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Öğe Ammi visnaga L. and Nanocarrier Approaches in the Treatment of Skin Diseases(Marmara Univ, 2022) Esenturk-Guzel, Imren; Topuzoglu, Sehernaz; Abdo, Luceyn; Gurer, Eda Sonmez; Yapar, Evren AlginAmmi visnaga L. is a plant that grows naturally in Europe and is very common in Turkiye. It has various pharmacological effects due to its gamma-pyrones, coumarins, flavonoids and essential oils content. And its major phytocontituent khellin, which has a furanochrorne structure obtained by extraction from the seeds of the Armin visnaga L. is effective on the photochemotherapy of skin diseases. In this context, researches on topical delivery of khellin has been increased and the use of nanocarriers has gain attention to achieve optimised efficacy and stability related khellin, for the treatment of some skin diseases especially psoriasis and vitiligo. In this review, studies on the efficacy of khellin, which is the major phytocontituent of Atnnti visnaga L.in the treatment of skin diseases and topical delivery of it via nanocarrier systems has been overviewed to draw attention to the potential of herbal sources accompained modern carrier systems in the treatment.Öğe Asian Veterinary Medicines: From the Past to the Future(Marmara Univ, 2023) Goyal, Shuchi; Thirumal, Divya; Yapar, Evren Algin; Gurer, Eda Sonmez; Kumar, Ashok; Babu, M. Arockia; Sindhu, Rakesh K.Asia has plentiful and varied vegetation which is made into active ingredients like probiotics, antimicrobials, and parasiticides are employed to cure or prevent transmission of pathogens as well as to enhance the health of viable cells. World Health Organization researchers have identified over 21,000 plant species that have been used medicinally across the globe. Herbal medicines are risk-free, low-cost, and easy to find. Plants provide 25% of the medications stipulated globally. Almost 75% of pharmaceutical plants grow in nature in various parts of Asia. These plants are known to provide therapeutic effects to various infirmities like poisoning, eczema, osteoporosis, stomachaches, and so on. Veterinary herbal medicines are herbal pharmaceuticals with their remedies, preventive, and indicative uses in zoological cures. Exploring the area of ethnoveterinary medicine is rather unkempt as compared to query on queriesntional cures to diagnose, although growing interest using driven in that prospect. The herbal possessions of Asia also offer the individuals who tend to stock a lush reservoir in contemplating the cure of the animals. Additionally, authenticating and registering the conventional aids and supplies are necessary to ensure it on better to the forthcoming vision. With their recognized molecular processes and potential for further analysis as a prospect for future pharmaceutical drug design and development, traditional medicine/herbal plants are used to treat various diseases in Asian nations.Öğe Casticin as potential anticancer agent: recent advancements in multi-mechanistic approaches(Frontiers Media Sa, 2023) Carbone, Katya; Gervasi, Fabio; Kozhamzharova, Latipa; Altybaeva, Nazgul; Gurer, Eda Sonmez; Sharifi-Rad, Javad; Hano, ChristophePlants, with their range of pharmacologically active molecules, represent the most promising source for the production of new anticancer drugs and for the formulation of adjuvants in chemotherapy treatments to reduce drug content and/or counteract the side effects of chemotherapy. Casticin is a major bioactive flavonoid isolated from several plants, mainly from the Vitex species. This compound is well known for its anti-inflammatory and antioxidant properties, which are mainly exploited in traditional medicine. Recently, the antineoplastic potential of casticin has attracted the attention of the scientific community for its ability to target multiple cancer pathways. The purpose of this review is, therefore, to present and critically analyze the antineoplastic potential of casticin, highlighting the molecular pathways underlying its antitumor effects. Bibliometric data were extracted from the Scopus database using the search strings casticin and cancer and analyzed using VOSviewer software to generate network maps to visualize the results. Overall, more than 50% of the articles were published since 2018 and even more recent studies have expanded the knowledge of casticin's antitumor activity by adding interesting new mechanisms of action as a topoisomerase IIa inhibitor, DNA methylase 1 inhibitor, and an upregulator of the onco-suppressive miR-338-3p. Casticin counteracts cancer progression through the induction of apoptosis, cell cycle arrest, and metastasis arrest, acting on several pathways that are generally dysregulated in different types of cancer. In addition, they highlight that casticin can be considered as a promising epigenetic drug candidate to target not only cancer cells but also cancer stem-like cells.Öğe Curcumin-loaded nanomedicines as therapeutic strategy in malaria management(Wiley, 2023) Amin, Ruhul; Devi, Chanam Melody; Sarkar, Dona; Sharifi-Rad, Javad; Gurer, Eda Sonmez; Docea, Anca Oana; Calina, DanielaMalaria, a parasitic protozoan disease widespread in tropical climates, is transmitted by Plasmodium spp. Many people are affected by this significant public health disease, which has a high incidence of illness and mortality worldwide. Because drug-resistant parasites are on the rise, there are not enough controls on mosquitoes, and there are not any malaria vaccinations. Malaria is particularly challenging in developing countries. Antimalarial drugs approved by Food and Drug Administration are the main options for combating and preventing malaria; also the control of transmission at the level of mosquitoes is important. Current antimalarial chemotherapeutic therapies have significant clinical flaws such as Plasmodium resistance, the drugs that call for the development of novel drug candidates. To combat malaria, nanotechnology may give a viable alternative that is both more effective and safer than current treatment options. Nanotechnology-based curcumin formulations have proved to overcome the limitations of current therapies in terms of optimum therapeutic benefits, safety, and cost-efficiency, which increases a patient's capacity to adhere to prescribed medicine. The limits of current malaria therapies and the need to employ nanotechnological curcumin to treat malaria were addressed and discussed in this paper.Öğe Design, 3D-QSAR, molecular docking, MD simulations, ADME/Tox properties and DFT study of benzimidazole derivatives as promising α-glucosidase inhibitors(Elsevier, 2025) Khaldan, Ayoub; Bouamrane, Soukaina; Ouabane, Mohamed; El-mernissi, Reda; Alaqarbeh, Marwa; Alnajjare, Radwan; Gurer, Eda SonmezAcarbose and miglitol are two distinct alpha-glucosidase inhibitors that are frequently used to manage diabetes mellitus. Unfortunately, the clinical usage of these medications comes with a number of undesirable side effects. Therefore, development of safer and potent alpha-glucosidase inhibitor became more necessary. For this reason, a set of 20 benzimidazole-based oxadiazole molecules was addressed using the three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) approach. Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) using steric (S), electrostatic (E) and hydrogen bond donor (D) models showed good statistical outcomes as Q2 (0.600 and 0.616 respectively) and R2 (0.958 and 0.928 respectively). The developed models were then validated for their external ability; the R2test values were 0.85 and 0.627, respectively. The CoMFA and CoMSIA/SED contour maps helped identify key regions influencing alpha-glucosidase inhibitory activity, leading to the design of four new benzimidazole-based oxadiazole inhibitors with strong predicted activity. The new recommended compounds confirmed promising consequences in the preliminary in silico ADME/Tox prediction. Molecular docking results showed good interactions of compounds M1 and M2 in the active site of the alpha-glucosidase receptor, and their stability was studied using molecular dynamics simulations throughout 200 ns. The reactivity and stability of compounds M1 and M2 were assessed using the DFT approach, suggesting that these compounds have strong inhibitory potential and may serve as effective anti-diabetic agents, warranting further experimental investigation.Öğe Experimental, density functional theory, molecular docking and ADMET analyses on the role of different plant extracts of Aronia melanocarpa (Michx) Elliot species on acetylcholinesterase enzyme activity(Elsevier, 2025) Gurer, Eda Sonmez; Yildirim, Suheda; Kocyigit, Umit M.; Berisha, Avni; Kaya, SavasIn the present study, different extracts obtained in different solvents from the fruits collected from the Aronia melanocarpa (Michx.) were prepared. The inhibition performances of these extracts on the inhibition of the acetylcholinesterase enzyme were checked via both theoretical and experimental analyses. Although all extracts used in experimental studies showed high inhibitory activity, it was observed that the extract obtained in methanol had higher inhibitory activity than the others. According to the enzyme activity results presented in the light of Ellman method, IC50 values were found between 0.0311-0.0857 mg/mL. Conceptual Density Functional Theory (CDFT) and Molecular Docking calculations were performed to identify the component or components of the extract with high inhibitory activity. Conceptual Density Functional Theoretical based data commented through popular electronic structure principles such as Maximum Hardness and Minimum Electrophilicity Principles showed that the most reactive one among studied dominant components of the extract is Malvin molecule. The interactions between studied molecules and AChE and mechanisms of these interactions were illuminated via Molecular Docking analyses and ADMET studies. As a result, it was shown that the most reactive molecule Malvin (with lowest hardness and the highest electrophilicity) interacts more powerful with AChE compared to other molecules. Within the framework of the theoretical analyses made, it was proposed that in the design and introduction of new AChE inhibitors, structures with low hardness and high electrophilicity values should be preferred.Öğe Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances(Frontiers Media Sa, 2023) Hafeez, Amna; Khan, Zeeshan; Armaghan, Muhammad; Khan, Khushbukhat; Gurer, Eda Sonmez; Razis, Ahmad Faizal Abdull; Modu, BabaganaMorusin is a natural product that has been isolated from the bark of Morus alba, a species of mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in the plant world and is recognized for its wide range of biological activities. Morusin has a number of biological characteristics, including anti-inflammatory, anti-microbial, neuro-protective, and antioxidant capabilities. Morusin has exhibited anti-tumor properties in many different forms of cancer, including breast, prostate, gastric, hepatocarcinoma, glioblastoma, and pancreatic cancer. Potential of morusin as an alternative treatment method for resistant malignancies needs to be explored in animal models in order to move toward clinical trials. In the recent years several novel findings regarding the therapeutic potential of morusin have been made. This aim of this review is to provide an overview of the present understanding of morusin's beneficial effects on human health as well as provide a comprehensive and up-to-date discussion of morusin's anti-cancer properties with a special focus on in vitro and in vivo studies. This review will aid future research on the creation of polyphenolic medicines in the prenylflavone family, for the management and treatment of cancers.Öğe Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications(Bmc, 2024) Khatua, Somanjana; Nandi, Sudeshna; Nag, Anish; Sen, Surjit; Chakraborty, Nilanjan; Naskar, Arghya; Gurer, Eda SonmezHHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was conducted across various academic databases, including ScienceDirect, Web of Science, Scopus, American Chemical Society, Google Scholar, PubMed/MedLine, and Wiley. The review highlights HHT's diverse mechanisms of action, ranging from its role in leukemia treatment to its emerging applications in managing other cancers and various biomedical conditions. It underscores HHT's influence on cellular processes, its efficacy in clinical settings, and its potential to alter pathological pathways. HHT demonstrates significant promise in treating various hematological malignancies and cancers, offering a multifaceted approach to disease management. Its ability to impact various physiological pathways opens new avenues for therapeutic applications. This review provides a consolidated foundation for future research and clinical applications of HHT in diverse medical fields.Öğe Myristicin: From its biological effects in traditional medicine in plants to preclinical studies and use as ecological remedy in plant protection(Wiley, 2023) Ramirez-Alarcon, Karina; Martorell, Miquel; Gurer, Eda Sonmez; Laher, Ismail; Lam, Hei-Long; Mohieldin, Ebtihal Abdalla M.; Muddathir, Ali MahoumdMyristicin is an allylbenzene and a major key constituent of many plant species, such as Myristica fragrans Houtt. (nutmeg), Foeniculum vulgare Mill. (fennel), and Petroselinum crispum (Mill.) Fuss (parsley). Their plant parts have been used in traditional medicine and as a flavoring seasoning for cooking but, and as biopesticides with natural compounds. Myristicin has been related with several biological effects, such as anticarcinogenic, anti-inflammatory, antimicrobial, antioxidant, antidiabetic, analgesic, and hepatoprotective. The traditional uses include the treatment of complications related to gastrointestinal tract, respiratory system, and gynecological disorders. However, several studies have been reported contraindications associated to high dose consumption of myristicin. This review summarizes the biological activities of myristicin and myristicin-rich plants, toxicological effects along with its bioavailability, and metabolism. In addition, their traditional uses and their role as ecological remedy in plants protection has been reviewed. Nutmeg is the myristicin-rich plant with more pharmacological effects reported but also with most contraindication and toxically reports. The aim of the present review is to highlight the traditional uses and pharmacological activities of myristicin-rich plants along with their contraindications and bioavailability.imageÖğe Natural products of relevance in the management of attention deficit hyperactivity disorder(Wiley, 2023) Custodio, Luisa; Vizetto-Duarte, Catarina; Cebeci, Fatma; Ozcelik, Beraat; Sharopov, Farukh; Gurer, Eda Sonmez; Kumar, ManojAttention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.Öğe Optimize the parameters for the synthesis by the ionic gelation technique, purification, and freeze-drying of chitosan-sodium tripolyphosphate nanoparticles for biomedical purposes(Bmc, 2024) Gutierrez-Ruiz, Stephany Celeste; Cortes, Hernan; Gonzalez-Torres, Maykel; Almarhoon, Zainab M.; Gurer, Eda Sonmez; Sharifi-Rad, Javad; Leyva-Gomez, GerardoBackgroundPolymeric nanoparticles can be used for wound closure and therapeutic compound delivery, among other biomedical applications. Although there are several nanoparticle obtention methods, it is crucial to know the adequate parameters to achieve better results. Therefore, the objective of this study was to optimize the parameters for the synthesis, purification, and freeze-drying of chitosan nanoparticles. We evaluated the conditions of agitation speed, anion addition time, solution pH, and chitosan and sodium tripolyphosphate concentration.ResultsChitosan nanoparticles presented an average particle size of 172.8 +/- 3.937 nm, PDI of 0.166 +/- 0.008, and zeta potential of 25.00 +/- 0.79 mV, at the concentration of 0.1% sodium tripolyphosphate and chitosan (pH 5.5), with a dripping time of 2 min at 500 rpm. The most representative factor during nanoparticle fabrication was the pH of the chitosan solution, generating significant changes in particle size and polydispersity index. The observed behavior is attributed to the possible excess of sodium tripolyphosphate during synthesis. We added the surfactants poloxamer 188 and polysorbate 80 to evaluate the stability improvement during purification (centrifugation or dialysis). These surfactants decreased coalescence between nanoparticles, especially during purification. The centrifugation increased the zeta potential to 40.8-56.2 mV values, while the dialyzed samples led to smaller particle sizes (152-184 nm). Finally, freeze-drying of the chitosan nanoparticles proceeded using two cryoprotectants, trehalose and sucrose. Both adequately protected the system during the process, and the sugar concentration depended on the purification process.ConclusionsIn Conclusion, we must consider each surfactant's benefits in formulations for selecting the most suitable. Also, it is necessary to do more studies with the molecule to load. At the same time, the use of sucrose and trehalose generates adequate protection against the freeze-drying process, even at a 5% w/v concentration. However, adjusting the percentage concentration by weight must be made to work with the CS-TPP NPs purified by dialysis.Öğe Supercharging metabolic health with Lycium barbarum L.: A review of the therapeutic potential of this functional food for managing metabolic syndrome(Wiley, 2024) Sharifi-Rad, Javad; Quetglas-Llabres, Maria Magdalena; Sureda, Antoni; Mardones, Lorena; Villagran, Marcelo; Gurer, Eda Sonmez; Zivkovic, JelenaMetabolic syndrome (MetS) is a common disorder involving a cluster of metabolic abnormalities, such as abdominal obesity, hypertension, dyslipidemia, insulin resistance, and atherogenic profile. MetS is characterized by an increase in oxidative stress and a chronic proinflammatory state, which are directly related to the development and progression of this pathology. It has been seen how a healthy lifestyle and good dietary practices are key to improving the different metabolic parameters and, therefore, play a fundamental role in reducing the risk of developing diabetes. The present review focuses on the research evidence related to the therapeutic properties of Lycium barbarum L. in MetS gathered in the last years. Several preclinical studies suggest that L. barbarum extracts are a good dietary supplement for the prevention of cardiovascular diseases in people with MetS. This compound has been used for years in traditional Chinese medicine for the treatment of atrophic gastritis, problems related to the lungs, kidneys, and liver, and as a supplement for eye health. In addition, different in vitro and in vivo studies have been carried out that support the properties attributed to metabolites derived from L. barbarum, such as polysaccharides that have been shown diverse biological activities. In conclusion, L. barbarum extracts have multiple benefits to increase general well-being and immune function. However, there are a limited number of studies related to effect of L. barbarum in MetS, but they demonstrated effectiveness in the treatment of obesity, diabetes mellitus type 2, and prevention of diabetes mellitus type 2 complication.Öğe Ursolic acid: a natural modulator of signaling networks in different cancers(Bmc, 2022) Zafar, Sameen; Khan, Khushbukhat; Hafeez, Amna; Irfan, Muhammad; Armaghan, Muhammad; Rahman, Anees Ur; Gurer, Eda SonmezIncidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality. Scientists are now looking for the solutions that could help prevent the disease occurrence and could provide a pain-free treatment alternative for cancers. Therefore, efforts are now put to find a potent natural compound that could sever this purpose. Ursolic acid (UA), a triterpene acid, has potential to inhibit the tumor progression and induce sensitization to conventional treatment drugs has been documented. Though, UA is a hydrophobic compound therefore it is usually chemically modified to increase its bioavailability prior to administration. However, a thorough literature indicating its mechanism of action and limitations for its use at clinical level was not reviewed. Therefore, the current study was designed to highlight the potential mechanism of UA, its anti-cancer properties, and potential applications as therapeutic compound. This endeavour is a valuable contribution in understanding the hurdles preventing the translation of its potential at clinical level and provides foundations to design new studies that could help enhance its bioavailability and anti-cancer potential for various cancers.
