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Öğe Effects of Lactobacillus Rhamnosus on dental implant osseointegration in osteoporotic rabbit model(Bayrakol Medical Publisher, 2021) Saygin, Aysegul Goze; Gorler, Oguzhan; Yildirim, Ali; Ercan, Nazli; Goze, Omer FahrettinAim: The effect of Lactobacillus rhamnosus (LR), probiotic bacteria that manage inflammatory disease, on osseointegration is unknown. The study aimed to evaluate the effects of LR administration on osseointegration in experimental osteoporosis induced by ovariectomy. Material and Methods: Sixteen New Zeland female rabbits were randomly divided into the following groups: SHAM (SH), SHAM and LR (SH+LR), Ovariectomy (OVX), OVX and LR (OVX+LR). Animals in the OVX group were subjected to bilateral ovariectomy to create artificial osteoporosis. After 16 weeks, a titanium dental implant was bilaterally implanted into each tibia of the animals. Animals in the SH+LR and OVX+LR groups were given oral probiotics. All animals were sacrificed and all tibia bones were separated at postoperative 8 weeks after implantation. Cardiac blood was taken to determine biochemical markers. Resonance frequency analysis (RFA) and bone-to-implant contact area (BIC) were administered. Results: RFA and BIC area were statistically significant for osseointegration in OVX+LR compared with OVX (p<0.05). The BIC area in the OVX group was statistically lower (p<0.05). ALP, BALP, Trap5b and MPO were highest in OVX groups(p<0.05). Discussion: This study concluded that osseointegration may be improved by LR administration in an estrogen-deficient state. The success rate of the implant may be increased by using probiotics in patients with osteoporosis.Öğe Evaluation of the effectiveness of different hemostatics and bioactive materials on the success of vital pulp therapy(Bayrakol Medical Publisher, 2022) Saygin, Aysegul Goze; Unal, Murat; Candan, Merve; Demir, Pinar; Akinci, Levent; Goze, Omer FahrettinAim: The aim of this study was to evaluate the response of the pulp in combination of hemostatic agents with pulp capping materials (PCMs). Material and Methods: A total of 96 rats were used. Two molar teeth of each rat were included and all groups were created of 4 animals. In the occlusal cavities of the teeth, pulp perforations were performed for direct pulp capping. Thereafter, three different agents, which were forming the main groups [Group1: Sterile saline, Group2: Sodium hypochlorite, Group3 :Mecsina Hemostopper] at different periods of time used on pulp perforations and according to PCMs coated on the exposed pulp area, were divided into subgroups (Dycal, Biodentine, Theracal, and MTA Repair HP). Subsequently, all groups were left for two different waiting periods of 7 and 28 days. Half of the rats were sacrificed on the 7th and the remaining half were sacrificed on the 28th day, followed by micro-CT and histological analyzes. Results: When the results of the study were examined, a statistical difference was observed between groups in terms of dentine bridge (DB) formation on the 7th and 28th days, while there was no statistical difference between inflammatory cell response and DB quality. Micro-CT images showed no formation of DB on the 7th day, while DB formation was observed on the 28th day on specimens. Discussion: The combination of MHS and NaOCl may be preferable in order to provide pulp bleeding control in dental applications.Öğe Humic Acid Enhances Wound Healing in the Rat Palate(HINDAWI LTD, 2018) Calisir, Metin; Akpinar, Aysun; Talmac, Ahmet Cemil; Alpan, Aysan Lektemur; Goze, Omer FahrettinIntroduction. Humic acid was previously shown to enhance cutaneous wound healing and show antibacterial properties; however, it has not been used for wound healing in the oral cavity. Thus, the goal of this study was the evaluation of the effect of the humic acid on the healing of excisional wounds in an experimental rat study. Materials and Methods. A circular wound on mid-palatal surfaces was made on a total of 77 Wistar rats by using a 3-mm biopsy punch under anesthesia. The animals were divided into 4 groups as baseline, saline control (0.09%), chlorhexidine gluconate (0.05%), and humic acid (80 mg/kg) and were treated with these materials for 7 days. Results. The rats were observed for 3 weeks in order to track the wound closure rates. Both humic acid treatment and chlorhexidine gluconate treatment resulted in statistically significant enhanced rate of wound closure compared to the saline control on both the 1st and 2nd weeks of treatment. Humic acid treatment for the wounds in the palate resulted in enhanced recovery compared to not only saline control but also chlorhexidine gluconate treatment. Conclusion. In this study, humic acid was shown to enhance healing of oral wounds for the first time in the literature. These findings indicate that humic acid can be used as an alternative to current treatment methods for oral wounds.Öğe The synthesis and anti-cancer efficacy of endoperoxide modified copper sulfide-ferritin nanocages as PDT and PTT agents(Springer, 2023) Kucukoflaz, Merve; Ulusoy, Sakine; Korkmaz, Bekir; Ozturk, Suleyman Can; Akyol, Melih; Hayta, Sibel Berksoy; Goze, Omer FahrettinPhotodynamic therapy (PDT) using endoperoxides is to produce toxic singlet oxygen of reactive oxygen species through heat from the endoperoxides present in the medium. Compared with conventional PDT, PDT using endoperoxides has some advantages, for instance, in the presence of endoperoxide, singlet oxygen efficiency is not affected by hypoxic environment, because endoperoxides are the source of singlet oxygen. On the other hand, the kinetic stabilities of endoperoxides are important in the body temperature. Another advantage of endoperoxides is that they can produce singlet oxygen upon warming, so regardless of the wavelength of the emitted light, they can selectively produce singlet oxygen in the heated region. The aim of this study is to synthesize core-shell nanocages (10-Aft-CuS) with the synergistic effect of both photothermal therapy (PTT) and PDT by functionalizing the surface of the Apoferritin (Aft) nanocage platform with an endoperoxide derivative and forming ultra-small CuS nanoparticles in its inner cavity for the first time. So, first of all, Aft-CuS nanoparticles were obtained by the synthesis of ultra-small CuS nanoparticles in the inner cavity of Aft nanocages. Then, the surfaces of these nanocages have been functionalized with the Compound 10, an endoperoxide anthracene derivative. While the synthesized nanoparticles in this way have the synergistic effects of PTT and PDT therapies, achieving this with a natural nanoparticle has also been tested in cell cultures in vitro and in mice with progressed melanoma in vivo by increasing the effectiveness against cancer cells. 10-Aft-CuS nanocages showed high anti-tumor efficacy against malignant melanoma in vitro and in vivo.Öğe Therapeutic and prophylactic effects of strontium on radiotherapy-induced skin toxicity in rats(TURKISH SOC DERMATOLOGY VENEROLOGY, 2017) Yucel, Birsen; Hayta, Sibel Berksoy; Goze, Omer Fahrettin; Erdis, Eda; Bahar, Seher; Celasun, Mustafa Gurol; Kacan, Turgut; Akyol, MelihBackground and Design: This study aimed to investigate whether 5% strontium (Sr) chloride hexahydrate has preventive or therapeutic effects on the radiotherapy (RT)-induced adverse skin effects. Materials and Methods: Sixty-four female Wistar albino rats weighing 200-210 g, aged 4.5-5 months were divided into eight groups. Results: There were significant differences between control group and the other groups according to the Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria (RTOG) and histopathological findings (p<0.050). However, there were no significant differences between RT group and treatment groups (p>0.05). In addition, there were no significant differences among treatment groups (p>0.05). Statistical results were as follows according to the immunohistochemical evaluation of transforming growth factor-beta: group 1 and 4 (p=0.015), group 1 and 5 (p=0.014), group 1 and 6 (p=0.035), group 1 and 8 (p=0.046), group 2 and 6 (p-0.047), group 4 and 6 (p=0.031); and according to the immunohistochemical evaluation of tumor necrosis factor-alpha: group 1 and 2 (p=0.024), group 1 and 8 (p=0.045). Conclusion: Topical treatment with Sr at a concentration of 5% is insufficient to prevent the side effects of RT involving the skin, as assessed by the RTOG scoring, histopathological findings, and immunological markers.
