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Öğe A rare case of necrotizing pneumonia due to brucellosis with blood and urine culture positivity(Elsevier Science Inc, 2024) Kiymaz, Yasemin Cakir; Yesildag, Sumeyye; Hasbek, Mursit; Buyuktuna, Seyit Ali; Elaldi, NazifBrucellosis is a zoonotic infectious disease widely seen worldwide, especially in developing countries and endemic regions where livestock farming is common. Brucella primarily affects the reticuloendothelial system and joints but can also localize in the central nervous, cardiovascular, and genitourinary systems. Pulmonary and urinary involvements are very rarely reported in the literature. This article presents a 24-year-old male patient who was admitted with syncope. Initially admitted with a preliminary diagnosis of Crimean-Congo hemorrhagic fever, the first thoracic computed tomography findings of the patient were considered alveolar hemorrhage. However, due to the growth of Brucella spp. in blood and urine cultures, the patient was diagnosed with necrotizing pneumonia due to brucellosis.Öğe Miliary Pneumocystis jiroveci pneumonia in a patient living with HIV(Sage Publications Ltd, 2024) Kiymaz, Yasemin Cakir; Buyuktuna, Seyit AliPneumocystis jirovecii pneumonia (PJP) is one of the leading opportunistic infections seen in people living with HIV. Bilateral infiltrations characterize PJP and miliary involvement is very rare. In this article, we report a 32-year-old person living with HIV who was followed up with a diagnosis of miliary PJP. Our patient was admitted to the hospital with complaints of cough, sputum, and weight loss. Initially, miliary tuberculosis was considered due to the presence of miliary involvement on chest radiography, but the diagnosis was made with P. jirovecii PCR positivity. This article aims to report a case of miliary PJP, a rare clinical form of PJP.Öğe Predictive role of non-viral leukocyte parameters in tracking the development and progression of Crimean-Congo hemorrhagic fever(Academic Press Ltd- Elsevier Science Ltd, 2025) Kiymaz, Yasemin Cakir; Bolat, Serkan; Hasbek, Mursit; Buyuktuna, Seyit Ali; Ipekten, Funda; Zararsiz, Gokmen; Dogan, KubraThis study aims to investigate the extended leukocyte parameters, known as cell population data (CPD), in Crimean-Congo hemorrhagic fever (CCHF) and to evaluate their diagnostic performance in assessing mortality risk and intensive care unit (ICU) admission requirements. The study included a total of 260 participants, comprising 200 individuals diagnosed with CCHF and 60 healthy controls. CPD analyses were conducted using a Sysmex-XN 9000 complete blood count analyzer. Elevated levels of immature granulocyte (IG) percentage, neutrophil reactivity indices (Ne-X, Ne-Y), dispersion of neutrophil NE-SSC and NE-SFL signals (Ne-WX, Ne-WY), monocyte metabolic activity (Mo-X), and lymphocyte metabolic activity (Ly-X) were observed in CCHF patients compared to controls. Conversely, lymphocyte metabolic activity (Ly-Y) and monocyte fluorescence intensity (Mo-WY) were lower in patients than in controls. In discriminating mortality, IG#, IG%, Ne-WY, and Ly-Y exhibited higher AUC values than other CPDs. Additionally, for predicting ICU requirements, IG#, IG%, and Ne-WY demonstrated higher AUC values compared to other CPDs. IG, Ne-WY, and Ly-Y have the potential to serve as biomarkers for predicting mortality in CCHF. Furthermore, IG and Ne-WY may emerge as innovative and reliable biomarkers for identifying severe cases and predicting ICU admission requirements.Öğe Spontaneous bacterial peritonitis due to Brucella in an HBV-positive cirrhotic patient(Elsevier, 2025) Kiymaz, Yasemin Cakir; Yesildag, Sumeyye Kara; Baltaci, Sevgi; Baysal, Aysenur Comez; Baysal, Cihad; Keskin, Ertugrul; Bozkurt, SunaSpontaneous bacterial peritonitis (SBP) is a severe complication of cirrhosis, occurring in approximately 15 % of cirrhotic patients. The most common causative pathogens of SBP are Escherichia coli and Klebsiella pneumoniae. Although brucellosis can cause various complications, it is a rare cause of peritonitis. Herein, we report a case of a 30-year-old male with chronic hepatitis B who presented with fever, night sweats, weight loss, abdominal pain, and distension. Brucella spp. was isolated from blood and peritoneal fluid cultures. The patient fully recovered following six weeks of treatment with oral doxycycline (100 mg twice daily) and rifampicin (600 mg/day). No relapses or complications were observed during follow-up.Öğe The great tularemia outbreak in Sivas: Evaluation of 205 cases(Elsevier Science Inc, 2025) Kiymaz, Yasemin Cakir; Bolat, Serkan; Katirci, Bilge; Aldemir, Ozlem; Altinkaya, Isik; Ozcan, Merdan Mustafa; Hopoglu, Serhat MuratThis study aimed to report a tularemia outbreak in Sivas and describe the epidemiological and diagnostic characteristics of the patients. Patients aged 18 and over followed up with a diagnosis of tularemia in Sivas Cumhuriyet University Hospital, Sivas Numune State Hospital, and Sivas State Hospital Infectious Diseases Outpatient Clinics and wards between November 2023 and May 2024 were evaluated. 205 adult patients with tularemia were included. The most common symptoms were sore throat (73.2 %, n=150), swelling in the neck (70.2 %, n = 144), and fatigue (55.1 %, n = 113). The most common form was oropharyngeal (82.4 %, n = 169) and glandular (14.6 %, n = 30). Lymphadenopathy was detected in 182 (88.8 %) patients, the most is cervical lymphadenopathy (60 %, n = 123). Lymph node drainage/excision was performed on 50 patients (24.3 %). There have been no deaths in this outbreak. This study presents patient data from the tularemia outbreak in Sivas.
