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Öğe A Study on Acne Patients’ Levels of Obtaining Information Through Social Media and Applying These Information(2019) Gencer, Zekiye Tamer; Hayta, Sibel BerksoyThe purpose of this study is to determine the level and way of the internet usagefor reaching alternative methods, the level of obtaining information about thetreatment of acne vulgaris (AV), i.e. pustule through social media, and the level ofusing this acquired information in patients diagnosed with AV which is known aspustule colloquially. In the study, the face-to-face interview technique was appliedto a total of 121 patients diagnosed with AV who applied to Dermatology OutpatientClinic of Sivas Cumhuriyet University. An interview form questioning the patients’socio-demographic characteristics, frequency of using internet and media, theirsocial media accounts, their level of searching about their diseases through thesetools, their level of acquiring information and status of realizing them as well asacne severity (PA), Dermatology Life Quality Index (DLQI) and Acne-Specific Qualityof Life Index (AQOL) was applied to the patients. The interviewed patients’ levelsof following the contents in the social and traditional media about the acne diseasewere found to be high, 51.2% of them were following the contents about the disease,and 55.4% were applying what they learnt. Variables of purchasing products atleast once from the social media for the acne disease (p=0.026<0.05) and counselinga physician before the usage (p=0.034<0.05) were determined to have a significanteffect on social media usage. It was concluded that the social media usage of acnepatients had a significant effect in terms of AQOL (p=0.012<0.05) and the probabilityof accessing information from social media in terms of this index increased by 2.444items (Exp:2.444). However, the effect of Acne Quality of Life Index was found tobe lower than the dermatology life quality index. As a result of this study, due tothe properties of acne vulgaris negatively reflecting disease on the social life of aperson emotionally and behaviorally, the frequency of using CAM (complementaryand alternative medicine) was high. Therefore, all mass media, especially socialmedia, are frequently used by the patients because of the information they provideconcerning this issue.Öğe Blood mean platelet volume may be predictive for disease course in the cases with pemphigus vulgaris.(SCIENTIFIC PUBLISHERS INDIA, 2017) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, MelihPemphigus vulgaris (PV) is an autoimmune blistering disorder treated with immunosuppressive agents. The patients with pemphigus vulgaris have remission and relapses and there is a need to have easy accessible and cheap laboratory monitoring markers. The aim of this study was to investigate the relationship between the course of the disease and the changes of the levels of neutrophil/lymphocyte ratio (NLR), platelet/lypmhocyte ratio (PLR), mean corpuscular volume (MCV) and mean platelet volume (MPV) in the patients with PV. Pemphigus patients (n=43) and healthy controls (n=40) were included in the study, retrospectively. Clinical and laboratory data, including C-reactive protein, erythrocyte sedimentation rate, hemoglobin, hematocrit, red cell distribution width, lymphocyte count, neutrophil count, platelet count, MPV, of the patients and healthy controls were obtained from our institutional computerized medical database. NLR and MPV levels in patients are higher than health controls (p<0.05) MPV changes are consistent with disease course according to variance analysis. MPV cut-off level is 8.45 and the specificity and sensitivity of this cut-off level is 65% and 76% to predict the pemphigus attacks, respectively (p=0.427). NL ratio, PL ratio and MPV may be accepted as inflammatory markers. MPV levels may be recommended as a marker for the determination of relapses in the patients with pemphigus vulgaris.Öğe Cutaneous manifestations of Crimean-Congo haemorrhagic fever: morbilliform eruptions may reflect a favorable outcome and not low platelet levels(JOHN LIBBEY EUROTEXT LTD, 2010) Akyol, Melih; Ozcelik, Sedat; Engin, Aynur; Hayta, Sibel Berksoy; Bicici, Fatma…Öğe Double serum sampled glomerular filtration rate measurement with technetium-99m diethylenetriamine-penta acetate for evaluation of renal functions in patients with psoriasis vulgaris(Deri Zuhrevi Hastaliklar Dernegi, 2021) Guner, Rukiye Yasak; Hayta, Sibel Berksoy; Akyol, Melih; Hasbek, Zekiye; Ozcelik, Sedat; Timucin, MeryemBackground and Design: Psoriasis is a common chronic inflammatory skin disease believed to affect renal functions. Glomerular filtration rate (GFR) is the most important indicator used to assess renal functions. The present study aims to measure the renal function of psoriasis patients via the technetium-99m diethylenetriamine pentaacetate (Tc-99m DTPA) method and compare the values obtained with those determined through indirect measurement methods, such as the modification of diet in renal disease (MDRD) and chronic kidney disease epidemiology collaboration (CKD-EPI), considering the effects of systemic treatments and comorbidities. Materials and Methods: Eighty-seven patients diagnosed with chronic plaque-type psoriasis vulgaris were included in this study. The patients' demographic characteristics, disease duration, psoriasis area and severity index score, drugs received for psoriasis treatment, comorbidities, and drugs received for comorbidity treatment were noted. Estimated GFRs were also calculated using the MDRD and CKD-EPI formulas. Results: Tc-99m DTPA values were affected only by age. As the patient age increased, a significant decrease in GFR measured with Tc-99m DTPA (r=0.289, p<0.001) was observed. Conclusion: Psoriasis, comorbidities, and nephrotoxic drugs used for treatment did not affect renal functions. GFR measurements were affected only by age.Öğe Epidemiology of Pemphigus in Turkey: One-year Prospective Study of 220 Cases(CROATION DERMATOVENEROLOGICAL SOC, 2017) Yayli, Savas; Harman, Mehmet; Baskan, Emel Bulbul; Karakas, Ayse Akman; Genc, Yeser; Turk, Bengu Gerceker; Demirsoy, Evren Odyakmaz; Gunasti, Suhan; Bilgili, Serap Gunes; Ilter, Nilsel; Ferahbas, Ayten; Savk, Ekin; Afsar, Fatma Sule; Aytekin, Sema; Kaya, Tamer Irfan; Hayta, Sibel Berksoy; Ozgen, Zuleyha; Gurel, Mehmet Salih; Caliskan, Ercan; Balci, Didem Didar; Gungor, Sule; Kapicioglu, Yelda; Ozuguz, Pinar; Aktan, Sebnem; Dogramaci, Asena; Kokcam, Ibrahim; Onsun, Nahide; Seckin, Deniz; Durdu, Murat; Dursun, Recep; Daye, Munise; Dilek, Nursel; Karabacak, Ercan; Temel, Asli Bilgic; Erdem, Cengizhan; Altun, Ece; Gungor, Dilek; Kartal, Demet; Akyol, Melih; Aksu, Esra Koku; Uzun, SonerPemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n= 192; 87.3%), followed by pemphigus foliaceus (n= 21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n= 83; 43.2%). The mean Pemphigus Disease Area Index was 28.14 +/- 22.21 (mean +/- Standard Deviation). The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.Öğe Evaluation of health literacy and drug use attitudes and behaviors of patients admitting to dermatology clinic(Sivas Cumhuriyet University, 2021) Yasak Güner, Rukiye; Tosun, Mustafa; Akyol, Melih; Hayta, Sibel Berksoy; Özpınar, SalihaObjective: In the present study, the purpose was to investigate the relationship between health literacy levels and drug use attitudes and behaviors of patients admitting to dermatology outpatient clinics.Method: A total of 295 volunteers admitting to Sivas Cumhuriyet University Dermatology Clinic between 1/03/2020 and 31/12/2020 were included in the study. Two forms were used to collect the data in the study. These were the Data Collection Form and the Health Literacy Scale.Results: The mean age of the participants was 33.0 ±16.36; and 62.0% of them were women. The mean score of the participants in Health Literacy Scale was 4.60±0.2; and it can be argued that the health literacy levels of the participants were high. The relations between health literacy and dermatological drug use attitudes and behaviors were evaluated with the Correlation Analysis; and a significant relation was detected between the two variables (p<0.05).Conclusions: Dermatology patients have high health literacy and their dermatological drug use attitudes and behaviors are at adequate levels.Öğe Evaluation of sleep quality in patients with psoriasis(TURKISH SOC DERMATOLOGY VENEROLOGY, 2015) Bicici, Fatma; Hayta, Sibel Berksoy; Akyol, Melih; Ozcelik, Sedat; Cinar, ZiynetBackground and Design: Psoriasis causes impairments in many daily activities, such as sleeping and occupational performance. One of the most important factors determining the quality of life of a person is sleeping. Studies about sleep quality in psoriasis are quite limited. In this study, we aimed to assess the quality of sleep and to examine the factors affecting the quality of sleep in patients with psoriasis. Materials and Methods: Seventy-three patients with psoriasis and 73 healthy subjects were included in the study. A sociodemographic data form was completed by all the participants and the Pittsburgh Sleep Quality Index (PSQI), 36-item Short-form Health Survey (SF-36), Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A) were administered to the patients and controls. Body Mass Index (BMI) was calculated in patient and control groups. The Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) were administered and pruritus was assessed in patient group. Results: PSQI global scores in patient group were found to be higher than in control group. Quality of sleep was worse in patient group. Severity of disease and sociodemographic features were found to be factors not affecting the quality of sleep. In patient group, the patients with higher sleep disturbances had higher rates of depression and anxiety scores. In patient group, the patients with severe pruritus had worse sleep quality. Conclusion: Psoriasis and psoriatic symptoms including pruritus impair sleep quality. Assessment of sleep quality and new strategies to improve sleep quality in patients with psoriasis may help improve quality of life.Öğe Increased expressed emotion in patients with psoriasis(TERMEDIA PUBLISHING HOUSE LTD, 2018) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, Melih; Albayrak, Funda; Kugu, Nesim; Ozcelik, SedatAim of the study: The aim of this study was to determine whether patients with psoriasis are affected by expressed emotion in their family environment. Material and methods: Participants included 62 patients with psoriasis and 83 healthy controls and their biological parent, wife or husband, or adult child as a key relative. Sociodeinographic data were recorded. Psoriasis area severity index was used to evaluate psoriasis severity. Hamilton depression and anxiety scales and the Expressed Emotion Questionnaire form were used to evaluate depression, anxiety, and expressed emotion. Results: The levels of expressed emotion and its subgroups in the patient group were higher than in the group of healthy controls (p < 0.05). Gender, disease duration, disease severity, and key relatives did not affect the levels of expressed emotion (LEEtotal) in the patients with psoriasis (p > 0.05). The LEEtotal of those with low educational level in the patient group was statistically significantly higher than those with higher educational level (p < 0.05). There was no correlation between the presence depression or anxiety and expressed emotion (p> 0.05). There was a negative correlation between age and the levels of expressed emotion in the patient group (p < 0.05). There was a negative correlation between age and intrusiveness in healthy controls (p < 0.05). Conclusions: Although decreasing with age, expression of emotion in patients with psoriasis is high, and psychosocial support should be provided to these patients.Öğe Photoimmunology(TURKISH SOC DERMATOLOGY VENEROLOGY, 2013) Akyol, Melih; Hayta, Sibel BerksoyThe human skin acts as a physical and immunological barrier to outside toxicants, microorganisms and harmful irradiations. Utraviolet radiation (UV) from the sun might potentially play an active role in regulating several biological events. It has become clear that UV exposure (especially 280-320 nm) can also affect spesific and nonspesific immun responses. Langerhans cells, regulatory T cells, active B cells, mast cells, NKT cells and some mediators, including cis-urocanic acid, serotonin, platelet activating factor (PAF), and nitric oxide (NO) seem to play a crucial role in the induction of UVB-induced immunsupression. IL-10 from keratinocytes, mast cells and supressor B cells is noteworthy as a most important cytokine in the development of immunsupression. UV-induced immunsupression may block antigenic stimulus on the skin, and allow of a balanced apoptosis and DNA repair.Öğe Pruritus is not sensorial in psoriasis: the mutual interactions between dermatologic life quality and pruritus(EDIZIONI MINERVA MEDICA, 2019) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, MelihBACKGROUND: Pruritus may emerge as affective or sensorial in psoriasis patients. It is not known whether the mediating effect of pruritus or disease severity on the quality of life is more pronounced. This study was conducted to determine the mediating effects and interactions between disease severity, pruritus and life quality in psoriasis patients. METHODS: 105 patients with psoriasis vulgaris were included in the study. Psoriasis Area and Severity Index (PAST) values, Dermatology Life Quality Index (DLQI), and visual analog scales for pruritus of each patient were analyzed by determining the correlations and the mediating interactions between these parameters. RESULTS: There was a moderate correlation between pruritus and DLQI (P=0.0001, r=0,528), a weak correlation between pruritus and PASI (P=0.005, r=0.273) and a moderate correlation between PASI and DLQI. The mediation effects of DLQI to pruritus, PASI to pruritus, PASI to DLQI and pruritus to DLQI were 25%, 0.047%, 22% and 25%, respectively. Also, the mediation effect of PASI plus pruritus to DLQI was 38%. CONCLUSIONS: The most obvious factor for pruritus is the impairment of DLQI rather than PASI in psoriasis patients. The mediating effect of PASI to DLQI increases the pruritus significantly.Öğe Psoriasis Vulgaris Hastalarında Subklinik Nörolojik Tutulumun İncelenmesi(Sivas Cumhuriyet Üniversitesi, 2024) Hayta, Sibel Berksoy; Çiğdem, Burhanettin; Guner, Rukiye; Gökçe, Şeyda Figül; Akyol, MelihÖZET Amaç: Bu çalışmanın amacı, psoriasis hastalarında subklinik nörolojik tutulum açısından bilişsel fonksiyonları P300 yöntemi ile değerlendirmek ve hastalık süresi ve şiddeti arasındaki ilişkiyi ortaya koymaktır. Yöntem: Çalışmaya 40 psoriasis vulgaris hastası ve 40 sağlıklı birey dahil edilmiştir. Her iki gruba standart mini mental test ve Beck Depresyon Envanteri uygulanmıştır. Psoriasis hastalarının PAŞİ (Psoriasis Alan ve Şiddet İndeksi) ve DYKİ (Dermatoloji Yaşam Kalitesi İndeksi) değerleri hesaplanmıştır. Her iki grubun P300 ölçümleri kaydedilmiş ve bilişsel fonksiyonları değerlendirmek amacıyla analiz edilmiştir. Bulgular: Sağlıklı ve psoriasis grupları arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.681, p=0.301, p=0.138, p=0.739). PAŞİ değerleri açısından karşılaştırıldığında, hasta grubunda PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.211, p=0.422, p=0.106, p=0.305). Hastalık süresine göre değerlendirildiğinde, gruplar arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.901, p=0.244, p=0.632, p=0.868). Sonuç: Psoriasis hastalarında bilişsel fonksiyonlar, hastalığın varlığı, şiddeti ve süresi ile etkilenmemektedir. Bildiğimiz kadarıyla, mevcut çalışma psoriasis hastalarında bilişsel fonksiyonları değerlendirmede elektrofizyolojik P300 yöntemini kullanan ilk çalışmadır.Öğe Psoriyazis hastalarında duygu dışa vurumunun değerlendirilmesi(Cumhuriyet Üniversitesi, 2009) Hayta, Sibel Berksoy; Akyol, MelihAmaç: Psoriyaziste psikosomatik köken tam olarak ispatlanamasa da genel kabul gören bir etyolojik özelliktir. Hastaların önemli bir kısmı başlangıç ve alevlenme dönemlerinde stres ve diğer emosyonel travmalardan söz ederler. Psoriyazisli hastalar ile yapılan çalışmalarda çeşitli depresyon ve anksiyete ölçekleri kullanılarak depresyon, anksiyete ve psoriyazis arası ilişkiler incelenmiştir. Fakat hastaların aile ortamındaki duygu dışavurumundan etkilenip etkilenmediğini gösteren bir çalışma daha önce yapılmamıştır. Biz bu çalışmada Duygu Dışavurumu Düzeyi `LEE' (Level of Expressed Emotion) ve Duygu Dışavurumu `EE' (Expressed Emotion) ölçeklerini kullanarak, psoriyazisli hastaların aile ortamında maruz kaldıkları duygu dışavurumu ve algıladıkları duygu dışavurumu düzeyi ile hastalık arasındaki ilişkiyi göstermeyi amaçladık.Materyal ve Metod: Çalışmaya psoriyazisli 62, egzemalı 32 hasta, dermatolojik hastalık öyküsü olmayan 35 sağlıklı birey ve bu kişilerin anahtar akraba olarak tanımladıkları yakınları alındı. LEE ölçeği psoriyazisli hastalar, egzemalı hastalar ve sağlıklı kontrol grubu tarafından dolduruldu. EE ölçeği psoriyazisli, egzemalı hasta yakınları ve sağlıklı kontrol grubu yakınları tarafından dolduruldu. Psoriyazisli hastaların hastalık şiddetleri PASİ skorlama sistemi ile hesaplandı. Psoriyazisli hastalar Hamilton depresyon ve anksiyete değerlendirme ölçekleri kullanılarak anksiyete ve depresyon varlığı açısından değerlendirildi. Çalışmaya alınan kişilerin yaş, cinsiyet, eğitim durumu, hastalık süreleri kaydedildi.Sonuçlar: Psoriyazisli ve egzemalı hastalar arasında LEE total puanı, LEE'nin alt ölçek puanları açısından istatistiksel olarak anlamlı bir fark bulunamazken, LEE total puanı ve LEE'nin alt ölçeklerinden aşırı müdahalecilik `İ' (intrusiveness), aşırı tepkisellik `E' (emotional response), hastalığa karşı olumsuz tutumlar `A' (attitude toward ilness) puanları psoriyazisli hastalarda sağlıklı kontrol grubundan daha yüksek bulundu. EE puanı açısından psoriyazisli ve egzemalı hasta yakınları arasında istatistiksel olarak anlamlı bir fark bulunamazken, EE puanı psoriyazisli hasta yakınlarında sağlıklı kontrol grubu yakınlarındakinden daha yüksek idi. Cinsiyetler açısından psoriyazis ve egzemalı hastalar arasında LEE, LEE'nin alt ölçekleri ve EE puanları arasında istatistiksel fark bulunamazken, psoriyazisli erkek ve kadın hastaların LEE total puanı sağlıklı kontrol grubunda ki erkek ve kadınların puanlarından daha yüksek idi. Psoriyazisli erkeklerdeki İ ve E puanları sağlıklı kontrol grubundaki erkeklerden, psoriyazisli kadınlardaki E ve A puanları sağlıklı kontrol grubundaki kadınlardan daha yüksek bulundu. Psoriyazisli kadın hasta yakınlarının EE puanı ile sağlıklı grubun yakınlarının EE puanları arasında istatistiksel bir fark bulunamazken, erkek hasta yakınlarının EE puanları sağlıklı grubun yakınlarının EE puanlarından daha yüksek bulundu. Eğitim düzeyinin ve anahtar akraba konumunda seçilen kişinin LEE ve hasta yakınlarındaki EE puanlarını etkilediği bulundu. Psoriyazisli hastalarda LEE puanlarının eğitim düzeyi ve yaştan etkilenirken EE puanlarının değerlendirilen parametrelerden etkilenmediği gösterildi.Yorum: Psoriyazis kronik bir hastalık olması nedeniyle kişinin aile içi ilişkilerini etkiliyor veya hastalığın kendisi aile içi etkileşimden etkileniyor olabilir. Aile ortamı psoriyazisli hastalar için dikkate alınması gereken bir faktördür. Aile içi çatışmalar sürekli bir stres kaynağı olarak hastalığın seyrine olumsuz etki yapabilir. LEE ve EE ölçekleri hastaların aile ortamının değerlendirilmesinde kullanılabilir ve yüksek duygu dışa vurumu saptanan aile bireylerine ve hastaya yapılacak stres azaltıcı psikososyal müdahaleler ve sosyal yapıdaki değişiklikler hastalık seyrini olumlu yönde etkileyebilir.Anahtar kelimeler: psoriyazis, duygu dışvurumuÖğe The reduction in inflammation and impairment in wound healing by using strontium chloride hexahydrate(TAYLOR & FRANCIS LTD, 2018) Hayta, Sibel Berksoy; Durmus, Kasim; Altuntas, Emine Elif; Yildiz, Esin; Hisarciklio, Mehmet; Akyol, MelihBackground: Numerous growth factors, cytokine, mitogen and chemotactic factors are involved in wound healing. Even though inflammation is important for the stimulation of proliferative phase, excessive inflammation also causes impairment in wound healing. Strontium salts suppress keratinocyte-induced TNF-alpha and interleukin-1 and interleukin-6 in in vitro cultures. This study was conducted to determine the effects of administration of topical strontium chloride hexahydrate on wound healing through TNF-alpha and TGF-beta in surgical wound healing model of in-vivo rat skin.Material and methods: Twenty-four rats were used in the study. After approximately 2cm cutaneous-subcutaneous incision was horizontally carried out on the mid-neckline of the rats, the incision was again closed using 2.0 vicryl. The rats were assigned into three groups including eight rats in each group. Placebo emollient ointment and also the ointments, which were containing 5% and 10% strontium chloride hexahydrate and were prepared at the same base with placebo ointment, were administered to the groups by a blind executor twice a day for a week. At the end of seventh day, the rats were sacrificed and cutaneous and subcutaneous tissue of their wound site was resected for histopathological examination. Scoring of histopathological wound healing and scoring of tissue TNF-alpha and TGF-beta level with immunohistochemical staining were performed.Results: The groups, to which both 5% and 10% strontium chloride hexahydrate was administered, had lower immunohistochemical TNF-alpha levels and histopathological wound scores compared to controls, which was statistically significant (p<0.05).Conclusion: Strontium chloride hexahydrate can lead to impairment in wound healing by suppressing inflammation through TNF-alpha.Öğe Supression of sweating in palmar hyperhydrosis with 5% strontium chloride hexahydrate(WILEY-BLACKWELL, 2015) Akyol, Melih; Hayta, Sibel Berksoy; Yasak, Rukiye; Ozcelik, Sedat…Öğe The incidence of Demodex folliculorum in patients with chronic kidney deficiency(2007) Ozçelik, Semra; Sümer, Zeynep; De?erli, Serpil; Ozyazici, Gonca; Hayta, Sibel Berksoy; Akyol, Melih; Candan, FerhanThe aim of this study was to evaluate the prevalence of Demodex folliculorum in immune suppressed patients. The present study was carried out on individuals being treated for chronic kidney deficiency and immune suppressed patients that were hospitalized in the Hemodialysis Units and Internal Disease Service of the Cumhuriyet University Hospital. Forty-seven patients with chronic kidney deficiency (CKD) and a control group of thirty-eight healthy and actively exercising individuals were included in this investigation. By means of a questionnaire given to the patients and control group, complaints of allergenic related dermal and optical disorders were detected and the prevalence of Demodex was also evaluated by this questionnaire. First, the presence of D. folliculorum was proven taking dermal specimens from the cheek of every individual. Afterwards, at least two eyelash specimens from the lower and upper eyelid-eyelash follicles of the right and left eyes were taken and examined in a drop of olive oil between slide and cover glass microscopically. The frequency of parasites in every preparation was also determined in each positive case. D. folliculorum was found in the eyelid-eyelash follicles of 6 (12.76 %) and 12 (25.53 %) of the dermal face specimens of the 47 chronic kidney deficiency patients. On the other hand, D. folliculorum was found in the eyes of 2 (5.26 %) persons and in the dermal face specimens of 7 (18.42 %) out of a total of 38 persons in the control group. In the present study, the difference in the Demodex prevalence and complaints of dermal disorder in the two groups was found to be insignificant. In the study group, the difference was insignificant as to dermal complaints and Demodex prevalence (p < 0.05), but considerably difference was observed between complaints about eyes and Demodex prevalence (p < 0.05). Consequently, it was concluded that Demodex folliculorum may be a cause of eye disorders such as blepharitis, and this parasite can be frequently observed in persons with immune system anomalies.Öğe The Level of Expressed Emotion (LEE) Scale (Short Version): The Turkish Validity and Reliability Study in Patients Admitting to Dermatology Clinic(Ümit Muhammet KOÇYİĞİT, 2021) Tosun, Mustafa; Yasak Güner, Rukiye; Hayta, Sibel Berksoy; Akyol, Melih; Çelikgün, SerkanPurpose: The purpose of the present study was to determine the Turkish validity and reliability of the LEE Scale (short version) in patients admitted to the Dermatology Clinic, and to ensure its use in patient evaluations for dermatology and other branches. Material and Methods: The LEE Scale (short version) had 38 items, and was developed originally in English. The scale was translated into Turkish by following the proper translation steps. The Turkish scale that was created was applied to the patients. A total of 510 people, 279 of whom were women (54.7%), and 231 men (45.3%), applying to Sivas Cumhuriyet University Hospital Dermatology Clinic were included in the study. The internal structure consistency and test-retest reliability were measured for reliability analyses. The Cronbach’s Alpha Coefficient was estimated for internal consistency. The scale was applied to 50 patients twice, at baseline and two weeks later for test-retest reliability, which was also statistically evaluated with the Pearson Correlation Test. The Exploratory Factor Analysis was performed to evaluate the construct validity of the scale. The significance level was taken as pÖğe The relationship between pityriasis rosea, seasonal factors, and other herpetic infections: A time series analysis(Wolters Kluwer Medknow Publications, 2019) Hayta, Sibel Berksoy; Guner, Rukiye; Cam, Selim; Akyol, MelihBackground: Data on seasonal variation and viral etiology in Pityriasis rosea (PR) have been conflicting. The aim of this study was to investigate the association of PR and other herpetic infections, taking seasonal changes into account. Methods: The data were collected retrospectively from electronic health registry systems in Sivas in the Central Anatolia region of Turkey between 2008 and 2016. According to their clinical types, other herpetic infections were investigated. Environmental factors such as humidity, temperature, and rainfall for the relevant period were added into the model. Time series methods (augmented Dickey-Fuller unit root test and regression analysis) were used in the analysis. Results: A total of 1207 PR patients were included in the study. The number of PR patients was calculated to be 0.462 times that of the same period in the previous year. The incidence of PR increased significantly when the rate of infections caused by varicella-zoster virus decreased and the rate of infections caused by herpesvirus Type 1 and humidity increased (P < 0.05). Conclusion: Environmental factors such as humidity are important in the emergence of the PR. Furthermore, the incidence of PR may be inversely affected by varicella-zoster infections contrary to the relationship between PR and herpesvirus Type 1 infections.Öğe The synthesis and anti-cancer efficacy of endoperoxide modified copper sulfide-ferritin nanocages as PDT and PTT agents(Springer, 2023) Kucukoflaz, Merve; Ulusoy, Sakine; Korkmaz, Bekir; Ozturk, Suleyman Can; Akyol, Melih; Hayta, Sibel Berksoy; Goze, Omer FahrettinPhotodynamic therapy (PDT) using endoperoxides is to produce toxic singlet oxygen of reactive oxygen species through heat from the endoperoxides present in the medium. Compared with conventional PDT, PDT using endoperoxides has some advantages, for instance, in the presence of endoperoxide, singlet oxygen efficiency is not affected by hypoxic environment, because endoperoxides are the source of singlet oxygen. On the other hand, the kinetic stabilities of endoperoxides are important in the body temperature. Another advantage of endoperoxides is that they can produce singlet oxygen upon warming, so regardless of the wavelength of the emitted light, they can selectively produce singlet oxygen in the heated region. The aim of this study is to synthesize core-shell nanocages (10-Aft-CuS) with the synergistic effect of both photothermal therapy (PTT) and PDT by functionalizing the surface of the Apoferritin (Aft) nanocage platform with an endoperoxide derivative and forming ultra-small CuS nanoparticles in its inner cavity for the first time. So, first of all, Aft-CuS nanoparticles were obtained by the synthesis of ultra-small CuS nanoparticles in the inner cavity of Aft nanocages. Then, the surfaces of these nanocages have been functionalized with the Compound 10, an endoperoxide anthracene derivative. While the synthesized nanoparticles in this way have the synergistic effects of PTT and PDT therapies, achieving this with a natural nanoparticle has also been tested in cell cultures in vitro and in mice with progressed melanoma in vivo by increasing the effectiveness against cancer cells. 10-Aft-CuS nanocages showed high anti-tumor efficacy against malignant melanoma in vitro and in vivo.Öğe Therapeutic and prophylactic effects of strontium on radiotherapy-induced skin toxicity in rats(TURKISH SOC DERMATOLOGY VENEROLOGY, 2017) Yucel, Birsen; Hayta, Sibel Berksoy; Goze, Omer Fahrettin; Erdis, Eda; Bahar, Seher; Celasun, Mustafa Gurol; Kacan, Turgut; Akyol, MelihBackground and Design: This study aimed to investigate whether 5% strontium (Sr) chloride hexahydrate has preventive or therapeutic effects on the radiotherapy (RT)-induced adverse skin effects. Materials and Methods: Sixty-four female Wistar albino rats weighing 200-210 g, aged 4.5-5 months were divided into eight groups. Results: There were significant differences between control group and the other groups according to the Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria (RTOG) and histopathological findings (p<0.050). However, there were no significant differences between RT group and treatment groups (p>0.05). In addition, there were no significant differences among treatment groups (p>0.05). Statistical results were as follows according to the immunohistochemical evaluation of transforming growth factor-beta: group 1 and 4 (p=0.015), group 1 and 5 (p=0.014), group 1 and 6 (p=0.035), group 1 and 8 (p=0.046), group 2 and 6 (p-0.047), group 4 and 6 (p=0.031); and according to the immunohistochemical evaluation of tumor necrosis factor-alpha: group 1 and 2 (p=0.024), group 1 and 8 (p=0.045). Conclusion: Topical treatment with Sr at a concentration of 5% is insufficient to prevent the side effects of RT involving the skin, as assessed by the RTOG scoring, histopathological findings, and immunological markers.
