Yazar "Hasbek, Zekiye" seçeneğine göre listele
Listeleniyor 1 - 20 / 39
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Boron-Doped Nano Hydroxyapatite Grafts for Bone Regeneration in Rat Mandibular Defects(Springernature, 2024) Demirkiran, Berat Baturay; Inan, Zeynep Deniz Sahin; Hamutoglu, Rasim; Oksuz, Kerim Emre; Hasbek, Zekiye; Altuntas, Emine ElifThe aim of this study was to evaluate the potential effects of boron-doped nano hydroxyapatite grafts on craniofacial bone regeneration in critical bone defects in the mandibular corpus of rats, in terms of scintigraphic and histopathological aspects. Forty Wistar albino rats, with an average weight of 200-220 g, aged 16-18 weeks, and all male, were used in the study. The rats were randomly assigned to five groups, each containing 8 rats, as follows: group C1 (no procedure applied to the mandible), group C2 (surgical defect created in the mandible but no treatment applied), group nHA (nano hydroxyapatite applied to the surgical defect area), group nHA + B1 (nano hydroxyapatite + 1% boron applied to the surgical defect area), and group nHA + B2 (nano hydroxyapatite + 2% boron applied to the surgical defect area). A standard 4 x 4 mm full-thickness transosseous bone defect was created in the mandibular corpus of all rats, except for those in group C1. The bone defect in the rats in group C2 was left to heal naturally. Nano hydroxyapatite (nHA), nano hydroxyapatite + 1% boron, and nano hydroxyapatite + 2% boron were applied to the surgical defect areas of the other three groups, respectively. Bone scintigraphy was performed on all rats on days 0 (following the surgical procedure) and 28 of the experimental period. At the end of the 28th day, the animals were sacrificed, and tissue samples were collected for histological examination. A standard grading system was used to evaluate fracture healing. When the groups were compared in terms of bone healing histopathological scores, a statistically significant difference was observed between group C1 and the other groups (p < 0.005). In the statistical evaluation made according to the histopathological mean scores, the least improvement was observed in group C2. No statistically significant difference was observed between group nHA and group nHA + B1 and group C2 and between group nHA and group nHA + B1 in terms of bone healing scores (p > 0.005). A statistically significant difference was found between group nHA + B2 and group C2 (p = 0.026). Although there was no statistically significant difference in histopathological scores, the mean score closest to group C1 was observed in group nHA + B2. A statistically significant difference was observed between the groups in the scintigraphic evaluation performed on the 28th day of the experimental procedure, and the difference was between group C1 and group nHA + B1 and between group nHA and group nHA + B1 (p = 0.004; p = 0.028, p < 0.005). In the comparison of the values obtained on days 0 and 28 within the group, a statistically significant change was observed in group nHA + B1 and group nHA + B2 (p < 0.005). When the results of the present study were evaluated, it was thought that the boron-doped nHA graft biomaterials may have positive effects on bone healing. Providing a different perspective for the development of an alternative new treatment modality that can be locally applied in the treatment of fractures a serious and common health problem can be interpreted as an important outcome of the present study. We believe that this study will serve as a preliminary study for more comprehensive future studies on this subject.Öğe Breast metastasis in follicular thyroid cancer patient(Wolters Kluwer Medknow Publications, 2022) Erturk, Seyit Ahmet; Hasbek, Zekiye; Duman, Gulhan; Sariakcali, BarisIn this case report, we aimed to present the findings of a follicular thyroid carcinoma patient with breast metastasis, which is rarely reported in the literature. A 33-year-old female who had been operated for thyroid cancer 17 years ago, but whose pathology report could not be reached was suspected of recurrence in the left lobe region of the thyroid gland. Fine-needle aspiration biopsy was done in this region, and the biopsy result was reported as thyroid follicular carcinoma. F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) was performed for re-staging before surgery. In the PET/CT, it was found that there was residual thyroid tissue in the right and left lobe region and superior to these lesions in the left side, there were lesions which destruct to the hyoid bone, and there were multiple nodular lesions in both lungs which measured with maximum 15 mm x 12 mm, and all these lesions have increased F-18-FDG uptake. In addition to these lesions, a nodular lesion with the size of similar to 11 mm x10 mm in the upper-middle quadrant of the right breast, and it was showing increased F-18-FDG uptake (maximum standardized uptake value: 3). Pathology results of the left neck region operation materials were reported as papillary and follicular carcinoma of the thyroid gland. Right lumpectomy was performed for the lesion in the right breast during the same session with thyroid operation. The pathology result of this lesion was also reported as metastasis of thyroid follicular cancer. Posttreatment iodine-131 whole-body scan after surgery was reported as there was abnormal accumulation in residual thyroid tissues on the right side of the neck and lung metastases. In patients with thyroid cancer, the possibility of metastasis of the breasts should be considered when there is a lesion in the breast tissue.Öğe Can We Predict the Sites of the Recurrence of Ovarian Cancer by F-18 FDG PET/CT Depending on CA-125 Level?(BENTHAM SCIENCE PUBL LTD, 2017) Turgut, Bulent; Ciftci, Esra; Erturk, Seyit Ahmet; Cetin, Bulent; Aker, Handan; Hasbek, ZekiyeObjectives: The purpose of the study is predicting the sites of the recurrence with PET/CT by serum CA-125 level and detecting the cut-off value of CA-125 for metastatic ovarian cancer (OC) in comparison with Fluorine-18 FDG PET/CT. Materials & Methods: For 38 patients with histological stage III-IV OC, F-18 FDG PET/CT studies (n=59) referred for suspicion of relapsing of OC were conducted. PET/CT images were assessed as positive/negative in 4 categories based on similar location as local recurrence, peritoneal metastasis, lymph node metastases and distant metastases. Patients were divided into five groups according to the levels of CA-125. The results of PET/CT imaging were compared with the level of CA-125. Results: Recurrence was confirmed in all FDG-PET/CT studies. In 7 of them (11.9%) CA-125 levels were normal (mean: 18.9 +/- 5.9) whereas in 52 of them (88%) were high (mean: 433.9 +/- 798.3). Moderate but highly significant positive correlation between CA-125 level and the number of metastatic foci detected by PET/CT was found. There was no statistically significant difference between CA-125 level subgroups and metastatic sites. However, the difference between CA-125 levels and location of metastasis was statistically significant only for distant metastasis and peritoneal metastasis with moderate accuracy (71% and %66, respectively). Conclusion: Since CA-125 has moderate but highly significant positive correlation with the number of metastatic foci, it is important in clinical management of OC patients. However, it may not predict the localization of the recurrence. When suspicious findings were reported at radiodiagnostic techniques in OC patients, FDG-PET is a useful technique for detecting recurrent ovarian carcer regardless of CA-125 level.Öğe Comparison of 99mTc-HMPAO-labeled leukocyte scintigraphy findings with systemic inflammatory markers(MediHealth Academy Yayıncılık, 2023) Ertürk, Seyit Ahmet; Hasbek, ZekiyeAims: Technetium-99m-hexamethylpropylene amine oxime (99mTc-HMPAO) labeled leukocyte scintigraphy is frequently used for infection imaging. The systemic immune-inflammation index is a new marker. In this study, we aim to investigate the relationship between 99mTc-HMPAO-labeled leukocyte scintigraphy findings and systemic inflammatory markers such as Neutrophil/lymphocyte ratios (NLR) and Platelet lymphocyte ratio (PLR) and systemic immune-inflammation index (SII). Methods: Patients who underwent 99mTc-HMPAO-labeled leukocyte scintigraphy between 2014 and 2020 due to suspected infection such as diabetic foot infection or prosthesis infection vs. in any part of the body were included in our study. In addition, a negative control group consisting of 19 normal subjects who had no leukocyte scintigraphy and had hemogram examination was added to the study. Cases with findings consistent with infection in labeled leukocyte scintigraphy and infectious symptoms in this area of involvement in the clinical examination were considered as the positive group. The data were evaluated with the SPSS 23.0 program. Results: Our study included 36 patients (28 males,8 females, mean age: 59.7). The mean SII was 1526±787 x109 cells/L in patients with positive findings in leukocyte scintigraphy that might be compatible with infection, while it was 1025 ± 370 x109 cells/L in patients who did not (p=0.017). The mean PLR was 183.95±68.30 in patients with positive findings in leukocyte scintigraphy that might be compatible with infection, while it was 145.81±58.30 in patients who did not (p=0.102). The mean NLR was 4.82±1.91 in patients with positive findings on leukocyte scintigraphy that might be compatible with infection, while it was 4.15±1.40 in patients who did not (p=0.181). While the negative control group and the patients who were considered positive in leukocyte scintigraphy were compared; a statistically significant difference was found between SII, NLR and PLR values. When the relationship between SII was evaluated, the mean SII was 1526±787 x109 cells/L in patients with involvement that may be compatible with infection in leukocyte scintigraphy, while it was 762±224 x109 cells/L in the negative control group (pÖğe Contrast-induced nephropathy: controlled study by differential GFR measurement in hospitalized patients(ROYAL SOC MEDICINE PRESS LTD, 2012) Erselcan, Taner; Egilmez, Hulusi; Hasbek, Zekiye; Tandogan, IzzetBackground: Without appropriate control measures, contrast-induced nephropathy (CIN) incidence has been claimed to be overestimated. Purpose: To evaluate the relationship and the difference between differential serum creatinine (DsCr), which is currently surrogating as a marker of GIN, and measured differential GFR values as a control measure (DGFR) in hospitalized patients. Material and Methods: GFR was measured two times by Tc-99m DTPA, before and 48 h after contrast media (CM), along with sCr and BUN in 35 inpatients (22 men, 13 women, mean age +/- SD = 61 +/- 14) with no known chronic kidney disease. Results: Relationship was moderate between GFR and sCr (R = 0.50, P < 0.01) in the study population. Pre-CM vs. post-CM values of GFR, sCr and BUN were not statistically different as (mean +/- SD); 78 +/- 36 vs. 73 +/- 35 mL/min/1.73m(2), 0.95 +/- 0.26 vs. 0.94 +/- 0.26 mg/dl and 21 +/- 16 vs. 19 +/- 13 mg/dl, respectively, in the study group. According to basal GFR values, 14 patients (40%) seemed carrying risk of GIN (GFR < 60 mymin/1.73m2) in whom only two had sCr >1.5 mg/dl. Twenty-five patients (71%) had discordant results in relation to Ds Cr and DGFR and two of them had GIN according to classical definition of Ds Cr, although having basal sCr <1.1 mg/dl. Yet, both had low, but stable GFR values. None of patient from the study group underwent hemodialysis. Conclusion: Significant discordance was observed between differential serum creatinine and measured differential GFR in hospitalized patients, suggesting that GIN incidence calculations only based on hospital registry may carry risk of error.Öğe Does hepatic visualisation show residual/metastatic thyroid tissue in differentiated thyroid cancer?(DERMAN MEDICAL PUBL, 2019) Hasbek, Zekiye; Gul, Serdar Savas; Ciftci, Esra; Erturk, Seyit Ahmet; Cakmakcilar, Ali; Duman, Gulhan; Turgut, BulentAim: Diffuse homogen hepatic uptake in whole-body scan (WBS) after radioiodine remnant ablation (RRA) suggests that there is occult or visible remnant thyroid tissue and/or tumor tissue. It is thought that the reason is hepatic metabolization of radioiodine (1311) marked thyroglobulin fragments which are secreted by remnant/tumor tissue. The aims of this study were to investigate whether the hepatic visualisation after radioiodine remnant ablation showed the presence of metastatic or residual disease in patients with differentiated thyroid cancer and also to investigate whether early or late WBS after RRA (RxWBS) had an effect on the physiological hepatic uptake. Material and Method: 201 DTC patients were evaluated (F/M: 152/49; mean age: 49.61 +/- 13 years (range: 18-85 years)) who referred for RRA. The therapeutic 1311 dose ranged from 100mCi to 200mCi. RxWBS was performed earlier (in 1-4th-day after RRA) in 106 patients (Group 1) and was performed later (in 5-9th-day after RRA) in 95 patients (Group 2). Results: Diffuse hepatic uptake were seen only in three patients (2.8%) and was not seen in 103 patients (97.2%) in Group 1. However, in Group 2 diffuse hepatic uptake was seen in 93 patients (97.9%) (p<0.05) and not seen only in 2 patients (2.1%). There is not a statistically significant relationship between the hepatic uptake and serum Tg. LT4 and TSH level. There is a statistically significant relationship between anti-Tg level and hepatic uptake. Discussion: Physiological diffuse hepatic uptake of radioiodine in WBS after RRA may not be seen during the early WBS. Thus, metastatic foci may be missed with early scanning. We conclude that RxWBS after RRA should be done in late period.Öğe Does the use of recombinant TSH in preparation for I-131 scintigraphy scan affect hearing function?(PLA General Hospital Department of Otolaryngology Head and Neck Surgery, 2018) Doğan, Mehtap; Durmuş, Kasım; Hasbek, Zekiye; Altuntaş, Emine ElifObjective: The objective of this study was to examine the effect of hypothyroidism on hearing function in patients surgically treated for differentiated thyroid cancer and subsequently experienced hypothyroidism during preparation for follow up I-131 scintigraphy scan by either recombinant human thyroid stimulating hormone (rhTSH) treatment or thyroid hormone withdrawal (THW). Methods: A total of 55 patients undergoing I-131 scintigraphy scan following surgeries for differentiated thyroid cancer were included in the study, including 25 patients prepared by administration of recombinant TSH (rhTSH Group) and 30 patients by thyroid hormone withdrawal (THW Group). Results: Air conduction thresholds at 1, 2 and 4 kHz for both ears were higher during hypothyroid period than during euthyroid period for patients in the THW group (p < 0.05) but not for patients in the rhTSH group. Conclusion: Sensorineural hearing loss was detected, especially at low frequencies, in patients with DTC after surgical treatment whose hormone replacement therapy was withdrawn but not in those receiving rhTSH. It is therefore preferred to use rhTSH when preparing for I-131 scintigraphy scan in patients at risk for hearing loss. © 2018 PLA General Hospital Department of Otolaryngology Head and Neck SurgeryÖğe Double serum sampled glomerular filtration rate measurement with technetium-99m diethylenetriamine-penta acetate for evaluation of renal functions in patients with psoriasis vulgaris(Deri Zuhrevi Hastaliklar Dernegi, 2021) Guner, Rukiye Yasak; Hayta, Sibel Berksoy; Akyol, Melih; Hasbek, Zekiye; Ozcelik, Sedat; Timucin, MeryemBackground and Design: Psoriasis is a common chronic inflammatory skin disease believed to affect renal functions. Glomerular filtration rate (GFR) is the most important indicator used to assess renal functions. The present study aims to measure the renal function of psoriasis patients via the technetium-99m diethylenetriamine pentaacetate (Tc-99m DTPA) method and compare the values obtained with those determined through indirect measurement methods, such as the modification of diet in renal disease (MDRD) and chronic kidney disease epidemiology collaboration (CKD-EPI), considering the effects of systemic treatments and comorbidities. Materials and Methods: Eighty-seven patients diagnosed with chronic plaque-type psoriasis vulgaris were included in this study. The patients' demographic characteristics, disease duration, psoriasis area and severity index score, drugs received for psoriasis treatment, comorbidities, and drugs received for comorbidity treatment were noted. Estimated GFRs were also calculated using the MDRD and CKD-EPI formulas. Results: Tc-99m DTPA values were affected only by age. As the patient age increased, a significant decrease in GFR measured with Tc-99m DTPA (r=0.289, p<0.001) was observed. Conclusion: Psoriasis, comorbidities, and nephrotoxic drugs used for treatment did not affect renal functions. GFR measurements were affected only by age.Öğe Effect of Botulinum Toxin-A Injected to Muscle Tissue on Perfusion and Survival of Fasciocutaneous Single Perforator-pedicled Propeller Flap in Rats(Galenos Publ House, 2020) Zereyak, Umut; Ozkaya, Nese Kurt; Hasbek, ZekiyeBackground: In plastic surgery practice, fasciocutaneous single-perforator-pedicled propeller flap is a preferred procedure; however, its survival rate is below than expected, especially in flaps with a big rotation arc. When botulinum toxin-A is injected into the muscle tissue that the perforator pedicle is arisen, the tonus of pertinent muscle can reduce and the blood flow of its perforator pedicle can increase. Therefore this procedure can improve the survival rate of single-perforator-pedicled propeller flap. Aims: To evaluate the effect of botulinum toxin-A injected with ultrasonographic guidance into the muscle tissue that the perforator pedicle is arisen from one month ago on the perfusion of flap scintigraphically and the survival rate of single-perforator-pedicled propeller flap in a rat model. Study Design: Animal experiment. Methods: Three study groups were receiving botulinum toxin-A (16 IU-0.4 mL), normal saline (0.4 mL), and no study drug one month ago before flap surgery. Injections were performed under ultrasonography guidance. Flaps were elevated fasciocutaneously over the right 2nd perforator pedicle, under the corneous, with a surgical loupe and microsurgery tool and were rotated clockwise 180 degrees. Then the scintigraphic measurements were obtained after flap elevations in the study groups, including the whole-body and flap perfusions in the study rats. The involvement rate presents the ratio of flap perfusion to whole-body perfusion. Flaps were sutured back to the abdominal wall at the latest twisting angles. With standard photographs taken in all the groups on day 8 after the operation, whole and necrotic flap areas were calculated. Results: Scintigraphically the involvement rate (the ratio of flap perfusion to whole-body perfusion) of the flaps in the botulinum toxin-A group were found significantly higher than those in the other groups (p<0.05). The area of a flap in the botulinum toxin-A group on day 8 post flap suturing was found to be significantly higher than those in the other groups (p<0.05). The area of a necrosis and the percentage of necrosis on day 8 post flap suturing in the botulinum toxin-A group was found significantly lower than those of the sham and null groups (p<0.05). Conclusion: In a rat model, if with the ultrasonographic guidance, botulinum toxin-A is injected to the muscle which perforator of the prospective single-perforator-pedicled propeller flap originated and flap surgery is performed one month later after this injection, the perfusion of single-perforator-pedicled propeller flap increases scintigraphically and this improves flap survival and reduces its necrosis.Öğe Effects of acute thyroxine depletion on hearing in differentiated thyroid carcinoma patients(Wolters Kluwer Medknow Publications, 2014) Hasbek, Zekiye; Karakus, Canan Filiz; Altuntas, Emine Elif; Kilicli, FatihIntroduction: Radioiodine ablation refers to the destruction of functioning remnants of normal thyroid tissue or metastatic foci remaining after thyroidectomy. Effective thyroid ablation requires adequate stimulation of thyroid-stimulating hormone. Our aim in this study was to evaluate the hearing changes of patients before ablation therapy in the iatrogenic hypothyroid period, which has been constituted with the purpose of treatment success and following the ablation therapy in the euthyroid period 1 month after the thyroid hormone (TH) replacement therapy was initiated. Materials and Methods: Patients who were diagnosed with thyroid cancer, treated with total/near-total thyroidectomy and referred for I-131 therapy or low-dose I-131 whole body scan were included in our study. Hearing tests as high-frequency audiometry, autoacoustic emission and tympanometry were made during hypothyroid and euthyroid periods on all the patients included in the study. Results: In the present study were enrolled 75 patients with a mean age of 46.6 +/- 12 years (range: 19-69 years). In hypothyroid period, while there was not any hearing-loss in 124 of 150 (82.7%) ears of 75 patients; mild hearing-loss in 18 (12%) ears, moderate hearing-loss in 7 (4.7%) ears and severe hearing-loss in 1 (0.07%) ear were detected. In euthyroid period, while there was not any hearing-loss in 132 of 150 (88%) ears; there were mild hearing-loss in 11 (7.3%), moderate hearing-loss in 6 (4%), and severe hearing-loss in 1 (0.07%) ear. However, there could not be found any significant difference between hearing levels of patients before and after treatment (P = 0.317). Conclusion: Although THs play an important role in the physiology of hearing, the hypothyroidism made in 4 weeks period causes serious damages on hearing functions of patients. However, with regard to temporary hearing losses that hearing levels could improved with treatment, we believe that hearing should also be questioned in the follow-up of patients with differentiated thyroid cancer.Öğe Evaluation of Myocardial Perfusion Imaging SPECT Parameters and Pharmacologic Stress Test with Adenosine Versus Coronary Angiography Findings: Are They Diagnostically Concordant?(GALENOS YAYINCILIK, 2019) Hasbek, Zekiye; Erturk, Seyit Ahmet; Cakmakcilar, Ali; Gul, Ibrahim; Yilmaz, AhmetObjectives: In this study our first aim was to evaluate the diagnostic concordance of myocardial perfusion scintigraphy (MPS) by pharmacological stress test with adenosine (APST) with coronary angiography (CAG). The secondary aim of this study was to evaluate the correlation between CAG findings and automated analysis parameters such as left ventricular ejection fraction, summed stress score (SSS), summed rest score, summed difference score (SDS), stress MPS defect percentage ratio (extent) and transient ischemic dilation (TID) obtained by myocardial perfusion imaging single-photon emission computed tomography (SPECT). Methods: A total of 129 patients (62 male, 67 female, median age: 60.02) undergoing MPS due to suspicion of coronary ischemia who also underwent subsequent CAG in the last year were included in this study, their MPS data and CAG results were compared. Results: There was no statistically significant diagnostic concordance when visual evaluation of MPS, quantitative MPS parameters and exercise treadmill test (ETT) electrocardiography results were used alone. In fact, diagnostic concordance was higher when automated analysis parameters like TID, SSS and extent values were added to MPS SPECT visual analyses. There was diagnostic concordance in 57.9% of APST patients and 41.7% of ETT patients. There was diagnostic concordance in 75.8% of APST patients and 52.6% of ETT patients who were older than 65 years of age. Conclusion: In our study, we found that the use of APST during MPS increases diagnostic concordance with CAG. Therefore, we think that it would be appropriate to use APST in women and elderly patients with limited exercise habits. The CAG diagnostic mismatch is far above what it should be when MPS reporting is only done with visual data, and it is not supported by quantitative data such as TID, SSS, SDS and extent.Öğe Evaluation of myocardial viability with thallium-201 infusion MPSPECT after oral glucose application in patients with chronic coronary artery disease(LIPPINCOTT WILLIAMS & WILKINS, 2009) Hasbek, Zekiye; Turgut, Bulent; Erselcan, Janer; Yalta, Kenan; Tandogan, Izzet; Ozer, Gurkan; Ozdemir, Umit; Turgut, Nergiz HacerAim The aim of this study was to evaluate the myocardial viability in nondiabetic patients with chronic coronary artery disease (CCAD) or past myocardial infarction (MI), using thallium-201 infusion myocardial perfusion single-photon emission computed tomography (MPSPECT) imaging after oral glucose application (Glu + Tl-201-infusion). Materials and methods In this study, 33 nondiabetic patients (three female, 30 male, mean age: 55.24 +/- 11 years, range: 33-77 years) with MI history or known CCAD were included. Rest/redistribution/24 h-late-MPSPECT imaging was performed for all patients. In all patients in whom fixed perfusion defect was observed on any wall of the left ventriculi, after 24 h-late-MPSPECT imaging, 75g oral glucose was given. Thirty minutes later, 1 mCi thallium-201 in 100 ml of physiological saline solution was applied in a period of 20 min by slow infusion. After infusion at the 10th minute, MPSPECT imaging was performed. Perfusion was evaluated visually for a total of 3432 segments with the 26-segment 5-point scoring technique. Scoring measured perfusion as 0=no perfusion defect, 1=mildly reduced, 2=moderately reduced, 3=severely reduced, and 4=absent uptake. Scores '0 and 1' were considered normal and scores '2-4' were considered abnormal. Results For serum insulin levels measured after glucose application, a significant increase was determined, according to the period before glucose application (P<0.001). When compared with rest MPSPECT images, segmental perfusion improvement both in redistribution and in the 24 h-late-MPSPECT images were 16.3 and 18.3%, respectively. This ratio was found to be 272% for Glu + Tl-201-infusion images. The ratios of segments in which perfusion was worsening were calculated to be 9.4, 14.5, and 7.3%, respectively, for redistribution, 24 h-late-MPSPECT, and Glu + Tl-201-infusion images. When this evaluation was made for all three vessel areas, again the highest perfusion improvement and the lowest perfusion worsening were detected for Glu + Tl-201-infusion images. In addition, when this evaluation was made for the three vessel areas according to the coronary narrowing degree, again the highest perfusion improvement was detected for Glu + Tl-201-infusion images, in segments in the left anterior descending artery, and right coronary artery areas with >= 90% narrowing. In rest images, in segments with segmental scores of 3 and 4, when the total reversibility ratio was evaluated, this ratio was calculated to be 0.7% for redistribution images and 4.5% for 24 h-late-M PSPECT. The highest total reversibility ratio in these segments was detected with Glu + Tl-201-infusion images to be 10.3%. When we evaluated the patients with respect to the MI history time, the highest segmental perfusion improvement was detected in patients with 0-3 months of MI history. Conclusion We conclude that in nondiabetic patients who are known to have CCAD or past MI history, Glu + (TI)-T-201-infusion is an easily applicable method that gives better results for the evaluation of myocardial viability. Nucl Med Commun 30:779-788 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.Öğe Evaluation of nasal mucociliary activity in iatrogenic hypothyroidism(SPRINGER, 2013) Uysal, Ismail Onder; Gokakin, Ali Kagan; Karakus, Canan Filiz; Deveci, Koksal; Hasbek, Zekiye; Sancakdar, EnverOur aim was to evaluate the effects of iatrogenic, acute and deep hypothyroidism on nasal mucociliary clearance. A total of 46 patients undergoing total or near total thyroidectomy for differentiated thyroid cancer between March and June 2012, and scheduled to undergo radioactive iodine (I-131) ablation therapy followed with an induced hypothyroidism for routine screening were included in the study. Mucociliary clearance test was made during hypothyroid and euthyroid periods in all the patients included in the study. Of the 46 patients included in the study, 37 (%80.4) were females, 9 (%19.6) were males, and the average mucociliary clearance times were 16.78 and 9.58 min during hypothyroid and euthyroid periods, respectively. When the results were compared statistically, mucociliary clearance time measured during hypothyroidism period was found to be significantly longer than the one measured during euthyroid period. Mucociliary clearance time was found to be long during iatrogenic acute and deep hypothyroid periods. During these periods, patients should be followed closely for lower and upper respiratory tract infections.Öğe Evaluation of the Relationship Between Mobile Phone Usage and miRNA-574-5p and miRNA-30C-5p Levels in Thyroid Cancer Patients(Galenos Publ House, 2024) Hasbek, Zekiye; Tas, Ayca; Erturk, Seyit Ahmet; Sariakcali, Baris; Babacan, Ozge Ulas; Duman, Gulhan; Silig, YavuzObjectives: This study aimed to evaluate the relationship between mobile phone usage and miRNA-574-5p and miRNA-30C-5p levels in patients diagnosed with differentiated thyroid cancer (DTC). Methods: Fifty patients diagnosed with DTC and 50 healthy volunteers were included in the study. miRNA-574-5p and miRNA-30C-5p gene expression levels in the blood of all subjects were analyzed by real time-polymerase chain reaction, and a questionnaire including various questions was administered to both groups. Results: Although there was a 7.60 -fold increase in miRNA-30C-5p gene expression levels in the patient group compared with the control group, it was not found to be statistically significant. Considering the miRNA-574-5p gene expression levels, although there was a 2.96 -fold increase in the patient group compared with the control group, no significant relationship was found. In our study, 85% of our patients were using mobile phones with internet access, whereas 98% of our healthy volunteers were using mobile phones (p<0.05). While 53.5% of the patients had their mobile phones with them while they were sleeping, this rate was 83.7% in healthy volunteers (p<0.05). However, 93.9% of the healthy volunteers did not have a Wi-Fi device in their bedrooms, and this rate was 75% in the patient group (p<0.05). Conclusion: Although miRNA-30C-5p and miRNA-574-5p gene expression levels were higher in patients than in healthy volunteers, the differences were not statistically significant. Although there was no significant difference in miRNA levels, we believe that due to the higher rate of Wi-Fi device presence in bedrooms in patients compared with healthy volunteers, the effects of electromagnetic radiation on the thyroid can be reduced by paying attention to this simple change.Öğe Importance of Postoperative Stimulated Thyroglobulin Level at the Time of I-131 Ablation Therapy for Differentiated Thyroid Cancer(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014) Hasbek, Zekiye; Turgut, Bulent; Kilicli, Fatih; Altuntas, Emine Elif; Yucel, BirsenBackground: Serum thyroglobulin detection plays an essential role during the follow-up of thyroid cancer patients treated with total/near total thyroidectomy and radioiodine ablation. The aim of this retrospective study was to evaluate the relationship between stimulated serum thyroglobulin (Tg) level at the time of high dose I-131 ablation and risk of recurrence, using a three-level classification in patients with differentiated thyroid cancer (DTC) according to the ATA guidelines. Also we investigated the relationship between postoperative stimulated Tg at the time of ablation and DxWBS results at 8-10 months thereafter. Materials and Methods: Patients with radioiodine accumulation were regarded as scan positive (scan+). If there was no relevant pathological radioiodine accumulation or minimal local accumulation in the thyroid bed region, this were regarded as scan negative (scan-) at the time of DxWBS. We classified patients in 3 groups as low, intermediate and high risk group for assessment of risk of recurrence according to the revised ATA guidelines. Also, we divided patients into 3 groups based on the stimulated serum Tg levels at the time of I-131 ablation therapy. Groups 1-3 consisted of patients who had Tg levels of <= 2 ng/ml, 2-10 ng/ml, and >= 10 ng/ml, respectively. Results: A total of 221 consecutive patients were included. In the high risk group according to the ATA guideline, while 45.5% of demonstrated Scan(+) Tg(+), 27.3% of patients demonstrated Scan(-) Tg(-); in the intermediate group, the figures were 2.3% and 90.0% while in the low risk group, they were 0.6% and 96.4%. In 9 of 11 patients with metastases (81.8%), stimulated serum Tg level at the time of radioiodine ablation therapy was over 10, however in 1 patient (9.1%) it was <2ng/mL and in one patient it was 2-10ng/mL (p=0.005). Aggressive subtypes of DTC were found in 8 of 221 patients and serum Tg levels were <= 2ng/ml in 4 of these 8. Conclusions: We conclude that TSH-stimulated serum thyroglobulin level at the time of ablation may not determine risk of recurrence. Therefore, DxWBS should be performed at 8-12 months after ablation therapy.Öğe The Importance of Tumor Size in Differentiated Thyroid Carcinomas(ORTADOGU AD PRES & PUBL CO, 2012) Hasbek, Zekiye; Turgut, Bulent; Erselcan, Taner; Borksuz, Mehmet Fatih; Yumuk, FadimeObjective: We aimed to assess the correlation of tumor size with other risk parameters in differentiated thyroid carcinomas. Material and Methods: Data of patients diagnosed with thyroid carcinoma, underwent bilateral total/near total thyroidectomy and treated with high doses of 1311 were examined retrospectively. In patients with tumor size <= 1 cm and >1 cm, the correlation between the tumor size and histopathologic classification, gender, age, multifocality and lymph-node was assessed. Results: The study included 285 patients; 237 (83.2%) were female, 48 (16.8%) were male. Two hundred and forty five patients (86%) had papillary carcinoma. The tumor was <= 1 cm in 6out of 23 male cases with a single focus (26.1%) and in 5 out of 14 male patients with multiple foic (35.7%). In those with tumor <= 1 cm multifocality rate was higher. In 32 out of 97 (33%) patients with tumor size <= 1 cm the tumor was multifocal, while in 46 out of 116 (39.7%) with tumor >1 cm there was uptake in many foci. For multifocality there was no significant difference for tumor size <= 1 cm and >1 cm (p=0.31). Of 65 patients aged >= 45 with a single focus, tumor size was <= 1 cm in 37 (56.9%), whereas in 21 out of 32 (65.6%) with multifocality, the tumor was <= 1 cm. In the patient group aged >= 45 the rate of multifocality was higher in those with tumor size <= 1 cm than those with tumors >1 cm. Conclusion: Although in patients with tumor size <= 1 cm and with no risk factor, lobectomy and isthmectomy is adequate and ablation therapy is not recommended, due to the high rate of multifocality, we suggest that total thyroidectomy and ablation therapy may be useful.Öğe Increased T-Allele Frequency of 677 C > T Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Differentiated Thyroid Carcinoma(MARY ANN LIEBERT INC, 2012) Ozdemir, Semra; Silan, Fatma; Hasbek, Zekiye; Uludag, Ahmet; Atik, Sinem; Erselcan, Taner; Ozdemir, OzturkBackground: Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic acid metabolism and plays an essential role in inherited DNA methylation profiles. The common 677 C > T and 1298 A > C polymorphisms in the MTHFR gene cause the production of a thermolabile enzyme with reduced function and, eventually, genomic DNA hypomethylation. The current preliminary study was designed to determine the association between germ-line polymorphism in the MTHFR gene and differentiated thyroid carcinoma (DTC). Methods: In the current case-control study of 60 thyroid carcinomas (TC); 45 papillary TC, 9 follicular TC, and 6 DTC of an uncertain malignant potential were examined. Genomic DNA was extracted from peripheral blood with EDTA, genotyped by a multiplex real-time polymerase chain reaction. Results: An elevated 2.33-fold risk was observed for DTC in individuals with the 677TT genotype when compared with the control group (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.03-3.58). Current DTC patients showed similar results as a control group for the 1298 A > C allele. No significant risk was detected for the homozygous 1298CC genotype (CC vs. AA or AC) (OR: 1.30, 95% CI: 0.73-2.29). Conclusion: The current results are supportive of the hypothesis that the homozygous MTHFR 677TT genotype increases the risk factor of developing thyroid cancer, and further large-scale studies are needed to validate this association.Öğe INVESTIGATION OF 18F-FDG PET / CT AND CLINICOPATHOLOGICAL DATA OF DIFFUSE TYPE GASTRIC CANCERS(2022) Gömeç, Muhammed; Hasbek, ZekiyeObjective: One of the subtypes of stomach cancer, which is one of the leading causes of cancer-related deaths, is diffuse-type stomach cancer. In our study, it was aimed to retrospectively investigate the results of F-18-labeled fluorodeoxyglucose positron emission tomography, which is an imaging method frequently used in the diagnosis and follow-up of gastric cancer, in diffuse type gastric cancer subtypes and to review patient data in the light of the literatüreMaterial and Methods: Forty-four patients diagnosed with diffuse-type gastric cancer in a single center were included in the study. Clinical, pathological and positron emission tomography data of the patients were analyzed.Results: The mean age of the patients was 61.93. Sixteen (36.4%) of the patients were female, 28 (63.5%) were male. When the histopathological results of specimens obtained by endoscopic and surgical methods are examined, diffuse-type stomach cancer patients; 36 (81.8%) were Signet-Ring Cell, 8 (18.2%) were weak poorly cohesive type gastric cancer. Low F-18-labeled fluorodeoxyglucose involvement was observed in 8 (18.2%) patients, while high involvement was observed in 36 (81.8%). Nineteen of the patients had metastases. When SUVmax, SUVmean, metabolic tumor volume and total lesion glycolysis values were compared, a significant correlation was found between signet ring cell gastric cancers and weak cohesive type gastric cancers, and between presence and absence of metastasis (p <0.05).Conclusion: Although SUVmax values were lower in our diffuse type gastric cancer patient series compared to other gastric cancer patients, it was observed that it was higher in advanced diffuse type gastric cancers than in early stage patients. In addition, when the diffuse type gastric cancer subtypes signet-ring cell and weak poorly cohesive type gastric cancers were compared in terms of positron emission tomography results, it was observed that there was no significant difference, and this is an information that is not available in the literature.Öğe Is sensorineural hearing loss related with thyroid metabolism disorders(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2015) Karakus, Canan Filiz; Altuntas, Emine Elif; Kilicli, Fatih; Durmus, Kasim; Hasbek, ZekiyeObjectives: In this study, we measured hearing thresholds in patients diagnosed with hyperthyroidism or hypothyroidism with high-frequency audiometry and otoacoustic emission before and after treatment to determine whether hearing losses were cochlear or retrocochlear and whether they would improve with medical therapy. Materials and Methods: This study was conducted on patients diagnosed with hyperthyroidism and hypothyroidism at Cumhuriyet University, Faculty of Medicine, Department of Endocrinology and Metabolism and accepting to participate in the study. We measured the hearing thresholds of the study population during the pretreatment period and in posttreatment euthyroid period. Result: The audiometric findings of patients with hyperthyroidism were better than those of the control group especially at high frequencies. Sensorineural hearing loss was detected in the euthyroid period. We compared the audiometric findings of the patients with hypothyroidism and the controls. We found sensorineural hearing loss in patients with hypothyroidism, especially at low frequencies. Conclusions: The results of this study showed that both hyperthyroidism and hypothyroidism may have an effect on hearing pathway disorders. Medical therapy may lead to hearing loss in patients with hyperthyroidism, and the underlying factors should be investigated in detailed future studies. It was shown in our study that the hearing loss induced by hypothyroidism may improve with medical therapy. Therefore, in all patients with thyroid dysfunction, hearing levels should be monitored closely with audiometric tests.Öğe Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Gömeç, Muhammed; Gedikli, Mustafa Asım; Ertürk, Seyit Ahmet; Hasbek, ZekiyePapillary thyroid cancer (PTC) is the most common type of thyroid cancer, and its incidence continues to increase. Multifocality is common in PTC, and it has been suggested in many studies that multifocality may be associated with poor prognosis. In this study, data of patients followed with multifocal PTC were evaluated. Following the approval of the local ethics committee, the data of patients who received total thyroidectomy and subsequent radioactive iodine (RAI) treatment for thyroid cancer between 2012 and 2020 were evaluated. Multifocality was detected in 142 (19.88%) of the 714 PTC patients studied. The rate of multifocality among PTC patients was 3.29% in 2012, 7.2% in 2013, 10.1% in 2014, 10.5% in 2015, 38.15% in 2016, 31.6% in 2017, 33.33% in 2018, 32.58% in 2019 and 22.22% in 2020. Of these patients, 52.1% had 2 foci, 20.4% had 3 foci, 15.5% had 4 foci, and 12% had 5 or more foci. Multifocality was observed in the right and left lobe in 54.2% of the patients, the right lobe in 21.1% of the patients and t he left lobe in 12.7% of the patients. Multifocality was not detected in the isthmus only. It was found that as the number of tumor foci increased, differentiation decreased. It was observed that multifocality was more common in microcarcinomas. In our clinic, it has been observed that the rate of multifocal PTC has increased in recent years. This significant increase may be the result of morphological changes as well as improvements in diagnosis and treatment. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
