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    Are pan-immune-inflammation value, systemic inflammatory response index and other hematologic inflammatory indexes clinically useful to predict first-trimester pregnancy loss?
    (2023) Genç, Şerife Özlem; Erdal, Hüseyin
    Aim: The purpose of the study is to investigate the importance of hematological inflammatory parameters in predicting pregnancy loss in the first trimester. Material and Methods: This study was conducted retrospectively between February and May 2022 in Aksaray University Training and Research Hospital, Obstetrics and gynecology outpatient clinic. Fifty-five of 110 patients diagnosed with first trimester pregnancy loss were included in the study. The control group consisted of 55 pregnant women with first trimester pregnancies. Results: When the whole groups were compared, no statistically significant difference was observed in terms of hemoglobin, platelet, neutrophil, lymphocyte count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), derived NLR ratio (dNLR), systemic inflammatory index (SII), systemic inflammatory response index (SIRI) and pan-immune-inflammation value (PIV). Discussion: NLR, PLR, LMR, dNLR, SII, SIRI and PIV parameters were not associated with first trimester abortions. In this study, unlike previous studies, no hematological parameters, including the pan-immune-inflammation value, were found to have a role in predicting first trimester pregnancy loss.
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    Assesment of the relationship between endometrial cancer and systemic inflammation
    (2023) Genç, Şerife Özlem; Erdal, Hüseyin
    Objective The relationship between endometrial cancer and systemic inflammation has been evaluated in recent years, particularly in terms of pre-treatment assessment, lymph node metastasis, and prognosis prediction. However, a conclusive consensus on this topic has yet to be reached. This study is based on the retrospective data from a tertiary center study conducted on patients who underwent surgery for endometrial cancer in our clinic within the past 2 years. The aim of this research is to assess the potential effects of age, gravidity, parity, hemoglobin (Hb), platelet (PLT), white blood cell count (WBC), lymphocyte count (LYM), monocyte count (MONO), and calculated systemic inflammatory indexes (NLR, PLR, LMR, dNLR, SII, SIRI, PIV) on the diagnosis and prognosis of endometrial cancer. Methods This study is based on the analysis of retrospective data from endometrial cancer patients treated at a single center. Patient data including age, obstetric characteristics, and hematologic parameters were recorded. Systemic inflammatory indexes were calculated using the following formulas: NLR (Neutrophil-to-lymphocyte ratio), PLR (Platelet-to-lymphocyte ratio), LMR (Lymphocyte-to-monocyte ratio), dNLR (Derived NLR ratio - neutrophil count divided by the result of leucocyte count minus neutrophil count), SII (Systemic inflammatory index - neutrophil x platelet / lymphocyte), SIRI (Systemic inflammatory response index - neutrophil x monocyte / lymphocyte count), and PIV (Pan-immune inflammation value - neutrophil x platelet x monocyte / lymphocyte count). Results Our study includes 21 patients who underwent surgery for endometrial cancer in our clinic within the past 2 years. We examined the relationships between age, obstetric characteristics, and hematologic parameters in endometrial cancer patients. The results indicated that the mean age was 56.6 years, with an average gravidity of 3. The average hemoglobin level was within the normal range at 12.7. The mean values for the systemic inflammatory indexes were as follows: SII (694.6 ± 319.1) SIRI (1.4 ± 0.9) PIV (346.8 ± 137.2), NLR (2.9 ± 2.6), PLR (147.3 ± 51.7), LMR (4.1 ± 1.43), and dNLR (2.03 ± 1.6). In conclusion, the relationship between endometrial cancer and systemic inflammation is a significant focal point for future cancer research and treatments. Current research findings in this area may contribute to a better understanding of this relationship and improve the healthcare of patients.
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    Effect of mode of delivery on neonatal oxidative stress and dynamic thiol–disulfide homeostasis
    (SAGE, 2023) Genç, Şerife Özlem; Erdal, Hüseyin
    Objective To evaluate the effect of the mode of delivery on neonatal oxidative stress and dynamic thiol–disulfide homeostasis. Methods Sixty women who were followed up in the Obstetrics and Gynecology clinic were included in this prospective study. Cord blood samples were obtained from women who underwent cesarean section (CS) and vaginal delivery (VD). Total oxidant status and total antioxidant status levels were measured by spectrophotometry. The dynamic thiol–disulfide balance was determined by colorimetry. Results The total antioxidant status and oxidative stress index levels were higher and total oxidant status levels were lower in the VD group compared with the CS group. Native and total thiol levels were higher while disulfide levels were lower in the VD compared with the CS delivery group, while disulfide levels were higher in the CS group. Conclusion These results indicate that disulfide formation leads to decreased antioxidant capacity in women undergoing CS. Monitoring of dynamic thiol–disulfide levels may thus provide clinicians with important information on the oxidative stress status in newborns.
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    Transient tachypnea of the newborn
    (Nova Science Publishers, Inc., 2023) Kiliçbay, Fatih; Erdal, Hüseyin
    Transient tachypnea of the newborn is a physiological lung parenchyma disorder that is frequently seen in term and late preterm neonates. It occurs due to insufficient clearing of the fetal alveolar fluid. The clinical status is expected to return to normal within 48-72 hours. Although there is a limited effect of vaginal contractions and starling forces on the pathophysiology of the clearance of fetal lung fluid, the key mechanism is the osmotic gradient formed by the amiloride-sensitive sodium transport via EnaC from pulmonary epithelial cells, which facilitates the transepithelial movement of alveolar fluid from the pulmonary epithelium. Clinically, in patients with tachypnea there is observed to be groaning, flaring of the nostrils when breathing, intercostal and subcostal contractions, a need for oxygen, hypoxia, and occasionally, cyanosis. Oxygen is required in treatment and, in some cases, continuous positive airway pressure. © 2023 Nova Science Publishers, Inc. All rights reserved.