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Öğe An Examination of Paraoxonase 1 Gene Polymorphism in Cases of Chronic Otitis Media(Dergipark Akad, 2020) Durmus, Kasim; Kurtulgan, Hande Kucuk; Bora, Adem; Yildirim, Malik Ejder; Altuntas, Emine ElifObjective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation which lies at the heart of the disorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene. Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department of Cumhuriyet University and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism. Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05). Conclusion: The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group may indicate a protective effect in COM.Öğe Are the sinonasal outcome test and nasal obstruction symptom evaluation scale questionnaires suitable for assessing the quality of life after septorhinoplasty? A prospective case-control study(2023) Bora, Adem; Durmus, Kasim; Cam, Selim; Altuntas, Emine ElifIn the evaluation after septorhinoplasty (SRP), the surgeon's plan and the patient's expectations may not always be realised. Therefore, in our prospective case- control study, we aimed to investigate whether the Sinonasal Outcome Test (SNOT-22) and Nasal Obstruction Symptom Evaluation Scales (NOSE), which have been validated in different patient populations in Turkish, are appropriate for evaluating SRP cases and their relationship with each other. Preoperative and postoperative data of NOSE and SNOT-22 questionnaires of 125 cases diagnosed with traumatic septum deviation and external nasal deformity and decided to be operated were analyzed. It was calculated that the SNOT-22 score of those with high/low preoperative NOSE scores was also high/low with a 53.6% probability and that the SNOT-22 score of those with high/low postoperative NOSE scores was also high/low with a 69.9% probability, indicating a positive and high-level relationship between postoperative NOSE and SNOT-22 measurements. When the answers given to all questions in SNOT-22 were evaluated separately, it was observed that the most disturbing symptoms of the cases were nasal obstruction at 78.4% and the need to blow the nose at 46.4% in the preoperative period, and nasal obstruction with 64.8% and the need to blow nose with 37.6% in the postoperative period. The most dramatic changes in the answers to SNOT-22 questions were observed in the patient's feelings of frustrated/restless/irritable, sadness, and embrassed. SNOT-22 and NOSE questionnaires can be used interchangeably to evaluate the functional status of patients undergoing SRP surgery.Öğe Assessing the Efficiency of Intranasal Steroid Treatment in Cases with Eustachian Dysfunction Via the Turkish Version of Eustachian Tube Dysfunction Questionnaire-7(Wolters Kluwer Medknow Publications, 2020) Bora, Adem; Durmus, Kasim; Demirkiran, Berat Baturay; Aslan, Yasin; Altuntas, Emine ElifAim: The aim of this study was to evaluate the efficiency of the treatment in the cases, who were diagnosed with Eustachian tube dysfunction (ETD) via history, physical examination, and tympanometry and for whom intranasal steroid treatment was planned to be used before surgical treatment options, by using Eustachian Tube Dysfunction Questionnaire (ETDQ)-7. Materials and Methods: Fifty-five cases, who applied to the otorhinolaryngology outpatient clinic due to the complaints suggesting Eustachian dysfunction such as aural fullness and pressure sensation and for whom the diagnosis of Eustachian dysfunction was considered due to the results of the examination, history, and physical examination, were included in the study. The 3rd and 6th weeks of intranasal steroid treatment ETDQ-7 scores were recorded. Results: ETDQ-7 mean scores of the cases were 2.72 +/- 0.97 at the time of initial diagnosis (minimum-maximum: 1-4.71), 2.31 +/- 0.85 in the 3rd week of the treatment (minimum-maximum: 1-5), and 2.12 +/- 0.78 (minimum-maximum: 1-4, 14) in the 6th week. A statistically significant difference was observed when statistically assessing the ETDQ-7 scores determined at the time of diagnosis and in the 3rd and 6th weeks of the treatment (P < 0.001). When ETDQ-7 scores were assessed based on gender in assessment time, there was a statistically significant difference in the assessment conducted in the 3rd week (P < 0.05; P = 0.039). Conclusion: It is believed that the current study is the first study that evaluates the efficiency of intranasal corticosteroid treatment, which is frequently used by the doctors in daily practice in pharmacotherapy in the cases with ETD from young adult and adult age groups, on the symptoms via ETDQ-7. In addition, the results of the present study indicated that intranasal steroid treatment in early periods caused a significant recovery in the symptoms, however this recovery also reached a plateau after the treatment.Öğe Assessment of Hematological Factors Involved in Development and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss(LIPPINCOTT WILLIAMS & WILKINS, 2016) Durmus, Kasim; Terzi, Hatice; Karatas, Tuba Dogan; Dogan, Mansur; Uysal, Ismail Onder; Sencan, Mehmet; Altuntas, Emine ElifObjective: The aim of this study was to investigate the possible effects of routine hematological parameters on the development and prognosis of idiopathic sudden sensorineural hearing loss in patients applying to our clinic. Study design: A retrospective clinical study. Setting One academic health center from 2008 to 2014. Patients and intervention: One hundred forty patients with sudden hearing loss and 132 healthy controls were included in the present study. Results: Patients having idiopathic sudden sensorineural hearing loss were divided into 2 subgroups based on whether they recovered (complete, partial, and slight recovery) (Group 1; n = 83, 59.3%) or not (Group 2; n = 57, 40.7%) during the follow-up term. Group 1, Group 2, and the controls differed statistically significantly in terms of neutrophil-to-lymphocyte ratio (P = 0.001), platelet-to-lymphocyte ratio (P = 0.001), lymphocytes%(P = 0.001), mean corpuscular hemoglobin (P = 0.019), mean corpuscular hemoglobin concentration (P = 0.015), platelet (P = 0.001), mean platelet volume (P = 0.001), platelet distribution width (P = 0.009), and glucose (P = 0.001). The study groups and the controls did not have any significant difference in terms of other laboratory parameters affecting the prognosis of Idiopathic sudden sensorineural hearing loss. Conclusions: The results the authors obtained showed that laboratory parameters such as lymphocyte, lymphocyte%, platelet, mean platelet volume, platelet distribution width, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration may be indicative for prognosis and treatment success in groups of patients suffering idiopathic sudden sensorineural hearing loss in whose etiology many factors play a role.Öğe Can local administration of humic acid shorten recovery time of mandibular fractures? Experimental study(DEOMED PUBL, ISTANBUL, 2017) Durmus, Kasim; Bora, Adem; Dogan, Mehtap; Ozer, Hatice; Tuncer, Ersin; Altuntas, Emine ElifObjective: The aim of the present pilot study was to evaluate the effects of a single local dose administration of humic acid on healing of subcondylar mandibular fractures in rats. Methods: In this study, a randomized experimental protocol was used. The study was conducted with 16 male Wistar-albino rats that were 16-18 weeks old. The rats (n=16) were randomly divided into two groups: Group HA received humic acid (0.3 cc/site, n=8) and Group C received no additional medical administration (control group, n=8). A full-thickness surgical osteotomy was performed in the subcondylar area. A single dose of humic acid (0.3 cc/site) was administered locally by spraying on the bone surfaces of the fracture line. Mandible was dissected on postoperative day 21. Then, fractured hemimandibles were obtained for histopathological examination. Results: The median score of bone fracture healing was 7.16 (range: 7 to 8) in the Group HA and 7.50 (range: 7 to 8) in the Group C. When the groups were compared in terms of bone healing scores, there was no statistical difference between the Group HA and the Group C (p>0.05). Conclusion: Results of this study showed that local administration of humic acid was not efficient for healing of bone fractures. However, we are of the opinion that it is required to conduct more comprehensive studies, including humic acid's different concentrations and administration manners, evaluating the effects of humic acid on tissue both histopathologically and in terms of inflammatory and proinflammatory cytokine levels.Öğe Comparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study(Springer, 2023) Bora, Adem; Durmus, Kasim; Inan, Zeynep D. Sahin; Demirkiran, Berat Baturay; Altuntas, Emine E.BackgroundTraumatic tympanic membrane (TM) perforations usually heal spontaneously. The aim of this study was to investigate whether the topical application of Triticum Vulgare (TV) in experimentally induced traumatic TM perforations in the rats has a positive effect on wound healing process.MethodsThe rats were randomly assigned to four experimental groups. Drugs were introduced twice a day for 7 days. On the 7th day, specimens were sent for histological examination.ResultsMean values found in group NC in terms of epithelial regeneration mean scores are as follows: fibroblast and collagen density, neovascularization, and density of inflammation cells were lower than all groups (p < 0.05).It was found that reepithelization on the post-perforation 7th day was better in the HO group than the TV group. In terms of the subepithelial fibroblast cells, density of collagen fibers, formation of new veins, and inflammatory cell accumulation, it was observed that the group TV was better than the group HO.ConclusionThis is the first study investigating the potential curative role of TV in an experimental rat model of tympanic membrane perforation. Considering these findings, it is concluded that TV can be more effective than HO on wound healing in TM perforation.Öğe Determination of nasal mucociliary clearance time and nasal symptom in patients with Crimean-Congo hemorrhagic fever(WILEY, 2017) Durmus, Kasim; Engin, Aynur; Karatas, Tuba Dogan; Gozel, Mustafa Gokhan; Altuntas, Emine ElifCrimean-Congo hemorrhagic fever (CCHF) is an important health problem in Turkey. Number of studies on symptoms of ear nose throat system and indicating whether or not the organs are affected in patients with CCHF is limited. The aim of the present study was to investigate whether CCHF infections caused any change in nasal physiology in adult patients or not by using saccharin transit time (STT) and nasal symptom scoring. Twenty subjects with laboratory-confirmed diagnosis of CCHF and 28 healthy control subjects were included in the present study. A saccharin test was used to evaluate nasal mucociliary clearance time (NMCT) and the nasal symptom scoring used in allergic rhinitis was modified and used to examine the symptoms of the patients. The average STT of CCHF and control groups were 472.70 +/- 151.58 and 276.07 +/- 89.65sec, respectively. The difference between them was statistically significant (P=0.00, P<0.05). When those in CCHF group were classified according to timing of the test, STT average of those undergoing the test on the 1st-3rd days (n=10) and 4th-6th (n=10) days was 547.00 +/- 154.37 and 398.40 +/- 111.39sec, respectively. The difference between them was statistically significant (P=0.024; P<0.05). The results of the present study showed that NMCT prolonged in adult patients with CCHF compared to those in the control group despite the fact that it was within normal limits. For these reasons, clinicians should follow-up CCHF patients more closely for respiratory tract diseases and sinonasal and middle ear infections. J. Med. Virol. 89:960-965, 2017. (c) 2016 Wiley Periodicals, Inc.Öğe Do Mean Values of the Peak Inspiratory Nasal Flowmeter Vary According to the Severity, Direction and Type of Nasal Septum Deviation?(Springer India, 2022) Bora, Adem; Aslan, Yasin; Durmus, Kasim; Demirkiran, Berat Baturay; Altuntas, Emine ElifThe aim is to investigate the contribution of the PNIF test in daily clinical practices in the objective evaluation of the early postoperative functional results of septoplasty and the effect of the severity, direction, and type of nasal septum deviation on mean PNIF values. Nasal septum deviation (NSDs) of the cases were grouped according to the Mladina classification and the severity of NSDs. An objective evaluation of the nasal airway was conducted via a peak flowmeter device in the preoperative and postoperative first month. When examining the mean PNIF values according to genders, it was observed that the values determined in male cases in the preoperative and postoperative period were higher. In the intragroup evaluation performed according the Mladina classification, a statistically significant increase was observed in the preoperative and postoperative PNIF values of the cases in Types 1-4. In the intragroup evaluation performed according to the severity of NSD, there was a significant increase in the preoperative and postoperative PNIF values of the mild and moderate cases. When comparing the preoperative and postoperative PNIF values of the groups in terms of the severity of NSD, it was observed that there was a significant difference. The PNIF can be used in routine clinical practices to evaluate the septoplasty results objectively. In the evaluation of functional results, the change in the mean PNIF values may also vary according to the direction and severity of septum deviation and the Mladina classification other than age, gender and ethnic origin.Öğe Evaluating the frequency of anatomical variations of the sinonasal region in pediatric and adult age groups according to gender: computed tomography findings of 1532 cases(Springer, 2021) Bora, Adem; Koc, Merve; Durmus, Kasim; Altuntas, Emine ElifBackground: The aim of the present study was to evaluate retrospectively the frequency of anatomical variations in sinonasal region, which were frequently seen in our cases, for whom coronal section paranasal computed tomography imaging (CPNCT) was taken, as well as the correlation of these variations with age and gender and correlations of identified anatomical variations with one another. In the study, CBCT scans of a total of 1532 (825 males and 707 females) cases were evaluated in order to determine the prevalence of anatomical variations of the nasal cavity and paranasal sinuses. All the images were taken by a multi-detector CT device (Aquilion, Toshiba medical system, Tokyo, Japan). Results: Most frequently detected three anatomical variations were septum deviation (79.7%), concha bullosa (40.9%), and ethmoid bulla (21.0%) according to the frequency order. When the frequency of anatomical variations was evaluated according to gender, septum deviation, concha bullosa, and anterior clinoid process pneumatization were more frequently observed in males and Onodi cell in females (p < 0.05). When the relationships of the anatomical variations with one another were evaluated, it was found that the possibility of the presence of concha bullosa in the septum deviation cases and the presence of ethmoid bulla in the cases with Haller cell septum were higher (p < 0.05). In terms of the anatomical variations that were evaluated by taking age as the independent variable, a statistically significant difference was observed in pterygoid process pneumatization, Haller cell, pneumatized crista galli, ethmoid bulla, and paradoxical middle concha between the adult and children age groups (p < 0.05). Conclusion: In terms of the frequency of occurrence to various sinonasal region variations, statistically significant differences were observed between both genders and age groups. The correlations of the detected variations with each other were also remarkable. Consequently, it is believed that comprehensive studies and serious objective evaluations evaluating the change of frequency of anatomical variations according to age and gender besides their correlation with each other are required.Öğe Evaluation of allergic rhinitis with nasal symptoms and nasal mucociliary clearance in patients with fibromyalgia syndrome(IOS PRESS, 2018) Dogan, Sevil Ceyhan; Karadag, Ahmet; Durmus, Kasim; Sahin, Ozlem; Altuntas, Emine ElifBACKROUND: The exact etiopathogenesis of fibromyalgia syndrome (FM) is still unclear but the pathogenesis of FM is associated with neurogenic inflammation. Allergic rhinitis (AR) is a common inflammatory and immunological disease of the nasal mucosa. As a result, it is known that neurogenic inflammation has a role in the pathophysiology of both FM and AR. OBJECTIVE: The aim of this study was to evaluate AR and nasal allergic inflammation using nasal mucociliary clearance time (NMC) in FM patients. METHODS: Forty-five FM patients and fifty healthy controls were included in the study. In both groups, AR was evaluated by total nasal symptom scoring (TNSS) and NMC was measured using saccharine transit time test (STT). RESULTS: TNSS was positive in 9 patients (20%) in the FM group and no positivity in the control group. In FM group, the mean value of TNSS was higher than that of the control group (p = 0.0001). The average value of STT of FM patients was statistically significantly longer when compared to the control group (p = 0.0001). CONCLUSION: The results we obtained suggest that there is a high possibility of coexistence of FM and AR. As a result, the coexistence of AR and FM cannot be denied but we believe that comprehensive clinical studies should be conducted on this subject.Öğe Evaluation of hearing in patients with familial Mediterranean fever(SPRINGER, 2013) Polat, Kerem; Uysal, Ismail Onder; Senel, Soner; Guler, Cemil; Durmus, Kasim; Muderris, SuphiFamilial Mediterranean fever (FMF) is a common and well-understood hereditary periodic fever syndrome. Hereditary periodic fever syndromes include a group of multisystem diseases characterized by recurrent fever attacks with inflammation affecting skin, joints, and some other tissues. These are FMF, tumor necrosis factor receptor, tumor necrosis factor receptor associated periodic syndrome, hyperimmunglobulinemia D syndrome, Muckle-Wells syndrome, and familial cold urticaria. In literature, it is determined that some of these diseases cause hearing loss. In light of the foregoing, we thought that FMF patients may have the same type of subclinical hearing loss and, therefore, the hearing ability of these patients was evaluated with otoacoustic emission and high frequency audiometry tests.Öğe Examination of ototoxicity induced by imatinib, being a tyrosine kinase inhibitor: An experimental study(Wolters Kluwer Medknow Publications, 2020) Altuntas, Emine Elif; Durmus, Kasim; Bora, Adem; Turgut, Nergiz Hacer; Terzi, Hatice; Kutluhan, AhmetObjectives: Two rats were excluded from the study. Because otitis media developing one rat in Group C (7th dayof the experiment) and bleeding-related death one rat in Group I-50 (14th day of the experiment). While the side effects of imatinib are investigated in the literature, it is remarkable that the case reports suggesting an ototoxic side effect also take place among the publications. The aim of this study was to investigate whether or not imatinib has any ototoxic effect on rats via auditory brainstem response (ABR) responses. Materials and Methods: Rats were divided into three groups as Group C (0.25 mL/kg/day), Group I-30 (30 mg/kg/day), and Group I-50 (50 mg/kg/day). In the ABR record, hearing threshold, latency, amplitude, and interpeak latency values on test days were recorded and assessed. Results: In the assessment made in terms of mean V Wave latency within the group, a difference was determined at all stimulus intensities at 8 kHz in Group I-50 (P < 0.05). In the within-group assessment performed in terms of mean Wave III latency, there were differences in Groups I-30 and I-50 (P < 0.05). In the within-group assessment performed in terms of I-III interpeak latency mean values, there was a difference at 4 kHz and 70 dB in Group I-30 (P < 0.05). In the within-group assessment in terms of mean III-V interpeak latency values, the difference between the groups was significant on the 7th day at 6 kHz and 50 dB (P = 0.044) and on the 14th day at 8 kHz and 70 dB (P = 0.036). In the within-group assessment in terms of Wave I amplitude mean values, the change in the amplitude values at 4 kHz (P = 0.003) and 6 kHz (P = 0.018) in Group I-50 was significant. Conclusion: It was observed that imatinib application caused elongation in latency and interpeak latency values and changes in amplitude values. These differences were not enough to state that imatinib is having an ototoxic side effect.Öğe Examining the Early Period Effect of Nilotinib on Hearing: An Experimental Study(Aves, 2020) Bora, Adem; Durmus, Kasim; Terzi, Hatice; Altuntas, Emine ElifOBJECTIVES: Nilotinib has very few side effects, including neutropenia, thrombocytopenia, cardiotoxicity, high pancreatic lipase, ischemia, and vascular occlusion. We aimed to investigate whether short-term administration of nilotinib had ototoxic effects in rats. MATERIALS and METHODS: Wistar-albino rats were categorized into three groups: group C (administered 0.25 mL of distilled water, no nilotinib), group N-20 (administered 20 mg/kg/day of nilotinib dissolved in distilled water), and group N-50 (administered 50 mg/kg/day of nilotinib dissolved in distilled water). A single dose was administered once per day, at the same hour, over 21 days. Auditory brainstem response (ABR) thresholds were recorded on day 0 and day 21. RESULTS: There were no changes in ABR threshold values obtained on day 0 (baseline) and on day 21 across all three groups. A statistically significant difference was not found in terms of the mean latency of waves V and III, interpeak latency values of waves III-V, and amplitude ratios of waves III-V and V/Va at baseline and on day 21 across all three groups on within-group or between-group evaluation. CONCLUSION: Consequently, further studies are needed that involve different drug doses, prolonged administration of drugs, as well as distortion otoacoustic emission test for the evaluation of cochlear activation and ABR. Furthermore, histopathological studies are needed to indicate whether the cochlea is affected to prove that nilotinib has definitively no ototoxic effect.Öğe Feasibility and Clinical Outcomes of Transoral Robotic Surgery and Transoral Robot-Assisted Carbon Dioxide Laser for Hypopharyngeal Carcinoma(LIPPINCOTT WILLIAMS & WILKINS, 2015) Durmus, Kasim; Kucur, Cuneyt; Uysal, Ismail O.; Dziegielewski, Peter T.; Ozer, EnverTransoral robotic surgery (TORS) has been used as a novel procedure for squamous cell carcinoma of the laryngopharyngeal cancers with encouraging outcomes. The safety, feasibility, and efficacy regarding this approach have previously been demonstrated. There are several studies proposing the benefit of combining TORS with carbon dioxide (CO2) laser in resecting upper aerodigestive tract tumors. We report a series of patients with hypopharyngeal carcinoma treated with primary TORS with or without the flexible carbon dioxide (CO2) laser. All TORS resections were completed without any intraoperative complication. None required conversion to an open procedure. Clinical outcomes in this preliminary analysis indicate that magnified view, 3D visualization with the wristed instruments and tremor reduction technology of robotic experience, allow en bloc resection of early stage hypopharyngeal cancers. TORS with CO2 laser is a promising, minimally invasive surgical alternative for the treatment of hypopharyngeal tumors with comparable oncologic outcomes.Öğe Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study(WROCLAW MEDICAL UNIV, 2017) Durmus, Kasim; Turgut, Nergiz Hacer; Dogan, Mehtap; Tuncer, Ersin; Ozer, Hatice; Altuntas, Emine Elif; Akyol, MelihBackground. Mandibular fractures are the most common facial fractures. They can be treated by conservative techniques or by surgery. The authors hypothesized that the application of a single local dose of strontium chloride would accelerate the healing of subcondylar mandibular fractures, shorten the recovery time and prevent complications. Objectives. The aim of the present pilot study was to evaluate the effects of a single local dose of strontium chloride on the healing of subcondylar mandibular fractures in rats. Material and methods. This randomized experimental study was carried out on 24 male Wistar albino rats. The rats were randomly divided into 3 groups: experimental group 1, receiving 3% strontium chloride; experimental group 2, receiving 5% strontium chloride; and the control group. A full thickness surgical osteotomy was created in the subcondylar area. A single dose of strontium solution (0.3 cc/site) was administered locally by injection on the bone surfaces of the fracture line created. Nothing was administered to the control group. The mandibles were dissected on postoperative day 21. The fractured hemimandibles were submitted to histopathological examination. Results. The median bone fracture healing score was 9 (range: 7-9) in experimental group 1; 8 (range: 7-10) in experimental group 2; and 7.50 (range: 7-8) in the control group. When the groups were compared in terms of bone healing scores, there was a statistically significant difference between experimental group 1 and the control group (p < 0.05). Conclusions. This study is the first to show that local strontium may have positive effects on the healing of subcondylar mandibular fractures. In the authors' opinion, 3% strontium was beneficial for accelerating facial skeleton consolidation and bone regeneration in rat subcondylar mandibular fractures. This treatment procedure may be combined with closed fracture treatment or a conservative approach.Öğe Inflammation-Based Prognostic Factor in Different Forms of Chronic Suppurative Otitis Media(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2017) Terzi, Hatice; Durmus, Kasim; Karatas, Tuba Dogan; Sencan, Mehmet; Altuntas, Emine ElifObjective: The aim of the present study was to investigate whether several blood tests could be used as inflammatory indicators in active or inactive chronic suppurative otitis media patients. Methods: Between 2007 to 2014, this study was conducted in 358 consecutive patients having chronic suppurative otitis media were included in the present retrospective clinical study. Patients were divided into two groups based on the clinical history, otologic examination, audiological evaluation and intraoperative finding. Group 1 consisted of 163 patients who had inactive chronic suppurative otitis media, while group 2 was comprised of 195 patients who had active chronic suppurative otitis media and cholesteatomatous otitis media. Results: With respect to the neutrophil-lymphocyte ratio (P = 0.001), the platelet-lymphocyte ratio (P = 0.001), absolute lymphocytes (P = 0.001), absolute neutrophil (P = 0.001), platelet (P = 0,001) and white blood cell (P = 0,02), Group 1 and Group 2 showed statistically significant differences. Conclusion: The results we obtained showed that markers such as neutrophil-lymphocyte ratio, the platelet-lymphocyte ratio, platelet, absolute neutrophil and white blood cell could be used as guide in evaluation of the prognosis of chronic suppurative otitis media.Öğe Investigating dizziness symptom in adult cases with Crimean-Congo hemorrhagic fever using various scales(Springer, 2021) Bora, Adem; Buyuktuna, Seyit Ali; Durmus, Kasim; Demirkiran, Berat Baturay; Aslan, Yasin; Oksuz, Caner; Altuntas, Emine ElifBackground This study was to investigate the frequency of self-reported dizziness symptom in cases with Crimean-Congo hemorrhagic fever (CCHF) and the severity of dizziness, if any, by using various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. Results The frequency of dizziness in CCHF cases included in the study was 11.11% and all the cases were involved in the mild category in terms of disease severity. When the results of the scales applied to all of the cases were evaluated in general, it was seen that there was no vertigo or dizziness. Conclusion According to the results of the present study, we consider that multicenter studies with large series investigating pathophysiological mechanisms underlying these clinical symptoms are needed in order to evaluate dizziness symptom and to make definitive interpretations in CCHF disease.Öğe Investigating the Effect of Hypericum Perforatum L. on Hearing in Rats: An Experimental Study(Wolters Kluwer Medknow Publications, 2020) Altuntas, Emine Elif; Bora, Adem; Durmus, Kasim; Kale, Hayati; Kutluhan, AhmetObjectives: Hypericum perforatum L. (HP) is among the oldest used and most comprehensively studied medicinal herbs. Anti-inflammatory activities of different Hypericum extracts on external auditory canal and also in the prevention of tympanic membrane perforation and myringosclerosis were investigated experimentally in the animal model. This study was to investigate whether or not intratympanic injection of H. perforatum L. in the middle ear of the rats causes ototoxicity, via auditory brainstem response (ABR). Materials and Methods: Rats were assigned to three groups as Group C, S, and D. Excessive external auditory canal edema developed in the rats in Group D as of the 5th day and Group D was excluded from the study by considering that ABR records could be affected. Results: A statistically significant difference was observed mean latency values of the wave V and III at the baseline and on the 7th day in Group S (P < 0.05). A significant shortening was calculated in the interpeak mean latency values of the waves III-V at the baseline and on the 7th day in Group S (P < 0.05). A statistically significant difference was observed between the baseline III-V wave interpeak mean latency values in the between-group evaluation on the 7th day (P < 0.05). A statistically significant difference was detected in the mean values of the wave V/Va amplitude ratios at the baseline and on the 7th day in Group S (P < 0.05).In the between-group evaluation, a statistically significant difference was found in the mean values of the wave V/Va amplitude ratios on the 7th day (P < 0.05). Conclusion: The results of the study conducted in accordance with the hypothesis point out that the intratympanic injection of H. perforatum L. may have an ototoxic effect.Öğe Investigating the Healing Effect of Hyperici Oleum and Triticum vulgare on Septal Perforation in Rats A Preliminary Study(Aves, 2023) Bora, Adem; Durmus, Kasim; Inan, Zeynep Deniz Sahin; Aslan, Yasin; Altuntas, Emine ElifObjective: The aim of this study was to investigate histopathologically the possible beneficial effects of hyperici oleum and Triticum vulgare , having anti-inflammatory, antioxidant, and antiproliferative properties, on the healing process of nasal septum perforation experimentally.Methods: Circular perforations of 2 mm diameter were performed at the nasal septum of 32 rats. Intranasal administration of hyperici oleum (HO), Triticum vulgare (TV), and thiocilline (T) was carried out twice a day for 7 days. After the rats were sacrificed at the end of the seventh day, their nasal septum specimens were sent for histological examination. The groups were compared in terms of epithelial regeneration, presence of fibroblasts and inflammatory cells, and capillary density parameters.Results: There was a statistically significant increase in the epithelialization mean scores in groups HO and TV compared to group P. When the groups were examined in terms of inflammation, a statistically significant increase was found in group HO. In terms of the fibroblast scores, a statistically significant increase was seen between group P and groups HO and T. The vascularization mean scores both in group HO and group TV were statistically significant when they were compared with groups C and P.Conclusion: The present study provides clues for preferring the use of TV and HO as a healer for the perforation area in the treatment of septum perforation. Based on the findings, widening the experiment and including additional parameters for understanding the healing mechanism will contribute to the clarification of the healing mechanism and thus to the development of the treatment options.Öğe Is sensorineural hearing loss related with thyroid metabolism disorders(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2015) Karakus, Canan Filiz; Altuntas, Emine Elif; Kilicli, Fatih; Durmus, Kasim; Hasbek, ZekiyeObjectives: In this study, we measured hearing thresholds in patients diagnosed with hyperthyroidism or hypothyroidism with high-frequency audiometry and otoacoustic emission before and after treatment to determine whether hearing losses were cochlear or retrocochlear and whether they would improve with medical therapy. Materials and Methods: This study was conducted on patients diagnosed with hyperthyroidism and hypothyroidism at Cumhuriyet University, Faculty of Medicine, Department of Endocrinology and Metabolism and accepting to participate in the study. We measured the hearing thresholds of the study population during the pretreatment period and in posttreatment euthyroid period. Result: The audiometric findings of patients with hyperthyroidism were better than those of the control group especially at high frequencies. Sensorineural hearing loss was detected in the euthyroid period. We compared the audiometric findings of the patients with hypothyroidism and the controls. We found sensorineural hearing loss in patients with hypothyroidism, especially at low frequencies. Conclusions: The results of this study showed that both hyperthyroidism and hypothyroidism may have an effect on hearing pathway disorders. Medical therapy may lead to hearing loss in patients with hyperthyroidism, and the underlying factors should be investigated in detailed future studies. It was shown in our study that the hearing loss induced by hypothyroidism may improve with medical therapy. Therefore, in all patients with thyroid dysfunction, hearing levels should be monitored closely with audiometric tests.
