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    In Vitro Antioxidant Evaluation of Some Mannich Bases which Contain Bis-1,2,4-Triazole Derivative
    (CHEM SOC PAKISTAN, 2015) Parlak, Akif Evren; Karatepe, Mustafa; Koparir, Metin; Dastan, Sevgi Durna; Alayunt, Naci Omer; Ulas, Mustafa; Keser, Serhat; Celik, Sait
    This study aims to examine the antioxidant effects of some Mannich bases containing bis-1, 2, 4 triazole, which are synthesized afresh. The antioxidant activities of the derivatives were measured using different methods in this study, including reducing power capacity, metal chelating activity, superoxide anion radicals scavenging activity, H2O2 scavenging activity and hydroxyl radical scavenging. As a result, derivatives had efficient antioxidant and free radical scavenging activity when compared to ascorbic acid, BHT and alpha-tocopherol as associated antioxidants.
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    Synthesis, Characterization and Biological Activities of Novel Chiral Bis 1,2-diolcarbothioamides
    (Niyazi BULUT, 2024) Karatepe, Arzu; Koparır, Pelin; Daştan, Taner; İnci, Şule; Keser, Serhat; Çetin, Ahmet
    2,2'- bis(N-aryl-alkylhydrazine-1-carbothioamide (T1–5) were obtained by the interaction of (2R,3R)-2,3-dihydroxybutanedihydrazide (1) with five different isothiocyanate alkyl(aryl) derivatives. The structures of the final compounds were confirmed by elemental analyses, FT-IR, ¹H-NMR and ¹³C-NMR. The antioxidant, antimicrobial and anticancer properties of the synthesized compounds were also investigated. Three of the triazole derivatives with p-tolyl, benzyl and phenyl substituents (T3–5) displayed good antioxidant and anticancer activity in comparison to the standards.