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    Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights
    (Wiley, 2024) Chowdhury, Raihan; Bhuia, Md. Shimul; Al Hasan, Md. Sakib; Hossain Snigdha, Shadid; Afrin, Sadia; Busselberg, Dietrich; Habtemariam, Solomon
    Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well-being due to its substantial morbidity and death rates worldwide. The potential of plant-derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti-inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy. The primary goal of the present study was to evaluate the anticancer abilities of mangrove plants and their compounds in great detail. In addition, we seek to investigate the molecular processes that give rise to mangrove plants and their phytochemical anticancer properties, focusing on their possible application in cancer treatment, which could provide valuable insights for future investigations and the development of novel therapeutic approaches.image
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    Protective Effect of Salvia cadmica on Fibroblast Cells from t-bhp-induced Oxidative Damage
    (Bentham Science Publ Ltd, 2024) Hepokur, Ceylan; Misir, Sema; Cicek, Mehmet; Habtemariam, Solomon; Sharifi-Rad, Javad
    Background: Salvia species known as Sage are among the important aromatic plants used in the world. This study, it was investigated the antioxidant capacity of Salvia cadmica and to investigate its protective effect on oxidative damage in t-BHP-induced fibroblast cells. Methods: Antioxidant activity and phenolic characterization of the extract were evaluated using DPPH, TPC, TFC, FRAP, and HPLC, respectively. TAS, TOS, MDA and 8-oxo-guanine, CAT, SOD, and GPx values were examined using enzyme-linked immunosorbent assay (ELISA). The antiproliferative and apoptosis effects of Salvia cadmica ethanolic extract were determined using XTT assay and fluorescent probes in fibroblast cells. Results: As a result of GC-MS analysis of Salvia cadmica ethanolic extract, carvacrol content was found to be high. The IC(50 )value of the DPPH antioxidant assay of the Salvia cadmica ethanolic extract was 80 +/- 0.51 mu g/mL. TPC, TFC, and FRAP values were found to be 18.25 +/- 0.64 (mg gallic acid/g powder), 1.691 +/- 0.314 (mg quercetin /g powder), 31.5 +/- 0.10 (mg Trolox/g powder), respectively. Total antioxidant and TOS values were found to be 0.383 +/- 0.033 (mmol Trolox Equ L-1), 16.31 +/- 0.71 (mu mol H2O2 L-1) for 0.25 mg/mL, and 0.725 +/- 0.05 (mmol Trolox Equ L-1), 12.02 +/- 0.56 (mu mol H2O2 L-1) for 0.5 mg/mL. In addition, while CAT and GPx significantly decreased enzyme activities, no significant change was observed in SOD enzyme activity. Ethanolic Salvia cadmica extract exhibited apoptotic features compared to only the t-BHP group. Conclusion: These results suggest that Slavica cadmica extract works through a free radical mechanism.