Yazar "Ismayilov, Rayyat Huseyn" seçeneğine göre listele

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    Bioactivity, crystal and molecular structure of vanadyl(III) complex with N-salicyloyl - N'(3,5-ditertbutyl-2-hydroxy)benzylidene hydrazine
    (Pergamon-Elsevier Science Ltd, 2024) Fatullayeva, Perizad Amrulla; Medjidov, Ajdar Akper; Safronenko, Marina Gennadievna; Khrustalev, Victor Nikolaevic; Ismayilov, Rayyat Huseyn; Bayramov, Mahammad Allahverdi; Yalcin, Bahattin
    N-salicyloyl-N'-(3,5-ditertbutyl-2-hydroxy)benzylidene hydrazine (H3sahz) and its complex with VO(III) have been synthesized. The molecular and crystal structure of the [(VO)2(sahz)2(C2H5O)2(C2H5OH)] complex by X-ray diffraction, as well as IR and electronic spectra, EPR spectrum etc., have been studied. The structure of the investigated VO(III) complex consists of binuclear units in which the monomeric complex molecules are linked to each other through vanadyl oxygen atom. Monomeric complexes differ between themselves in the character of coordination. Both vanadium atoms have a distorted octahedral environment. The biological activity of this compound has been studied. Lastly, the activities of the studied ligand against various enzyme proteins including acetylcholinesterase (AChE), butrylcholinesterase (BChE) and alpha-glycosidase (alpha-Gly) enzyme were compared. ChE inhibitory activities of the new complex against alpha-Gly, AChE and BChE were determined by Tao and Ellman's methods. The new complex was shown to have IC50 values of 42.60 mu M for BChE, 91.43 mu M for AChE, and 196.49 mu M for alpha-glycosidase.
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    Trinuclear nickel (II) string complexes and copper (II) coordination polymer with pyrazine modulated unsymmetrical dipyridylamino ligand: Synthesis, structure and bioactivity properties with molecular docking
    (Elsevier, 2024) Ismayilov, Rayyat Huseyn; Valiyev, Fuad Famil; Tagiyev, Dilgam Babir; Song, You; Medjidov, Ajdar Akber; Fatullayeva, Perizad Amrulla; Tuzun, Burak
    The unsymmetrical pyrazine-modulated ligand, N-(pyridine-2-yl)pyrazin-2-amine (Hppza) (1), its 1D straightchain copper (II) coordination polymer [Cu2(Hppza)2 center dot(NO3)4]n (2) and trinuclear metal string [Ni3(mu 3ppza)4Cl2] (3) and [Ni3(mu 3-ppza)4(NCS)2] (4) complexes have been successfully synthesized and structurally characterized. The free ligand Hppza (1) exhibits anti-syn conformation. In an asymmetric unit of 2, there are two kinds of Cu(II) atoms, both of which have elongated octahedral coordination geometry, and the copper(II) centers are linked by oxygen atoms of one nitrate anion. There are only minor differences in Ni...Ni bond lengths between pyrazine-modulated ligand complexes of [Ni3(mu 3-ppza)4x2] (X = Cl-(3), NCS- (4)) and their unmodulated analogs, while the distances between the terminal nickel atoms and the axial ligands 3 and 4 are shorter. The results of magnetic susceptibility measurements showed an antiferromagnetic exchange constant (J) of about J = -199.2 cm-1 for 3 and J = -178.0 cm-1 for 4. The electrochemical properties of nickel strings of Hppza differ significantly from their unmodulated counterparts. The activities of ligands and their metal complexes against various proteins that are AChE (PDB ID: 4M0E), BChE (PDB ID: 5NN0), alpha-Gly (PDB ID: 1UAS), hCA I (PDB ID: 2CAB), and hCA II (PDB ID: 3DC3) were compared, and then the ADME/T properties of molecules were examined. Afterward, the interactions occurring in the docking calculation were examined in detail with the Protein-Ligand Interaction Profiler (PLIP) service. These complexes were inhibitors of BChE, hCA I and II, alpha-glycosidase and AChE enzymes for complex 3 and 5 with Ki values of 12.65 and 42.95 mu M for hCA I, 3.64 and 15.84 mu M for hCA II, 5.44 and 50.07 mu M for BChE, 15.85 and 4.77 mu M for alpha-glycosidase and 8.58 and 86.24 mu M for AChE, respectively.