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Öğe Acute phase proteins, clinical, hematological and biochemical parameters in dairy cows naturally infected with Anaplasma marginale(Veteriner Fakultesi Dergisi, 2012) Coşkun, Alparslan; Ekici, Özlem Derinbay; Güzelbekteş, Hasan; Aydo?du, U?ur; Şen, IsmailThe aim of the study was to evaluate acute phase response via Haptoglobin and serum amyloid-A concentrations in dairy cows naturally infected with Anaplasma marginale. The second aim of the study was to determine the changes in clinical, hematological and biochemical parameters in dairy cows naturally infected Anaplasma marginale. A total of 40 dairy cattle suffering from bovine anaplasmosis were included to the study from a dairy cattle herd. A total of 10 healthy dairy cattle were selected for control group. Analysis of acute phase proteins, hematologic analysis and biochemical analysis was performed in this study. Serum haptoglobin and serum amyloid-A concentrations significantly increased in cattle infected with Anaplasma marginale compared to healthy cattle. All cattle in infected group demonstrated clinical signs of anaplasmosis. Significantly decreased red blood cell count, packed cell volume, and hemoglobin concentration were observed in infected cattle compared to the control group. Serum aspartate aminotransferase, alkaline phosphatase, creatinine and bilirubin concentrations were significantly increased in infected cattle compared with the control group. In conclusion, the changes of biochemical and hematological parameters may be indicate of anemia and tissue damage in cattle with anaplasmosis. Serum haptoglobin and serum amyloid-A concentrations could be usefull in evaluate of acute phase response in cattle infected with Anaplasma marginale.Öğe Endotoksemili buzağıların tedavisinde tek başına kolistin'in ve kolistin+meloksikam kombinasyonunun etkisi(2014) Coşkun, Alparslan; Güzelbekteş, Hasan; Şen, İsmail; Constable, Peter David[Abstract Not Available]Öğe Response of inflammatory cytokine levels in calves with LPS-induced endotoxemia(Springer Science and Business Media Deutschland GmbH, 2025) Şen, İsmail; Güzelbekteş, Hasan; Aydoğdu, Uğur; Coşkun, AlparslanThe most common form of toxemia observed in large animals is endotoxemia. Endotoxemia is caused by the presence of lipopolysaccharide cell wall components of gram-negative bacteria in the blood and characterized clinically by abnormalities of many body systems. This study aimed to determine changes in serum inflammatory cytokine levels in calves with LPS-induced endotoxemia. Ten healthy Holstein breed calves were used in the study. To create experimental endotoxemia, LPS at 0.1 µg/kg dose was given intravenously to the calves from the vena jugularis as an infusion within 30 min. Blood samples to evaluate cytokines, biochemical, blood gases, and hematological parameters were collected before LPS infusion (0. hour) and at 1, 2, 3, 4, 6, 12, 24, and 36 h following LPS infusion. In the first 4 h following the LPS infusion, calves’ body temperature, heart and respiratory rate, and capillary refill time increased, while a decrease was observed in the following hours. Significant changes were detected in blood pH, WBC, and glucose levels after LPS administration. Serum TNF-α, IL-6, IL1-β, IL-10, and IFN-γ levels were low before the LPS infusion in the calves, while increased within the first 4 h following the LPS infusion, however, statistical significance was observed in TNF-α, IL-6, and IFN-γ. Cytokine levels decreased back to baseline levels after the fourth hour. As a result, it was found that 0.1 µg/kg dose of LPS administrated as infusion caused changes in clinical, hematological, blood gases, biochemical parameters, and significant increases in the levels of circulating cytokines. The results of this study showed that the changes observed in the organism during natural endotoxemia can also be revealed experimentally by administering LPS intravenously. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2024.Öğe Yenidoğan İshalli Buzağılarda Mortalite İndikatörü Olarak Kan Laktat, Glikoz, Total Protein ve Gama Glutamil Transferaz Seviyeleri(2019) Aydoğdu, Uğur; Yıldız, Ramazan; Güzelbekteş, Hasan; Coşkun, Alparslan; Şen, İsmailBu çalışmanın amacı, yenidoğan ishalli buzağılarda prognoz ve mortalite indikatörü olarak hangi parametrelerin kullanılabileceğini araştırmaktı. Araştırmada 51 yenidoğan ishalli buzağı kullanıldı. İshalli buzağılar ölen (n=16) ve hayatta kalan (n=35) olarak iki gruba ayrıldı. Tüm buzağıların rutin klinik muayeneleri yapıldıktan sonra hematolojik, kan gazları ve biyokimyasal analizler için kan alındı. Tüm buzağılarda ishal, dehidrasyon, emme refleksinde azalma, kapiler tekrar dolum zamanında uzama, hipotermi ve solunum sayısında artış belirlendi. Ölen ve hayatta kalan buzağılarda Şiddetli metabolik asidoz ve hiperkalemi mevcuttu. Hayatta kalan buzağılar ile karşılaştırıldığında ölen ishalli buzağıların kan laktat seviyesi önemli oranda (P<0.05) yüksek, kan glikoz, ortalama eritrosit hemoglobin konsantrasyonu (MCHC), total protein (TP) ve gama glutamil transferaz (GGT) seviyeleri ise önemli oranda (P<0.05) dü?üktü. ?shalli ölen ve ya?ayan buzağılar arasında laktat cut-off değeri 4.5 mmol/L olarak değerlendirildiğinde, sensitivite ve spesifitesinin sırasıyla %81.3 ve %71.4 olduğu tespit edildi. Sonuç olarak, neonatal ishalli buzağılarda kan laktat ve glikoz seviyesinin prognoz ve mortalite göstergesi olarak kullanılabileceği, TP seviyesi ve GGT aktivitelerinin düşük olmasının pasif transfer yetmezliğine bağlı hastalıklara karşı predispoze faktör olabileceği değerlendirilmiştir.
