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    Changes in Plasma Amino Acid Levels in Crimean-Congo Hemorrhagic Fever Patients
    (Pera Yayincilik Hizmetleri, 2024) Ertemur, Zeynep; Aydin, Huseyin; Engin, Aynur
    Objective: Crimean Congo Hemorrhagic Fever (CCHF) has an important place in viral hemorrhagic fever. Plasmaaminoacid (AA)levels of patientswhowerediagnosedwith CCHF in the acute and convalescent period of the disease were investigated in this study. Methods: 35 patients were included in the study specific polymerase chain reaction (PCR) and/or IgM antibody positivity for CCHF virus. AA levels were measured in the plasma derived from the blood samples of the patient and control groups, using liquid chromatography-mass spectrometry (LC-MS/MS) technique. Results: In our study, we observed that plasma aspartate, glutamate, histidine, leucine, phenylalanine, tyrosine levels increased statistically significantly (p<0.05), while some AAlevelsdecreased(p<0.05)inacutestagepatientscomparedtothecontrolgroups.In addition,whiletherewasanincreaseinplasmaglutamatelevelsofconvalescentpatients compared to the control groups (p<0.05), there was a significant decrease in other AA levels (p<0.05). Conclusion: Further studies to investigate the relationship between increased or decreased AAs in the plasma levels of these patients and the immune system are likely to contribute to a better understanding of the pathogenesis of the disease and to guide the approach to whether AA supplementation is necessary for treatment.
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    Glutamine depletion in patients with Crimean-Congo hemorrhagic fever
    (Wiley, 2020) Aydin, Huseyin; Engin, Aynur; Keles, Sami; Ertemur, Zeynep; Hekim, Nezih
    Crimean-Congo hemorrhagic fever (CCHF) is a viral disease. There is not enough knowledge about plasma amino acid levels in CCHF. Therefore, we investigated plasma amino acid levels in patients with CCHF and the association between the levels of these amino acids and disease severity. The plasma amino acid levels (including glutamate [Glu], aspartate [Asp], glutamine [Gln], asparagine [Asn] and gamma-aminobutyric acid [GABA]) in CCHF patients and controls were measured by using liquid chromatography-mass spectrometry. Plasma levels of Gln were lower while Asp, Glu, and GABA levels were higher in patients. In fatal CCHF patients, we found the plasma level of Asn was increased whereas the plasma level of GABA was decreased. This study is the first in the literature to evaluate the plasma Gln, Glu, Asn, Asp, and GABA levels in CCHF patients. We found that the plasma Gln levels were significantly lower in CCHF patients while Asp, Glu, and GABA levels were elevated. Considering that these amino acids are important for immune cells, the plasma amino acid levels of CCHF patients may contribute to the understanding of the pathophysiology of disease and it can be important for supportive treatment of CCHF.
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    The significance of taurine for patients with Crimean-Congo hemorrhagic fever and COVID-19 diseases: a cross-sectional study
    (Walter De Gruyter Gmbh, 2025) Celik, Simsek; Aydin, Huseyin; Tekin, Yusuf Kenan; Ertemur, Zeynep; Korkmaz, Ilhan; Yurtbay, Sefa; Engin, Aynur
    Objectives: In this study, we aimed to evaluate the change in taurine levels in two diseases [Crimean-Congo hemorrhagic fever (CCHF) and novel coronavirus disease (COVID-19)], which have a significant impact on public health as they frequently cause mortality and morbidity. Methods: This observational, cross-sectional study was conducted between September 15, 2023, and November 30, 2023, at the Emergency Department, Sivas Cumhuriyet University Faculty of Medicine. There were three groups in our study. These groups were 35 COVID-19 patients with confirmed diagnosis, 35 CCHF patients, and a control group consisting of 35 healthy volunteers who were similar to these patient groups in terms of age and gender. Plasma amino acid levels of taurine, beta-alanine, arginine, carnosine, cystine, histidine, lysine, and methionine were measured and compared in these three groups. Results: In the pairwise comparison of the groups, the increase in taurine plasma levels in CCHF (p<0.001) and COVID-19 (p=0.002) patients compared to the control group was statistically significant, whereas the difference between CCHF and COVID-19 patient groups was not significant (p=0.303). Multinomial logistic regression analysis revealed that taurine, beta-alanine, arginine, and lysine levels were significant predictors in differentiating patients with CCHF and COVID-19 from healthy individuals. Conclusions: We concluded that it may be important to determine taurine levels during the treatment and observation processes of these two diseases, which seriously affect public health. This study will contribute to a better understanding of the pathogenesis of the CCHF and COVID-19 diseases.