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Öğe Blood mean platelet volume may be predictive for disease course in the cases with pemphigus vulgaris.(SCIENTIFIC PUBLISHERS INDIA, 2017) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, MelihPemphigus vulgaris (PV) is an autoimmune blistering disorder treated with immunosuppressive agents. The patients with pemphigus vulgaris have remission and relapses and there is a need to have easy accessible and cheap laboratory monitoring markers. The aim of this study was to investigate the relationship between the course of the disease and the changes of the levels of neutrophil/lymphocyte ratio (NLR), platelet/lypmhocyte ratio (PLR), mean corpuscular volume (MCV) and mean platelet volume (MPV) in the patients with PV. Pemphigus patients (n=43) and healthy controls (n=40) were included in the study, retrospectively. Clinical and laboratory data, including C-reactive protein, erythrocyte sedimentation rate, hemoglobin, hematocrit, red cell distribution width, lymphocyte count, neutrophil count, platelet count, MPV, of the patients and healthy controls were obtained from our institutional computerized medical database. NLR and MPV levels in patients are higher than health controls (p<0.05) MPV changes are consistent with disease course according to variance analysis. MPV cut-off level is 8.45 and the specificity and sensitivity of this cut-off level is 65% and 76% to predict the pemphigus attacks, respectively (p=0.427). NL ratio, PL ratio and MPV may be accepted as inflammatory markers. MPV levels may be recommended as a marker for the determination of relapses in the patients with pemphigus vulgaris.Öğe Increased expressed emotion in patients with psoriasis(TERMEDIA PUBLISHING HOUSE LTD, 2018) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, Melih; Albayrak, Funda; Kugu, Nesim; Ozcelik, SedatAim of the study: The aim of this study was to determine whether patients with psoriasis are affected by expressed emotion in their family environment. Material and methods: Participants included 62 patients with psoriasis and 83 healthy controls and their biological parent, wife or husband, or adult child as a key relative. Sociodeinographic data were recorded. Psoriasis area severity index was used to evaluate psoriasis severity. Hamilton depression and anxiety scales and the Expressed Emotion Questionnaire form were used to evaluate depression, anxiety, and expressed emotion. Results: The levels of expressed emotion and its subgroups in the patient group were higher than in the group of healthy controls (p < 0.05). Gender, disease duration, disease severity, and key relatives did not affect the levels of expressed emotion (LEEtotal) in the patients with psoriasis (p > 0.05). The LEEtotal of those with low educational level in the patient group was statistically significantly higher than those with higher educational level (p < 0.05). There was no correlation between the presence depression or anxiety and expressed emotion (p> 0.05). There was a negative correlation between age and the levels of expressed emotion in the patient group (p < 0.05). There was a negative correlation between age and intrusiveness in healthy controls (p < 0.05). Conclusions: Although decreasing with age, expression of emotion in patients with psoriasis is high, and psychosocial support should be provided to these patients.Öğe Pruritus is not sensorial in psoriasis: the mutual interactions between dermatologic life quality and pruritus(EDIZIONI MINERVA MEDICA, 2019) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, MelihBACKGROUND: Pruritus may emerge as affective or sensorial in psoriasis patients. It is not known whether the mediating effect of pruritus or disease severity on the quality of life is more pronounced. This study was conducted to determine the mediating effects and interactions between disease severity, pruritus and life quality in psoriasis patients. METHODS: 105 patients with psoriasis vulgaris were included in the study. Psoriasis Area and Severity Index (PAST) values, Dermatology Life Quality Index (DLQI), and visual analog scales for pruritus of each patient were analyzed by determining the correlations and the mediating interactions between these parameters. RESULTS: There was a moderate correlation between pruritus and DLQI (P=0.0001, r=0,528), a weak correlation between pruritus and PASI (P=0.005, r=0.273) and a moderate correlation between PASI and DLQI. The mediation effects of DLQI to pruritus, PASI to pruritus, PASI to DLQI and pruritus to DLQI were 25%, 0.047%, 22% and 25%, respectively. Also, the mediation effect of PASI plus pruritus to DLQI was 38%. CONCLUSIONS: The most obvious factor for pruritus is the impairment of DLQI rather than PASI in psoriasis patients. The mediating effect of PASI to DLQI increases the pruritus significantly.Öğe Psoriasis Vulgaris Hastalarında Subklinik Nörolojik Tutulumun İncelenmesi(Sivas Cumhuriyet Üniversitesi, 2024) Hayta, Sibel Berksoy; Çiğdem, Burhanettin; Guner, Rukiye; Gökçe, Şeyda Figül; Akyol, MelihÖZET Amaç: Bu çalışmanın amacı, psoriasis hastalarında subklinik nörolojik tutulum açısından bilişsel fonksiyonları P300 yöntemi ile değerlendirmek ve hastalık süresi ve şiddeti arasındaki ilişkiyi ortaya koymaktır. Yöntem: Çalışmaya 40 psoriasis vulgaris hastası ve 40 sağlıklı birey dahil edilmiştir. Her iki gruba standart mini mental test ve Beck Depresyon Envanteri uygulanmıştır. Psoriasis hastalarının PAŞİ (Psoriasis Alan ve Şiddet İndeksi) ve DYKİ (Dermatoloji Yaşam Kalitesi İndeksi) değerleri hesaplanmıştır. Her iki grubun P300 ölçümleri kaydedilmiş ve bilişsel fonksiyonları değerlendirmek amacıyla analiz edilmiştir. Bulgular: Sağlıklı ve psoriasis grupları arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.681, p=0.301, p=0.138, p=0.739). PAŞİ değerleri açısından karşılaştırıldığında, hasta grubunda PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.211, p=0.422, p=0.106, p=0.305). Hastalık süresine göre değerlendirildiğinde, gruplar arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.901, p=0.244, p=0.632, p=0.868). Sonuç: Psoriasis hastalarında bilişsel fonksiyonlar, hastalığın varlığı, şiddeti ve süresi ile etkilenmemektedir. Bildiğimiz kadarıyla, mevcut çalışma psoriasis hastalarında bilişsel fonksiyonları değerlendirmede elektrofizyolojik P300 yöntemini kullanan ilk çalışmadır.Öğe The relationship between pityriasis rosea, seasonal factors, and other herpetic infections: A time series analysis(Wolters Kluwer Medknow Publications, 2019) Hayta, Sibel Berksoy; Guner, Rukiye; Cam, Selim; Akyol, MelihBackground: Data on seasonal variation and viral etiology in Pityriasis rosea (PR) have been conflicting. The aim of this study was to investigate the association of PR and other herpetic infections, taking seasonal changes into account. Methods: The data were collected retrospectively from electronic health registry systems in Sivas in the Central Anatolia region of Turkey between 2008 and 2016. According to their clinical types, other herpetic infections were investigated. Environmental factors such as humidity, temperature, and rainfall for the relevant period were added into the model. Time series methods (augmented Dickey-Fuller unit root test and regression analysis) were used in the analysis. Results: A total of 1207 PR patients were included in the study. The number of PR patients was calculated to be 0.462 times that of the same period in the previous year. The incidence of PR increased significantly when the rate of infections caused by varicella-zoster virus decreased and the rate of infections caused by herpesvirus Type 1 and humidity increased (P < 0.05). Conclusion: Environmental factors such as humidity are important in the emergence of the PR. Furthermore, the incidence of PR may be inversely affected by varicella-zoster infections contrary to the relationship between PR and herpesvirus Type 1 infections.
