant differences in the viability of HUVECs were found among the different measurement times. Conclusions The findings of the current study support the safety of the studied neuromuscular blocking drugs in clinically relevant concentrations regarding their effects on endothelial cell proliferation.Öğe Evaluation of allergic rhinitis with nasal symptoms and nasal mucociliary clearance in patients with fibromyalgia syndrome(IOS PRESS, 2018) Dogan, Sevil Ceyhan; Karadag, Ahmet; Durmus, Kasim; Sahin, Ozlem; Altuntas, Emine ElifBACKROUND: The exact etiopathogenesis of fibromyalgia syndrome (FM) is still unclear but the pathogenesis of FM is associated with neurogenic inflammation. Allergic rhinitis (AR) is a common inflammatory and immunological disease of the nasal mucosa. As a result, it is known that neurogenic inflammation has a role in the pathophysiology of both FM and AR. OBJECTIVE: The aim of this study was to evaluate AR and nasal allergic inflammation using nasal mucociliary clearance time (NMC) in FM patients. METHODS: Forty-five FM patients and fifty healthy controls were included in the study. In both groups, AR was evaluated by total nasal symptom scoring (TNSS) and NMC was measured using saccharine transit time test (STT). RESULTS: TNSS was positive in 9 patients (20%) in the FM group and no positivity in the control group. In FM group, the mean value of TNSS was higher than that of the control group (p = 0.0001). The average value of STT of FM patients was statistically significantly longer when compared to the control group (p = 0.0001). CONCLUSION: The results we obtained suggest that there is a high possibility of coexistence of FM and AR. As a result, the coexistence of AR and FM cannot be denied but we believe that comprehensive clinical studies should be conducted on this subject.Öğe In Urban Areas of Sivas City The Determination of Bone Mineral Density Reference Values of Healthy Women who Admitted to Cumhuriyet University Hospital Physical Medicine and Rehabilitation Outpatient Clinic(CLINICAL & EXPER RHEUMATOLOGY, 2014) Tunc, Gokay; Dogan, Sevil Ceyhan; Hizmetli, Sami; Hayta, Emrullah; Cengiz, Ahmet Kivanc…Öğe Pulse Steroid Therapy Induced Multifocal Osteonecrosis(AVES, 2014) Dogan, Sevil Ceyhan; Elden, Hasan; Hayta, Emrullah; Guler, Emel; Salk, Ismail…
