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Öğe A Cause of Right-Sided Flank Pain: Retrocaval Ureter(Erciyes Univ Sch Medicine, 2024) Ergin, Ismail Emre; Ozturk, Abuzer; Velibeyoglu, Arslan Fatih; Saygin, HuseyinBackground: The retrocaval ureter represents a rare congenital anomaly that occurs 0.1% of the population and causes progressive ureterohydronephrosis, most of which asymptomatic. Case Report: In this case report, the retrocaval ureter detected in an adult male complaining of right-sided colicky flank pain is discussed. Conclusion: This condition, whose main cause is an anomaly in the development of vena cava, is easily diagnosed with imaging methods, and its symptoms can be completely corrected with surgical treatment.Öğe Clinical characteristics and results of 45 patients who had adrenalectomy in our clinic(Bayrakol Medical Publisher, 2024) Asdemir, Aydemir; Ergin, Ismail Emre; Ozturk, Abuzer; Saygin, Hueseyin; Korgali, EsatAim: Laparoscopic adrenalectomy is a widely preferred method today. In recent years, many studies have reported that laparoscopic adrenalectomy requires less analgesic, less bleeding, lower complication rates and less hospitalization compared to open surgery. This study aimed to compare the surrenalectomy data performed in our clinic. Material and Methods: The data of surrenalectomies performed in our urology clinic between December 2010 and March 2022 were compared. Age, sex, side information, surgical method, and pathology results were recorded. Results: Forty five patients, aged between 26 and 83, were retrospectively analyzed. Of 45 patients who underwent surrenalectomy, 1 (2.2%) was bilateral, 25 (55.5%) were right, and 19 (42.3%) were left (42.3%) adrenalectomy. Of these cases, 18 (39.6%) were male, 27 (59.4%) were female, 31 (on one side of the bilateral) (67.4%) laparoscopic operation and 15 (on the other side of the bilateral) (32.6%) of them were open operation. Postoperative histopathological results were 17 (36.95%) adrenal cortical adenomas, 8 (17.4%) benign pheochromocytomas, 2 (4.35%) malignant pheochromocytomas, 6 (13.04%) adrenal cysts, 5 (10.86%) carcinoma metastases, 2 (4.36%) myelolipomas, 2 (4.36%) benign adrenal cortical oncocytomas, 1 (2.17%) borderline adrenal cortical oncocytoma, 1 (2.17%) oncocytic adrenal cortical carcinoma, 1 (2.17%) hydatid cyst and 1 (2.17%) adrenal tissue containing areas of bleeding and necrosis. Discussion: Histopathological results of surrenalectomy are not only significant in terms of malignancy but also important in terms of the treatment plan.Öğe Comparison of Prostate Specific Antigen and Neuropeptide Y Parameters in Patients with Prostate Cancer(Galenos Publ House, 2024) Ozturk, Abuzer; Saygin, Huseyin; Asdemir, Aydemir; Bolat, Serkan; Ergin, Ismail Emre; Kirac, Emre; Korgali, EsatObjective: Prostate cancer is a solid tumor that can be fatal in men. Early detection and proper management are essential for improving outcomes and reducing mortality rates associated with this disease. This study aimed to evaluate the potential of neuropeptide Y (NPY) as a biomarker to enhance the effectiveness of prostate specific antigen (PSA) testing in diagnosing and predicting prostate cancer prognosis. NPY, a well-known sympathetic neurotransmitter, possesses growth-promoting and angiogenic properties in various cell types, including those relevant to prostate cancer. Additionally, NPY has been linked to neuroendocrine differentiation of prostate cancer cells. By comparing the efficacy of PSA testing alone with the addition of NPY, this study aimed to determine whether NPY could offer additional predictive value for prostate cancer progression and prognosis. Materials and Methods: This study involved 90 patients each diagnosed with localized prostate cancer (LPC), metastatic prostate cancer (mPC) at diagnosis, and metastatic castration-resistant prostate cancer (mCRPC) who visited our urology clinic between 2022 and 2023. Blood samples were collected from all participants between 08:00 and 09:00 after a 12 hour fast. In the LPC and mPC groups, samples were collected upon diagnosis, whereas in the mCRPC group, samples were collected upon development of treatment resistance. NPY levels in blood samples were analyzed using enzyme-linked immunosorbent assay method. Serum NPY levels were compared between the LPC, mPC, and mCRPC groups. Results: PSA values were calculated as 12.6 (7.08-32.47) ng/L in the LPC group, 159 (73.1-405.2) ng/L in the mPC group, and 38.33 (18.4-132) ng/L in the mCRPC group, with a statistically significant difference between the groups (p<0.001). The average NPY values were 351.3 +/- 162.7 ng/L in the LPC group, 276.5 +/- 85 ng/L in the mPC group, and 272.13 +/- 94.7 ng/L in the mCRPC group. NPY values were found to be statistically significantly higher in the LPC group (p=0.018). Conclusion: The serum NPY levels were notably elevated in the LPC group compared with the mPC and mCRPC groups. This finding implies a potential association between low NPY levels and mPC as well as mCRPC.Öğe Correlation Between PSA Density and Multiparametric Prostate MRI in the Diagnosis of Prostate Cancer(Galenos Publ House, 2024) Aslanoglu, Ahmet; Saygin, Huseyin; Ozturk, Abuzer; Ergin, Ismail Emre; Asdemir, Aydemir; Velibeyoglu, Arslan Fatih; Korgali, EsatObjective: In the diagnosis of prostate cancer, only digital rectal examination and prostate -specific antigen (PSA) testing cause unnecessary prostate biopsies, excessive cost, and treatment burden. Therefore, PSA density (PSAD) and multiparametric magnetic resonance imaging (mp-MRI) of the prostate are becoming common. In this study, we aimed to investigate the predictiveness of PSAD and mp-MRI of the prostate in the diagnosis of prostate cancer, which are non-invasive diagnostic methods. Materials and Methods: The files of 193 patients who applied to the urology outpatient clinic for approximately 5 years were reviewed and evaluated retrospectively. Serum PSAD values and prostate imaging reporting and data system (PIRADS) scores were recorded. Prostate biopsies were performed. The cut-off value for PSAD was 0.15 ng/mL/cc. Patients with <0.15 were divided into group 1, and those with >= 0.15 were divided into group 2. Patients with a PIRADS score of 3 were divided into the suspicious group, and patients with a PIRADS score of 4 or 5 were divided into the risky group. Results: Prostate volume, PSA, and PSAD were significantly different between the benign and malignant groups. PSAD was positively correlated with the PIRADS score. Of the 123 patients with a PIRADS score of 3, 82.9% had benign prostatic enlargement (BPE) and 17.1% had prostate cancer. Of the 70 patients with a PIRADS score of 4 or 5, 45.7% had BPE and 54.3% had prostate cancer (p<0.001). Clinically significant prostate cancer rates were significantly different between the PSA score groups and were also different for PIRADS (p<0.001). The sensitivity and specificity of PSAD in the diagnosis of prostate cancer were 67.8% and 64.9%, respectively. The sensitivity and specificity of the PIRADS score in the diagnosis of prostate cancer were 64.4% and 76.1%, respectively. When these two parameters were used in combination, the specificity was 87.3% and the sensitivity was 81.4% in the presence of at least one. Conclusion: According to the data of the study, it was concluded that PSAD and PRIDAS scores are complementary diagnostic methods in the diagnosis of prostate cancer and are indispensable elements in the diagnosis. PSAD and PRIDAS scores are important diagnostic parameters in making the biopsy decision in the diagnosis of prostate cancer and help to prevent unnecessary prostate biopsies.Öğe Determination of kidney stone prevalence in Sivas city center: A retrospective research(Bayrakol Medical Publisher, 2021) Saygin, Huseyin; Cinar, Ziynet; Ozturk, Abuzer; Kirac, Emre; Ergin, Ismail Emre; Velibeyoglu, Arslan Fatih; Korgali, EsatAim: In this study, it was aimed to determine the prevalence of urinary stone disease (USD) in the center of Sivas based on data from patients who were diagnosed with USD at the urology clinic of the hospitals in Sivas center. Material and Methods: This is a retrospective study. The records of the patients who applied to the Urology Department of the Faculty of Medicine of Sivas Cumhuriyet University and Sivas Numune Hospital i between 2014 and 2019 were examined in this research. Evaluations of statistics were made on the basis of data to determine the prevalence of USD in Sivas center. Results: The data of 30218 people (20114 mates and 10104 females) who applied to the Urology Policlinic of Sivas Central Hospitals in 2014 and 2019 were evaluated for USD. Also, 4739 patients who were operated in both hospitals were evaluated according to gender and age. Results significantly increased with age for both genders (p<0.05). On the other hand, the number of people treated with Extracorporeal Shock Wave Lithotripsy (ESWL) in both hospitals was 1543. They were evaluated by age and gender, and results were not statistically significant (p>0.05). The prevalence of USD in the Sivas Center was determined as 8%. Agglomeration was observed in 31-70 age groups in both sexes. The results showed that the risk of USD was twice as high among men in both Numune Hospital and C.U Hospital. Discussion: Our country is one of the regions where USD is common, but there are not enough prevalence studies on this subject. It is a known fact that processes of diseases and treatment put a great burden on the economy of the country. Knowing the frequency of the disease makes it easier to take precautions. More epidemiological studies in larger populations are needed to direct health policies.Öğe Digit Length Ratio as an Indicator of Fetal Androgen Levels: Relationship to Prostate Volume-Related Men Lower Urinary Tract Symptoms(Wiley, 2025) Ergin, Ismail Emre; Ozturk, Abuzer; Asdemir, AydemirObjective: This study aimed to investigate the relationship between the 2nd and 4th digit ratios, which are associated with fetal androgen exposure, and prostate volume and testosterone levels, both of which are linked to lower urinary tract symptoms (LUTS). Methods: Male patients presenting to our urology clinic with increased prostate volume and LUTS were categorized into two groups: those with BPH and those without (non-BPH). For both groups, the right-hand 2D:4D finger ratio, testosterone levels, prostate volume, uroflow parameters, and IPSS scores were recorded. Results: The 2D:4D ratio, prostate volumes, Qmax, and IPSS scores differed significantly between the BPH and non-BPH groups (p = 0.023, 0.002, 0.000, 0.001). No significant difference was observed in total testosterone levels between the groups (p = 0.381). The 2D:4D ratio was negatively correlated with prostate volume and IPSS (r = -0.389, -0.308) and positively correlated with Qmax (r = 0.301). Conclusions: Our study demonstrates that the 2D:4D ratio is a straightforward and effective tool for assessing BPH patients, as it correlates with the severity of LUTS symptoms. This non-invasive measure offers potential value in evaluating LUTS, and with age standardization, it could be applied more broadly across age groups. Further large-scale studies are needed to refine its standardization and expand upon current findings.Öğe Effects of psoriasis and metabolic syndrome on male sexual functions(Imr Press, 2021) Saygin, Huseyin; Tosun, Mustafa; Ozturk, Abuzer; Ergin, Ismail Emre; Kirac, Emre; Asdemir, Aydemir; Velibeyoglu, Arslan FatihBackground and Objective: Psoriasis is a chronic inflammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis. Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded. Results: IIEF, HAM-D scores and MetS were significantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a significant negative correlation with age, HAM-D and PASI scores (r = -0.405, -0.217 and -0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment. Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.Öğe Fluoroquinolone Resistance Level in Rectal Swab Taken Before Transrectal Ultrasound Prostate Biopsy(Galenos Publ House, 2022) Saygin, Huseyin; Ozturk, Abuzer; Asdemir, Aydemir; Ergin, Ismail Emre; Velibeyoglu, Arslan Fatih; Kirac, Emre; Hasbek, MursitObjective: It has been shown that antibiotic prophylaxis before transrectal ultrasound prostate biopsy (TRUS-Bx) reduces the incidence of post-biopsy infectious complications. Without the superiority of a particular antibiotic regimen, there are differences in the antibiotic regimens used by clinics. However, recently, there have been serious concerns about TRUS-Bx-related infectious complications due to the increase in fluoroquinolone (FQ)-resistant bacterial strains. To overcome this global problem, alternative antibiotic prophylaxis should be investigated and appropriate antibiotic management should be applied in patients who will undergo TRUS-Bx. This study aimed to determine the antibiotic susceptibility of the rectal flora based on rectal cultures before TRUS-Bx, to systematically determine the basic prevalence of FQ resistance, to investigate the relationship between FQ resistance and the risk of infection after TRUS-Bx, and to determine the susceptibility of Fosfomycin and trimethoprim-sulfamethoxazole (TMP-SMX) as an alternative to the FQ group.Materials and Methods: Rectal swab cultures were taken from each patient to undergo TRUS-Bx two days before the procedure. Two daily doses of 500 mg ciprofloxacin were given orally for one week, starting one hour before the procedure. All patients underwent 12 core biopsies.Results: Antibiograms obtained from rectal swabs showed sensitivity to FQ in 78 patients (89.7%), to Fosfomycin in 85 patients (97.7%), to TMP-SMX in 78 patients (89.7%).Conclusion: Although different antibiotic prophylaxis methods are discussed due to FQ resistance in today's medical practices, FQ sensitivity continues at a high rate of 89.7% in our region and still seems to be a viable prophylaxis method.Öğe Mobile app communication to prevent ER visits post-circumcision: a prospective observational study(Springer, 2025) Sanci, Adem; Ergin, Ismail Emre; Ozturk, Abuzer; Asdemir, AydemirPurpose To assess the impact of a mobile phone application facilitating real-time visual and verbal communication on reducing emergency-room admissions following circumcision. Methods This prospective observational study included circumcision surgeries performed by one surgeon at our clinic between April and June 2024, after obtaining parental consent. Parents were divided into two groups: one received a mobile app phone number, while the other did not. The mobile app group was based on parents' communication needs, such as distance or socioeconomic factors. Follow-up appointments were scheduled for one week and one month; the mobile app group had follow-ups via the app, while the non-communicating group followed up in person. WhatsApp was used due to its cost-effectiveness and accessibility. Data on emergency visits, communications, and complications were recorded prospectively and analyzed retrospectively using SPSS with t tests and Mann-Whitney U tests (p < 0.05). Results A total of 200 patients were enrolled, with 162 meeting the inclusion criteria. The study was divided into two groups: 'Communicating group' (Group 1, 75 patients) had access to the mobile app, while 'Non-communicating group' (Group 2, 87 patients) received routine post-operative instructions. No significant differences in age or weight were found. The most common complications included wound infection, non-healing wounds, swelling, bleeding, and micturition issues. Emergency visits were significantly higher in Group 2 (12.64%) compared to Group 1 (1.33%) (p = 0.01). Conclusion The use of a mobile app for post-surgical communication may significantly reduce emergency-room visits following circumcision.
