Yazar "Khan, Khushbukhat" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
    (Frontiers Media Sa, 2023) Sousa-Pimenta, Mario; Estevinho, Leticia M.; Szopa, Agnieszka; Basit, Mahnoor; Khan, Khushbukhat; Armaghan, Muhammad; Ibrayeva, Manshuk
    Over the years, many biological and synthetic agents have been explored and tested in attempts to halt the spread of cancer and/or cure it. Currently, several natural compounds have and are being considered in this regard. For example, paclitaxel is a potent anticancer drug that originates from the tree Taxus brevifolia. Paclitaxel has several derivatives, namely, docetaxel and cabazitaxel. These agents work by disrupting microtubule assembling dynamics and inducing cell cycle arrest at the G2/M phase of the cell cycle, ultimately triggering apoptosis. Such features have helped to establish paclitaxel as an authoritative therapeutic compound against neoplastic disorders. After the completion of compound (hemi) synthesis, this drug received approval for the treatment of solid tumors either alone or in combination with other agents. In this review, we explore the mechanisms of action of paclitaxel and its derivatives, the different formulations available, as well as the molecular pathways of cancer resistance, potential risks, and other therapeutic applications. In addition, the role of paclitaxel in hematological malignancies is explored, and potential limitations in the therapeutic use of paclitaxel at the clinical level are examined. Furthermore, paclitaxel is known to cause increased antigen presentation. The immunomodulatory potential of taxanes, alone or in combination with other pharmacologic agents, is explored. Despite terpene-alkaloids derivatives' anti-mitotic potential, the impact of this class of drugs on other oncogenic pathways, such as epithelial-to-mesenchymal transition and the epigenetic modulation of the transcription profile of cancer cells, is also analyzed, shedding light on potential future chemotherapeutic approaches to cancer.
  • Küçük Resim Yok
    Öğe
    Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances
    (Frontiers Media Sa, 2023) Hafeez, Amna; Khan, Zeeshan; Armaghan, Muhammad; Khan, Khushbukhat; Gurer, Eda Sonmez; Razis, Ahmad Faizal Abdull; Modu, Babagana
    Morusin is a natural product that has been isolated from the bark of Morus alba, a species of mulberry tree. It belongs to the flavonoid family of chemicals, which is abundantly present in the plant world and is recognized for its wide range of biological activities. Morusin has a number of biological characteristics, including anti-inflammatory, anti-microbial, neuro-protective, and antioxidant capabilities. Morusin has exhibited anti-tumor properties in many different forms of cancer, including breast, prostate, gastric, hepatocarcinoma, glioblastoma, and pancreatic cancer. Potential of morusin as an alternative treatment method for resistant malignancies needs to be explored in animal models in order to move toward clinical trials. In the recent years several novel findings regarding the therapeutic potential of morusin have been made. This aim of this review is to provide an overview of the present understanding of morusin's beneficial effects on human health as well as provide a comprehensive and up-to-date discussion of morusin's anti-cancer properties with a special focus on in vitro and in vivo studies. This review will aid future research on the creation of polyphenolic medicines in the prenylflavone family, for the management and treatment of cancers.
  • Küçük Resim Yok
    Öğe
    Notch signaling and MicroRNA: The dynamic duo steering between neurogenesis and glioblastomas
    (C M B Assoc, 2021) Javed, Zeeshan; Khan, Khushbukhat; Raza, Qamar; Sadia, Haleema; Shah, Faiez Ahmad; Ahmad, Touqeer; Bentivegna, Angela
    Notch signaling is an evolutionary conserved pathway that plays a central role in development and differentiation of eukaryotic cells. It has been well documented that Notch signaling is inevitable for neuronal cell growth and homeostasis. It regulates processes of differentiation from early embryonic stages to fully developed brain. To achieve this streamlined development of neuronal cells, a number of cellular processes are orchestrated by Notch signaling. Abrogated Notch signaling is related to several brain tumors, including glioblastomas. On the other hand, microRNAs are small molecules that play decisive roles in mediating and modulating Notch signaling. This review discusses the crucial role of Notch signaling in the development of the nervous system and how this versatile pathway interplays with microRNAs in glioblastoma. This review sheds light on the interplay between abrogated Notch signaling and miRNAs in the regulation of neuronal differentiation with special focus on miRNAs-mediated regulation of tumorigenesis in glioblastoma. Furthermore, it discusses different aspects of neurogenesis modulated by Notch signaling that could be exploited for the identification of new diagnostic tools and therapies for the treatment of glioblastoma.
  • Küçük Resim Yok
    Öğe
    Ursolic acid: a natural modulator of signaling networks in different cancers
    (Bmc, 2022) Zafar, Sameen; Khan, Khushbukhat; Hafeez, Amna; Irfan, Muhammad; Armaghan, Muhammad; Rahman, Anees Ur; Gurer, Eda Sonmez
    Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality. Scientists are now looking for the solutions that could help prevent the disease occurrence and could provide a pain-free treatment alternative for cancers. Therefore, efforts are now put to find a potent natural compound that could sever this purpose. Ursolic acid (UA), a triterpene acid, has potential to inhibit the tumor progression and induce sensitization to conventional treatment drugs has been documented. Though, UA is a hydrophobic compound therefore it is usually chemically modified to increase its bioavailability prior to administration. However, a thorough literature indicating its mechanism of action and limitations for its use at clinical level was not reviewed. Therefore, the current study was designed to highlight the potential mechanism of UA, its anti-cancer properties, and potential applications as therapeutic compound. This endeavour is a valuable contribution in understanding the hurdles preventing the translation of its potential at clinical level and provides foundations to design new studies that could help enhance its bioavailability and anti-cancer potential for various cancers.