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Öğe Alkali hasara bağlı gelişen korneal anjiogenez modelinde topikal, subkonjonktival bevacizumab ve florometolon asetatın topikal uygulanması(Cumhuriyet Üniversitesi, 2010) Dursun, Ayhan; Arıcı, KemalÖZETBu çalışma? topikal ve subkonjonktival bevacizumabın alkali yanığa bağlı gelişen korneal anjiogenez modelindeki yeni damar gelişimi üzerine etkisini araştırmak amacıyla yapıldı.Çalışmada 24 adet Wistar-Albino cinsi rat kullanıldı. Kornealarda kimyasal koterizasyonu takiben ratlar randomize olarak 4 gruba ayrıldı. Grup 1'e suni gözyaşı damlası günde iki kez, grup 2'ye, topikal florometolon asetat günde iki kez, grup 3'e, subkonjonktival bevacizumab 2,5 mg olarak tek doz, grup 4'e ise topikal bevacizumab 5mg/ml konsantrasyonunda uygulandı. Tüm damlalar koterizasyonu takiben hemen damlatılmaya başlandı ve 21 gün boyunca uygulandı. Üç hafta sonra rat korneaları yarık lamba biyomikroskobuyla muayene edildi ve kornea fotoğrafları çekilip denekler sakrifiye edildi. Alkali yanığa bağlı gelişen korneal neovaskülarizasyonu değerlendirmek için toplam korneal alan, neovaskülarize alan, neovaskülarize alanın oranı ve gelişen en uzun damarın boyu ölçüldü. Korneal ödem ve opasite skoru değerlendirildi.Subkonjonktival ve topikal bevacizumab grupları ile florometolon asetat grubunda korneal neovaskülarizasyon alanı, en uzun damar boyu, korneal ödem ve opasite skoru? kontrol grubuna göre istatiksel olarak anlamlı şekilde düşüktü (p<0.05). Subkonjonktival ve topikal bevacizumab grubunda yine aynı parametreler florometolon asetat grubuna göre istatiksel açıdan anlamlı bir şekilde düşüktü (p<0.05). Subkonjonktival ve topikal bevacizumab grupları arasında korneal neovaskülarizasyon alanı, korneal ödem ve opasite açısından anlamlı bir fark yoktu. Fakat en uzun damar boyu topikal bevacizumab grubunda istatiksel açıdan anlamlı şekilde düşüktü (p<0.05).Sonuç olarak? topikal florometolon asetat, topikal ve subkonjonktival bevacizumab, deneysel kornea neovaskülarizasyonunun kontrolünde etkili yöntemlerdir. Bununla birlikte topikal bevacizumab, kornea neovaskülarizasyonunun kontrolünde subkonjonktival bevacizumab ve florometolon asetattan daha etkili olarak görüldü.Öğe Apoptotic effects of topical antiglaucoma medications on conjunctival epithelium in glaucoma patients(SAGE PUBLICATIONS LTD, 2014) Arici, Mustafa Kemal; Arici, Dilek Sema; Ozec, Ayse Vural; Dursun, Ayhan; Toker, Mustafa Ilker; Erdogan, HaydarPurpose: In this study, we aimed to investigate the apoptotic effects of topical antiglaucoma medications on the conjunctival epithelium. Methods: A total of 65 patients were included in the study. Thirty patients were included in the first group who had received antiglaucomatous therapy before trabeculectomy. In the second group, 20 patients who had received no drugs before trabeculectomy were included, while the third group underwent only cataract surgery as control. During the surgery, 2 x 4 mm conjunctival samples were harvested from the upper bulbar conjunctiva. The mean apoptosis rate was calculated by determining apoptosis at conjunctival epithelium using the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) method. Results: The mean apoptosis rate was 0.537 +/- 0.369 (0.026 +/- 0.962) in group 1, 0.139 +/- 0.162 (0.005 +/- 0.676) in group 2, and 0.078 +/- 0.035 (0.035 +/- 0.142) in the control group (group 3). The mean apoptosis rate was significantly higher in the first group than the other 2 groups (p = 0.0001). Conclusions: Apoptotic effects of topical antiglaucoma drugs on the conjunctival epithelial cells were found. However, our results revealed that the number of medications, duration of medication, and type of glaucoma had no effect on the apoptotic effect.Öğe Application of Topical/Subconjunctival Bevacizumab and Topical Fluorometholone Acetate in Alkali Burn-induced Model of Corneal Angiogenesis(Turkish Ophthalmological Soc, 2010) Dursun, Ayhan; Arici, Mustafa Kemal; Ozec, Ayse Vural; Dursun, Feyza; Toker, Mustafa Ilker; Topalkara, AysenPurpose: To investigate the effect of bevacizumab on corneal neovascularization in an alkali burn -induced model of corneal angiogenesis. Material and Method: Twenty-four Wistar albino rats were used in our study. After chemical cauterization of the cornea, the rats were divided randomly into four groups. Group 1 (control group) received artificial tears twice a day, group 2 received topical fluorometholone acetate twice a day, in group 3, a single dose of bevacizumab (2.5 mg) was administered by a subconjunctival injection, and group 4 received topical bevacizumab 5mg/ml twice a day. Three weeks later, the rat corneas were evaluated by slit-lamp biomicroscopy and corneal photographs were taken with a digital camera, followed by sacrifice of the subjects. The proportional area of vascularized cornea, length of the longest neovascular sprout, corneal oedema and corneal opacity score were assessed. Result: The analysis of digital photographs showed less corneal neovascularization, corneal oedema, corneal opacity score and shorter length of the longest neovascular sprout in the three drug groups than in the control one (p<0.05). The area of corneal neovascularization in groups 3 and 4 was less than in group 2 (p=0.035 and p=0.027, respectively). Corneal neovascularization, corneal oedema and corneal opacity did not differ significantly between the subconjunctival and topical bevacizumab groups. However, statistically significant decrease was observed in the length of the longest neovascular sprout in the topical bevacizumab group (p=0.029). Discussion: Subconjunctival/topical bevacizumab treatment is an effective method in reducing corneal neovascularization. However, we observed that topical bevadzumab is more efficient than subconjunctival bevacizumab and fluorometholone acetate in preventing corneal neovascularization.Öğe Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients(SPRINGER JAPAN KK, 2014) Ozec, Ayse Vural; Dursun, Ayhan; Toker, Mustafa Ilker; Demirci, Yuksel; Topalkara, Aysen; Erdogan, Haydar; Arici, Mustafa Kemal; Ersalcan, TanerPurpose To investigate levels of ghrelin in the aqueous humour (AqH) of patients with exfoliation syndrome and exfoliation glaucoma and compare them to levels of ghrelin in control subjects. Methods This cross-sectional study involved 15 patients with exfoliation syndrome, 8 with exfoliation glaucoma and 12 control subjects for whom cataract surgery was indicated. The AqH was aspirated from the anterior chamber with a 27-G needle under sterile conditions prior to tissue manipulation. Ghrelin levels were quantified using radioimmunassay kits. Results Levels of ghrelin in the AqH were 187.87 +/- 80.1 pg/mL in the eyes exhibiting exfoliation syndrome, 98.53 +/- 50.9 pg/mL in the eyes exhibiting exfoliation glaucoma and 111.40 +/- 77.5 pg/mL in the controls. Ghrelin level of patients with exfoliation syndrome were significantly higher than those of patients with exfoliation glaucoma and the controls (P<0.05). Ghrelin levels of patients with exfoliation glaucoma were lower than those of the controls but were not reach statistically significant (P>0.05). Age, gender and IOP did not have a significant effect on ghrelin levels in patients with exfoliation syndrome and exfoliation glaucoma. Conclusion This study is the first to report elevated levels of ghrelin in the AqH in eyes exhibiting exfoliation syndrome. Findings suggest ghrelin might play role in the etiopathogenesis of exfoliation syndrome to exfoliation glaucoma.Öğe The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor(HINDAWI PUBLISHING CORPORATION, 2014) Kirboga, Kadir; Ozec, Ayse V.; Kosker, Mustafa; Dursun, Ayhan; Toker, Mustafa I.; Aydin, Huseyin; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa K.Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P = 0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P = 0.004). Mean TOS levels in the serum were 2.93 +/- 0.19 in the DRP group and 2.61 +/- 0.26 in the control group (P = 0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.Öğe Association of neutrophil/lymphocyte ratio and retinal vein occlusion(WICHTIG PUBL, 2015) Dursun, Ayhan; Ozturk, Sultan; Yucel, Hasan; Ozec, Ayse Vural; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Topalkara, AysenPurpose: To evaluate the association between neutrophil/lymphocyte ratio (NLR) and the development of retinal vein occlusion (RVO). Methods: Forty patients were included in the study. Forty age- and sex-matched healthy volunteers were recruited as the control group. The RVO diagnosis was made clinically, based on the findings of fundus examination. The NLR and file records of the patients and the control group were compared. Results: The mean age of patients was 64 +/- 12 years. Neutrophil levels were higher in RVO patients compared to the control subjects (5.1 +/- 1.9 vs 3.6 +/- 1.0, p<0.001). Lymphocyte levels were lower in RVO patients compared with the control subjects (2.0 +/- 0.7 vs 2.6 +/- 0.9, p = 0.005). The NLR was significantly higher in RVO patients compared with the control subjects (3.0 +/- 2.7 vs 1.5 +/- 0.3, p<0.001). According to the receiver operator characteristics curve analysis, the optimal cutoff value of NLR to predict RVO was > 1.89, with 72.5% sensitivity and 100% specificity. Conclusions: The current study demonstrated that higher NLR was associated with the development of RVO. The NLR may be used as a predictive tool for identifying risk for RVO.Öğe Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model(IJO PRESS, 2012) Dursun, Ayhan; Arici, Mustafa Kemal; Dursun, Feyza; Ozec, Ayse Vural; Toker, Mustafa Ilker; Erdogan, Haydar; Topalkara, AysenAIM: To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali bum-induced model of corneal angiogenesis. METHODS: Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. RESULTS: The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P<0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. CONCLUSION: Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization.Öğe Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma(HINDAWI PUBLISHING CORP, 2016) Dursun, Ayhan; Ozec, Ayse Vural; Dogan, Oznur; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Topalkara, Aysen; Arici, Mustafa Kemal; Erdogan, HaydarPurpose. To compare the macular and peripapillary choroidal thickness in eyes with pseudoexfoliation (PEX) syndrome and PEX glaucoma with the normal eyes of healthy controls. Materials and Methods. In this prospective study, 30 eyes of 30 patients with PEX syndrome, 28 eyes of 28 patients with PEX glaucoma, and 30 eyes of 30 age-matched healthy subjects were enrolled. Choroidal thicknesses in the macular and peripapillary areas were measured by using spectral domain optical coherence tomography. Results. Gender, age, and axial length did not significantly differ between the groups (all, p > 0.05). The mean values of choroidal thickness in the macular and peripapillary areas (except the superior quadrant) in the patients with PEX syndrome and PEX glaucoma were lower compared with controls (all p < 0.05). The mean values of the macular and peripapillary choroidal thickness in the PEX glaucoma group were lower compared with PEX syndrome group; however this difference was not significant. Conclusions. The findings of this study revealed that macular and peripapillary choroidal thicknesses were decreased in PEX syndrome and PEX glaucoma cases. The role of choroid in the development of glaucomatous damage in patients with PEX syndrome remains unclear.Öğe Evaluation of Foveal Thickness and Macular Choroidal Thickness with Optical Coherence Tomography in Behcet's Disease(Marmara Univ, Inst Health Sciences, 2021) Bozali, Erman; Erdogan, Haydar; Dursun, Ayhan; Ozec, Ayse Vural; Toker, Mustafa Ilker; Arici, Mustafa KemalObjective: To evaluate the foveal thickness and macular choroidal thickness on patients who were diagnosed with Behcet's Disease (BD). Methods: A total of 60 patients were included in this prospective cross-sectional study. Patients were divided into two groups. Group 1 consisted of 30 patients who were diagnosed with BD and Group 2 consisted of 30 healthy controls. Detailed ophthalmological examination was performed on both groups and foveal thickness and macular choroidal thickness were measured with Spectral-Domain Optical Coherence Tomography (SD-OCT). To measure the choroidal thickness enhanced depth imaging OCT (EDI-OCT) technique was used. Results: Mean foveal thickness in BD patients was 216.06 +/- 53.14 mu m and mean subfoveal choroidal thickness was 363.21 +/- 85.22 mu m. Mean foveal thickness and subfoveal choroidal thickness in healthy controls was 211.65 +/- 16.60 mu m and 352.83 +/- 87.11 mu m respectively. There was no statistical significance between patients with BD and patients of the control group regarding foveal and subfoveal choroidal thickness. However, anatomical deformation of Ellipsoid Zone structure in OCT had the most effect on visual acuity (p=0.001). Conclusion: This study shows that there was no statistically significant difference in terms of foveal thickness and macular choroidal thickness in patients with BD.Öğe Evaluation of inner and outer retinal thickness in patients receiving intravitreal ranibizumab injections for diabetic macular edema(SAGE PUBLICATIONS LTD, 2016) Dursun, Ayhan; Ozec, Ayse Vural; Kirboga, Kadir; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa KemalPurpose: To measure inner and outer retinal thickness with optical coherence tomography (OCT) in patients in whom intravitreal ranibizumab was administered due to diabetic macular edema (DME) and to investigate its relation to the visual prognosis. Methods: In this retrospective case series, there were 60 consecutive eyes with DME in which intravitreal ranibizumab injection was performed for 3 times in 1-month intervals. All patients underwent full ophthalmic examination and spectral-domain OCT (SD-OCT). The total retinal thickness, the inner thickness, and the outer thickness in 4 parafoveal subfields were measured. The correlation between the retinal thickness and logMAR best-corrected visual acuity (BCVA) was investigated. Results: No significant correlation was found between the total retinal thickness in the central and other subfields and either the baseline or final visit logMAR BCVA values (p>0.05). There was a significant positive correlation between the final visit logMAR BCVA values and pretreatment inner retinal thickness in the nasal and inferior subfields (r = 0.270, p = 0.037, and r = 0.410, p = 0.001, respectively). There was significant negative correlation between the final visit logMAR BCVA values and pretreatment outer retinal thickness in nasal and temporal parafoveal subfields (r = -0.297, p = 0.021, and r = -0.268, p = 0.038, respectively). Conclusions: It could be beneficial to use inner and outer retinal thickness instead of total retinal thickness in determination of short-term prognosis in patients who had intravitreal ranibizumab injection for DME.Öğe The prevalence of exfoliation syndrome in Turkey(WILEY, 2016) Kilic, Rasit; Karagoz, Naim; Cetin, Abdi Bahadir; Cakmak, Yasin; Sezer, Hafize; Ozay, Yusuf; Comcali, Sebile Ustun; Dursun, AyhanPurpose: To investigate the prevalence of the exfoliation syndrome and its relationship with ocular and cardiovascular diseases in the Central Anatolia region of Turkey. Methods: This cross-sectional and population-based study was conducted at the Sivas Province among the population aged 40 years and over. The diagnosis of XFS was made when exfoliative material was found on the anterior lens capsule or iris on slit-lamp examination. The subjects were divided into an XFS group and a non-XFS group according to the presence of exfoliative material, and the groups were compared for the presence of glaucoma, cataract, age-related macular degeneration, phacodonesis, hypertension, diabetes mellitus, coronary artery disease, smoking and alcohol-use frequency. Results: XFS was present in 63 subjects consisting of 42 males (8.0%) and 21 females (3.6%) for an overall rate of 5.7% (95% CI: 0.054-0.060). Once we adjusted the values for age, we found a statistically significant relationship of increased age and male gender with the presence of XFS (p = 0.001, p = 0.027, respectively). The relationship between XFS and glaucoma, cataract and phacodonesis was found to be statistically significant (p = 0.001). No relationship was found between exfoliation syndrome and hypertension, diabetes mellitus and coronary artery disease. Conclusion: The prevalence of exfoliation syndrome was 5.7% in this population-based study. There was a statistically significant relationship between XFS and advancing age and male gender.Öğe Relationship between mean platelet volume and central serous chorioretinopathy(SPRINGER, 2017) Dursun, Ayhan; Toker, Mustafa Ilker; Ozec, Ayse Vural; Bozali, Erman; Kirboga, Kadir; Dursun, Feyza Gulac; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa KemalThe aim of this study was to investigate the mean platelet volume (MPV) of patients with central serous chorioretinopathy (CSCR). Thirty patients were included in the study. Thirty healthy volunteers were recruited as the control group. All patients and control subjects underwent complete ocular examination. Hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet count, and MPV of the participants were recorded. Data of patients with CSCR were compared with the control subjects. Patients with CSCR had significantly higher MPV values (9.76 +/- 1.36 fL) compared with the control subjects (8.37 +/- 0.72 fL) (p = 0.004). No significant difference was found in platelet counts between the CSCR group and the control group (259 +/- 53.75 and 243 +/- 52.11 K/Ul, p = 0.253). According to the receiver operator characteristics curve analysis, the optimal cut-off value of MPV to predict the CSCR was > 9.4, with 60.0 % sensitivity and 93.3 % specificity. Our results demonstrated that the MPV values were significantly higher in patients with CSCR. MPV may be used as a predictive tool for identifying risk for CSCR.Öğe Safety of Polyacrylamide 1.5% Left in Anterior Chamber in Combined Phacoemulsification and Pars Plana Vitrectomy Surgery(TAYLOR & FRANCIS INC, 2016) Karaca, Emine Esra; Ozdek, Sengul; Ozmen, Mehmet Cuneyt; Dursun, Ayhan; Yalcin, Nuriye GokcenPurpose: To evaluate safety, efficacy and postoperative characteristics of polyacrylamide 1.5% ophthalmic viscosurgical device (OVD) left in anterior chamber during and at the end of combined phacoemulsification and pars plana vitrectomy surgery. Materials and Methods: This prospective study comprised 20 eyes that received combined phacoemulsification and pars plana vitrectomy performed by the same surgeon. Polyacrylamide 1.5% was left in anterior chamber at the end of the surgery. Preoperative and postoperative examinations (4, 12 and 24 hours; 14 days; 1 and 3 months) included measurement of intraocular pressure (IOP), central corneal thickness (CCT), endothelial cell density and assessment of any ocular adverse reactions. Results : Four of the 20 patients (20%) showed increased IOP at hours postoperatively and needed medical treatment for IOP control. There was no significant difference in IOP between the preoperative visit and postoperative 3 months (p>0.05). CCT measurements were similar between preoperative and postoperative visits (p>0.05). A mean endothelial cell density loss of 6.7% was observed at postoperative day 14, however there was no change after this visit. Conclusion: Polyacrylamide 1.5% is safe, well-tolerated and protective in eyes undergoing combined phacoemulsification and pars plana vitrectomy.Öğe Yag laser capsulotomy rates of 50 years and older individuals after use of the Zaraccom Ultraflex intraocular lenses(DRUNPP-SARAJEVO, 2012) Toker, Mustafa Ilker; Ozec, Ayse Vural; Dursun, Ayhan; Yurdakul, Ismail; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa KemalAim: to evaluate the rate of symptomatic posterior capsule opacification requiring Nd:YAG capsulotomy in patients who underwent cataract extraction and implantation of zaraccom ultraflex lenses (one-piece hydrophobic acrylic square edged intraocular lens). Methods: 142 eyes of 103 patients who had cataract extraction and implantation of zaraccom ultraflex lenses (IOLs) were evaluated for rate of nd:yag capsulotomy from april 2008 to august 2009. The cases that received Nd:YAG capsulotomies were evaluated for visual acuity, lens position and centralization and the frequency of nd: yag laser determined. Results: the mean preoperative best corrected visual acuity (BCVA) was 0.31 +/- 0.20 And the final mean BCVA was 0.96 +/- 0.06 With snellen chart. The rate of nd: yag capsulotomy was 0.7%. The mean time to Nd: YAG capsulotomy was 24.34 Months (range: 12 to 30 months). Conclusion: posterior capsule opacification was significantly less for the patients 50 years and over with the Zaraccom Ultraflex IOLs at 2 years.
