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    Antioxidant and antimicrobial properties of the lichens Cladonia foliacea, Dermatocarpon miniatum, Everinia divaricata, Evernia prunastri, and Neofuscella pulla
    (TAYLOR & FRANCIS LTD, 2006) Aslan, Ali; Gulluce, Medine; Sokmen, Munevver; Adiguzel, Ahmet; Sahin, Fikrettin; Ozkan, Hakan
    The aim of this study was to investigate in vitro antimicrobial and antioxidant activities of the methanol extracts of Cladonia foliacea Willd. Hudson, Dermatocarpon miniatum (L.) Mann., Everinia divaricata (L.) Ach., Evernia prunastri (L.) Ach., and Neofuscella pulla (Ach.) Essl. Antioxidant activity was evaluated by two separate methods: scavenging of free radical DPPH and the inhibition of linoleic acid oxidation. Extracts of C. foliacea , E. divaricata , E. prunastri , and N. pulla did not exert any activity in both assays, whereas those of D. miniatum provided 50% inhibition at 396.1 mu g/ml concentration in the former and gave 49% inhibition in the latter. Total phenolic constituents of extracts from lichen species tested ( C. foliacea , D. miniatum , E. divaricata , E. prunastri , and N. pulla ) were 1.7% (w/w), 2.9% (w/w), 3.0% (w/w), 2.6% (w/w), and 1.5% (w/w), respectively (as gallic acid equivalent), implying that the observed activity could be related to the amount of polar phenolics. Extracts were also found to possess antimicrobial activity against some of the bacteria and fungi tested, but no activity was observed against the yeasts.
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    The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.
    (Marmara Univ, 2023) Sezen, Selma; Ertugrul, Muhammed Sait; Bayram, Cemil; Ozkaraca, Mustafa; Koc, Taha Yasin; Demir, Abdussamed Yasin; Gulluce, Medine
    Products from Mentha species are widely used in medical applications, including wound healing, due to the bioactive compounds they may contain. However, data on the effect of Mentha longifolia L. on wound healing are limited. This study investigated the antimicrobial and wound healing-promoting effects of Mentha longifolia L. essential oil using in vitro methods. The chemical compositions of the essential oil were identified using gas chromatography/mass spectrometry, while the agar well diffusion and disk diffusion methods were used to determine antimicrobial activity against pathogenic strains. A scratch wound healing assay was performed following determination of the cytotoxic dose in human fibroblast cell lines. The media were used for biochemical analysis 48 h after the in vitro wound model. Immunohistochemical staining was applied to determine the contribution of the essential oil to wound healing. The essential oil exhibited varying levels of antimicrobial activity against the tested pathogens and increased cell viability. All doses in the scratch wound healing assay promoted wound closure in a shorter time than in the control group. TAC levels were higher in the treated groups than in the control group, while TOS, IL-6, and TNF-alpha levels were lower. Levels of expression of FGF 2, IGF, and TGF-beta were higher in the treated groups than in the control group at increasing doses. The essential oil of Mentha longifolia L. exhibited antimicrobial effects and improved wound healing at doses of 5 mu g/mL and 10 mu g/mL.