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Analyses of Preoperative Presumptive Diagnosis in Lung and Mediastinal Lesions
(Derman Medical Publ, 2010) Sahin, Ekber; Karadayi, Sule; Nadir, Aydin; Celik, Burcin; Sezer, Hafize; Kaptanoglu, Melih
Aim The aim of this study was to investigate the correlation of preoperative presumptive and final histological diagnosis in patients without previous histological evaluation. Matherial and Methods We enrolled sixty-five patients who were operated for lung and mediastinal lesions between December 2005 and December 2008. In all patients, three presumptive diagnosises were established and they were compared to final histological diagnosis. ROC curve was used for analysing data. Results Postoperative histological diagnosis were as follows: lung cancer 23.1 % (15/65), hydatid cyst 23.1% (15/65), sarcoidosis 13.8% (9/65), tuberculosis 9.2% (6/65) and other disease 30.8 % (20/65). Sensitivity of presumption in the diagnosis of lung cancer, hydatid cyst, tuberculosis and sarcoidosis were 80%, 93.3%, 50%, 66.7% respectively. Conclusion We think that the exploratory thoracotomy should be performed when the lung cancer and hydatid cyst are suspected for diagnosis. For accurate diagnosis of tuberculosis and sarcoidosis, more detailed and careful preoperative laboratory studies should be done.
An analysis of 214 cases of rib fractures
(HOSPITAL CLINICAS, UNIV SAO PAULO, 2011) Karadayi, Sule; Nadir, Aydin; Sahin, Ekber; Celik, Burcin; Arslan, Sulhattin; Kaptanoglu, Melih
INTRODUCTION: Rib fractures are the most common type of injury associated with trauma to the thorax. In this study, we investigated whether morbidity and mortality rates increased in correlation with the number of fractured ribs. MATERIALS AND METHODS: Data from 214 patients with rib fractures who applied or were referred to our clinic between January 2007 and December 2008 were retrospectively evaluated. The patients were allocated into three groups according to the number of fractures: 1) patients with an isolated rib fracture (RF1) (n = 50, 23.4%), 2) patients with two rib fractures (RF2) (n = 53, 24.8%), and 3) patients with more than two rib fractures (RF3) (n = 111, 51.9%). The patients were evaluated and compared according to the number of rib fractures, mean age, associated chest injuries (hemothorax, pneumothorax, and/or pulmonary contusion), and co-existing injuries to other systems. FINDINGS: The mean age of the patients was 51.5 years. The distribution of associated chest injuries was 30% in group RF1, 24.6% in group RF2, and 75.6% in group RF3 (p < 0.05). Co-existing injuries to other systems were 24% in group RF1, 23.2% in group RF2, and 52.6% in group RF3 (p < 0.05). Two patients (4%) in group RF1, 2 patients (3.8%) in group RF2, and 5 patients (4.5%) in group RF3 (total n = 9; 4.2%) died. CONCLUSION: Patients with any number of rib fractures should be carefully screened for co-existing injuries in other body systems and hospitalized to receive proper treatment.
Analysis of 264 Patients with Stab and Gunshot Wounds in Abdominal and Thoracic Regions
(DRUNPP-SARAJEVO, 2010) Korkmaz, Ilhan; Karadayi, Sule; Guven, Fatma Mutlu Kukul; Eren, Sevki Hakan; Sahin, Ekber; Nadir, Aydin; Beydilli, Inan; Kaptanoglu, Melih
Introduction: Penetrating traumas are life-threatening situations which can be encountered in emergency services. In this study, epidemiological data, treatment approaches and the results pertaining to penetrant abdominal and/or thoracic injuries, which occured due to gunshot or stab wounds, are evalauted retrospectively. Material-method: Two hundred and sixty four patients who admitted to emergency department with penetrating thoracic and/or abdominal trauma between 2002 and2009 were retrospectively analyzed. Patients were divided into 3 groups according to their shock indexes including Low risk (<= 0.5), medium risk (> 0.5-<= 1) and high risk (> 1) groups. Results: The study group included 244 male (92.4%) and 20(7.6%) female participants. Age distribution of the groups was as follows; 58 (22.0%) patients were in the 0-19 years group, 139 patients (52.6%) were in the 20-40 years group and 67 patients (25.4%) were over 40 years. Two hundred and fifteen injuries (81.4%) were caused by stab wounds and 49 (18.6%) were due to gunshots. When the patients were evaluated considering the injury site, isolated thoracic trauma was seen in 93 patients (35.3%) and isolated abdominal injuries were found in 74 patients (28.0%). The most common organ injuries among the patients who underwent laparotomy (n=73) were as follows; bowel injury in 28 patients (38.3%), stomach injuries in 20 patients (27.4%) and liver-spleen injuries in 17 patients (23.28 %). Of 189 patients with thoracic trauma, 17 patients (8.9 %) had hemothorax, 44 (23.28 %) had pneumothorax, 46 (24.33 %) had hemopneumothorax and 2 patients (1.05 %) had pulmonary contusion. Seven patients (2.65 %) died. Two patients were considered as exitus in the initial examination. Two of the 5 exitus cases had shock index ranging within the medium risk group and 3 were in the high-risk group. Conclusion: It must be considered that penetrating trauma patients with medium or high shock index have a higher mortality rate. Therefore, those patients must be closely monitored and the health services should be improved for immediately and appropriately transferring them.
Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo
(SPRINGER, 2013) Tepe, Bektas; Tuncer, Ersin; Saraydin, Serpil Unver; Ozer, Hatice; Sen, Metin; Karadayi, Kursat; Inan, Deniz Sahin; Karadayi, Sule; Polat, Zubeyde; Akpulat, Askin; Duman, Mustafa; Koksal, Binnur; Turan, Mustafa
This work aims to investigate the antiproliferative properties of Allium sivasicum (AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses. AS showed cytotoxicity to three cancer cell lines. Annexin-positive cells level in AS treated cell lines were higher than the untreated control cells. The expressions of caspase-7 protein and TUNEL positive cells were much higher for the rats treated by AS, compared with the untreated control group. The expressions of the Ki-67 decreased in treatment groups compared with the control group. In vivo studies showed that mean tumor volume inhibition ratio in AS treated group was 38 % compared with the untreated rats. These results indicate that A. sivasicum has antitumoral potential against breast cancer.
Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2012) Saraydin, Serpil Unver; Tuncer, Ersin; Tepe, Bektas; Karadayi, Sule; Ozer, Hatice; Sen, Metin; Karadayi, Kursat; Inan, Deniz; Elagoz, Sahande; Polat, Zubeyde; Duman, Mustafa; Turan, Mustafa
Background: There is a long standing interest in the identification of medicinal plants and derived natural products for developing cancer therapeutics. Here we investigated the antiproliferative properties of Melissa officinalis (MO) from Turkey on breast cancer. Methods: MO extracts were studied for cytotoxicity against breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231). In vitro apoptosis studies were performed by annexin V staining and flow cytometry analyses. Immunohistochemistry for Ki-67 and caspase 7 in the tumoral tissue sections of DMBA-induced mammary tumors in rats was also performed, along with TUNEL assays to detect apoptotic cells. In vivo anticancer activity testing was carried out with reference to inhibition of growth of DMBA induced mammary tumors in rats. Results: MO showed cytotoxicity against three cancer cell lines, inducing increase in Annexin-positive cells. Expression of caspase-7 protein and TUNEL positive cells were much higher in rats treated by MO, compared with the untreated control group, while expression of Ki-67 was decreased. Furthermore, in vivo studies showed that mean tumor volume inhibition ratio in MO treated group was 40% compared with the untreated rats. Conclusion: These results indicated that MO extrcts have antitumoral potential against breast cancer.
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk
(SPRINGER, 2011) Arslan, Sulhattin; Karadayi, Sule; Yildirim, Malik Ejder; Ozdemir, Ozturk; Akkurt, Ibrahim
This study aimed to determine the relation between methylene-tetrahydrofolate reductase (MTHFR) gene polymorphism and lung cancer risk and the frequency of this polymorphism. The study involved 64 lung cancer patients (the study group) with definitive diagnosis and 61 noncancerous subjects (the control group). MTHFR C677T and A1298C mutation analysis was made using DNA isolated from peripheric blood and multiplex PCR and reverse hybridization strip test. Eighty-four percent of the patients were male. The age, gender, and history of alcohol use of the patients and control group were statistically similar. While MTHFR 677T and 677C allele frequency was 0.33 and 0.67 in the patients respectively, it was 0.29 and 0.71 in the control group. The frequencies of MTHFR 1298C and 1298A were 0.33 and 0.67 in the patients, and it was 0.31 and 0.69 in the control group respectively. When MTHFR 677TT and 677CT genotypes were compared with 677CC genotype, lung cancer risk was 2.4 times higher in the 677TT genotype. When MTHFR 1298AC and 1298CC genotypes were compared with 1298AA genotype, lung cancer risk was 1.5 times higher in 1298CC genotype. According to the results, allele frequency of homozygote T and C was high in lung cancer patients. It was 3.05 and 1.29 times higher in smokers than in non-smokers, and 3.05 and 1.64 times higher in males than in females; 3.0 and 2.44 times higher in those with non-small cell lung cancer than in those with small-cell lung cancer.
Comparison of trauma scores for predicting mortality and morbidity on trauma patients
(TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2014) Orhon, Reyhan; Eren, Sevki Hakan; Karadayi, Sule; Korkmaz, Ilhan; Coskun, Abuzer; Eren, Mehmet; Katrancioglu, Nurkay
BACKGROUND: In this study, we compared the anatomical, and physiological scoring systems trauma revised injury severity score (TRISS), revised trauma score (RTS), injury severity score (ISS), new injury severity score (NISS) to each other, to find out the most accurate and reliable trauma score for the risk classification of morbidity and mortality among the trauma patients. METHODS: This is a cross-sectional study, which included 633 patients who admitted to our University Hospital Emergency Department during an 8-month period due to trauma. All blunt and penetrating traumas (traffic accident, assault, etc.) patients above 16 years were included. RESULTS: Arrival time trauma scores (ISS, NISS, RTS, and TRISS) of the patients was calculated. Mean trauma score for the mortality prediction was calculated, and the p value was equal for all (p=0.001). Trauma scores were also analyzed for the hospitalization time in intensive care unit (ICU). While NISS, RTS, and TRISS values were significant (p=0.048, p=0.048, and p=0.017, respectively), ISS value was not significant (p=0.257) for predicting the ICU hospitalization time. Only TRISS was a good predictor for the mechanically ventilation time in ICU patients (p=0.01). CONCLUSION: In conclusion, we determined that the anatomical trauma scores (NISS, ISS) predicted the hospitalization and ICU necessities better, whereas TRISS, an anatomo-physiological trauma score, defined the ICU hospitalization and mechanically ventilation time better.
Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy: Morbidity and Mortality Analysis of Our Patients
(ORTADOGU AD PRES & PUBL CO, 2012) Karadayi, Kursat; Turan, Mustafa; Karadayi, Sule; Alagozlu, Hakan; Kilickap, Saadettin; Buyukcelik, Abdullah; Sarkis, Cihat; Yucel, Birsen; Boztosun, Abdullah; Cetin, Meral; Yilmaz, Abdulkerim; Yanik, Ali; Sen, Metin
Objective: The purpose of this study was to analyze the morbidity and mortality of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) with closed abdomen technique in the treatment of peritoneal surface malignancies. Material and Methods: Twenty-six patients (8 with ovarian cancer, 7 peritoneal mesothelioma, 6 colorectal cancer, 3 uterine sarcoma, 1 peritoneal carcinoma and 1 with gastric cancer) underwent 27 procedures. Peritonectomy was performed with complete removal of all the involved visceral and parietal peritoneum. HIPEC was performed with the closed abdominal technique using preheated (42.5 degrees C) perfusate for 60 minutes. EPIC was continued for postoperative 5 days. Results: All patients underwent resection of the lesions. Total pentonectomy was performed in 12 patients, while subtotal or partial peritonectomy was carried out in 14 according to the spread of carcinomatosis. Completeness of cytoreduction score of our patients was 0 in 18 patients, 1 in 6 patients and 2 in 2 patients. Major morbidity developed in 7 patients (27%). CRS+HIPEC+EPIC yielded acceptable morbidity and mortality rates. Of the 26 patients, 20 (77%) were alive without evidence of disease with a mean follow-up period of 13 6 months. Overall 1 year survival was 60%. Conclusion: Cytoreductive approach combined with intraperitoneal chemotherapy prolongs survival in selected patients with peritoneal carcinomatosis (PC) with acceptable morbidity and mortality.
Diagnostic and therapeutic approaches in tracheobronchial rupture: analysis of 23 patients
(EKIN TIBBI YAYINCILIK LTD STI-EKIN MEDICAL PUBL, 2010) Sahin, Ekber; Nadir, Aydin; Karadayi, Sule; Celik, Burcin; Manduz, Sinasi; Akkas, Yuecel; Kaptanoglu, Melih
Background: In this article we examined diagnostic and therapeutic results of tracheobronchial ruptures which we treated. Methods: In our study the records of 23 patients (19 mates, 4 females; mean age 21.0 +/- 15.8 years; range 1 to 64 years) who were admitted to and treated in our clinic between June 1992 and October 2008 due to tracheobronchial rupture caused by trauma or iatrogenic factors were examined retrospectively. Patients were evaluated in terms of injury type, localization of lesion. diagnostic and therapeutic methods. Results: A bronchus was ruptured in 17 patients (73.9%) and trachea was ruptured in six patients (26.1%). Bronchoscopy provided the diagnosis in 91%. Computed tomography was performed in four patients (17%). Eleven of the ruptures were in the right bronchial tree (47.8%), whereas six were in the left bronchial tree (26.1%) and six were in the trachea (26.1%). While surgical therapy was performed in 17 patients (73.9%), conservative therapy was administered in six (26.1%) patients. Morbidity occurred in two (8.7%) patients and one patient died (4.3%). Conclusion: Immediate or delayed surgical treatment can be successful in rupture or complete disruption of tracheobronchial ruptures. Multitrauma patients should be surgically treated as soon as cardiopulmonary status was stabilized. If there is a suspicion of tracheobronchial trauma. bronchoscopy should not be spared. If suspicion continues, repetitive bronchoscopy shouldn't be avoided.
Does hydatid disease have protective effects against lung cancer?
(SPRINGER, 2013) Karadayi, Sule; Arslan, Sulhattin; Sumer, Zeynep; Turan, Mustafa; Sumer, Haldun; Karadayi, Kursat
We hypothesized that solid tumors rarely occur in patients with hydatid disease. We obtained the serum of 14 patients diagnosed with hydatid disease, the serum of 10 patients who did not have a history of hydatid disease, and the hydatid cyst fluid from six patients. These sera and fluid samples were added at different concentrations to NCI-H209/An1 human lung small cell carcinoma cells and L929 mouse fibroblasts as a control group. Sera of patients with hydatid diseases had cytotoxic effects on NCI-H209/An1 cells, but they did not have cytotoxic effects on fibroblast cells. Sera from healthy subjects did not have a cytotoxic effect on the tumor cell line or control fibroblasts. Cyst fluid, also, did not have toxic effects on the NCI-H209/An1 cell line, but was toxic to fibroblasts up to a 1:32 dilution. Sera from patients with hydatid disease had cytotoxic effects on human small cell lung cancer cells in vitro.
An experimental model to study pneumothorax in Rats
(ACADEMIC JOURNALS, 2010) Akkas, M. D. Yucel; Sahin, Ekber; Celik, Burcin; Nadir, Aydin; Karadayi, Sule; Gumus, Cesur; Cinar, Ziynet; Kaptanoglu, Melih
Researchers have used various techniques to form pneumothorax in animals, but to date, no standard method or rate of pneumothorax has been defined. We tried to develop a standard and a safe method of pneumothorax model in this study. 12 female Wistar Albino rats weighing 200-220 g were used. Two groups (6 rats in each) were formed. Open pneumothorax was formed by 0.5 cm incision through the right, 5(th) intercostal space. The first group was held in open pneumothorax position for 1 min and the second group, for 2 min and the incisions were sutured. After 48 h, computed tomography of the rats were obtained and the pneumothorax rates were measured. The mean pneumothorax value was greater in Group II (13.89%) than in Group I and it was statistically significant (p < 0.05). The above mentioned method produces low rates of pneumothorax (10 - 15%), without injuring lung tissue. It should be useful for researchers, who plan to study lung physiology with low rates of pneumotohorax.
Factors determining the complications in Nuss procedure
(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2018) Katrancioglu, Ozgur; Akkas, Yucel; Sahinoglu, Tuba; Sahin, Ekber; Karadayi, Sule; Katrancioglu, Nurkay
Background: This study aims to share our experiences in complications developing in patients who underwent Nuss procedure and the management of these complications. Methods: In the study, files of 59 patients (50 males, 9 females; mean age 17.6 +/- 5.1 years; range, 2.5 to 33 years) who were applied Nuss procedure for pectus excavatum in our clinic between July 2007 and May 2016 were retrospectively assessed. Patients' age, gender, surgical method-complications and hospitalization durations were recorded. Fisher's chisquare test and logistic regression analysis were used for data evaluation. Results: Nuss procedure was performed in all patients without severe complications such as death, organ injury or massive hemorrhage. The most frequently observed postoperative earlyperiod complication was minimal pneumothorax (n=16, 27.1%), while bar dislocation was most frequently observed in the lateperiod (n=5, 8.3%). Conclusion: Being male and/or over 23 years of age were determined as risk factors for complication development after Nuss procedure. Still, being a minimally invasive and manageable approach with its success in correcting the deformity, short operation duration, and low complication rates, Nuss procedure can be safely performed in selected patients.
Investigation of wound healing in rat lung tissues in the postpartum period
(SPANDIDOS PUBL LTD, 2012) Karadayi, Sule; Sahin, Ekber; Nadir, Aydin; Tuncer, Ersin; Silig, Yavuz; Korkmaz, Ilhan; Tanzer, Fatos; Sezer, Hafize; Kaptanoglu, Melih
To assess the wound healing capabilities of damaged lung tissue in the postpartum period, we investigated the parameters related to wound healing in a rat model of lung damage. Rats were divided into six groups: IA, I B, II, IIIA, IIIB and IV (n=7 in each group). Group IA included rats not in the postpartum period that were sacrificed on the third day after lung injury, group IB included rats not in the postpartum period that were sacrificed on the tenth day after lung injury, group II included rats not in the postpartum period that did not receive lung injury, group IIIA included rats in the postpartum period that were sacrificed on the third day after lung injury, group IIIB included rats in the postpartum period that were sacrificed on the tenth day after lung injury and group IV included rats in the postpartum period without lung injury. Wound healing was evaluated histopathologically and measurements of hydroxyproline levels, serum alanine and glutamine were taken. A significant difference in serum alanine levels was evident between groups IA and IIIA. Significant differences were also observed between serum alanine and glutamine levels in groups IB and IIIB. In conclusion, we demonstrated that serum alanine levels were reduced in the postpartum period following lung injury, which may be expected to negatively impact wound healing in this period. The administration of exogenous alanine for traumatic events occurring during the postpartum period may thus contribute positively to wound healing capabilities during this period.
Is the Abramson technique effective in pectus carinatum repair?
(ELSEVIER SINGAPORE PTE LTD, 2018) Katrancioglu, Ozgur; Akkas, Yucel; Karadayi, Sule; Sahin, Ekber; Kaptanoglu, Melih
Background: The minimally invasive pectus carinatum (PC) surgery described by Abramson has been performed in many centers. We have been using this technique since 2011. This article describes our experience with PC correction. Methods: Between 2011 and 2016, 32 patients at our institution underwent minimally invasive repair of a PC deformity. All patients presented with cosmetic complaints. The deformity involved the lower sternum (all had chondrogladiolar type PC), and three patients had asymmetrical deformities. All operations followed the principles defined by Abramson. Results: Satisfactory esthetic results were achieved in our patients. The hospital stay averaged 5.3 days (range 4-7 days). The most common early complication was pneumothorax, and the most common late complication was wire suture breakage. Conclusion: The Abramson technique is an effective, minimally invasive procedure for PC with shorter operating and hospitalization times and low morbidity rates. (C) 2016 Asian Surgical Association and Taiwan Robotic Surgical Association. Publishing services by Elsevier B.V.
Paraoxonase levels in acute mushroom poisoning cases treated in emergency department
(ACADEMIC JOURNALS, 2011) Eren, Sevki Hakan; Korkmaz, Ilhan; Guven, F. Mutlu Kukul; Aydin, Huseyin; Karadayi, Sule
The present study was undertaken to investigate the activities of paraoxonase in acute mushroom poisoning cases. This investigation was made between June 2009 to June 2010 with 64 mushroom poisoning patients who admitted to our emergency department in which we analyzed the 6 and 48 h paraoxonase 1 (PON 1) levels. Mean value of PON1 A(6 h) was 74.83 +/- 41.68 U/ml and PON1 B(48 h) 91.90 +/- 51.08 U/ml. The difference was statistically significant (p = 0.001) Mushroom poisoning cases, which are a public health problem, are frequently reported in Europe, United States, and in the Far East. Paraoxonase levels can be used as prognostic markers for acute mushroom poisoning.
Predictive significance of KRAS point mutation in patients with non-small cell lung carcinoma relation to smoking and asbestos exposure in middle Anatolia population
(DRUNPP-SARAJEVO, 2010) Arslan, Sulhattin; Akkurt, Ibrahim; Koksal, Binnur; Karadayi, Sule; Ozdemir, Ozturk
Persons who have been occupationally exposed to environmental mutagens have a substantially increased risk for somatic oncogene mutations. Structural mutation in viral kristen rat sarcoma oncogene homolog 2 (KRAS; v-Ki-ras 2) has been assessed as a mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine-kinase inhibition in patients with non-small-cell lung cancer (NSCLC). The aim of the current study was to investigate the predictive significance of KRAS mutations in patient with NSCLC in relation to cigarette smoking and asbestos exposure. We have investigated 42 fresh tumoral tissue samples of cases that were histopathologically diagnosed as lung carcinomas. Patients were evaluated for clinical findings; tumoral tissue samples were examined histopathologically and genomic DNA from tumoral tissue samples were isolated. The KRAS point mutations were assessed by strip-Assay reverse hybridization method and compared with the healthy controls. A total of 24 patients (57%) demonstrated KRAS point mutations in their tumoral tissues, while 18 (43%) patients did not. Mutations were accumulated in current cases of NSCLC, which were active smokers and exposed to the asbestos. Current results showed that the combined effects of somatic mutations in KRAS may play an active role in development of primary lung carcinomas due to heavy smoke and asbestos exposure. Results also may have important implications for molecular diagnosis and targeted therapies in NSCLC.
Predictive significance of KRAS point mutation in patients with nonsmall cell lung carcinoma relation to smoking and asbestos exposure in middle anatolia population
(2010) Arslan, Sulhattin; Akkurt, Ibrahim; Koksal, Binnur; Karadayi, Sule; Ozdemir, Oztürk
Persons who have been occupationally exposed to environmental mutagens have a substantially increased risk for somatic oncogene mutations. Structural mutation in viral kristen rat sarcoma oncogene homolog 2 (KRAS; v-Ki-ras 2) has been assessed as a mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine-kinase inhibition in patients with non-smallcell lung cancer (NSCLC). The aim of the current study was to investigate the predictive significance of KRAS mutations in patient with NSCLC in relation to cigarette smoking and asbestos exposure. We have investigated 42 fresh tumoral tissue samples of cases that were histopathologically diagnosed as lung carcinomas. Patients were evaluated for clinical findings; tumoral tissue samples were examined histopathologically and genomic DNA from tumoral tissue samples were isolated. The KRAS point mutations were assessed by stripAssay reverse hybridization method and compared with the healthy controls. A total of 24 patients (57%) demonstrated KRAS point mutations in their tumoral tissues, while 18 (43%) patients did not. Mutations were accumulated in current cases of NSCLC, which were active smokers and exposed to the asbestos. Current results showed that the combined effects of somatic mutations in KRAS may play an active role in development of primary lung carcinomas due to heavy smoke and asbestos exposure. Results also may have important implications for molecular diagnosis and targeted therapies in NSCLC.
Surgical treatment in malignant pleural effusion
(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2021) Karadayi, Sule; Sahin, Ekber
Malignant pleural effusion can be described as the presence of exudate in the pleural space, accompanied by the detection of cancer cells in pleural fluid or tissue, which is the indicator of the disease in its advance stages, and survival time of these patients ranges between 3 and 12 months. Treatment options for malignant pleural effusion vary from observation in asymptomatic patients to pleurectomies or even extrapleural pneumonectomies in severe cases.
The effects of chlorhexidine gluconate and silver nitrate on rabbit lung: an experimental study
(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2011) Sahin, Ekber; Elagoz, Sahande; Celik, Burcin; Nadir, Aydin; Karadayi, Sule; Akkas, Yucel; Kaptanoglu, Melih
Background: In this study, we investigated the effects of chlorhexidine gluconate and silver nitrate on the lungs and determine their utility in operations for pulmonary hydatid cysts. Methods: Thirty New Zealand Wistar albino rabbits weighing between 2750 and 3000 grams were used in the study and divided into three groups. In the first (control) group, normal saline (0.09% NaCl); in the second group, silver nitrate (0.5%); and in the third group, chlorhexidine gluconate (0.04%) was administered intrathraceally. Thirty days after the procedure, the tracheobronchial and parenchymal changes in the subjects were evaluated histopathologically. Tracheobronchial changes were evaluated with respect to tracheal pathology whereas peribronchial lymphocytic infiltration and parenchymal changes were evaluated with respect to interstitial lymphocytic infiltration, hemorrhage-edema, fibrosis and pneumonitis. Results: The rate of interstitial lymphocytic infiltration was higher in the chlorhexidine gluconate group than in the control group, and the rates of fibrosis and fibrin accumulation were higher in the silver nitrate group than in the control group. No statistically significant differences in other parameters were found between the groups. Conclusion: The results of the study indicate that chlorhexidine gluconate (0.04%) has minimal negative effects on the rabbit lung and tracheobronchial mucosa and is a more reliable agent than silver nitrate.
Therapeutic approaches in tracheal stenosis: analysis of fifteen cases
(EKIN TIBBI YAYINCILIK LTD STI-EKIN MEDICAL PUBL, 2010) Sahin, Ekber; Nadir, Aydin; Celik, Burcin; Karadayi, Sule; Manduz, Sinasi; Arslan, Sulhattin; Kaptanoglu, Melih
Background: In this study, results of treatment of patients who had tracheal stenosis were evaluated. Methods: The clinical records of 15 patients (6 males, 9 females; mean age 39+/-23.2 years; range 8 to 70 years) who were treated for tracheal stenosis between June 1992 and October 2008 were analyzed retrospectively. The diagnostic method, localization, therapeutic approach and results of tracheal stenosis were investigated. Results: Tracheal stenosis was due to tracheostomy in six, prolonged intubation in five and malignancy in four patients. Rigid bronchoscopy was the most frequent diagnostic tool. Eight patients were treated conservatively. Diathermic resection was the first treatment of choice in nine patients. Resection and end-to-end anastomosis was used in seven patients and tracheal stent was used in six patients. Stents of three patients were removed within 12 to 18 months. Median duration of hospitalization was 12 days. Morbidity was seen in four patients; mortality was seen in three patients. Conclusion: The success rate in tracheal stenosis treated by surgery is 71 to 97% and it is 65 to 70% by conservative methods. Surgical options should be considered first, but conservative methods should keep in mind.

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