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Öğe EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION(Cumhuriyet University Faculty of Dentistry, 2017) Özeç, Emin Ün1 İlker; Taşdemİr, Ufuk; Kirtay, Mustafa; Esen, Hacı Hasan; Avunduk, Mustafa CihatObjectives: The aim of this study was to evaluate effect of local rifamycin application on BMP-2 expression and bone healing. Materials and Methods: A standardized 5.0-mm-diameter critical size bone defect was created mandible angulus region. In the control group (8 rats) defects were left empty. In the Group 1 (n=8 rats) defect was irrigated with rifamycin solution and 25 mg rifamycin solution injected defect area at 1, 3, 7 days after surgery. In the group 2 (n=8 rats) defects were grafted with a gelatin sponge mixed 25 mg rifamycin solution. Rats were sacrificed at 21 days after surgery. Histological slides were prepared from defect site for both immunohistochemical analysis (bone morphogenetic protein-2 (BMP-2) antibody) and histomorphometric analysis. Data were analyzed using Mann Whitney U and Kruskall Wallis test. Results: The average new bone formation, number of osteoblast and new vessel formation count were increased more in both of experimental groups in comparison with control group. Anti-BMP-2 labelling (Cell count) was increased more in both of experimental groups in comparison with control group. Conclusion: Local rifamycin application has positive effects on BMP-2 expression and bone regeneration at critical sized bone defects. © 2017. Cumhuriyet Dental Journal. All Rights Reserved.Öğe An evaluation of factors associated with persistent primary teeth(OXFORD UNIV PRESS, 2012) Aktan, Ali Murat; Kara, Isa; Sener, Ismail; Bereket, Cihan; Celik, Salih; Kirtay, Mustafa; Ciftci, Mehmet Ertugrul; Arici, NurselThe aim of the present study was to investigate the reasons for the persistence of primary teeth and also use panoramic radiography to determine the characteristics of persistence teeth. Four-hundred and twenty-six panoramic radiographies, which diagnosed one or more retained primary teeth, were selected from 100,577 panoramic radiographic image files from nine clinics and six different cities in Turkey. The selected radiographies were evaluated to determine the reasons for the persistence of primary teeth; furthermore, this study analyzed the characteristics of the retained primary teeth including tooth type, number, location, and root resorption, and whether, or not, the primary teeth showed evidence of pathological conditions, such as periodontal problems, caries, ankylosis, infra-occlusions, or tipping of the adjacent permanent teeth. Six hundred and seventy-seven retained primary teeth were determined in 426 patients (148 males and 278 females). Retained primary teeth were found most frequently in the mandible rather than the maxilla and the left side was more frequently affected than the right side. Level 1 was found as a most frequently encountered root resorption level. Within the limitation of the present study, the most common type of persistent primary teeth seen on the dental arch were mandibular primary second molars, followed by maxillary primary canines. The most frequent reason for the persistence was the congenital absence of successors to the primary teeth, followed by impaction of the successor teeth.Öğe Prevalence of congenitally missing second premolars(Cumhuriyet University Faculty of Dentistry, 2010) Ezirganli, Seref; Hüseyin Koçger, H.; Ozer, Koray; Kirtay, Mustafa; Ün, EminPurpose: The purpose of this study was to evaluate the prevalence and distribution of congenitally missing second premolars according to gender and localization. Materials and Methods: This study was performed on panoramic radiographs and clinical records of 7753 patients (4573 females and 3180 males) who referred to Oral and Maxillofacial Surgery Department from January 2000 to December 2009. A total of 52 cases with congenitally missing second premolars were detected. The cases were evaluated according to gender, localization, unilateral or bilateral of occurrence, and anomaly. Results: 70 congenitally missing second premolars in 52 cases (13 males and 39 females) were found on 7753 radiographs. The prevalence of congenitally missing second premolars was found 3 times higher in females than in males, 4 times higher in mandible than in maxilla. A congenital anomaly was not determined. Conclusion: In this study, the prevalence of congenitally missing second premolars was found to be as 0.67%.Öğe The Prevalence of Impacted Premolars in the Anatolian Population(Aves, 2013) Ezirganli, Seref; Kirtay, Mustafa; Ozer, Koray; Un, Emin Celalettin; Kosger, Hasan Huseyin; Kazancioglu, Hakki OguzObjective: The aim of this study was to determine the prevalence of impacted premolars and the associated pathology of these teeth in the Anatolian population. Methods: This retrospective cohort study was composed of 10246 panoramic radiographs of patients (6074 females, 4172 males) between 2000 and 2011. We reviewed the panoramic radiographs and clinical data and determined the prevalence of impacted premolars to be associated with sex, age, and number of premolars. We investigated the associated pathology and approach of treatment. Results: A total of 83 patients (43 females, 40 males; mean age 23.42 +/- 11.18 years, range 12 to 69) had 101 impacted permanent premolars that were either mesioangular (n=47, 46.54%), vertical (n=32, 31.68% 9), distoangular (n=14, 13.86%), horizontal (n=6, 5.94%), and/ or buccolingual (n=2, 1.98%). Premolar transmigration was absent. Of these premolars, 7 (6.93%) were associated with cystic lesions. In this study, 61.39% of impacted premolars were extracted; 39 (38.61%) were followed up. Conclusion: The prevalence of impacted premolars in the Anatolian population was determined to be 0.98%. Although premolar impaction is infrequent, early diagnosis is important because most of the cases (93.07%) are asymptomatic.
