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    ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort
    (Professional Medical Publications, 2021) Alakus, Huseyin; Kaya, Mustafa; Ozer, Hatice; Egilmez, Hatice Reyhan; Karadayi, Kursat
    Objective: Gastric cancer is among the most common human cancers with high mortality rates. ADAM10, a member of the ADAM (a disintegrin and metalloproteinase) family has also been found to be associated with gastric carcinoma and has been suggested as a potential therapeutic target. Here, we investigated the association of ADAM10 expression with prognosis in gastric adenocarcinoma patients that underwent gastric resection with D2 lymph node dissection. Methods: Total 86 consecutive patients that underwent resection for gastric adenocarcinoma were included. Immunohistochemical ADAM10 expression and its association with clinicopathological parameters were analyzed. Univariate and multivariate analyses and survival analyses were performed using SPSS ver.22. Results: High grade tumors, advanced stage tumors and diffuse type tumors showed significantly worse prognosis. A statistically significant association between ADAM10 expression and overall survival (OS) was observed in the univariate analysis, however, this association did not maintain its significance in the multivariate analysis. No statistically significant association was found ADAM-10 expression and clinicopathological parameters. Conclusion: Immunohistochemical ADAM10 expression may be used as a prognostic marker in gastric adenocarcinoma, however, introduction of a standardized immunohistochemical scoring system seems to be necessary for evaluation of ADAM10 staining.
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    Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice
    (TAYLOR & FRANCIS LTD, 2016) Turgut, Nergiz Hacer; Mert, Derya Guliz; Kara, Haki; Egilmez, Hatice Reyhan; Arslanbas, Emre; Tepe, Bektas; Gungor, Huseyin; Yilmaz, Nese; Tuncel, Necati Baris
    Context: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet. Objective: The objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. Materials and methods: Phenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, d-galactose, d-galactose + M. nigra 50, and d-galactose + M. nigra 100). Mice were administered d-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver. Results: In extract, vanillic (632.093 mu g/g) and chlorogenic acids (555.0 mu g/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H2O2. Morus nigra significantly improved learning dysfunctions (p< 0.01), increased memory retention (p < 0.01), reduced MDA levels (p < 0.05), and elevated SOD, GPx, and CAT activities (p < 0.05) compared with the d-galactose group. Discussion and conclusion: These results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity.
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    Evaluation of the Effect of Gabapentin on Tendon Healing in an Experimental Rat Model
    (Aves, 2020) Kilinc, Seyran; Egilmez, Hatice Reyhan; Pazarci, Ozhan; Altunisik, Muhammed Yasir
    BACKGROUND/AIMS To investigate the effect of gabapentin used in postoperative pain prophylaxis on tendon healing. MATERIAL and METHODS A total of 32 Wistar albino rats were randomly divided into 4 groups. Groups A and C were administered gabapentin by oral gavage, while Groups B and D were defined as the control groups. In all the rats, a transverse cut was made on the left Achilles tendon, approximately 0.5 cm proximal to the attachment point of the bone, then it was sutured using the Kessler method. Rats in Groups A and B were sacrificed on day 15 and those in Groups C and D on day 45. Differences between the groups were evaluated biomechanically using the tensile test, and immunohistochemically by examinations of collagen type 1 (COL1A), Proliferating Cell Nuclear Antigen (PCNA), and Transforming Growth Factor beta 1 (TGF-beta 1). RESULTS In the biomechanical evaluations, no significant difference was found between the study and control groups on days 15 and 45 in terms of the tensile test results (day 15, p=0.908; day 45, p=0.798). In the semi-quantitative comparisons of positive cell involvement in the immunohistochemical data evaluations, no statistically significant difference was also found. [TGF-beta 1, p(15)=0.328, p(45)=0.195; PCNA p(15)=0.645]. PCNA-positive cells were seen at a high rate in the first 15 days in both groups and the involvement of these cells was found to be similar on day 45. CONCLUSION In the immunohistochemical and biomechanical evaluations, gabapentin was not found to have any negative effect on tendon healing. It can be concluded that gabapentin can be used in cases with appropriate indications after tendon surgery. Nevertheless, there is a need for further studies in this area to investigate the mechanism of gabapentin's effect on the tendon.
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    Extraskeletal chondroblastic osteosarcoma in the left atrium
    (OXFORD UNIV PRESS, 2014) Korkmaz, Ozge; Goksel, Sabahattin; Egilmez, Hatice Reyhan; Berkan, Ocal
    Primary cardiac extrasceletal osteosarcomas are uncommon tumours. They have aggressive behaviour and thus poor prognosis. This report describes a 40-year old female patient who was referred to our hospital with dyspnoea, weakness and syncopal attacks. Echocardiography and chest computed tomography showed a left atrial mass, and tumour excision revealed a cardiac chondroblastic osteosarcoma. After pathological diagnosis, she was scheduled for chemotherapy and radiotherapy by the related departments.
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    Megacystis Microcolon Intestinal Hypoperistalsis Syndrome in Which a Different De Novo Actg2 Mutation was Detected: A Case Report
    (TAYLOR & FRANCIS INC, 2018) Korgali, Elif Unver; Yavuz, Amine; Simsek, Cemile Ece Caglar; Guney, Cengiz; Kurtulgan, Hande Kucuk; Baser, Burak; Atalar, Mehmet Haydar; Ozer, Hatice; Egilmez, Hatice Reyhan
    Introduction: Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is characterized by bladder distension without urinary tract obstruction, decreased or absent intestinal peristalsis and microcolon. Although the definitive cause remains unknown, changes in the ACTG2 gene are thought to be responsible for the intestinal and bladder hypoperistalsis. Case report. This female newborn with MMIHS had a c.532C > A /p.Arg178Ser heterozygous de novo mutation detected in the ACTG2 gene. Normal immature ganglion cells, normal calretinin punctate positivity, maintence of smooth muscle actin immunoreactivity, and decreased numbers of interstitial cells of Cajal(ICCs) were detected. Conclusion: This previously unreported c.532C >A /p.Arg178Ser heterozygous de novo mutation in the ACTG2 gene may lead to a severe form of MMIHS.
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    Nuclear factor erythroid-2-related factor 2 (Nrf2) is a potential prognostic factor in patients with gastric adenocarcinoma
    (Elsevier, 2023) Alakus, Huseyin; Kaya, Mustafa; Ozer, Hatice; Egilmez, Hatice Reyhan; Karadayi, Kursat
    Background: Gastric cancer is one of the leading causes of cancer-related death, and many researchers are focused on the discovery and use of different biomarkers in prognosis prediction. The use of Nrf2 as a prognostic marker in patients with gastric cancer remains controversial. In this study, we evaluated the expression of Nrf2 protein in gastric adenocarcinoma.Patients and methods: A total of 86 patients who underwent gastric resection and D2 lymph node dissection due to gastric adenocarcinoma were included. Clinicopathological characteristics, such as age, gender, gastrectomy type, pathologic T (pT) and N (pN) stages, tumor grade, tumor type per Lauren's classification, presence of lymphovascular invasion, and Nrf2 expression were evaluated.Results: While pT, pN, and Nrf-2 expression were found to be negative prognostic predictors for overall survival in one-way analysis of variance, Nrf-2 expression was the only significant negative prognostic predictor in multi -variance analysis. pT, pN, diffuse type, high tumor grade, and Nrf-2 expression significantly affected overall survival in Kaplan-Meier survival analyses (p = 0.02, p = 0.03, p < 0.01, p = 0.027, and p = 0.001, respectively).Conclusions: Our findings support that Nrf2 is a prognostic marker in patients with gastric adenocarcinoma. Anti-Nrf2 therapy options should be investigated to improve prognosis in gastric cancer patients.
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    Prognostic Biomarkers in Isocitrate Dehydrogenase Wild-Type Glioblastoma: A Focus on B7-H3
    (MDPI, 2025) Yuceer, Ramazan Oguz; Kaya, Seyhmus; Balci, Sema Nur; Egilmez, Hatice Reyhan; Yilmaz, Mukaddes; Erdis, Eda
    Background: Isocitrate dehydrogenase (IDH) wild-type (wt) glioblastoma is an aggressive malignancy associated with poor clinical outcomes, marked by high heterogeneity and resistance to treatment. This study aims to investigate the prognostic significance of B7-H3 expression in IDH wt glioblastoma and its potential association with clinical outcomes, including overall survival (OS) and progression-free survival (PFS). Additionally, the relationship between B7-H3 and PD-L1 expression was explored. Methods: A retrospective cohort of 86 IDH wt glioblastoma patients, all of whom underwent surgery, radiotherapy, and temozolomide treatment, was analyzed. B7-H3 expression was quantified using an immunoreactivity score (IRS), classifying samples as low (IRS <= 4) or high (IRS > 4). PD-L1 expression was evaluated based on tumor and immune cell staining, with >5% positivity indicating significant expression. Results: High B7-H3 expression was significantly associated with poorer OS and PFS. Co-expression of B7-H3 and PD-L1 was prevalent, particularly among younger male patients with unifocal tumors; however, PD-L1 expression did not show a significant correlation with clinical outcomes. Conclusions: B7-H3 appears to be a promising prognostic biomarker in IDH wt glioblastoma and may serve as a target for developing combination therapies, integrating B7-H3-targeting treatments with immune checkpoint inhibitors. Further prospective studies are necessary to validate these findings and to explore potential therapeutic strategies.
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    The prognostic value of UHRF-1 and p53 in gastric cancer
    (MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) Babacan, Nalan A.; Egilmez, Hatice Reyhan; Yucel, Birsen; Parlak, Ilknur; Seker, Mehmet Metin; Kacan, Turgut; Bahceci, Aykut; Cihan, Sener; Akinci, Bulent; Eriten, Berna; Kilickap, Saadettin
    Background/Aims: This study aimed to examine whether UHRF-1 and p53 overexpression is a prognostic marker for gastric cancer. Patients and Methods: Sixty-four patients with gastric cancer (study group) and 23 patients with gastritis (control group) were evaluated. Immunohistochemistry was used to examine expression of UHRF-1 and p53 in gastric cancers and a control group diagnosed with gastritis. Results: The median age was 63 years (18-83 years) in the study group. UHRF-1 was positive in 15 (23%) patients with gastric cancer and fi ve (21.7%) patients with gastritis (P = 0.559). UHRF1 expression level in gastric cancer is more powerful than in gastritis (P = 0.046). Thirty-seven (61%) patients with gastric cancer and only one patient with gastritis were p53 positive (P < 0.001). After a median follow-up of 12 months (1-110), the 2-year overall survival rates were 55% and 30% in negative and positive p53, respectively (P = 0.084). Also, the 2-year overall survival rates were 45% and 53% in negative and positive UHRF-1, respectively (P = 0.132). Conclusion: According to this study, UHRF-1and p53 were not prognostic factors for gastric cancer, whereas they may have a diagnostic value for differantiating between gastric cancer and gastritis.
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    Values of GLUT-1, COX-2, MMP-19 and p53 in the Differential Diagnosis of Squamous Cell Carcinoma and Keratoacanthoma
    (GALENOS YAYINCILIK, 2019) Sahin, Havva Hande Keser; Bas, Yilmaz; Egilmez, Hatice Reyhan
    Objective: The aim of this study is to investigate whether the expression of GLUT-1, COX2, MMP-19, p53 and Elastic-van Gieson (EVG) protein are significant in the differential diagnosis of squamous cell carcinoma (SCC) and keratoacanthoma (KA). Methods: A total of 156 cases, 105 of whom were SCC and 51 were KA, which were diagnosed between 2001 and 2011 years in Cumhuriyet University Department of Pathology, were examined histochemically by EVG and immunohistochemically by GLUT-1, COX-2, MMP-19 and p53. Results: Expression values of GLUT-1, COX-2, MMP-19, p53, and EVG were found to be statistically significant in the differential diagnosis of SCC and KA (p<0.05). The highest staining was seen with GLUT-1 (54%) and minimal staining with COX-2 (9%) among the tumor groups. The SCC and KA cases in the study were 60% and 41% immunoreactive with GLUT-1; 13% and 2% immunoreactive with COX-2; 24% and 0% immunoreactive with MMP-19; 31% and 16% immunoreactive with p53; 20% and 56.9% historeactive with EVG, respectively. Conclusion: All markers used in our study were found to be useful in the differential diagnosis of SCC and KA, but, we think that further molecular and genetic studies will facilitate the correct diagnosis.