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Öğe Additional Therapeutic Effect of Balneotherapy in Low Back Pain(LIPPINCOTT WILLIAMS & WILKINS, 2011) Dogan, Murat; Sahin, Ozlem; Elden, Hasan; Hayta, Emrullah; Kaptanoglu, EceObjectives: Balneotherapy has been widely used for treatment of chronic low back pain recently. However there are only a few clinical controlled trials on balneotherapy. The aim of the present study was to evaluate the effects of balneotherapy in patients with chronic low back pain. Methods: Sixty patients with lumbar spondylosis were included in the study. In Group 1, patients received both balneotherapy and physiotherapy and in Group 2, patients received only physiotherapy for three weeks. The intensity of the pain was evaluated by Visual Analog Scale (VAS) and functional disability was scored according to Revised Oswestry Index (ROI). Spinal mobility was assessed by the Schober and lateral flexion tests. Variables were evaluated before and after the three weeks of treatment. Results: The groups were comparable regarding age (P = 0.970) and sex (P = 0.357). There was no statistically significant difference between the two groups for baseline VAS (P = 0.838), Schober test (P = 0.226), and right (P = 0.642) and left (P = 0.674) lateral flexion measurements, and ROI scores (P = 0.798). At the end of the therapy, all clinical parameters significantly improved in patients in both of the groups (P < 0.05). VAS, Schober test, and ROI scores after the therapy were clearly superior in Group 1 in comparison to Group 2 (P < 0.05). Conclusion: The results of the present study reiterate that besides conventional physiotherapy, balneotherapy may be effective in the treatment of patients with chronic low back pain.Öğe Alcohol Consumption Among Inflammatory Rheumatic Patients: A Survey From Turkey(TURKISH LEAGUE AGAINST RHEUMATISM, 2012) Cay, H. Fatih; Illeez, Ozge; Kocabas, Hilal; Sezer, Ilhan; Kaptanoglu, Ece; Kacar, CahitObjectives: In this study, we aimed to evaluate alcohol consumption of Turkish rheumatic patients. Patients and methods: A total of 332 subjects [185 males and 147 females; mean ages of 41.2 (95% CI 39.5-43.0) and 45.2 (95% CI 43.4-47.1) years, respectively] with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and healthy controls were questioned regarding their alcohol habits. Alcohol consumers were asked to fill out the Turkish version of the Michigan Alcoholism Screening Test (MAST). Results: A total of 37.3% of all subjects were alcohol consumers. Nearly 50% of males and 20% of females drank alcohol. Rheumatoid arthritis group had the lowest rate of alcohol consumption (23.0%), while healthy controls had the highest rate (45.6%). The mean MAST scores were 3.02 (95% CI: 2.36-3.69) and 3.13 (95% CI: 1.76-4.5) for the AS and RA groups, respectively, indicating statistically lower rate compared to the healthy controls [4.94 (95% CI: 4.14-5.73) (p<0.001)]. An analysis of the MAST scores by categories revealed that most of the alcohol abusers/alcoholics were in the healthy control group. Conclusion: Our results showed that alcohol consumption, an important public health problem, has not been regarded as a major issue for the patients with rheumatic diseases. Further studies are required to evaluate the potential factors which may play a role in the alcohol consumption habits of rheumatic patients.Öğe Assessment of Joint Inflammation By Ultrasonography (US) in Patients with Rheumatoid Arthritis (RA) in Clinical Remission(CLINICAL & EXPER RHEUMATOLOGY, 2014) Ozer, Pinar Kaplan; Sahin, Ozlem; Ozer, Zafer; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Kaptanoglu, Ece…Öğe Association Between Familial Mediterranean Fever and Cachexia in Females(Turkish League Against Rheumatism, 2020) Durmaz, Yunus; Ilhanli, Ilker; Cengiz, Ahmet Kivanc; Kaptanoglu, Ece; Ozkan Hasbek, Zekiye; Hizmetli, SamiObjectives: This study aims to investigate the association between familial Mediterranean fever (FMF) and cachexia in females. Patients and methods: The study included 32 female FMF patients (median age 27.50 years; range, 18 to 50 years) and 30 female healthy controls (median age 32 years; range, 18 to 50 years). Patients were classified according to Tel-Hashomer criteria. Circumference of arm, waist, and thigh was recorded. Short form 36 (SF-36) and Multidimensional Assessment of Fatigue (MAF) scale were applied. Composition of the body was measured with dual X-ray absorption. Muscle strength was measured with an isokinetic dynamometer, and strength of hand grip was measured from dominant hand with a hand dynamometer. C-reactive protein, erythrocyte sedimentation rate, fibrinogen and serum creatinine kinase (CK) levels were recorded. Results: Body mass index was significantly higher in controls. Twelve patients and one control had cachexia. CK level was significantly higher in patients than controls. Mass of muscle without fat was significantly higher in patients than controls. Peak torque values of extension and flexion at the velocity of 60 degrees/second [Newton meter (Nm)], and value of total work during extension at the velocity of 240 degrees/second (Nm) in isokinetic measures were significantly higher in controls. MAF score was significantly higher in patients with cachexia than patients without cachexia where the subscale scores of SF-36, except the vitality score, were significantly lower in patients with cachexia. However, Tel-Hashomer score was significantly higher in patients with cachexia. Conclusion: This study pointed at a significant association between cachexia and FMF in females. Muscle endurance was not affected in FMF patients with cachexia; however, decreased muscle strength, impaired quality of life and increased fatigue were observed in these patients.Öğe Autoantibodies are not associated with familial mediterranean fever(MEDFARMA-EDICOES MEDICAS, LDA, 2012) Guler, Emel; Kaptanoglu, Ece; Sahin, Ozlem; Candan, Ferhan; Hayta, Emrullah; Elden, HasanObjective: It has been suggested that Mediterranean fever (MEFV) gene mutations are also seen in certain autoimmune diseases and are related to severity of the disease activity. As most of the clinical symptoms of these inflammatory diseases are related to autoantibody positivity, we assessed autoantibody prevalence in patients with Familial Mediterranean fever (FMF) and investigated the relationship between clinical involvement of FMF and the autoantibodies. There are a few studies on this subject with conflicting results. Patients and Methods: Fifty patients with FMF without attack and 27 healthy controls were enrolled to the study Clinical characteristics of the patient group were questioned. Rheumatoid factor (RE), anti-cyclic citrullinated peptide (anti-CCP) values, Fluorescent antinuclear antibody (ANA), extractable nuclear antigen (ENA) profile was studied in both groups. Results: No statistically significant difference was found in ANA, ENA profile, anti-CCP, and RF positivity between the groups (p>0.05). There was no relationship between the autoantibodies and the clinical status in patients with FME MEFV gene mutations were identified in 98% of the FMF patients. Conclusion: In conclusion, autoantibody positivity is similar to the healthy population in FME Although MEFV mutations affect clinical course in other autoantibody mediated diseases, it is not related to autoantibody formation in FMEÖğe Body Composition in Patients with Ankylosing Spondylitis on Anti-Tumor Necrosis Factor Alpha Treatment(KUWAIT MEDICAL ASSOC, 2017) Sahin, Ozlem; Kaptanoglu, Ece; Dinler, Mustafa; Dogan, Sevil Ceyhan; Kurt, Kibar GultekinObjectives: To examine the body composition (BC) of the Ankylosing spondylitis (AS) patients on anti-TNF therapy and to evaluate the clinical parameters in obese AS patients Design: Cross-sectional case-control study Setting: Department of Physical Medicine and Rehabilitation, Cumhuriyet University, Medical Faculty, Sivas, Turkey Subjects: Thirty-four AS patients and 34 healthy subjects as controls were included in the study between November 2014 and May 2015 Main outcome measures: Waist circumference (WC), body mass index (BMI), percent body fat (PBF), fat mass (FM) and fat free mass (FFM) were measured in patients and control group. In AS group, disease activity, functional status, spinal mobility and life quality were examined by standard AS questionnaires. Results: WC, BMI, PBF, FM, and FFM were comparable in AS patients and controls. There was a positive correlation between the duration of the anti-TNF treatment and BMI (p = 0.02, r = 0.409). In obese AS patients, the duration of the anti-TNF treatment was significantly longer than the normal weight AS patients (for BMI p = 0.02, for PBF p = 0.03). Obese and normal weight AS patients were comparable regarding disease duration, disease activity, functional status, spinal mobility and life quality. Conclusions: The BC of AS patients on anti-TNF treatment was similar to healthy controls. Anti-TNF treatment has comparable effects on disease parameters in both the normal weight and obese AS patients. Long-term treatment with anti-TNF drugs may lead to obesity. Prospective controlled studies with more patients to clarify this probable effect of anti-TNF drugs are required.Öğe Bone mineral density in familial Mediterranean fever(SPRINGER HEIDELBERG, 2012) Siverekli, Neslihan Berkdemir; Sahin, Ozlem; Senel, Soner; Hayta, Emrullah; Kaptanoglu, Ece; Elden, HasanThe aim of this study was to evaluate the bone mineral density (BMD) in familial Mediterranean fever (FMF) and to search the effects of genetic factors, family history of FMF and types of clinical attacks on BMD. Forty-four attack-free patients with FMF and 36 healthy voluntary subjects were included in the study. BMD measurements of lumbar spine and left proximal femur were performed by dual energy X-ray absorptiometry (DEXA). There was no statistically significant difference between patient and control groups regarding median values of lumbar BMD (P = 0.06), lumbar T (P = 0.08) and Z (P = 0.12) scores, femoral neck BMD (P = 0.13), femoral T (P = 0.22) and Z (P = 0.16) scores and total femur BMD (P = 0.14), T (P = 0.19) and Z (P = 0.27) scores. Patients with negative FMF family history had significantly lower femoral neck BMD (P = 0.018), femoral neck T (P = 0.009) and Z (P = 0.01) scores and total femur BMD (P = 0.033) than patients with positive FMF family history. There was no significant difference among the groups regarding mutation characteristic and types of attacks in lumbar BMD, T and Z scores, femoral neck BMD, T and Z scores and total femur BMD, T and Z scores (P > 0.05). We found that the bone loss of patients with FMF is not different from that of the controls. The increased bone loss in the patients with negative family history for FMF should be further investigated with larger patient groups taking into consideration of the risk factors related to family history for osteoporosis.Öğe Coexistence of Familial Mediterranean Fever and Juvenile Idiopathic Arthritis with Osteoporosis Successfully Treated with Etanercept(JAPAN SOC INTERNAL MEDICINE, 2010) Kaya, Sunay; Kaptanoglu, Ece; Elden, Hasan; Hizmetli, SamiFamilial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent febrile polyserositis and arthritis attacks. Accompanying seronegative spondyloarthropathy has been reported in FMF in addition to its own joint involvement. However, the coexistence of FMF with juvenile idiopathic arthritis (JIA) is very rare, only three cases with severe joint involvement and mortal outcome have been reported in the literature. Here, we present another case with FMF and JIA with osteoporosis, successfully treated with etanercept with a four-year follow-up.Öğe Complementary and alternative treatment methods in chronic rheumatic diseases in the Central Anatolia(MODESTUM LTD, 2018) Karadag, Ahmet; Hayta, Emrullah; Kaptanoglu, Ece; Konak, AkinBackground: The aim of the study is to identify the kind of traditional practices used for the rheumatic diseases in the central Anatolia. Materials and Methods: A total of 440 volunteer patients with chronic rheumatic diseases including osteoarthritis (OA), fibromyalgia, rheumatoid arthritis (RA), spondyloarthropathy (SpA), familial Mediterranean fever (FMF), Behcet's disease (BD), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD) were enrolled in the study. All patients were administered a 36-item questionnaire. Results: Of the patients, 49.3 % were using CAM. Herbal medicine was the most commonly (58.1 %) preferred methods. The CAM was used by 86 (48%) of 179 patients with OA and by 51 (60%) of 85 patients with RA. The difference in the CAM use across the disease groups was not statistically significant (chi(2)=7.343; p=0.290). When the patients using or not using CAM were assessed according to their education status, it was found that CAM was used by 59 (66.3%) of 89 patients with university degree and indicating a statistically significantly higher number of patients from higher education status among the CAM users (chi(2)=17.651; p=0.001). Conclusions: Our study results suggest that among patients with rheumatic disease, patients with RA more commonly resort to the methods of CAM.Öğe Complementary and Alternative Treatment Methods in Rheumatic Diseases(CLINICAL & EXPER RHEUMATOLOGY, 2014) Karadag, Ahmet; Kaptanoglu, Ece; Hayta, Emrullah; Konak, Akin; Hizmetli, Sami…Öğe Differentiation of Rheumatoid Arthritis From HCV Infection: Rheumatoid Factor, Anti-Cyclic Citrullinated Peptide or Anti-Mutated Citrullinated Vimentin?(AVES YAYINCILIK, IBRAHIM KARA, 2010) Kaptanoglu, Ece; Nadir, Isilay; Bakici, Zahir; Hayta, Emrullah; Turkmen, Mehmet; Sezer, Hafize; Hizmetli, Sami; Elden, HasanObjective: Differentiation of rheumatoid arthritis (RA) from other diseases with joint involvement such as hepatitis-C virus (HCV) infection represents a diagnostic problem. In addition to the rheumatoid factor (RF), more specific and sensitive auto-antibodies are under evaluation in recent years with conflicting results. In this study, we tested the diagnostic value of rheumatoid factor, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) in distinguishing RA from hepatitis C patients. Materials and Methods: Sera of 34 RA patients and 30 hepatitis C patients were tested for RF, anti-CCP anti-MCV. Disease activity was determined by disease activity score (DAS-28) 28 in RA and by modified Knodell score in hepatitis C patients. Extra-articular involvement in RA and rheumatologic involvement in hepatitis C patients were documented. Results: In roc analysis, area under curve (AUC) was the highest in anti-CCP. Sensitivity and specificity was 82% and 53%, 79%, and 96% and 70%, and 73% for RF, anti-CCP and anti-MCV respectively. DAS-28 has a weak correlation with RF (r=0.406), anti-CCP (r=0.433), and anti-MCV (r=0.453). There was no difference between the patients in autoantibody levels regarding extra-articular involvement and DAS-28 in RA, and joint involvement in hepatitis C patients. Conclusion: Anti-MCV antibodies may be useful in distinguishing RA however it seems to have no additional value over anti-CCP or RF in hepatitis C patients. Anti-CCP antibodies are more reliable in diagnosis of RA due to their high specificity. (Turk J Rheumatol 2010; 25: 19-23)Öğe Diffuse Alveolar Hemorrhage: A Life-Threatening Complication of Systemic Lupus Erythematosus(CLINICAL & EXPER RHEUMATOLOGY, 2014) Cengiz, Ahmet Kivanc; Durmaz, Yunus; Dinler, Mustafa; Dogan, Sevil Ceyhan; Hayta, Emrullah; Akin, Recep; Gumus, Cesur; Kaptanoglu, Ece; Hizmetli, Sami…Öğe Disease Activity, Fatigue and Quality of Life in Patients with Coexisting Ankylosing Spondylitis and Familial Mediterranean Fever(CLINICAL & EXPER RHEUMATOLOGY, 2014) Kaptanoglu, Ece; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Hayta, Emrullah; Dogan, Sevil Ceyhan; Hizmetli, Sami…Öğe Does Mean Platelet Volume Really Reflect Disease Activity in Rheumatoid Arthritis?(CLINICAL & EXPER RHEUMATOLOGY, 2014) Hizmetli, Sami; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Hayta, Emrullah; Dogan, Sevil Ceyhan; Kaptanoglu, Ece…Öğe EMDR treatment of fibromyalgia, a study of seven cases(CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI, 2012) Kavakci, Onder; Semiz, Murat; Kaptanoglu, Ece; Ozer, ZaferObjective: Fibromyalgia syndrome (FMS) is a nonarticular rheumatic disease with unknown etiology and is characterized by widespread pain, increased tenderness in some anatomical regions, increased pain sensitivity, sleep disorders, fatigue and frequently by psychological distress. Though many approaches have been tried there is no effective treatment for FMS. The relationship between FMS and psychiatric disorders is known, recently some researches point to the frequency of psychological trauma in patients with FMS. The search for treatment for chronic painful conditions has more and more focused to psychotherapeutic approaches. In this study, seven patients diagnosed were attempted to be treated with EMDR approach. Methods: 22-41years aged six women and one man diagnosed with FMS were admitted to the study. Before and after the treatment tender point count was identified and patients scored their pain levels at Visuel Analog Scale. Patients filled in Beck Depression Inventory (BDI), The Posttraumatic Diagnostic Scale (PDS), Pittsburg Sleep Quality Index (PSQI), State-Trait Anger Scale (STAS). If the patients have reported, trauma was focused on, if they have not reported any trauma, pain was focused. Five-eight sessions of EMDR was applied to the patients. Results: After the treatment, there were statistically significant reduction in patient reported VAS, PSQI, FIQ, PDS, and BDI scores. There was signify-cant decrease in tender point counts. Though there was no change in trait anger, anger-in and anger-out subscores of STAS, the increase in anger management subscore was significant. After the treatment, none of the patients met the FMS criteria but one patient (6th patient). Conclusion: EMDR therapy was effective in the treatment of these patients with FMS. (Anatolian Journal of Psychiatry 2012;13:75-81)Öğe Low-back pain in geriatric patients - Remember abdominal aortic aneurysm!(LIPPINCOTT WILLIAMS & WILKINS, 2007) Hocaoglu, Sehriban; Kaptanoglu, Ece; Hocaoglu, Siyami…Öğe Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report(WILEY, 2017) Kaptanoglu, Ece; Sahin, Ozlem; Tuncer, Tiraje; Hizmetli, Sami; Altan, Lale; Ayhan, Figen; Bal, Ajda; Bilgilisoy, Meral; Bozbas, Gulnur; Cerrahoglu, Lale; Cevik, Remzi; Duruoz, Tuncay; Dulgeroglu, Deniz; Gurer, Gulcan; Gursoy, Savas; Hepguler, Simin; Kacar, Cahit; Kaya, Taciser; Melikoglu, Meltem; Nas, Kemal; Ozcakir, Suheda; Ozdolap, Senay; Saridogan, Merih; Sarikaya, Selda; Sindel, Dilsad; Sendur, Omer F.; Tikiz, Canan; Ugurlu, Hatice…Öğe Post-Traumatic Stress Disorder, Alexithymia and Somatoform Dissociation in Patients with Fibromyalgia(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2014) Semiz, Murat; Kavakci, Onder; Peksen, Halil; Tuncay, Mehmet Siddik; Ozer, Zafer; Semiz, Esra Aydinkal; Kaptanoglu, EceObjective: We investigated the prevalence of post-traumatic stress disorder, alexithymia, and somatoform dissociative symptoms in patients with fibromyalgia (FM). Material and Methods: Fifty-six consecutive patients with FM admitted to the outpatient department were enrolled in this study after providing informed consent. Forty-six patients with rheumatoid arthritis (RA) were enrolled as controls. Participants completed the Somatoform Dissociation Questionnaire (SDQ), the Post-traumatic Diagnostic Scale (PDS), the Toronto Alexithymia Scale (TAS), and The Childhood Trauma Questionnaire (CTQ). The impact of FM was measured with the Fibromyalgia Impact Questionnaire (FIQ). Results: The number of patients reporting at least one traumatic event was higher in the FM (19, 33.9%) than in the RA (6, 13%) (X2=5.9, p=0.015) group. Post-traumatic stress disorder (PTSD) was found in six (10.7%) of the 56 subjects with FM. In the RA group, no patients met the criteria for PTSD. Current PTSD prevalence was higher in the FM than in the RA group. Among those with FM group and traumatic experiences, FIQ scores were higher in patients with than without PTSD (p=0.02). Additionally, a positive correlation between traumatic experiences and use of analgesics (r=0.415, p=0.002) was also observed. FM patients had significantly higher scores than did RA patients on the CTQ, SDQ and TAS. Conclusion: The results of this study indicate that PTSD, alexithymia, and dissociative symptoms positively influence the levels of pain and FM-related disability in FM patients. Treatment strategies may be developed to manage psychiatric conditions in fibromyalgia.Öğe Psychopathology, Family Functioning and Marital Relationship in Female Patients with Fibromyalgia Syndrome(UNIVERSITATSVERLAG ULM GMBH, 2010) Kugu, Nesim; Kaptanoglu, Ece; Kavakci, Onder; Guler, EmelObjective: Fibromyalgia syndrome (FMS) is a chronic widespread painful syndrome of middle-aged women. Psychological problems, especially depression and anxiety are common among the FMS patients. High alexithymia scores have been reported before. It is suggested that FMS has a negative effect on family and marital relationships. In this study, we aimed to search whether there is a difference between the FMS and osteoarthritis patients with chronic pain regarding the psychopathologic features, alexithymia and the effects of these diseases on family and marital relationships. Patients and Methods: Fifty-four female FMS patients and 33 osteoarthritis patients as controls were included in the study. All patients were given a socio-demographic Data Form, Visual Analogue Scale (VAS) for pain, Toronto Alexithymia Scale (TAS), Symptom Check List-90 Revised (SCL-90-R), Marital Life Scale (MLS), Marital Conflict Questionnaire (MCQ), and Family Assessment Device (FAD). Fibromyalgia Impact Questionnaire (FIQ) was given only to the FMS patients. Results: TAS Scale 1 (difficulty in describing the feelings) and TAS total mean scores of FMS patients were significantly higher compared to the control group (p<0.05). The mean scores of SCL-90-R and Global Symptom Index (GSI) subscales, except the paranoid ideation were also significantly higher in FMS group compared to control group (p<0.05). MLS scores were comparable in the FMS and control groups (p>0.05). Regarding MCQ, both Conflict Expansion Score (CES) and Frequency of Conflict Score (FCS) mean values were significantly higher in FMS patients (p<0.05). The mean scores of roles and affective responsiveness subscales of FAD were higher in the FMS group compared to the controls (p<0.05). There were positive correlations between the FIQ scores and obsessive-compulsive (r=0.35, p=0.01), interpersonal sensitivity (r=0.28, p=0.04), depression (r=0.36, p=0.00), anxiety (r=0.41, p=0.00), phobic anxiety (r=036, p=0.00), hostility (r=0.30, p=0.03) and psychoticism (r=0.39, p=0.00) subscales of SCL-90-R. Conclusion: According to the results of our study, there is a "difficulty in describing the feelings" which is an alexithymic component, more general psychopathology regarding SCL-90-R, more conflict in marital relations, and more problems in family functioning especially in areas of affective responsiveness and roles within the family in FMS patients compared to the controls with chronic pain. These findings indicate that multi-dimensional interventions are necessary in the treatment of FMS and instead of concentrating only on chronic pain handling of the family and marital relations negatively affected by accompanying psychopathologic features and disorders of the FMS patients should also be cared.Öğe Routine Assessment Of Patient Index Data 3 In Fibromyalgia: A Rapid and Reliable Instrument For Evaluating Disease Severity?(WILEY-BLACKWELL, 2013) Kaptanoglu, Ece; Sahin, Ozlem; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Hizmetli, Sami…
