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    A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds
    (2024) Korkmaz, Gürsel; Karaman, Isa; Gezegen, Hayreddin
    Thiosemicarbazones can be synthesized by condensation of thiosemicarbazides with ketones or aldehydes and play a role as precursors in the synthesis of many compounds such as thiazoles. They can exhibit many biological activities such as anti-inflammatory, antitumor, and antimicrobial properties. The discovery of antibiotics was an important milestone in the treatment of bacterial infections. However, antimicrobial resistance developed by microorganisms has created the need to discover new antimicrobial agents. Thiosemicarbazones and thiosemicarbazone-based compounds show significant antimicrobial potential. This review investigates the antimicrobial activity results of 244 Thiosemicarbazones and Thiosemicarbazone-based compounds over the last five years. We summarized some articles on thiosemicarbazones and their hybrids showing only antibacterial and antifungal activity in Web of Science (WOS) between 2019 and 2024.
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    Anti-biofilm and antimicrobial activity of Mentha pulegium L essential oil against multidrug-resistant Acinetobacter baumannii
    (PHARMACOTHERAPY GROUP, 2016) Tutar, Ugur; Celik, Cem; Karaman, Isa; Atas, Mehmet; Hepokur, Ceylan
    Purpose: To investigate the antimicrobial and anti-biofilm activities of essential oil from Mentha pulegieum L. (EOMP) on multi-drug resistant (MDR) isolates of A. baumannii, as well as its phytochemical composition, antioxidant properties and cytotoxic activity. Methods: The phytochemical composition of EOMP was analyzed by gas chromatography, while its antimicrobial activities were determined by disc diffusion and broth micro-dilution methods. Minimal biofilm inhibition concentration (MBIC) and minimal biofilm eradication concentration (MBEC) tests were used for assessment of its anti-biofilm properties. Viability in the biofilm was studied using 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay, while colorimetric assay was used to assess its cytotoxicity on L929 cells Results: D-isomenthone, pulegone, isopulegone, menthol and piperitenone were the major components of the plant extract. EOMP produced > 22 mm inhibition zone for the isolates, with minimum inhibitory concentration (MIC) and MBIC of 0.6 -2.5 and 0.6 -1.25 mu L/mL, respectively, while MBEC was >= 10 mu L/msL. EOMP damaged biofilm structures formed by A. baumannii strains at MIC by 26 - 91 %. Conclusion: These results suggest that EOMP contains agents that may be useful in the development of new drugs against A. baumannii infections.
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    Evaluation of the Antibiofilm and Antimicrobial Properties of Ziziphora tenuior L. Essential Oil Against Multidrug-resistant Acinetobacter baumannii
    (ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET, 2016) Celik, Cem; Tutar, Ugur; Karaman, Isa; Hepokur, Ceylan; Atas, Mehmet
    Acinetobacter baumannii is one of the most important gram-negative microorganisms which lead to opportunistic hospital-acquired infections. A great part of the infections it causes is produced by strain resistant to all the antibiotics used. In our study, the Essential Oil (EO) of the Ziziphora tenuior L. antimicrobial and antibiofilm effects on multidrug resistant (MDR) A. baumannii isolates were researched. In addition, antioxidant, cytotoxic activity and chemical composition of EO were investigated. As a result of the gas chromatography-mass spectrometry (GC-MS) analysis of the Z. tenuior EO pulegone was found as the major component by 74.37%. It was observed when the antimicrobial activity of the EO was examined that it had >30 mm disc diffusion values. Minimal Inhibition Concentration (MIC) values were found between 0.6-1.25 mu L mL(-1) and Minimal Bactericidal Concentration (MBC) values were found between 2.5-5 mu L mL(-1). Minimal biofilm inhibition concentration (MBIC) values of the EO were found as 0.3-1.25 mu L m L-1 and Minimal Biofilm Eradication Concentration (MBEC) value as 5-10 mu L mL(-1). It was seen that the MIC value damaged the biofilm formations constituted by the A. baumannii strains by 51-84%. At 25, 12.5 and 6.25% EO concentrations, no cytotoxic appeared for the fibroblast cells in terms of the cytotoxic activities (p>0.05). Findings that were obtained in our study seem promising for the development of phytotherapeutic agents that could be used in the treatment of the MDR A. baumannii infections.