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Öğe IL-22 and Reg3? overexpression affects Experimental Autoimmune Encephalomyelitis Severity(Amer Assoc Immunologists, 2019) Eken, Ahmet; Yetkin, Mehmet Fatih; Okus, Fatma Zehra; Cakir, Mustafa; Karayigit, Mehmet Onder; Erdem, Serife; Haliloglu, Yesim[Abstract Not Available]Öğe Phytochemicals, antioxidant, and antityrosinase activities of Achillea sivasica Celik and Akpulat(TAYLOR & FRANCIS INC, 2017) Haliloglu, Yesim; Ozek, Temel; Tekin, Mehmet; Goger, Fatih; Baser, Kemal Husnu Can; Ozek, GulmiraThe present study is the first report on essential oil (EO) composition, phytochemicals, and biological potential of Achillea sivasica tested against free radicals, oxidative damage, and tyrosinase enzyme. Gas-Chromatography Flame Ionization Detector (GC-FID) and gas chromatography/mass spectrometry (GC/MS) analyses revealed that beta-pinene (11.5%, 9.3%, and 6.7%), beta-pinene (7.0%, 3.0%, and 6.9%), 1,8-cineole (18.0%, 22.1%, and 6.7%), and camphor (7.6%, 4.1%, and 9.0%) were the major constituents in the EOs from the herb, flower, and leaves, respectively. Liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analysis of the extracts revealed the presence of caffeoylquinic acid derivatives, luteolin, apigenin, patuletin, isorhamnetin, cirsimaritin, and santin. The leaf extracts demonstrated strongest free radical scavenging, cupric reducing, lipid peroxidation inhibition, and antityrosinase activities.