Yazar "Guclu, Gulsen" seçeneğine göre listele

Listeleniyor 1 - 7 / 7
  • Küçük Resim Yok
    Öğe
    An Analysis of the Relationship Between Premenstrual Syndrome and Aggression Tendencies Among Turkish Adolescent Girls
    (Bentham Science Publ, 2022) Evcili, Funda; Guclu, Gulsen
    Background Premenstrual syndrome affects women's physical, psychological, and social health negatively. Moreover, it causes behavioral disorders such as anger, crime, and aggression tendencies. However, there is a limited number of studies in the literature which examined the relationship between premenstrual syndrome and crime, aggression, or violence. Objective The objective of this study was to identify the relationship between premenstrual syndrome and aggression tendencies. Methods This is a descriptive study. The 774 voluntary adolescent girls studying at a state university in Turkey constituted the sample of the research. Results The mean age of adolescent girls was 19.05 +/- 1.64. The mean age of first menstruation for the participants was 13.35 +/- 1.23. It was determined that 58.3% of the participants had a premenstrual syndrome. Premenstrual syndrome intensity levels were higher among adolescent girls whose menstruation interval was < 28 days, those who had irregular menstrual cycles, those who found their menstruation-related knowledge inadequate, those diagnosed with anemia and those who thought their anger/aggression tendencies increased in their premenstrual period (p<0.05). Moreover, aggression tendencies increased among adolescent girls as the intensity of premenstrual syndrome increased (p<0.05). Conclusion Health professional's premenstural symptoms were carefully evaluated and individualized care and treatment plans were created.
  • Küçük Resim Yok
    Öğe
    Anticancer Activity of Water and Methanol Extracts of Hypericum scabrum L. on Different Cancer Cell Lines
    (Horticulture and Forestry Society from Transylvania, 2019) Guclu, Gulsen; Tas, Ayca; Tulimat, Manhal; Eruygur, Nuraniye; Silig, Yavuz
    Hypericum scabrum L. is an endemic medicinal plant with antimicrobial, anticancer and anti-inflammatory, antiviral effect. In this study, we aimed to investigate the cytotoxic effect of water and methanol extracts on different cancer cell lines such as osteosarcoma cancer, cervical cancer and prostate cancer. The data showed that the methanol extract had a highly effective cytotoxic effect on all three cell lines. Although water extract caused less cell loss than methanol extract, it was found that the cells were inhibited in all three cell lines. DU-145, which is the prostate cell line, was more effective in both extracts. As a result, the water and methanol extract of Hypericum scabrum L. have an anticancer effect on Saos-2, HeLa and DU-145 cells. There is a need for further and comprehensive studies by isolating the main active ingredient of this plant which is a candidate for drug of cancer in the future. Our study is expected to lead the studies in this direction. © 2019. All Rights Reserved.
  • Küçük Resim Yok
    Öğe
    Anticancer, Antioxidant, Antimicrobial and Enzyme Inhibitory Activities of Inula aucheriana
    (Kahramanmaras Sutcu Imam Univ Rektorlugu, 2022) Guclu, Gulsen; Ergul, Merve; Ucar, Esra; Eruygur, Nuraniye; Atas, Mehmet; Akpulat, Huseyin Askin
    The Inula aucheriana, of the Asteraceae family, is widespread in Turkey. The aim of this study was to investigate different biological properties and thereby reveal the pharmacological potential of this plant, which is already known to be used in the treatment of various diseases,. Following the preparation of 80% ethanol extract from I. aucheriana, qualitative and quantitative methods were used to investigate the chemical composition (Q-TOF analysis), antioxidant (spectrophotometric analysis), inhibitory enzyme (Ellman's method), antimicrobial (MIC concentration value), and anti-cancer (XTT analysis) activities. The results showed that 80% ethanol extract from I. aucheriana was a potent antioxidant, with anti-cancer and enzyme inhibitor effects. In the chemical composition analysis, the primary compound of the extract was determined to be luteolin (32.55%). I. aucheriana extract was seen to have AChE and BChE inhibition, , and when compared with the reference drug, the extract was determined to have an inhibitory effect an enzyme called alpha-glucosidase. Besides, relatively high tyrosinase enzyme inhibition was also detected. The extract significantly showed antiproliferative activity on the MDA-MB-231 cells at 0.0625 mg/mL and higher concentrations,for 24 hours in a a dose-dependent manner.This study is the first to evaluate enzyme inhibitory effect and antioxidant activity of I. aucheriana.
  • Küçük Resim Yok
    Öğe
    Biological activities of different plant species belonging to the Asteraceae family
    (Pamukkale University, 2023) Guclu, Gulsen; Inanir, Merve; Ucar, Esra; Eruygur, Nuraniye; Atas, Mehmet; Uskutoğlu, Tansu; Senkal, Belgin Cosge
    Achillea biebersteinii and Anthemis tinctoria, which are widely distributed species of the Asteraceae family, are used in folk medicine in the form of herbal tea or extract in the treatment of many diseases. The aim of this study was to investigate the chemical content, antimicrobial, antioxidant, enzyme inhibitor activities and cytotoxic effects of 80% ethanol extract of these two species and make a comparative analysis. In accordance with the data obtained, the major component of A. biebersteinii was determined as Cyclododecane (14.47%), while that of A. tinctoria was determined as Phytol (23.15%). A. biebersteinii, which showed moderate activity in terms of antimicrobial activity, produced more active inhibition than A. tinctoria did. Both plants showed high levels of antioxidant activity. The total phenol and total flavonoid contents of A. tinctoria were higher than those of A. biebersteinii. It was determined that there was no significant activity when the extracts were compared with galanthamine, which is the reference drug in terms of enzyme inhibitory activity. When the in vitro anticancer activity of human breast cancer cell line was examined, it was determined that A. tinctoria had a cytotoxic effect at high concentrations (IC50;0.82mg/mL), and A. biebersteinii showed strong cytotoxicity at all concentrations (IC50;<0.0625mg/mL). These two plants of the same family were evaluated in terms of many different biological parameters and it was revealed that A. biebersteinii was more active than A. tinctoria. However, in vivo studies are needed to determine whether these plants can be used as phytotherapeutic agents. © 2023 The Author(s).
  • Küçük Resim
    Öğe
    Biological evaluation and in silico molecular docking studies of Abies cilicica (Antoine & Kotschy) Carrière) resin
    (Elsevier, 2023/9/15) Guclu, Gulsen; Tas, Ayca; Dincer, Emine; Ucar, Esra; Kaya,Savaş; Berisha, Avni; Dural, Emrah; Silig, Yavuz
    Abies cilicica (Antoine & Kotschy) Carri`ere) is an endemic species of industrial and medicinal importance. The resin obtained from this plant is effective for different diseases. The chemical content of the ethanol extract of Abies cilicica resin by GC-MS method, its antimicrobial activity on 12 different microorganisms by MIC value, antibiofilm activity on six microorganisms by Christensen method and biological activities on three different cancer cell lines by MTT method were investigated in this study. The findings showed that antimicrobial and antibiofilm activity was high in L. monocytogenes. The resin extract showed strong anticancer activity on all three DU-145, HeLa and SaOS-2 cells. The major component of the resin was abietic acid. A molecular docking simulation of the major compounds from resin extracts was conducted. In this study, in which the strong bio logical properties of A.cilicica resin were revealed, which suggests that the resin can increase the inhibition of cancer cell growth while strengthening the immune system against pathogenic microorganisms. Molecular docking analysis performed supported the experimental observations. Further extensive studies will support the possibility of using this resin as a therapeutic agent.
  • Küçük Resim Yok
    Öğe
    IN VITRO ANTIOXIDANT, ANTIMICROBIAL, ANTICANCER ACTIVITIES ASSESSMENT OF THYMUS PECTINATUS, SCREENING OF ENZYME INHIBITORY
    (Parlar Scientific Publications (P S P), 2021) Ergul, Merve; Guclu, Gulsen; Atas, Mehmet; Cetin, Metin Durmus; Eruygur, Nuraniye; Ucar, Esra; Akpulat, Huseyin Askin
    According to the data obtained in this study, Thymus pectinatus has antioxidant and enzyme inhibitory activities while has not showed antimicrobial activities. The results of the current study provide valuable information, showing that the major component of the water extract of T. pectinatus is 1,3-Propanediol, 2 -methyl-, dipropanoate (59.34 %). This is the first investigation of the antioxidant and enzyme inhibitory activity of T. pectinatus. The results showed that the water extract had high antioxidant, anti-amylase, and anticancer effects, and a higher total phenolic content. Therefore, further phytochemical and bioactivity-guided isolation of T. pectinatus water extract could be carried out to identify the active compounds.
  • Küçük Resim Yok
    Öğe
    Leptin/Melanocortin Pathway in Cholelithiasis Patients: A Diagnostic Perspective
    (Bentham Science Publ Ltd, 2025) Agbektas, Tugba; Guclu, Gulsen; Tas, Ayca; Ozmen, Esma; Topcu, Omer; Aydin, Suleyman; Silig, Yavuz
    Background: Cholelithiasis is the most prevalent inflammatory condition of the gallbladder. The regulation of biological processes, including energy homeostasis, and control of body weight are key mechanisms that the leptin and melanocortin pathways play a role in Cholelithiasis is the most prevalent inflammatory condition of the gallbladder. There are various risk factors for the development of gallstone disease, especially weight gain, and obesity is just one of them. This risk factor can be minimized by maintaining appetite and energy balance. Here, leptin and melanocortin pathways are the key mechanisms in maintaining appetite and energy homeostasis. Objectives: The aim of this study was to investigate the relationship between the levels of LEP, LEPR, TrkB, BDNF, POMC, and MC4R proteins in patients with Cholelithiasis. This study aims to determine the relationship between LEP, LEPR, TrkB, BDNF, POMC, and MC4R protein levels, which play a role in maintaining appetite and energy homeostasis, and cholelithiasis. Methods This study examined 44 patients diagnosed with Cholelithiasis and 44 healthy control subjects who had not previously been diagnosed with any form of Cholelithiasis. The levels of leptin (LEP), Leptin Binds To Leptin Receptors (LEPR), Tropomyosin Receptor Kinase B (TrkB), Brain-Derived Neurotrophic Factor (BDNF), Pro-OpioMelanoCortin (POMC), and Melanocortin-4 Receptors (MC4R) molecules were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The results were analyzed using the SPSS Software (Version 22.0) program and GraphPad Prism 8.0.1 software. Results: The study found a statistically significant decrease (p < 0.05) in MC4R, TrkB, BDNF, and POMC protein levels in Cholelithiasis patients compared to the control group. There was no statistically significant difference in LEP and LEPR concentration values between the two groups (p = 0.247, p = 0.674). Conclusion: The proteins MC4R, TrkB, BDNF, and POMC, which are involved in the leptin and melanocortin pathways may play a significant role in Cholelithiasis disease. However, more detailed research on the relevant proteins is needed. Nevertheless, this research will guide new studies.