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Öğe Distribution of AB0 and Rh blood groups in cancer patients; is A Rh (+) blood group a risk factor in colorectal cancer development?(Sivas Cumhuriyet University, 2021) Gömeç, Muhammed; Özden, HüseyinObjective: Genetic factors have been the subject of many studies in cancer etiology. One of the most striking of these is the relationship between blood groups and cancer. Therefore, in our study, we examined the relationship between blood groups of stomach, colorectal, breast, thyroid and pancreatic cancers, which are common in general surgery practice, with single-center data.Method: We retrospectively analyzed cancer cases who applied to our University Hospital between 2005-2021. This analysis was done using a hospital database. 7899 cancer patients were included in the study. Cancer types, blood types, ages and gender of the patients were recorded. Results were analyzed statistically.Results: 55.2% of the patients included in the study were male and 42.8% were female. Of the patients, 553 (7%) were stomach, 767 (9.7%) colorectal, 779 (9.9%) breast, 625 (55.15%) thyroid, 209 (2.6% ) pancreatic cancer. 87.4% of the patients were Rh (+), 12.6% of them were Rh (-). 38% of patients A Rh (+), 5.2% A Rh (-), 13.8% B Rh (+), 2.2% B Rh (-), 7.7% AB Rh (+), 1.3% AB Rh (-), 28% 0 Rh (+), 3.8% 0 Rh (-). With the blood group distribution of all cancers; When the blood group distribution of gastric, colorectal, breast, thyroid and pancreatic cancers were compared, no statistically significant difference was found. However, it was found that the A Rh (+) blood group was higher in colorectal cancers compared to other cancers.Conclusions: In our study, no relationship was found between all cancers and blood type. In addition, no relationship was found between blood type and stomach, colorectal, breast, thyroid and pancreatic cancers, which are common in general surgery practice. Although it is generally accepted that especially A blood group is a risk factor for gastric cancer, there was no significant difference in our patient series. When AB0 and Rh blood groups were evaluated together, the A Rh (+) blood group was seen more in colorectal cancers.Öğe Effect of Wheat Germ Oil on Wound Healing: An In Vitro Study in Fibroblast Cells(Ümit Muhammet KOÇYİĞİT, 2022) Gömeç, Muhammed; İpek, Gülnihal; Öztürk, Ayşegül; İnan, Deniz ŞahinPurpose: Wound healing is a set of mechanisms that are activated to restore structurally damaged tissue. There are many studies aimed at accelerating wound healing. In this context, products obtained from plants come to the fore. In this article, the effects of wheat germ oil (WGO), which is known to have antioxidant and anti-inflammatory properties, on wound healing were investigated by in vitro method. Material and Methods: Wheat germ oil and α-tocopherol were applied to L929, a healthy fibroblast cell line, at different doses for 24, 48 and 72 hours. Cell viability was measured by XTT colorimetric method. In vitro wound healing model was applied at the dose where the oil was effective. Obtained results were analyzed statistically. Results: As a result of the application of α-tocopherol to L929 cells at different doses, it was observed that there was no significant contribution to cell proliferation compared to the control group. However, WGO was observed to significantly increase proliferation at the 100 ng/ml concentration. In the wound healing model, cells treated with WGO at 48 hours were observed to proliferate faster and invade the wound site more rapidly. (pÖğe The Healing Effects of The Topical Mesenchymal Stem Cells Application on Colonic Anastomosis Subjected to Ischemia Reperfusion Injury(2021) Özden, Hüseyin; Karaca, Gökhan; Bulut, Huri; Niyaz, Mehmet; Gömeç, Muhammed; Daphan, Çağatay E.Intestinal ischemia reperfusion injury (IRI) is a challenging problem and it adversely affects the healing of colonic anastomosis. Our experimental study aimed to investigate the role of mesenchymal stem cells (MSC) administration in the healing of colonic anastomosis. A total of 33 rats were grouped as Control, IRI and MSC treatment groups. Three rats were reserved for obtaining MSCs. Colonic resection and anastomosis procedure was performed in all groups. Anastomotic line was wrapped with MSCs impregnated spongostan after colonic anastomosis in the rats of the MSC treatment group. All rats were sacrificed and anastomotic line were sampled for examination on the post operative seventh day. Tissue hydroxyproline (HP) levels and anastomotic bursting pressures were statistically compared. Anastomotic bursting pressures were found to be significantly high in MSC treatment group rats. The lowest anastomotic bursting pressure was detected in IRI group rats. Hydroxyproline content of the anastomotic sites were also found to be significantly higher in the rats of the MSC treatment group when compared with the IRI group rats. Our study showed that the detrimental effects of IRI on the healing process of colonic anastomosis in an experimental model may be alleviated with the treatment of MSCs.Öğe Hemoroid Tedavisinde Stapler Hemoroidopeksi Deneyimlerimiz(2020) Gömeç, Muhammed; Özden, HüseyinAmaç: Stapler hemoroidopeksi (Longo prosedürü) ile yapılan hemoroid ameliyatları, daha az ağrı ve daha kısa hastanede kalış süresi ile özellikle evre III-IV hemoroidli hastaların tedavisinde sık tercih edilebilen bir cerrahi yöntemdir. Bu çalışmanın amacı kliniğimizde stapler hemoroidopeksi (SH) yöntemi ile tedavi etmiş olduğumuz hastalarla ilgili klinik deneyimlerimizi değerlendirmektir. Araçlar ve Yöntem: İkinci basamak bir devlet hastanesinde Haziran 2018 ile Ekim 2019 tarihleri arasında SH yöntemi uygulanarak tedavi edilen evre III-IV hemoroidli 26 hastanın tıbbi kayıtları retrospektif olarak incelendi. Hastaların demografik verileri, eşlik eden anal bölge hastalıkları, ameliyat ve hastanede yatış süreleri, postoperatif dönemde gelişen ağrıları, komplikasyonları ve erken dönem nüks oranları değerlendirildi. Bulgular: Çalışmaya dahil edilen 26 hastanın 18'i erkek (%69), 8'i kadındı (%31). Hastalar 18-64 yaş aralığında ve ortalama yaş 36,4 olarak hesaplandı. Ortalama ameliyat süresi 14 dakika ve ameliyat sonrası ortalama hastanede kalış süresi 2.8 gündü. Bir hastada kanama (% 3,8), 2 hastada idrar retansiyonu (% 7,7) ve 2 hastada deri katlantısı (skin tag) (% 7,7) görüldü. 1 hastada ilk 6 ayda nüks izlendi. Hiçbir hastada tenesmus, apse, inkontinans, rektovajinal fistül veya anal darlık görülmedi. Sonuç: Stepler hemoroidopeksi, evre III-IV hemoroid hastalarını tedavi etmek için kullanılan, tek seansta etkili bir tedavi ortaya koyabilen, minimal invaziv, uygulanabilir bir tekniktir. Ancak erken ve geç dönemde nüks ve kanama gibi komplikasyonlar nadir de olsa görülebildiğinden cerrahi prosedür seçiminin önemli olduğu kanaatindeyiz.Öğe INVESTIGATION OF 18F-FDG PET / CT AND CLINICOPATHOLOGICAL DATA OF DIFFUSE TYPE GASTRIC CANCERS(2022) Gömeç, Muhammed; Hasbek, ZekiyeObjective: One of the subtypes of stomach cancer, which is one of the leading causes of cancer-related deaths, is diffuse-type stomach cancer. In our study, it was aimed to retrospectively investigate the results of F-18-labeled fluorodeoxyglucose positron emission tomography, which is an imaging method frequently used in the diagnosis and follow-up of gastric cancer, in diffuse type gastric cancer subtypes and to review patient data in the light of the literatüreMaterial and Methods: Forty-four patients diagnosed with diffuse-type gastric cancer in a single center were included in the study. Clinical, pathological and positron emission tomography data of the patients were analyzed.Results: The mean age of the patients was 61.93. Sixteen (36.4%) of the patients were female, 28 (63.5%) were male. When the histopathological results of specimens obtained by endoscopic and surgical methods are examined, diffuse-type stomach cancer patients; 36 (81.8%) were Signet-Ring Cell, 8 (18.2%) were weak poorly cohesive type gastric cancer. Low F-18-labeled fluorodeoxyglucose involvement was observed in 8 (18.2%) patients, while high involvement was observed in 36 (81.8%). Nineteen of the patients had metastases. When SUVmax, SUVmean, metabolic tumor volume and total lesion glycolysis values were compared, a significant correlation was found between signet ring cell gastric cancers and weak cohesive type gastric cancers, and between presence and absence of metastasis (p <0.05).Conclusion: Although SUVmax values were lower in our diffuse type gastric cancer patient series compared to other gastric cancer patients, it was observed that it was higher in advanced diffuse type gastric cancers than in early stage patients. In addition, when the diffuse type gastric cancer subtypes signet-ring cell and weak poorly cohesive type gastric cancers were compared in terms of positron emission tomography results, it was observed that there was no significant difference, and this is an information that is not available in the literature.Öğe Investigation of the potential antitumor activity of PLK1 inhibitor SBE13 in colon cancer cell line HT29(Sivas Cumhuriyet University, 2022) Gömeç, Muhammed; Yulak, Fatih; Ergül, MustafaBackground: High levels of Polo-like kinase 1 (PLK1), which are abnormally expressed in many tumor types, are known to contribute to tumorigenesis and poor prognosis. Therefore, specific targeting of PLK1 is an important strategy for cancer therapy. This study, it was aimed to investigate the cytotoxic effect of SBE13, one of the PLK1 inhibitors, against HT29 colon adenocarcinoma cells and its apoptotic potential.Methods: The cytotoxic effect of SBE13 on HT29 was determined by XTT colorimetric assay. Flow cytometry was also used to determine apoptosis.Results: SBE13 showed a dose-dependent cytotoxic effect in HT29 cells and its IC50 value was calculated as 11.79 µM for 48 h. Moreover, the Annexin V binding assay revealed that SBE13 treatment significantly increased apoptosis in HT29 cells.Conclusion: Generally, SBE13 exerts a cytotoxic effect promoted by apoptosis in colon cancer cells HT29. Although the anticancer efficacy of SBE13 in colon cancer is promising, this potential effect should be reinforced by further studies.Öğe Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Gömeç, Muhammed; Gedikli, Mustafa Asım; Ertürk, Seyit Ahmet; Hasbek, ZekiyePapillary thyroid cancer (PTC) is the most common type of thyroid cancer, and its incidence continues to increase. Multifocality is common in PTC, and it has been suggested in many studies that multifocality may be associated with poor prognosis. In this study, data of patients followed with multifocal PTC were evaluated. Following the approval of the local ethics committee, the data of patients who received total thyroidectomy and subsequent radioactive iodine (RAI) treatment for thyroid cancer between 2012 and 2020 were evaluated. Multifocality was detected in 142 (19.88%) of the 714 PTC patients studied. The rate of multifocality among PTC patients was 3.29% in 2012, 7.2% in 2013, 10.1% in 2014, 10.5% in 2015, 38.15% in 2016, 31.6% in 2017, 33.33% in 2018, 32.58% in 2019 and 22.22% in 2020. Of these patients, 52.1% had 2 foci, 20.4% had 3 foci, 15.5% had 4 foci, and 12% had 5 or more foci. Multifocality was observed in the right and left lobe in 54.2% of the patients, the right lobe in 21.1% of the patients and t he left lobe in 12.7% of the patients. Multifocality was not detected in the isthmus only. It was found that as the number of tumor foci increased, differentiation decreased. It was observed that multifocality was more common in microcarcinomas. In our clinic, it has been observed that the rate of multifocal PTC has increased in recent years. This significant increase may be the result of morphological changes as well as improvements in diagnosis and treatment. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe Manyetik Rezonans Kolanjiyopankreatografi Biliyer Görüntü Verilerinin Laboratuvar Verileri ile Korelasyonu(Ümit Muhammet KOÇYİĞİT, 2021) Gömeç, Muhammed; Gedikli, Mustafa AsımAmaç: Safra kesesi taşlarının oluşumunda, özellikle safranın kimyasal içeriği ve safra kesesinin bozulmuş hareketliliği başta olmak üzere birçok etiyoloji ön plana çıkmaktadır. Bu çalışma, merkezimizde herhangi bir nedenle MRCP çekilen hastaların radyolojik görüntüleri ve laboratuvar verilerini değerlendirerek bağlantılarını ortaya çıkarmayı amaçlamaktadır. Gereç ve Yöntem: 2019-2020 yıllarında etik kurul onayı ile tek merkezde kolestaz ön tanısıyla MRCP yapılan hastaların verileri geriye dönük olarak incelendi. MRCP görüntülerinde koledok çapı, kolelitiyazis ve koledokolitiazis varlığı ve sistik kanal varyasyonları değerlendirildi. Ayrıca laboratuvar verileri incelenmiş ve aralarındaki ilişki istatistiksel olarak karşılaştırılmıştır. Bulgular: Safra yolu patolojisi ön tanısıyla MRCP yapılan 193 hastanın% 59.1'i kadın (n = 114),% 40.9'u erkekti (n = 79). Ortalama yaşları 63,1 ± 19,4'tür. Hastaların% 35,3'ünde (n = 68) sistik kanal normal iken,% 64,7'sinde (n = 125) anatomik varyasyon vardı. Sistik kanalda varyasyon varlığı açısından cinsiyetler arasında fark yoktu. Varyasyon varlığı ile safra kesesi taşları arasında anlamlı bir ilişki yoktu. Ortak safra kanalı çapı ile safra kesesi taşı varlığı ve WBC, nötrofil ve ALP değerleri arasında pozitif bir korelasyon bulundu. Sonuç: Safra kanalı varyasyonlarının safra taşı oluşumunda etkili olabileceği düşünülse de, olgu serimizde varyasyonel sistik kanalın safra taşı oluşumunda etkili olmadığı görüldü. MRCP görüntülerinde, ortak safra kanalının çapındaki artışın ve WBC, nötrofil ve ALP değerlerindeki yüksekliğin safra taşı varlığını desteklediğini gördük.Öğe Our Experience of Stapler Hemorrhoidopexy in the Treatment of Hemorrhoids.(Kırşehir Ahi Evran Üniversitesi, 2020) Gömeç, Muhammed; Özden, HüseyinPurpose: Hemorrhoid surgeries performed with stapler hemorrhoidopexy are frequently preferred in the treatment of patients with stage III-IV hemorrhoids, with less pain and shorter hospital stay. The aim of this study is to evaluate our clinical experiences in patients underwent SH.Material and Method: Hospital records of 26 patients with stage III-IV hemorrhoids treated with SH procedure be-tween June 2018 and October 2019 at a secondary center were retrospectively analyzed. Demographic data of patients, accompanying anal diseases, duration of surgery and hospital stay, postoperative pain, complications and early recur-rence rates were reviewed.Results: A total of 26 patients was included in the study, 18 males (69%) and 8 females (31%). The mean age of the patients was 36,4 years (age range: 18-64). The mean operation time was 14 minutes and the mean hospital stay after the operation was 2.8 days. Bleeding was observed in one patient (3.8%), urinary retention in 2 (7.7%) and skin tag (7.7%) in 2. Recurrence was observed in one patient in the first six months. None of the patients had tenesmus, ab-scess, incontinence, rectovaginal fistula, or anal stenosis.Conclusion: SH is a minimally invasive, feasible technique that can be used to treat stage III-IV hemorrhoids and can provide effective treatment in a single session. However, we believe that the choice of surgical procedures is important since complications such as recurrence and bleeding are rarely seen in the early and late periods.Öğe Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus(Selçuk BAŞAK, 2021) Özden, Hüseyin; Gömeç, Muhammed; Şahin, Yaşar; Karaca, Gökhan; Bulut, Huri; Kilitci, AsumanBackground/Aim: Tacrolimus is a commonly used agent for immunosuppression in organ transplantation with known nephrotoxic effects. We think that kidney-sparing therapy should be added to current treatment protocols. We aimed to observe the protective effect of resveratrol (RSV) against the adverse effects of tacrolimus (TAC) on rat kidneys. Methods: Twenty-four rats were randomly divided into the following three groups of eight rats each: Control, TAC, and RSV. The control group was not treated in any way. Tacrolimus was administered to the TAC group. In addition to tacrolimus use, resveratrol was administered to the RSV group. At the end of the experiment, one kidney was used for histopathological examination and the other, for biochemical examination. Results were analyzed statistically. Results: IL-1β, IL-6, TNF-Alpha levels in the control group were significantly lower than those in TAC and RSV groups (IL-1; P<0.001, P<0.001, IL-6; P<0.001 P=0.002, TNF-Alpha; P<0.001, P<0.001), and those in the RSV group were significantly lower than those in the TAC group (IL-1: P=0.032, IL-6: P=0.001 TNF-Alpha: P=0.026). TAS levels of the control group were significantly higher than those of the TAC group (P=0.030). TOS and OSI levels of the control group were significantly lower than those of the TAC and RSV groups (TOS: P=0.002, P=0.012, OSI: P=0.001, P=0.004). In histopathological evaluation, the TAC group showed the highest levels of fibrosis. The differences between the control and TAC groups and the TAC and RSV groups were statistically significant (P=0.003, P=0.003). Conclusion: Resveratrol has a protective effect against the adverse effects of tacrolimus on the kidney, which may be because of its anti-inflammatory and antioxidant properties.Öğe Sıçanlarda Mastektomi ve Aksiller Diseksiyon Sonrası Seroma Gelişimi Üzerine Kriyoprezerve İnsan Amniyotik Membran ve Trombositten Zengin Plazmanın Etkileri(Düzce Üniversitesi, 2022) Gömeç, Muhammed; Özkaraca, MustafaAmaç: Seroma, mastektomi ve aksiller lenf nodu diseksiyonu sonrası en sık görülen komplikasyonlardan bir tanesidir. Yara iyileşmesinin eksüdatif ve inflamatuar fazının uzamasının bir sonucu olarak ortaya çıkar. Bu çalışmanın amacı, insan amniyotik membranı (human amniotic membrane, HAM) ve trombositten zengin plazma (platelet-rich plasma, PRP)’nın seroma oluşumu üzerindeki etkilerini değerlendirmektir. Gereç ve Yöntemler: Toplam 24 adet sıçan kontrol, PRP ve HAM grubu olarak gruplara ayrıldı. Tüm sıçanlara radikal mastektomi ve aksiller lenf nodu diseksiyonu yapıldı. Diseksiyon bölgesine kontrol grubunda salin, ikinci grupta PRP ve üçüncü grupta ise HAM uygulandı. Tüm gruplar cerrahi alanın durumu, seroma hacmi ve histopatolojik değişiklikler açısından karşılaştırıldı. Bulgular: PRP grubunda seroma hacminde azalma görüldü, ancak HAM grubunda azalma gözlenmedi. Hem PRP hem de HAM grubunda lenfosit, eozinofil, histiyosit ve fibroblast seviyeleri kontrol grubuna göre anlamlı derecede daha düşük olduğu tespit edildi. PRP ve HAM gruplarının E-cadherin ve TGF-β1 immünreaktivitelerinin de kontrol grubuna göre daha yüksek olduğu tespit edildi. Sonuç: Bu çalışmada PRP ve kriyoprezerve HAM'ın doku iyileşmesini arttırdığı ve inflamatuar süreci azalttığı gözlendi. Ancak lokal PRP uygulanması seroma oluşumunu önemli ölçüde azaltsa da lokal HAM uygulamasının seroma oluşumunu azaltmadığı belirlendi. Bunun HAM'ın pürüzsüz yüzeyinin mekanik olarak dokuların yapışmasını engellemesinden kaynaklanabileceği düşünüldü. HAM'ın hazırlanmasında ve uygulanmasında yapılacak olan modifikasyon ile daha faydalı sonuçlar elde edilecektir.Öğe The Effects of Cryopreserved Human Amniotic Membrane and Platelet-Rich Plasma on Seroma Development after Mastectomy and Axillary Dissection in Rats(Duzce University Medical School, 2022) Gömeç, Muhammed; Özkaraca, MustafaAim: Seroma is one of the most common complications after mastectomy and axillary dissection. It occurs as a result of prolongation of the exudative-inflammatory phase of wound healing. The aim of this study is to evaluate the effects of human amniotic membrane (HAM) and platelet-rich plasma (PRP) on seroma formation. Material and Methods: A total of 24 rats were grouped as control, PRP, and HAM groups. All rats underwent radical mastectomy and axillary lymph node dissection. Saline in the control group, PRP in the second group, and HAM in the third group were applied to the dissection area. The groups were compared in terms of the condition of the surgical field, seroma volume, and histopathological changes. Results: Seroma volume decreased in the PRP group, but not in the HAM group. Lymphocyte, eosinophil, histiocyte, and fibroblast levels were significantly lower both in the PRP and HAM groups compared to the control group. E-cadherin and TGF-?1 immunoreactivities of PRP and HAM groups were higher than in the control group. Conclusion: In this study, it was observed that PRP and cryopreserved HAM increased tissue healing and decreased the inflammatory process. However, although local PRP application significantly reduced seroma formation, it was determined that HAM application did not reduce seroma formation. It was thought that this might be due to the fact that the smooth surface of HAM mechanically prevents the adhesion of the tissues. More beneficial results will be obtained with the modification to be made in the preparation and application of HAM. © 2022, Duzce University Medical School. All rights reserved.Öğe The Healing Effect of Resveratrol and Platelet Rich Plasma in Corrosive Esophagitis Model in Rats(Sivas Cumhuriyet University, 2022) Özden, Hüseyin; Gömeç, Muhammed; Şahin, Yaşar; Karaca, Gökhan; Bulut, Huri; Kilitci, AsumanBackground: Corrosive esophageal burns have high morbidity and mortality. The effective treatment is controversial. In our study, we aimed to examine the effects of resveratrol (RSV) and platelet rich plasma (PRP) on healing in the corrosive esophagitis model in rats. Material and methods: A total of 24 rats were randomly divided into 4 groups each as esophagitis, control, PRP and RSV groups. No treatment was administered to the control group. The esophagitis model was induced in the esophagitis and treatment groups. The esophagitis group was not treated. PRP group was treated with PRP, RSV group was treated with RSV. Pathological and biochemical examinations were performed from distal esophagitis. Results: The highest tissue IL-1, IL-6, and TNF-α levels were observed in the esophagitis group. The lowest tissue IL-1, IL-6, and TNF-α levels were noted in the control group. The highest tissue TAS levels were observed in the control group. The lowest tissue TAS levels were noted in the esophagitis group. The other groups had significantly lower mean tissue TOS and OSI levels than the esophagitis group (P<0.05). Conclusions: PRP and RSV have a healing effect on esophagitis. We are of the opinion that it may be included in clinical practice over time if the dose and duration of treatment can be adjusted better for RSV.
