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    Comparison of Oxidant and Antioxidant Parameters in Patients with Sjogren's Syndrome and Healthy Subjects
    (Georg Thieme Verlag Kg, 2020) Dogan, Ismail; Erten, Sukran; Sahin, Ali; Isikoglu, Semra; Neselioglu, Salim; Ergin, Merve; Erel, Ozcan
    Objective Oxidative stress may have an effect on the pathogenesis of diseases, including autoimmune rheumatic diseases. We aimed to investigate the serum paraoxonase activity and other oxidant/antioxidant parameters in patients with Sjogren's syndrome (SS) and healthy controls. Methods 85 patients with SS and 65 healthy subjects were included in the study. Groups were age and gender-matched and had no liver disease. Serum paraoxonase (PON)-1 activity, stimulated paraoxonase (SPON), PON-1 phenotypes that represent polymorphism (Q192R; QQ, QR, RR), arylesterase (ARE), total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), advanced oxidative protein products (AOPP), total thioles (TTL) and ischaemia-modified albumin (IMA) were measured in all study participants. Results Statistically significant differences were found in the QQ and QR + RR phenotype of PON-1 for TAC, TOS and TTL (p < 0.001) between SS and healthy groups. The other parameters were statistically insignificant. Conclusion Antioxidant parameters were lower in SS patients compared with healthy controls. Conversely, oxidant parameters were higher. This imbalance may play a role in SS pathogenesis.
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    Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients with attack free period
    (PUBLISAUDE-EDICOES MEDICAS LDA, 2014) Sahin, Ali; Erten, Sukran; Altunoglu, Alpaslan; Isikoglu, Semra; Neselioglu, Salim; Ergin, Merve; Atalay, Haci Veil; Erel, Ozcan
    Objective. Familial Mediterranean fever (FMF) is an autoinflammatory, autosomal recessive, inherited disease characterized by recurrent self-limiting attacks of serosal surfaces. The imbalance of oxidants/antioxidants may play a role in such attacks. In this study, we aimed to evaluate the relationship between serum paraoxonase (PON1) activity PON1 phenotype, and other parameters in patients with FMF and healthy controls. Methods: A total of 120 FMF patients with an attack-free period (AFP) and 65 healthy subjects were included in this study The serum PON1 activity, stimulated paraoxonase (SPON) activity, PON1 phenotype (representing Q192R polymorphism; QQ, QR, RR), arylesterase activity, total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), advanced oxidative protein products (AOPP), total thiols (TTL), and ischemia-modified albumin (IMA) and cystatin-c (CYS-C) levels were measured. Results: For the QQ phenotype, the median TTL and AOPP levels of the control group were 264.50 (57.75) mu Amol/L and 21.26 (21.17) mmol/L, respectively, whereas the median TTL, AOPP levels of the patients were 309.00 (47.00) mu mol/L and 12.98 (6.96) mmol/L, respectively There was a statistically significant difference between the patients and controls with the QQ phenotype in terms of TTL and AOPP (p< 0.001 and p= 0.004, respectively). However, there were no statistically significant differences between the QQ and QR+FRR phenotypes with respect to TAC, TOS, OSI, or the other parameters. Conclusions: The FMF patients with AFP had higher TTL and lower AOPP levels than the controls. However, other oxidant and antioxidant parameters were similar among the patients during AFP and the controls.
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    Relationship between serum cystatin C level and M694V homozygosity in patients with familial Mediterranean fever
    (Bayrakol Medical Publisher, 2020) Erzurum, Cahide; Erten, Sukran; Akan, Selcuk; Sahin, Ali; Isikoglu, Semra; Erel, Ozcan
    Aim: In this study we aimed to evaluate the relation of cystatin C with proteinuria, estimated glomerular filtration rate (eGFR), and disease activity in patients with familial Mediterranean fever (FMF). Material and Methods: One hundred twenty four patients with FMF and 66 healthy controls were included in the study. Complete blood count (CBC), acute phase reactants (erythrocyte sedimentation rate, c-reactive protein), routine biochemical tests, thyroid function tests (TFT), FMF gene analysis, 24-hour urine analysis and serum cystatin C levels were evaluated. Results: Patients and controls had similar cystatin C levels. A significant negative relationship between creatinine clearance and cystatin C, and a significant positive relationship between microalbuminuria and cystatin C were detected (p=0.008 and p=0.005, respectively) in FMF patients. Cystatin C levels were significantly higher in M694V homozygotes than in M694V mutation-negative patients (p=0.016). Cystatin C levels were higher in men than in women in FMF and control groups (p=0.008, and p=0.003, respectively). Discussion: In accordance with the literature, creatinine clearance and microalbuminuria were found to be related to serum cystatin C levels. Therefore, cystatin C or cystatin C-based eGFR measurement is important for early detection of nephropathy and early treatment of the disease.