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    Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review
    (2021) Durna Daştan, Sevgi; hossain, rajib; Quispe, christina; Herrera-Bravo, jesus; Islam, shahazul; Sarkar, chandan; Islam, Muhammed toregul; Morterell, Miguell; Cruz-martins, natalia; al-harrasi, Ahmed; Al-rawahi, Ahmed; Rad, Javad sharifi; Ibrayeva, Manshuk; Al-shehri, Mohammed; Calina, daniela; Cho, William c
    Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, and Google Scholar using the keywords: “Lasia spinosa,” then combined with “ethnopharmacological use,” “phytochemistry,” and “pharmacological activity.” This updated review included studies with in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological Hindawi Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 1602437, 12 pages https://doi.org/10.1155/2021/1602437 mechanisms. The research results showed that L. spinosa contains many important nutritional and phytochemical components such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence supports the fact that the plant has antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive. Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these data, L. spinosa can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in humans.
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    Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective.
    (2021) Durna Daştan, Sevgi; Islam, Muhammed toregul; Quispe, christina; Herrera-Bravo, jesus; Sarkar, chandan; Sharma, rohit; Garg, Neha; Fredes, larry ıberra; Morterell, Miguell; Alshehri, Mohammed; Rad, Javad sharifi; Calina, daniela; Alsafi, radi; Alghamdi, saad; Batiha, gaber el-saber; Cruz-martins, natalia
    Dengue remains one of the most serious and widespread mosquito-borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths. Dengue virus infection is especially transmitted through bites of Aedes mosquitos, hugely Hindawi BioMed Research International Volume 2021, Article ID 4224816, 23 pages https://doi.org/10.1155/2021/4224816 spread in tropical and subtropical environments, mostly found in urban and semiurban areas. Unfortunately, there is no particular therapeutic approach, but prevention, adequate consciousness, detection at earlier stage of viral infection, and appropriate medical care can lower the fatality rates. This review offers a comprehensive view of production, transmission, pathogenesis, and control measures of the dengue virus and its vectors.
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    Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
    (2021) Durna Daştan, Sevgi; Al-shehri, Mohammed; Rad, Javad sharifi; Herrera-Bravo, jesus; Jara, evelyn L.; Salazar, luis A.; Kregiel, dorota; Uprety, yadav; Akram, Muhammad; Iqbal, Mehwish; Morterell, Miguell; Torrens-Mas, Margalida; Pons, daniel gabriel; Cruz-martins, natalia; Ozdemir, fethi Ahmet; Kumar, Manoj; Cho, William c
    analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with Hindawi Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 6331630, 15 pages https://doi.org/10.1155/2021/6331630 estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.