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    Alendronate enhances osseous healing in a rat calvarial defect model
    (PERGAMON-ELSEVIER SCIENCE LTD, 2012) Toker, Hulya; Ozdemir, Hakan; Ozer, Hatice; Eren, Kaya
    Aim: The aim of this study was to evaluate the effect of alendronate on osseous wound healing in an experimental model. Methods: Critical size defects were created in calvaria of 40 male Wistar rats. The animals were divided into four groups of 10 animals each: autogenous bone graft group; autogenous bone graft with systemic alendronate group (0.01 mg /kg body weight per day for 8 weeks); autogenous bone graft with local alendronate group (1 mg/mL for 5 min); non-treatment (control) group. Animals were sacrificed after 8 weeks; osteoblast number, lamellar bone formation, and area of newly formed bone were analysed. Results: The osteoblast number significantly increased in the autogenous bone graft with local alendronate group compared to the autogenous bone graft group (p < 0.05). Both systemic and local application of the alendronate significantly increased the new bone formation compared to the autogenous bone graft group (p < 0.05) with no significant difference between local or systemic use (p > 0.05). Local alendronate and autogenous bone graft use significantly increased the total bone area compared to autogenous bone graft alone (p < 0.05). Conclusion: Alendronate enhances the new bone formation by autogenous bone graft in the rat calvarial defect model suggesting that the inhibition of the osteoclastic activity allows an increased rate of bone apposition, which could be applicable to the inflammation-induced destruction of the periodontal tissues during disease. (C) 2012 Elsevier Ltd. All rights reserved.
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    Biocompatibility of fiber-reinforced composite (FRC) and woven-coated FRC: an in vivo study
    (Springer Heidelberg, 2023) Nalbantoglu, Ahmet Mert; Eren, Kaya; Yanik, Deniz; Toker, Hulya; Tuncer, Ersin
    Objectives To investigate biocompatibility and bone contact area of FRC and woven-coated FRC (FRC-C) in rats. Materials and methods Sixty rats were allocated to three groups: FRC (n=20), FRC-C (n=20), and control group (n=20). Subgroups were determined as 4th (n=10) and 12th weeks (n=10). The specimens were placed in the femur of rats. In the control group, the bone defects were left empty and sutured. Four and 12 weeks after implantation, the rats were sacrificed. Histopathological examinations were performed in a semi-quantitative manner. Twenty rats (n=20) were used for scanning electron microscopy (SEM) examination. Bone contact surfaces were calculated in SEM analysis. A chi-square test was performed to analyze the data. Results No statistical difference was detected between the 4th and 12th weeks in the quality of bone union. Quality of bone union was lower in FRC compared to the control group in the 4th week (p=0.012) and the 12th week (p=0.017). The periosteal reaction at the 12th week was lower in FRC than in the control group (p=0.021). Bone contact of FRC and FRC-C was 85.5% and 86.3%, respectively. Conclusions FRC and FRC-C were biocompatible and showed no inflammation. The woven coating did not increase the quality of bone union and bone contact area, while not reducing biocompatibility.
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    A comparative evaluation of the systemic and local alendronate treatment in synthetic bone graft: a histologic and histomorphometric study in a rat calvarial defect model
    (ELSEVIER SCIENCE INC, 2012) Toker, Hulya; Ozdemir, Hakan; Ozer, Hatice; Eren, Kaya
    Objective. The purpose of this study was to compare the relative efficacy of systemic and local alendronate treatment of synthetic bone graft in a rat calvarial defect model. Study Design. Forty Wistar rats were divided into 4 groups: experimental animals received alendronate systemically or locally combined with micro-macroporous biphasic calcium phosphate (MBCP) graft material. In the control group, the defect was left empty. On each animal, a 5-mm standardized bone defect was created with a standard trephine bur in calvarium. All animals were killed after 8 weeks. The number of osteoclasts, osteoclast morphology, resorption lacunae, osteoblastic activity, and lamellar bone formation were histopathologically evaluated and the newly formed bone area was analyzed histomorphometrically. Results. Eight weeks after surgery, the number of osteoclasts and the resorption lacunae in the MBCP group using systemic alendronate therapy was significantly higher than those of the other groups (P < .05). Osteoblast number in the MBCP group using systemic alendronate treatment was significantly increased (P < .05). No significant difference was found among all MBCP groups using local or systemic alendronate treatments with regard to new bone formation (P > .05). Conclusions. Within the limits of the study, alendronate, when administered systemically or locally, did not increase bone regeneration with MBCP graft in the rat calvarial defect model. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114(suppl 5):S146-S152)
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    Effect of periodontal treatment on IL-1 beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis
    (WILEY, 2008) Toker, Hulya; Poyraz, Omer; Eren, Kaya
    Aim:The aim of this study was to examine the effect of phase I periodontal treatment on the levels of interleukin (IL)-1 beta, IL-1ra, and IL-10 in gingival crevicular fluid (GCF) in patients with generalized aggressive periodontitis (G-AgP). Material and Methods: Data were obtained from 15 patients with aggressive periodontitis and 15 healthy controls. GCF was collected from at least four pre-selected sites (one shallow, at least two moderate, or at least one deep pockets) in patients with G-AgP. In the healthy group, GCF samples were collected from one site. The cytokine levels were determined by an enzyme-linked immunosorbent assay. Probing depth, clinical attachment level (CAL), gingival and plaque indices, and bleeding on probing were measured. The GCF sampling and clinical measurements were recorded at baseline and 6 weeks later after periodontal treatment. Results: IL-1 beta levels were significantly higher at the moderate and deep pocket sites compared with the shallow sites (p < 0.05). After periodontal therapy, IL-1 beta levels were significantly reduced in the moderate and deep pocket sites (p<0.05). IL-1ra levels at baseline of the moderate and deep pocket sites were significantly lower than the control sites (p < 0.05). IL-10 levels were similar in all pockets and did not change after periodontal therapy. Conclusions: The periodontal treatment improves the clinical parameters in G-AgP, and this improvement is evident in deep pocket sites for pocket depth and CAL values. These results confirm that IL-1 beta is effective for evaluating the periodontal inflammation and can thus be used as a laboratory tool for assessing the activity of periodontal disease.
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    A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats
    (AMER ACAD PERIODONTOLOGY, 2008) Toker, Hulya; Ozan, Fatih; Ozer, Hatice; Ozdemir, Hakan; Eren, Kaya; Yeler, Hasan
    Background: Propolis collected by honeybees from various plant sources is a resinous hive product possessing a broad spectrum of biologic activities. Propolis has been used extensively in the diet to improve health and prevent disease. The purpose of this study was to analyze the morphometric and histopathologic changes associated with experimental periodontitis in rats in response to the systemic administration of propolis. Methods: Forty Wistar rats were divided into four experimental groups: non-ligated (NL; IN = 10); ligature only (LO; N = 10); and systemic administration of ligature and propolis (100 mg/kg body weight per day [Pro100; N = 10] or 200 mg/kg body weight per day [Pro200; N = 10]). Silk ligatures were placed at the gingival margin of the lower first molars in both mandibular quadrants. The study duration was 11 days, and the animals were sacrificed at the end of this period. Changes in alveolar bone levels were clinically measured, and tissues were histopathologically examined to assess the differences among the study groups. Results: At the end of 11 days, alveolar bone loss was significantly higher in the LO group compared to the NL, Pro 100, and Pro200 groups (P<0.05). Osteoclast numbers in the LO group were significantly higher than those of the NL, Pro 100, and Pro200 groups (P<0.05). Both dosages of propolis significantly reduced the periodontitis-related bone loss, but the differences between the two propolis groups were not statistically significant (P>0.05). Conclusion: The findings of this study provide morphologic and histologic evidence that propolis, when administered systemically, prevents alveolar bone loss in the rat model.
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    N-Acetylcysteine, a Thiol Antioxidant, Decreases Alveolar Bone Loss in Experimental Periodontitis in Rats
    (AMER ACAD PERIODONTOLOGY, 2009) Toker, Hulya; Ozdemir, Hakan; Eren, Kaya; Ozer, Hatice; Sahin, Gonul
    Background: The purpose of this study was to analyze the morphometric and histopathologic changes associated with experimental periodontitis in rats in response to systemic administration of N-acetylcysteine (NAC). Methods: Forty-three Wistar rats were divided into five experimental groups: non-ligated (NL) group (n = 10), ligature only (LO) group (n = 10), and groups that were administered NAC systemically (7, 35, or 70 mg/kg body weight per day [NAC7, NAC35, and NAC70 groups, respectively]; n = 8, 9, and 6). Silk ligatures were placed at the gingival margin of the lower first molars in a mandibular quadrant. The study duration was 11 days, and the animals were sacrificed at the end of this period. Changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences among the study groups. Results: At the end of 11 days, the alveolar bone loss was significantly higher in the LO group compared to NL, NAC7, NAC35, and NAC70 groups (P<0.05). There was no statistically significant difference in the osteoclast numbers among the study groups (P>0.05), whereas the effect of NAC was dose-dependent. Conclusion: NAC prevented alveolar bone loss in the rat model, in a dose-dependent manner, when administered systemically. J Periodontol 2009;80:672-678.