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Öğe Assessment of Joint Inflammation By Ultrasonography (US) in Patients with Rheumatoid Arthritis (RA) in Clinical Remission(CLINICAL & EXPER RHEUMATOLOGY, 2014) Ozer, Pinar Kaplan; Sahin, Ozlem; Ozer, Zafer; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Kaptanoglu, Ece…Öğe Association Between Familial Mediterranean Fever and Cachexia in Females(Turkish League Against Rheumatism, 2020) Durmaz, Yunus; Ilhanli, Ilker; Cengiz, Ahmet Kivanc; Kaptanoglu, Ece; Ozkan Hasbek, Zekiye; Hizmetli, SamiObjectives: This study aims to investigate the association between familial Mediterranean fever (FMF) and cachexia in females. Patients and methods: The study included 32 female FMF patients (median age 27.50 years; range, 18 to 50 years) and 30 female healthy controls (median age 32 years; range, 18 to 50 years). Patients were classified according to Tel-Hashomer criteria. Circumference of arm, waist, and thigh was recorded. Short form 36 (SF-36) and Multidimensional Assessment of Fatigue (MAF) scale were applied. Composition of the body was measured with dual X-ray absorption. Muscle strength was measured with an isokinetic dynamometer, and strength of hand grip was measured from dominant hand with a hand dynamometer. C-reactive protein, erythrocyte sedimentation rate, fibrinogen and serum creatinine kinase (CK) levels were recorded. Results: Body mass index was significantly higher in controls. Twelve patients and one control had cachexia. CK level was significantly higher in patients than controls. Mass of muscle without fat was significantly higher in patients than controls. Peak torque values of extension and flexion at the velocity of 60 degrees/second [Newton meter (Nm)], and value of total work during extension at the velocity of 240 degrees/second (Nm) in isokinetic measures were significantly higher in controls. MAF score was significantly higher in patients with cachexia than patients without cachexia where the subscale scores of SF-36, except the vitality score, were significantly lower in patients with cachexia. However, Tel-Hashomer score was significantly higher in patients with cachexia. Conclusion: This study pointed at a significant association between cachexia and FMF in females. Muscle endurance was not affected in FMF patients with cachexia; however, decreased muscle strength, impaired quality of life and increased fatigue were observed in these patients.Öğe Diffuse Alveolar Hemorrhage: A Life-Threatening Complication of Systemic Lupus Erythematosus(CLINICAL & EXPER RHEUMATOLOGY, 2014) Cengiz, Ahmet Kivanc; Durmaz, Yunus; Dinler, Mustafa; Dogan, Sevil Ceyhan; Hayta, Emrullah; Akin, Recep; Gumus, Cesur; Kaptanoglu, Ece; Hizmetli, Sami…Öğe Disease Activity, Fatigue and Quality of Life in Patients with Coexisting Ankylosing Spondylitis and Familial Mediterranean Fever(CLINICAL & EXPER RHEUMATOLOGY, 2014) Kaptanoglu, Ece; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Hayta, Emrullah; Dogan, Sevil Ceyhan; Hizmetli, Sami…Öğe Does Mean Platelet Volume Really Reflect Disease Activity in Rheumatoid Arthritis?(CLINICAL & EXPER RHEUMATOLOGY, 2014) Hizmetli, Sami; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Hayta, Emrullah; Dogan, Sevil Ceyhan; Kaptanoglu, Ece…Öğe Evaluation of hepatitis serology and frequency of viral reactivation in patients with inflammatory arthritis receiving biologic agents: a multicenter observational study(Springer Heidelberg, 2023) Capkin, Erhan; Yazici, Ali; Karkucak, Murat; Durmaz, Yunus; Toprak, Murat; Ataman, Sebnem; Sahin, NilayTo evaluate of hepatitis serology and reactivation frequency in patients with rheumatic disease receiving biologic agents. Our study included patients with inflammatory rheumatic diseases from 23 centers, who were followed up with biological therapy. Demographic and clinical characteristics of the patients, duration of drug use and hepatitis serology and the state of viral reactivation were analyzed. A total of 4060 patients, 2095 being males, were included in our study. Of the patients, 2463 had Ankylosing Spondylitis (AS), 1154 had Rheumatoid Arthritis (RA), 325 had Psoriatic Arthritis (PsA), and 118 had other inflammatory rheumatic diseases. When the viral serology of the patients was evaluated, 79 patients (2%) who were identified as HBs Ag positive, 486 (12%) patients who were HBs Ag negative and anti-HBc IgG positive and 20 patients (0.5%) who were anti-HCV positive. When evaluated on a disease-by-disease basis, the rate of HBsAg was found to be 2.5% in RA, 2% in AS and 0.9% in PsA. Viral reactivation was detected in 13 patients while receiving biologic agents. HBs Ag was positive in nine patients with reactivation and negative in four patients. Anti-HBc IgG, however, was positive. Six of these patients had AS, four had RA, and three had PsA. The development of hepatitis reactivation in 11.4% of HBs Ag positive patients and 0.82% of anti-HBc IgG positive patients due to the use of biologic agents is an important problem for this group of patients. Antiviral prophylaxis is recommended to be started especially in patients who are HBs Ag positive and who are using biologic agents due to viral reactivation. Therefore, it is important to carry out hepatitis screenings before biologic agent treatment and to carefully evaluate the vaccination and prophylaxis requirements.Öğe Evaluation of ovarian reserve using anti-mullerian hormone and antral follicle count in Sjogren's syndrome: Preliminary study(WILEY, 2017) Karakus, Savas; Sahin, Ali; Durmaz, Yunus; Aydin, Huseyin; Yildiz, Caglar; Akkar, Ozlem; Dogan, Mansur; Cengiz, Ahmet; Cetin, Meral; Cetin, AliAimThe aim of this study was to determine ovarian reserve status using anti-mullerian hormone (AMH) level and antral follicle count (AFC) in patients with Sjogren's syndrome (SS). MethodsTwenty-four women with SS diagnosed according to the classification criteria proposed by the American-European Consensus Group and 25 healthy women as controls were enrolled in this study. Ovarian reserve was assessed on clinical findings, AFC, and serum AMH and reproductive hormone levels. ResultsCompared with the healthy controls, in the SS patients, the duration of menstrual cycle was significantly shorter (P = 0.043); serum AMH (P = 0.001) and AFC (P = 0.001) were significantly lower, and serum luteinizing hormone (LH) was significantly higher (P = 0.019). The right (P = 0.555) and left ovarian (P = 0.386) volumes were also lower but this did not reach statistical significance. Serum follicle-stimulating hormone (P = 0.327), estradiol (P = 0.241), and prolactin (P = 0.55) were similar between the two groups. ConclusionsOvarian reserve may be reduced in SS patients. For the assessment of ovarian reserve, serum AMH and ovarian AFC with serum LH may be useful. Further studies with long-term follow-up are required to determine the course of ovarian reserve abnormalities and best possible biomarkers of reduced ovarian reserve in SS patients.Öğe Evaluation of Ovarian Reserve with Anti-Mullerian Hormone in Familial Mediterranean Fever(HINDAWI LTD, 2015) Sahin, Ali; Karakus, Savag; Durmaz, Yunus; Yildiz, Caglar; Aydin, Huseyin; Cengiz, Ahmet Kivanc; Guler, DuyguObjective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Mullerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters. Methods. Thirty-three AF-FMF patients aging 18-45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd-4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes. Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P = 0.018). There was no statistically significant difference in median AMH levels between E148 Qmutation positive patients and the negative ones (P = 0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P = 0.868). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (P = 0.868). We realized that there was no difference in comparisons between ovarian volumes, number of follicles, and AMH levels ovarian reserves when compared with FMF patients and healthy individuals. Conclusions. Ovarian reserves of FMF pateints were similar to those of healthy subjects according to AMH. However, AMH levels were lower in FMF patients with M694V mutation.Öğe Ovarian reserve is preserved in Behcet's disease(WILEY, 2017) Sahin, Ali; Karakus, Savas; Durmaz, Yunus; Yildiz, Caglar; Aydin, Huseyin; Cengiz, Ahmet KivancAimTo compare ovarian reserve with anti-mullerian hormone (AMH) levels, antral follicle counts (AFCs) and ovarian volume in patients with Behcet's disease (BD) and healthy subjects. MethodThis study included 35 women with BD (mean age: 34.45.3years) and 35 healthy controls (mean age: 34.16.0years). Venous blood samples collected from groups on menstrual cycle Days 2-4 were analyzed using the enzyme-linked immunosorbent assay to measure follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E-2), prolactin (PRL) and AMH levels. The AFCs and ovarian volumes were estimated by ultrasonography on the same day. The body mass index (BMI), duration and severity of the disease, medications, and number of children were recorded. ResultsThere was no statistically significant difference in the mean age, median gravida/para/abortus and the number of live births and mean BMI between the patient and control groups (P>0.05). No statistically significant difference in the median FSH, LH, E2, PRL levels, right and left ovarian volumes, and right and left ovarian AFCs was observed among the patients and the controls (P>0.05). There was no statistically significant difference in the mean AMH levels (P=0.468). Bonferroni correction showed no statistically significant correlation between AMH levels and age, BMI, FSH, LH, E2, PRL levels, right and left ovarian AFCs, right and left ovarian volume (P>0.025) among the controls and the patients. ConclusionOur study results suggest that ovarian reserve is preserved in patients with BD. In addition, AMH levels of the BD patients were similar to levels of healthy subjects.Öğe Prevalence of juvenile fibromyalgia syndrome in an urban population of Turkish adolescents: impact on depressive symptoms, quality of life and school performance(CHINESE MEDICAL ASSOC, 2013) Durmaz, Yunus; Alayli, Gamze; Canbaz, Sevgi; Zahiroglu, Yeliz; Bilgici, Ayhan; Ilhanli, Ilker; Kuru, OmerBackground Juvenile Fibromyalgia Syndrome (JFMS) is a chronic health condition characterized by widespread musculoskeletal pain and multiple tender points (TP). The objective of this study was to determine the prevalence of JFMS in the urban population of Samsun and to determine the impact of JFMS on depression symptoms, school performance and quality of life (QOL). Methods A cross-sectional study was conducted in 1109 children (mean age (14.8+/-2.0) years old). A questionnaire was applied to the children and a medical examination including TP was performed. Yunus and Masi's criteria were used for diagnosis of JFMS. The children with JFMS were compared with an age and sex matched non-JFMS group. Depression was assessed with Children's Depression Inventory (CDI) and QOL was evaluated with Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results Sixty-one (5.5%) (13 boys and 48 girls) of 1109 children met the diagnostic criteria of JFMS. While PedsQL scores of children with JFMS were lower than the non-JFMS group for physical, emotional, social, school functioning and total score (P=0.001), CDI total score was higher in the JFMS group than in the non-JFMS group (P=0.001). The JFMS group reported more school absences (P=0.001) and the average school grade was lower in the JFMS group than in the non-JFMS group (P=0.03). Conclusion The prevalence of JFMS is high in school age children. Since JFMS is a common problem of childhood, early diagnosis and identification of the disorder and more comprehensive and successful treatment approaches with appropriate psychological assistance may prevent more complex and severe problems in adulthood.Öğe Routine Assessment Of Patient Index Data 3 In Fibromyalgia: A Rapid and Reliable Instrument For Evaluating Disease Severity?(WILEY-BLACKWELL, 2013) Kaptanoglu, Ece; Sahin, Ozlem; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Hizmetli, Sami…Öğe Ultrasound-defined remission for good functional status in rheumatoid arthritis(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2017) Ozer, Pinar Kaplan; Sahin, Ozlem; Ozer, Zafer; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Kaptanoglu, EceBackground & objectives: It has been shown that joint damage due to subclinical synovitis progresses despite apparent clinical remission in rheumatoid arthritis (RA). Hence, finding more objective methods to investigate subclinical synovitis has become a current issue. Ultrasonography (US) has been among the most investigated methods. This study was conducted to detect whether there was subclinical inflammation in RA patients in clinical remission by power Doppler ultrasonography (PDUS) and to evaluate the effects of this inflammation on upper extremity function. Methods: Forty five RA patients fulfilled the remission criteria of disease activity score 28 using erythrocyte sedimentation rate (DAS28-ESR), were enrolled in the study. Bilateral wrist, 2nd and 3th metacarpophalangeal and proximal interphalangeal joints and 2nd and 5th metatarsophalangeal joints were examined by PDUS. Upper extremity function was assessed with Michigan Hand Outcomes Questionnaire (MHQ) and handgrip strength. The pain was evaluated by visual analogue scale (VAS). Results: In 29 of 45 RA patients in clinical remission, synovitis was detected by PDUS at least in one joint. VAS and DAS28-ESR scores were significantly lower and total MHQ, some subgroup scores of MHQ (overall hand function, activity of daily living and work performance) and grip strength of the dominant hand were higher in patients with PD signal negativity. Interpretation & conclusions: PDUS showed a crucial role in determining the subclinical synovitis. Subclinical synovitis negatively affects the upper extremity function. Ultrasound-defined remission may be considered for good functional status and real remission in patients with RA.
