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  • Küçük Resim Yok
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    Effects of three different irrigating solutions and KTP laser irradiation on apical leakage: An electrochemical study
    (INFORMA HEALTHCARE, 2012) Kustarci, Alper; Arslan, Dilara; Kaya, Betul
    Objective. The purpose of this study was to evaluate the effect of three different irrigating solutions (17% EDTA, 10% citric acid and 2.5% NaOCl) and KTP laser irradiation on apical leakage using an electrochemical method. Materials and methods. Sixty extracted single-rooted human teeth with mature apices were instrumented up to a size 35 K-file. After using each file and before proceeding to the next, canals were irrigated with 2 ml of 2.5% NaOCl. All teeth were then randomly divided into four groups. In group 1, the root canals were irrigated with a final flush of 17% EDTA. In group 2, the root canals were irrigated with a final flush of 10% citric acid. In group 3, the root canals were irradiated with KTP laser at 1W, 4.45 J/cm(2). In group 4, the root canals were irrigated with a final flush of 2.5% NaOCl. The root canals were then filled using the cold lateral condensation method. Apical leakage was evaluated using an electrochemical method over a period of 10 days. Data were analysed using Tukey HSD and Friedmann tests with p = 0.05 as the level for statistical significance. Results. The 17% EDTA and 10% citric acid groups had statistically less apical leakage than the 2.5% NaOCl group at days 7, 8, 9 and 10 (p < 0.05); however, no significant differences were found between the tested groups at the other time intervals (p > 0.05). No significant difference was found between the KTP laser group and other groups tested at all time intervals (p > 0.05). Conclusion. All groups were unable to eliminate apical leakage. However, final irrigation with 17% EDTA and 10% citric acid following root canal preparation reduced postobturation apical leakage compared with 2.5% NaOCl irrigation. When KTP laser and the other three irrigants were compared, no siginificant difference was found.
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    Synthesis, antibacterial, anti-urease, DFT and molecular docking studies of novel bis-1,3,4-thiadiazoles
    (Elsevier, 2025) Kaya, Betul; Cevik, Ulviye Acar; Behcet, Mustafa; Karayel, Arzu; Daoud, Nour El-Huda; Bostanci, Hayrani Eren; Kaplancikli, Zafer Asim
    A series of 2-substitutedamino-1,3,4-thiadiazoles (4a-4j) were synthesized starting from various isothiocyanate derivatives. The newly synthesized compounds were characterized by H-1 NMR, C-13 NMR, and elemental analysis. All compounds were tested for antibacterial activity against Proteus vulgaris (ATCC 7829) via the microbroth dilution technique. Among them, compound 4h emerged as the most potent antibacterial agent with MIC value of 4.1 mu M. All synthetic compounds were additionally evaluated for their urease inhibitory activity and exhibited good inhibitory potential against urease with IC50 values in the range of 1.732 +/- 0.186 - 3.786 +/- 0.300 mu M as compared to the standard thiourea (IC50 = 11.008 +/- 0.932 mu M). Compounds 4d, 4h and 4i showed significant inhibitory effects with IC50 values of 1.981 +/- 0.265, 1.732 +/- 0.186 and 1.937 +/- 0.173 mu M, respectively. In silico molecular docking study showed the critical interactions of compound 4h with the active site of the urease. According to DFT, compounds 4j and 4d (with low Delta E=4.536 eV and 4.629 eV values, respectively) are more chemically reactive than the other molecules, in which consistent with their inhibitory potentials against the urease enzyme. Molecular Dynamics simulations also were performed to assess the energetic features of the urease in complex with compound 4h. Furthermore, the predicted ADMET characteristics of the compound 4h was calculated using QikProp to gain insights into its pharmacokinetic properties. These newly identified inhibitors of the urease enzyme can serve as leads for further antibacterial drug research and development.
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    Synthesis, α-Glucosidase, α-Amylase, and Aldol Reductase Inhibitory Activity with Molecular Docking Study of Novel Imidazo[1,2-a]pyridine Derivatives
    (Amer Chemical Soc, 2024) Kaya, Betul; Cevik, Ulviye Acar; Ciftci, Bilge; Duran, Hatice Esra; Turkes, Cuneyt; Isik, Mesut; Bostanci, Hayrani Eren
    Inhibition ofaldose reductase (AR), alpha-glycosidase (alpha-GLY), and alpha-amylase (alpha-AMY) are some of the essential targets in diabetes mellitus (DM). Here, a series of imidazo[1,2-a]pyridine-based 1,3,4-thiadiazole derivatives (8a-k) were successfully synthesized and characterized using 1H NMR, 13C NMR, and HRMS spectroscopic techniques. The inhibition effects of the synthesized derivatives against AR, alpha-GLY, and alpha-AMY were evaluated using both in vitro and in silico methods. In vitro studies revealed that the derivatives (8a-k) showed significant inhibition activity. The results showed that the novel derivatives (8a-k) demonstrated potential inhibitory activity, with K I values covering the following ranges: 23.47 +/- 2.40 to 139.60 +/- 13.33 nM for AR and 6.09 +/- 0.37 to 119.80 +/- 12.31 mu M for alpha-GLY, with IC50 values 81.14 to 153.51 mu M for alpha-AMY. Furthermore, many of these compounds exhibited high inhibition activity, while some of them showed higher potency than the reference compounds. Molecular docking of the target compounds was carried out in the active sites of AR (PDB ID: 4JIR) and alpha-GLY (PDB ID: 5NN8).