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    Diagnostic value of C-reactive protein and soluble urokinase plasminogen activator receptor in canine monocytic ehrlichiosis
    (Chulalongkorn Univ, 2021) Erdogan, Songul; Basbug, Onur; Aydogdu, Ugur; Pasa, Serdar; Erdogan, Hasan; Ural, Kerem
    Canine monocytic ehrlichiosis is a vector-borne disease that can induce renal failure in dogs. In this study we aimed to describe the potential diagnostic efficiency of CRP and suPAR in dogs infected with E. canis and the association between suPAR and CRP with renal failure. For this purpose, the study consisted of a total of 17 dogs, 8 of infected with E. canis and 9 of healty. For evaluating renal failure, plasma urea-creatinine and UPC were determined and also measurements of plasma CRP and suPAR were analysed with ELISA test kits. Mean CRP, suPAR, urea, creatinine and UPC levels of the infected dogs were significantly higher compared with healthy ones (P 0.01) but the correlation of all parameters with each group was not significant (P 0.05). As to be a result of ROC curve analysis and Youdens index, the cut-off values for diagnosis of ehrlichiosis were identified to be 9.68 mg/L for CRP and 168.2 ng/L for suPAR. Furthermore, the specificity and sensitivity of both markers according as a potential biomarkers cut-off values were determined higher. In conclusion, traditionally CRP and currently suPAR can be considered as potential biomarkers and have a diagnostic significance following inflammation in canine ehrlichiosis.
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    Serum trace element levels in dogs with canine visceral leishmaniasis
    (Tubitak Scientific & Technological Research Council Turkey, 2023) Gazyagci, Aycan Nuriye; Bilgic, Bengu; Bakay, Berna Baysal; Tarhan, Duygu; Ercan, Alev Meltem; Erdogan, Songul; Erdogan, Hasan
    Canine visceral leishmaniasis has been denoted as neglected despite being a very well-known disease. Trace element alteration has been recognized in humans with visceral and cutaneous leishmaniasis, together with canine visceral leishmaniasis. The trace elements occupy a vital position in the immunological system, and host immune responses mitigate defense against leishmaniasis. We aimed to select trace elements in a total of 45 dogs of several breeds; those at the age of 11 months to 6 and from both sexes (26 male and 19 female) were enrolled in the study. The dogs included in the study were divided into leishmaniasis-infected and noninfected groups. All cases in this study were included according to written owner consent. The trace element analysis of serum samples was carried out by using an inductively coupled plasma-optical emission spectrometry. The results of our study revealed that between the canine visceral leishmaniasis infected group and the uninfected group, Leishmania-positive dogs had significantly lower levels of Se (p < 0.001) and Zn (p < 0.001) compared to the negative ones. These results should be carefully elucidated in an attempt to analyze immune responses in dogs with canine visceral leishmaniasis.