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Öğe Adenosine deaminase and xanthine oxidase levels in multiple sclerosis patients(Bayrakol Medical Publisher, 2020) Gokce, Seyda Figul; Demirpence, Ozlem; Cigdem, Burhanettin; Bolayir, Asli; Ersan, SerpilAim: Multiple sclerosis represents an autoimmune, chronic, inflammatory, and demyelinating disease of the central nervous system. Inflammation and oxidative stress are considered to take a significant part in its pathogenesis. Adenosine deaminase (ADA) and xanthine oxidase (XO) enzymes, which are involved in purine metabolism, are critical for regulating inflammation and oxidative stress. Therefore, this study's goal is to evaluate the levels of these two enzymes in patients with the relapsing-remitting type of multiple sclerosis (MS) in their remission period. Material and Methods: Thirty patients with relapsing-remitting multiple sclerosis (RRMS) who were in their remission period and diagnosed in accordance with the Mc Donald 2010 criteria along with 30 healthy volunteer controls, matched with regard to age and gender, were enrolled in the research. Serum ADA levels were studied by the sensitive colorimetric method that was defined by Giusti, while XO levels were studied by the Worthington method. Results: RRMS patients had significantly higher serum ADA and XO levels compared to the control subjects (both of the P values = 0.004). Discussion: In our study, we conclude that two of the most crucial underlying pathogenic mechanisms of MS, inflammation and oxidative stress, may be associated with the increased levels of ADA and XO, and an approach of targeting the activity of these two enzymes can be considered in treatment strategies. Furthermore, we also demonstrated that ADA and XO enzymes were elevated even in the remission phases of RRMS, reflecting the continuity of inflammation through the whole course of RRMS. Thus, in this disease, which is thought to have a dynamic process, the importance of continuous immunomodulatory treatment is emphasized once again.Öğe Aortic Dissection Presenting with Transient Paraplegia(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Donmez, Recep; Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Balaban, Hatice; Bolayir, Ertugrul; Topaktas, Suat…Öğe Brain and Spinal Cord Biopsy in the Diagnosis Demyelinating Diseases(Wiley, 2019) Gokce, Seyda Figul; Gelfand, Jeffrey M.; Bove, Riley; Krishnakumar, Tanya; Villanueva-Meyer, Javier; Tihan, Tarik[Abstract Not Available]Öğe Can SCUBE1 be used to predict the early diagnosis, lesion volume and prognosis of acute ischemic stroke?(WALTER DE GRUYTER GMBH, 2019) Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Bolayir, Hasan Ata; Gulunay, Aydin; Celik, Veysel Kenan; Kapancik, Serkan; Yildiz, Oztem KayimObjective: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] is a novel biochemical marker. SCUBE1 is thought to play roles both in platelet activation and inflammation, which are important stages for the development of acute ischemic stroke (AIS). The purpose of our study was to determine the diagnostic and prognostic values and temporal change of plasma SCUBE1 levels in AIS patients. Materials and methods: Thirty-five patients diagnosed with AIS at the Cumhuriyet University Faculty of Medicine Neurology Department, between June and December 2017, and a control group of 35 healthy volunteers were included. Results: Median first day SCUBE1 value in the patient group was 97.51 ng/mL, and the median 7th day SCUBE1 value was 32.72 ng/mL. Median control group SCUBE1 value was 27.51 ng/mL. The first day SCUBE1 levels were significantly higher than the 7th day and the control group SCUBE1 levels (p = 0.001, p < 0.001, respectively). The ROC analysis showed that SCUBE1 levels above 68.8 ng/mL can be used as an indicator with high sensitivity and specificity for AIS diagnosis. Multivariate analysis revealed that the first day SCUBE1 had significant independent effects on development of AIS. In correlation analysis, plasma SCUBE1 levels showed a significantly positive correlation with lesion volume, NIHSS and MRS values (p < 0.01). Conclusion: First day plasma SCUBE1 values in AIS patients rised at significant levels compared to the control group. SCUBE1 could use both in the early diagnosis and prediction of prognosis and lesion volume of AIS patients.Öğe Case report: Nonobstructive giant urethral stone with two safety pins(SPRINGER, 2003) Gokce, Gokhan; Topsakal, Kahraman; Ayan, Semih; Kilicarslan, Hakan; Gokce, Seyda Figul; Gultekin, Emin YenerThe urethra can be the site of various types of foreign bodies. A 61-year-old man having a giant urethral stone with two safety pins was evaluated according to the literature. To our knowledge, we report the first case of foreign bodies in urethra in which existing non-obstructive giant urethral stone with two safety pins.Öğe Case report: Nonobstructive giant urethral stone with two safety pins(Springer Netherlands, 2003) Gokce, Gokhan; Topsakal, Kahraman; Ayan, Semih; Kilicarslan, Hakan; Gokce, Seyda Figul; Gultekin, Emin YenerThe urethra can be the site of various types of foreign bodies. A 61-year-old man having a giant urethral stone with two safety pins was evaluated according to the literature. To our knowledge, we report the first case of foreign bodies in urethra in which existing non-obstructive giant urethral stone with two safety pins. © 2004 Kluwer Academic Publishers.Öğe The Effect of Eosinopenia on Mortality in Patients with Intracerebral Hemorrhage(ELSEVIER SCIENCE BV, 2017) Bolayir, Asli; Cigdem, Burhanettin; Gokce, Seyda Figul; Bolayir, Hasan Ata; Yildiz, Ozlem Kayim; Bolayir, Ertugrul; Topaktas, Suat AhmetIntroduction: Inflammation may determine the prognosis of intracerebral hemorrhage (ICH), which has high mortality and morbidity rates. Recent studies have increasingly demonstrated eosinopenia as a prognostic factor, particularly in bacteremia, chronic obstructive pulmonary disease, and myocardial and cerebral infarction. Nonetheless, its significance regarding the determination of prognosis in patients with ICH has not yet been clarified. Materials and Methods: Our study included 296 patients who presented to our clinic within 24 hours of the onset of symptoms and who were diagnosed with ICH between January 2008 and June 2016, along with 180 age- and sex-matched controls. During their hospitalization, 120 of these 296 patients died. Patients and controls were compared in terms of neutrophil count/percentage and eosinophil count/percentage; these were also compared between nonsurviving and surviving patients. The significance of eosinopenia in predicting mortality was also evaluated. Results: Patients had a significantly higher neutrophil count/percentage and a significantly lower eosinophil count/percentage than controls; these results were similar between nonsurviving and surviving patients (P < .001). Consequently, the patient group was divided into 4 subgroups depending on the presence of eosinopenia and/or neutrophilia. The mortality rate was highest (62%) in the group that had both eosinopenia and neutrophilia. Univariate and multivariate logistic regression analyses indicated that neutrophilia and eosinopenia were independent predictors of mortality in ICH (P = .002; P = .004) Discussion: These results indicate that eosinopenia can occur in patients with ICH and that although the mechanism is unclear, eosinopenia is closely associated with mortality in these patients, particularly when accompanied by neutrophilia.Öğe Effects of ApaI, FokI, and BsmI gene polymorphisms of the vitamin D receptor on serum vitamin D level in Turkish MS patients with different types and severities of the disease(2021) Çetinel, Tuğba; Gokce, Seyda Figul; Yıldırım, Malik Ejder; Bolayır, AslıAim: Adequate vitamin D levels may reduce the risk of multiple sclerosis (MS) development and progress. It is believed that a number of genes cause the disease, including the genes that function on vitamin D metabolism, although information about the role of the said genes is quite contradictory. We aimed to investigate the status of serum vitamin D and ApaI, FokI, and BsmI gene polymorphisms of the vitamin D receptor in Turkish MS patients with different types and severities of the disease. Materials and Methods: The patients were divided into three groups in accordance with the types of MS: relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS). Serum D vitamin level was studied, and polymerase chain reaction (PCR) applications were performed by designing primers suitable for the vitamin D receptor (VDR) gene regions in which FokI (rs2228570), BsmI (rs1544410), and ApaI (rs7975232) polymorphisms are localized. The Expanded Disability Status Scale (EDSS) was utilized to determine the disability status of MS patients. Results: Although vitamin D levels were inadequate in MS patients and controls, the mean serum vitamin D level of MS patients was significantly higher than the controls (p<0.05). There was a statistically significant correlation with A/A, C/C, and A/C genotypes in SPMS patients and with ApaI A/A and A/C genotypes in PPMS patients. The rate of the EDSS score in the range of 0-6 was significantly higher in MS patients with BsmI G/G genotype in comparison with the other genotypes (p<0.05). Conclusion: In the Turkish population, while all alleles of the ApaI gene are associated with SPMS, the A/A and A/C alleles of ApaI are related to PPMS, and the BsmI G/G genotype may be associated with less disability in MS patients.Öğe H1N1-Related Encephalitis in the Postpandemic Era(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Oztoprak, Ibrahim…Öğe Is there a relationship between CSF Interleukin 34 Level and clinicoradiological activity and IgG index in patients with MS?(Elsevier Sci Ltd, 2024) Gokce, Seyda Figul; Bolayir, Asli; Cigdem, BurhanettinBackground: Multiple sclerosis is an autoimmune, inflammatory, and disabling disease that is subject to research, with the aspects of its pathogenesis awaiting clarification. It is essential to predict the prognosis of the disease and find the responsible mechanisms and molecules to become a treatment option. In this regard, researching the impact of Interleukin 34, with its immunomodulatory properties, on the clinicoradiological activity effect of MS and determining its role, if any, may be guiding. Methods: The study included 52 MS patients who underwent lumbar puncture at the diagnosis stage, and dimethyl fumarate treatment was initiated in these patients. During a one-year prospective follow-up, CSF IL-34 levels of 26 patients with clinical and/or radiological activity and 26 patients without activity were evaluated for prediction of disease activity. Additionally, CSF IL-34 levels of 26 control patients who underwent lumbar puncture due to pseudotumor cerebri but were not diagnosed with this disorder and whose CSF examinations were normal and were compared with MS patients. Our study also included the Immunoglobulin G index and investigated its relationship with IL-34. Results: The IL-34 level was higher in the MS patient group compared to the control group. No significant difference was identified between MS patient groups with and without clinical and/or radiological activity. A weak correlation without statistical significance was found between IL-34 and the IgG index. Conclusion: The IL-34 level did not correlate with clinical and radiological activity in MS patients. However, the high IL-34 level observed in the patient group in comparison with the control group may be significant for MS pathogenesis. Furthermore, IL-34 may be a useful biomarker candidate for MS diagnosis, similar to the IgG index.Öğe Magnetic Resonance Imaging in Delayed Carbon Monoxide Leukoencephalopathy: Diffusion and Spectroscopy Findings(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Yildiz, Bulent; Polat, Selim; Gokce, Seyda Figul; Bolayir, Asli; Cigdem, Burhanettin…Öğe Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients(ELSEVIER URBAN & PARTNER SP Z O O, 2018) Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Bolayir, Hasan Ata; Yildiz, Ozlem Kayim; Bolayir, Ertugrul; Topaktas, Suat AhmetObjective: The inflammatory process is a very important stage in the development and prognosis of acute ischemic stroke (AIS). The monocyte to high-density lipoprotein (HDL) ratio (MHR) is accepted as a novel marker for demonstrating inflammation. However, the role of MHR as a predictor of mortality in patients with AIS remains unclear. Methods: We retrospectively enrolled 466 patients who were referred to our clinic within the first 24 hours of symptom presentation and who were diagnosed with AIS between January 2008 and June 2016. Four hundred and eight controls of similar age and gender were also included. The patient group was classified into two groups according to 30-day mortality. The groups were compared in terms of monocyte counts, HDL, and MHR values. Results: The patient group had significantly higher monocyte counts and lower HDL levels; therefore, this group had higher values of MHR compared to controls. Additionally, the monocyte count and MHR value were higher, and the HDL level was lower in non-surviving patients (p < 0.001). The MHR value was also observed as a significant independent variable of 30-day mortality in patients with AIS (p < 0.001). The optimum cut-off value of MHR in predicting the 30-day mortality for patients with AIS was 17.52 (95% CI 0.95-0.98). Conclusion: Our study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS. (c) 2017 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.Öğe Neuroradiologic Findings of Intracranial Hypotension: Two Cases(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Donmez, Recep; Gokce, Seyda Figul; Bolayir, Asli; Cigdem, Burhanettin; Balaban, Hatice; Yildiz, Bulent; Bolayir, Ertugrul; Topaktas, Suat…Öğe Prevalence of multiple sclerosis in an urban population of Sivas province in Turkey(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2019) Gokce, Seyda Figul; Cigdem, Burhanettin; Karaca, Sanem Nemmezi; Bolayir, Asli; Yildiz, Ozlem Kayim; Topaktas, Ahmet Suat; Balaban, HaticeBackground/aim: Multiple sclerosis (MS) is a common neurological disorder that can be a leading cause of nontraumatic disability in several countries. Recent reports have indicated a moderate to high risk of MS in European countries. In this study, we examined the prevalence of MS in a well-defined urban population of provincial center in Sivas Province in Turkey. Materials and methods: This study sampled all registered residents of urban areas of provincial center in Sivas Province in April 2017 and 2018 January. All the included patients met the McDonald 2010 criteria. Medical records were reviewed, including all available previously acquired magnetic resonance imaging data. All patients were subsequently subjected to neurologic examination to confirm the MS diagnosis. Results: We identified 21 possible MS patients, with MS diagnosis confirmed in 19. The prevalence of MS was 288 per 100,000 inhabitants. Conclusion: For future studies, these high ratio results can be used in regional and national comparisons to determine cofactors contributing to the high prevalence of MS in our region and can help health-decision makers to better plan healthcare policies to improve neurological services and awareness about multifaceted clinical presentations of MS.Öğe Severity and frequency of restless legs syndrome in patients with familial Mediterranean fever(SAGE PUBLICATIONS LTD, 2017) Yilmaz, Samet; Cigdem, Burhanettin; Gokce, Seyda Figul; Ceyhan-Dogan, Sevil; Balaban, HaticeObjective: Restless legs syndrome (RLS) is a common sensory motor disorder. RLS an urge to move the extremities that may be accompanied by dysesthesias, and significantly affects quality of life of affected patients. The frequency of RLS is higher in different systemic inflammatory diseases. Familial Mediterranean fever (FMF) is an inherited inflammatory disease characterized by attacks of polyserositis, arthritis, and fever. The prevalence of RLS in patients with FMF is unknown. This study aimed to evaluate the prevalence rate of RLS in a sample of patients with FMF and compare this prevalence with that of a matched normal population. Method: A total of 60 patients with FMF and 60 healthy controls were studied. All participants underwent a neurological examination. Diagnostic criteria as proposed by the International Restless Legs Syndrome Study Group (IRLSSG) were used to define RLS. The IRLSSG rating scale for the severity of RLS was applied to determine the severity of symptoms. Results: The prevalence of RLS was not significantly different between patients and controls. Although the mean International Restless Legs Syndrome Rating Scale (IRLSRS) scores tended to be higher in patients compared with controls, this difference was not significant. When each item of the severity scale was compared between the two groups, significantly higher scores were found in some items of the IRLSRS in patients with FMF compared with controls. Conclusion: According to this result, RLS symptoms in patients with FMF were more frequent and lasted longer than those in controls.Öğe The role of systemic immune inflammatory index in showing active lesion in patients with multiple sclerosis SII and other inflamatuar biomarker in radiological active multiple sclerosis patients(Bmc, 2023) Gokce, Seyda Figul; Bolayir, Asli; Cigdem, Burhanettin; Yildiz, BulentBackground Multiple sclerosis (MS) has two pathophysiological processes, one inflammatory and the other degenerative. We investigated the relationship between active lesions on magnetic resonance imaging showing the inflammatory phase in MS patients and serum parameters that can be used as inflammatory biomarkers. Thus, we aim to detect the inflammatory period in clinical and radiological follow-up and to reveal the period in which disease-modifying treatments are effective with serum parameters. Methods One hundred eighty-six MS patients presented to our hospital between January 2016 and November 2021 and 94 age- and sex-matched healthy volunteers were recruited for our study. While 99 patients had active lesions on magnetic resonance imaging, 87 patients did not have any active lesions. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) were determined. The SII (systemic immune inflammatory index) value was calculated according to the platelet X neutrophil/lymphocyte ratio formula. Results NLR, MLR, PLR and SII values were found to be statistically significantly higher in MS patients than in the control group. The NLR, MLR, PLR and SII were higher in the active group with gadolonium than in the group without active lesions. In addition, the cutoff values that we can use to determine the presence of active lesions were 1.53, 0.18, 117.15, and 434.45 for NLR, MLR PLR and SII, respectively. Conclusions We found that all parameters correlated with radiological activity. In addition, we showed that we can detect the inflammatory period with high sensitivity and specificity with the cutoff value used for SII and PLR. Among these easily accessible and inexpensive evaluations, we concluded that SII, including the values in the PLR formula, can come to the fore.
