Yazar "Kariper, I. Afsin" seçeneğine göre listele

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    Antiproliferative effects of 5FU-AgNPs on different breast cancer cells
    (Taylor & Francis Ltd, 2024) Danisman-Kalindemirtas, Ferdane; Kariper, I. Afsin; Ustundag, Hilal; Ozsoy, Ceylan; Erdem-Kuruca, Serap
    Breast cancer is a leading cause of cancer-related deaths in women, and researchers are seeking more effective treatments. Nanotechnology offers a promising approach by creating nanocarriers to reduce the side effects of cancer drugs. This study synthesized AgNPs-5FU nanoparticles by binding the anticancer drug 5-fluorouracil (5FU) to a silver nanocarrier, significantly increasing 5FU's cytotoxicity. Characterization using DLS, SEM, UV-Vis, and FTIR confirmed the nanoparticles' properties, with a size of 18-28 nm and a PDI of 0.598. The release of 5FU from AgNPs-5FU was about 70%, demonstrating sustained and controlled release. Cytotoxicity results showed that AgNPs-5FU had an IC50 value of 23.006 in MCF-7 cells and 10.41 in 4T1 cells, making it 2.14 and 4.64 times more effective than free 5FU, respectively. Low cytotoxicity was observed in HUVEC cells. This study indicates that AgNPs-5FU has significantly higher potential activity against cancer cells compared to free 5FU.
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    Applications of Nanocellulose in Drug Release
    (World Scientific Publ Co Pte Ltd, 2025) Usan, Huseyin; Kariper, S. Esra Bolsu; Kariper, I. Afsin
    In this study, it is examined how nanocellulose has been used in drug release so far. In the thinning, information is given briefly on controlled drug release and its importance, nanomaterials in controlled release, structure, and production of nanocellulose. Then, examples of the use of nanocellulose in drug release are given. The disadvantage of still having a slightly high production cost has been identified. However, it is understood that it is a very suitable material for drug release due to its abundance in nature, easy availability, and biocompatibility. Therefore, at the end of the study, it is recommended that nanocellulose of different sizes would be very useful for producing nanocellulose in different sizes and its applications in drug release and nanocellulose with other functional groups for drug release. In this respect, it is predicted that studies on nanocellulose as a natural product in terms of drug release will accelerate.
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    Hydrovoltaic energy
    (Elsevier Science Sa, 2024) Kariper, S. Esra Bolsu; Kariper, I. Afsin
    Researchers focused on searching for low-cost, eco-friendly, renewable, high-performance materials for energy generation to handle the increase in production costs, decrease in natural resources, and adverse effects of raw materials and intermediate and final products on the environment. Nanotechnology allowed the development of new technologies to protect the environment, meet energy needs, achieve the desired efficiency, and address the lack of resources and waste problems. Renewable energy generation has focused on producing electrical energy from water, the most abundant matter in the world. The hydrovoltaic effect allows the development of low-cost and high-efficiency systems that can directly convert thermal energy into electrical energy through the interaction of water with nanomaterials such as carbon nanotubes, carbon nanoparticles, conductive polymers, and graphene. This study reviews the development of hydrovoltaic energy by discussing the nanomaterials used to create this energy, the performance of the devices, the effect of material properties on device efficiency, and recent developments. Nanostructured carbon materials increase water evaporation significantly, achieving continuous electricity generation. Studies on developing self-running systems using nanostructured materials are continuing. However, researchers should also concentrate on increasing the electrical output of the devices to increase hydrovoltaic energy usage.
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    Pectin Supercapacitor Applications
    (World Scientific Publ Co Pte Ltd, 2024) Usan, Huseyin; Kariper, S. Esra Bolsu; Kariper, I. Afsin; Koc, Dilek Imren
    In today's energy wars, the decrease in fossil fuels and the increase in pollution reuses the question of energy and clean merit production. For this reason, supercapacitor electrodes are available for supercapacitor applications, which are synthesized using biodegradable materials or hybrids by taking nature as an example. In synthesizing our example electrode pectin, we will examine the methods of obtaining pectin, which is abundant in nature and can be used effectively in terms of its physicochemical properties, by purification or synthesis methods. Supercapacitors are essential in storing energy with their fast charge/discharge properties. This includes using pectin and other materials in energy storage systems. We will present other materials preferred in supercapacitor applications and modified compilations of these applications. In conclusion; a porous material such as pectin has a large surface area. Materials with large surface areas are very suitable electrodes for charge storage in supercapacitor applications. If some problems in pectin production and electrical conductivity can be resolved, it will be a very suitable natural electrode material for supercapacitors.
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    Release of Doxorubicin's Active Ingredient from the Hydrogels Derived from Acrylamide and their Biological Functions
    (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2019) Misir, Sema; Hepokur, Ceylan; Kariper, I. Afsin
    Poly (HEMA/acrylamide/methyl methacrylate) (PHAM) and Poly (Acrylamide/methyl methacrylate)(PAM) polymers were synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/methyl methacrylate) (PHAM) and Poly (Acrylamide/methyl methacrylate) (PAM) composite hydrogels were prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, and methacrylamide, with the presence of N, N'-methylenebisacrylamide. The characterization of the polymer was performed by FTIR analysis. Swelling and drug absorption properties of the polymers were analyzed in distilled water. Polymers' toxic effects were investigated by XTT assay. It has been observed that the entire drug, which was added to the solution with 1 g of polymer, was absorbed for 3.5 h. The absorption of these polymers was found quite high. PHAM polymer showed >800% swelling and PAM polymer showed >600% at 600 min. PHAM polymer was less toxic than PAM polymer. These results, this new polymer is very suitable for the release of Doxorubicin drug.
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    Resveratrol-Loaded Silver Nanoparticles as an Effective Strategy for Targeted Breast Cancer Therapy
    (Wiley-V C H Verlag Gmbh, 2024) Topcu, Ege; Hepokur, Ceylan; Kariper, I. Afsin; Oksuz, Kerim Emre; Yaylim, Ilhan
    The AgNPs-Rsvl complex was investigated for its anti-cancer effects on human breast cancer cell lines. The UV-vis spectrophotometer was used to perform synthesized AgNPs-Rsvl binding analyses. The size and morphology of the AgNPs were determined by field emission gun-transmission electron microscopy (FEG-TEM). The surface chemical signatures of AgNPs nanocomposites were assessed using FT-IR spectroscopy, and the zeta potential (zeta potential) of various AgNPs colloids was measured using the Zetasizer Nano ZS analyzer. Cell proliferation was analyzed using the XTT method and cell apoptosis was analyzed using the AnnexinV-fluorescein isothiocyanate (FITC)/PI method. The effects of resveratrol were evaluated on human breast cancer cell lines (MDA-MB-231 and MCF-7). As a result of flow cytometry, a decrease in viability was observed in the MDA-MB-231 cells, and an increase in early apoptotic, late apoptotic, and necrotic values was observed. Resveratrol arrests the cell cycle in the G0/G1 phase but when used with AgNPs, the cell cycle arrests at the S phase. The combination of resveratrol and AgNPs exhibited a cytotoxic effect on cancer cells, with MDA-MB-231 breast cancer cells being the most sensitive to AgNPs-Rsvl. Resveratrol and AgNPs arrested the cell cycle and increased apoptosis, indicating their potential use in breast cancer treatment.
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    Selective cytotoxicity of paclitaxel bonded silver nanoparticle on different cancer cells
    (Elsevier, 2021) Danisman-Kalindemirtas, Ferdane; Kariper, I. Afsin; Hepokur, Ceylan; Erdem-Kuruca, Serap
    Paclitaxel (PTX) is one of the most effective drugs in the treatment of cancer. However, its usability is limited due to low solubility and side effects. In this study, we investigated anticancer effects of PTX bonded silver nanoparticles (AgNPs-PTX) on 4 different cancer cells, namely MDA-MB-231, MCF-7, 4T1, Saos-2, and on noncancerous HUVEC cells. The silver nanoparticles (AgNPs) that we synthesized were first characterized by UV-VIS, FTIR, SEM, and DLS analysis. The size of AgNPs was measured to be around 3 nm and AgNPs-PTX around 10 nm. AgNPs-PTX were found to be 2 to 10 times more effective than PTX alone. Especially, Saos-2 cells were found to be approximately 10 times more sensitive to AgNPs-PTX than PTX alone. AgNPs-PTX did not caused toxicity on non-cancerous HUVEC cell and significantly reduced the viability of all cancer cells we tested. Our findings suggest that AgNPs-PTX may be an anticancer agent candidate that is more effective than PTX alone and specific to Saos-2 cells.