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Öğe Association of visceral and subcutaneous adiposity with tumor and histologic grade in breast cancer(2024) Atik, Irfan; Gul, Enes; Başpinar, Nisa; Koç, TülayAims: Obesity is a risk factor for breast cancer. This study aims to evaluate the relationship between abdominal fat tissue and the risk of breast cancer and the histological degree of cancer with the help of computed tomography (CT). Methods: This study is a retrospective, cross-sectional study. It consists of patients diagnosed with breast cancer and a control group. Abdominal fat tissue measurements were taken from the navel or 4th lumbar vertebra level using an abdominal CT workstation. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), fat ratio (FR), and waist circumference measurements were made. The relationship between the obtained measurements and breast cancer, histological grade, and hormone status was analyzed. Results: Forty-one breast cancer patients and forty-two individuals without known diseases were examined. VAT and SAT were found to be higher in patients with breast cancer and it was statistically significant (p<0.05). Estrogen and/or progesterone receptor-negative patients tended to have a higher VAT rate. An increase in VAT and FR in breast cancer patients was found to have a more significant effect in patients with negative hormone receptors than in positive ones (estrogen receptor r: 0.585 p<0.05, progesterone receptor r: 0.579, p<0.05). Conclusion: The relationship between breast cancer and abdominal adipose tissue has been demonstrated. In addition, a correlation was found between high VAT and FR and histological grade in patients with hormone receptor-negative.Öğe Biocompatibility of Different Universal Adhesives During Short and Long Periods on Rat Model(Journal of Photopolymer Science and Technology,, 2021) Ünal, Murat; Göze Saygın, Ayşegül; Ünal, Murat; Koç, Tülay; Candan, Merve; İpek, İremThis in vivo research aimed to compare the biocompatibility of five different Universal adhesives (UAs) in short and long periods. 108 polyethylene tubes filled with five UAs [Group 1: All Bond Universal (ABU), Group 2: Prime Bond Elect Universal (PBU), Group 3: Single Bond Universal (SBU), Group 4: Clearfil Universal Bond Quick (CUB), Group 5: Futurabond U (FBU)] or Group 6: empty (control group)] were implanted into the dorsal connective tissue of 36 rats. Groups 1, 2 and 3 were implanted in 18 rats, the other groups Groups 4, 5 and 6 were implanted in 18 rats. Then, the rats were sacrificed after time intervals 7, 30 and 90 days (n=12). Biopsy samples were examined in terms of inflammatory reaction, necrosis, macrophage infiltrate, giant cell and fibrous capsule criteria. When the UAs groups and control group were compared on the 7th, 30th and 90th days, significant statistical differences were found only on the 7th day in terms of fibrous capsule and macrophage infiltrate (p<0.05). In addition, statistical significant differences were found upon within the control group in terms of inflammation, necrosis, giant cell, fibrous capsule and macrophage infiltrate criteria on the 7th, 30th and 90th days (p<0.05). The all UAs that we used in our study have showed good biocompatibility in the subcutaneous tissues of the rats, and we think that they could be used clinically with resin-based restorative materials in all restorative treatments including deep dentine caries restorations.Öğe Cancer Incidence During The Covid-19 Pandemic In A Middle Anatolian City In Turkey(Sivas Cumhuriyet University, 2022) Çelikgün, Serkan; Koç, Tülay; Uçku, ReyhanObjective: Cancer-related deaths in all countries of the world, including our country, are the second leading cause of deaths after cardiovascular diseases. Covid-19 is a pandemic disease affecting many organs but primarily the lung. The aim of this study is to compare the cancer incidences in the pre-Covid-19 period and during Covid-19 pandemic period in Sivas province by means of age, gender and cancer type distribution of the patients.Methods: The population of the study consists of the patients who applied to health institutions in Sivas between 01.11.2018 and 30.06.2021 and were diagnosed as cancer for the first time. The main variable of the study was cancer incidence. The time variable was the 16-monthtime period comprising before Covid-19 pandemic and during the pandemic period separately. In addition, patients diagnosed with cancer in both periods wasevaluated and compared according to age groups, gender and the type of cancer.Results: In this study, the pre-pandemic period and the pandemic period were compared. It was determined that 1355 patients were diagnosed as cancer during the pre-pandemic period and 1720 patients during the pandemic period. The incidence, which was 212.1 per hundred thousand in the previous period, increased to 270.5 per hundred thousand during the 16-month pandemic period.Conclusion: The incidence of cancer increased during the pandemic period compared to the pre-pandemic period.Öğe ISOLATED INVERTED PAPILLOMA AT INFERIOR TURBINATE(2020) Şan, Furkan; Nursaçan, Onur; Koç, TülayInverted papilloma (IP) is one of the benign sinonasaltumors and usually originates from lateral nasal wallmucosa. Despite being a benign tumor, IPs mightinvade neighboring structures such as paranasalsinuses, orbita, even skull base. IPs are known for highrecurrence rates after incomplete resection. Due to thisimportant feature of tumor, total resection of thetumor is a must for optimal treatment. Technologicaladvancements within recent years made transnasalendoscopic techniques new gold standard for patientswith limited disease. Fontanelle area of lateral nasalwall is the most common location for invertedpapilloma. There are hardly any report for any caseshaving isolated inverted papilloma of the inferiorturbinate without involvement of middle meatus incurrent literature. This paper reports a rarepresentation of isolated inverted papilloma at inferiorturbinate and aims to increase our knowledge aboutthis common sinonasal tumor.Öğe Kaposi Sarcoma: Single Center 10 Years Of Experience(Manisa Celal Bayar Üniversitesi, 2025) Kaya, Şeyhmus; Aydın, Sedanur; Yüceer, Ramazan Oğuz; Koç, Tülay; Eğilmez, ReyhanAim: Kaposi sarcoma is a rare angioproliferative disease associated with human herpesvirus-8. There are limited studies in our country regarding its epidemiology and clinical features. This study aims to explore cases diagnosed with Kaposi sarcoma at Sivas Cumhuriyet University Medical Faculty Research Hospital. Materials and Methods: The records of patients (n:18) diagnosed with Kaposi sarcoma between January 1, 2013, and June 30, 2023, in the Department of Medical Pathology were retrospectively reviewed. When recurrences were considered, the total number of cases increased to 27. The clinical, histopathological, and demographic characteristics of the patients were examined. Results:The mean age of the patients was 69.3±13.3 years (range:32–88). Thirteen patients (72.2%) were male, and five (27.7%) were female. None of the patients had a history of HIV. Of the lesions, 66.6% (n=12) were localized in the lower extremities, 22.2% (n=4) in the upper extremities, and 11.1% (n=2) in non-extremity regions. Histopathological examination revealed that 72.7% (n=13) of the patients were in the tumor (nodule) stage, 22.2% (n=4) in the patch stage, and 5.6% (n=1) in the plaque stage. All patients were treated surgically. Among the recurrence cases, a total of nine cases involved five patients. Additional diseases observed in the patients included heart disease, hypertension, and diabetes. Conclusion:To better evaluate the demographic data and clinical features of Kaposi sarcoma in our country, multicenter studies are needed, as well as increased awareness of this disease among relevant physicians.Öğe Meme kanserlerinde, tümör kök hücre belirteçlerinin (ALDH1, SOX2) prognoz ve diğer prognostik parametreler ile ilişkisi(Cumhuriyet Üniversitesi, 2014) Koç, Tülay; Elagöz, ŞahandeMeme kanseri kadınlarda görülen en sık malignite olmak ile beraber farklı tedavi seçenekleri ile sağkalım oranları son yıllarda artmaktadır. Klinik ve patolojik çalışmalar göstermiştir ki bu kanserlerin bazı tiplerinde tedaviye rağmen prognoz kötüdür. Bu durum, sınırsız kendi kendini yenileme ve farklılaşma yeteneğine sahip kök hücreler ile açıklanmaya çalışılmıştır. Kanser kök hücre (KKH) hipotezine göre; KKH tümörün başlangıç, ilerleme, tümör göçü, tedaviye direnç ve nüksünden sorumlu olup hücre çeşitliliğine ve tümör heterojenitesine yol açmaktadır. Bu çalışmada, meme kanserinde güvenilir bir kök hücre belirteci olan ALDH1 ve memede daha az çalışılmış olan, ancak diğer kanser tiplerinde güvenilirliği ortaya konmuş SOX2 immünohistokimyasal (İHK) olarak çalışıldı. Çalışma kapsamına prognostik özellikler yönünden heterojen olan ve onkolojik takipleri yapılmış 100 invaziv meme karsinomu alındı. Olgulara ait ALDH1, SOX2 ekspresyonları ve prognostik faktörler ile sağkalım (SK) ve hastalıksız sağkalım (HSK) oranları karşılaştırıldı. ALDH1epitelyal (ep) ve SOX2'nin SK ve HSK üzerine etkisi olmamak ile beraber, ALDH1stromal (str) ekspresyonu ile SK arasında anlamlı bir ilişki tespit edildi. ALDH1ep ile tümör grade'i, histolojik tipi, östrojen/progesteron (ER/PR) negatifliği; SOX2 ile tümör çapı arasında anlamlı bir ilişki bulundu. ALDHstr ekspresyonunun SK'ı öngören olumlu bir belirteç olabileceği, ALDH1ep ve SOX2 ekspresyonlarının SK ve HSK üzerine bir etkisi saptanamamasına rağmen, olumsuz prognostik faktörlerden birkaçı ile ilişkisinin bulunması nedeniyle bu belirteçlerin meme kanserinin prognozunu öngörmede kullanılabileceği düşünüldü.Öğe Salivary Gland Ductal Carcinoma of Accessory Parotid Gland(Sivas Cumhuriyet Üniversitesi, 2023) Bora, Adem; Göksu, Esra Nur; Koç, TülaySalivary gland ductal carcinoma (SDC) is a rare, aggressive tumor with a highly malignant course and originates most frequently from the parotid gland among the major salivary glands. The incidence of accessory parotid gland (APG) varies between 21-56% and the incidence of tumor in APG is 1-8% of all parotid tumors. SDC is rarely seen in accessory glands. It was aimed to present our case, which was diagnosed with SDC in APG, in the light of the literature.Öğe Tavşan Vajinal Yara Modelinde Propolis Uygulamasının Yara İyileştirici Etkisi(Tokat Gaziosmanpasa University, 2022) Kurt, Begüm; Yıldız, Çaglar; Özkaya, Neşe Kurt; Koç, Tülay; Çelikgün, SerkanAmaç: Bu çalışmanın amacı, tavşan vajinal yara modelinde propolis uygulamasının yara iyileştirici etkisini değerlendirmektir. Gereç ve Yöntemler: Hayvanlar kontrol grubu ve propolis uygulama grubu olarak rastgele iki gruba ayrıldı ve her grupta 5'er adet tavşan kullanıldı. Tüm tavşanlarda vajinal yaralanma introitustan orta vajinal epitel ve stromaya kadar tam kat arka duvar insizyonu ile gerçekleştirildi. Çalışma grubundaki hayvanlara lokal olarak %15 saf Anadolu Propolisi uygulandı ve uygulamaya üç günde bir devam edildi. Kontrol grubuna herhangi bir uygulama yapılmadı. 21 gün sonunda tavşanlar sakrifiye edildi. Diseksiyon ile vajina ve çevresindeki perineal doku çıkarıldı. 3 mikron kalınlığında vajinal kesitler alındı. Bu kesitlerin bir kısmı hematoksilin-eozin (HE) ve Mason's Tricrome (MT) boyaması için normal lamlara, bir kısmı da anti-vasküler endotelyal büyüme faktörü (VEGF-1) immünohistokimya boyaması için pozitif yüklü bir lam üzerine alındı. Bulgular: Her iki grup fibrozis ve MT boyaması açısından karşılaştırıldı. Her iki grup arasında istatistiksel olarak anlamlı fark bulundu (p=0,039, p=0.039). Her iki grup inflamasyon ve VEGF açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı fark bulunmadı (p=0,285, p=0,428). Sonuç: Birinci derece perineal yaraların iyileşme sürecinde yarada aktif kanama yoksa ve yara kenarları düzgün ve birbirine yakın ise propolis uygulaması olumlu katkı sağlayabilir.Öğe The Effect of Rectal Ozone Use on Bacterial Translocation and Oxidative Stress in Experimental Colitis Model(İstanbul Üniversitesi, 2022) Bostancı, Meriç Emre; Avcı, Onur; Taş, Ayça; Koç, Tülay; Gürsoy, Sinan; Siliğ, YavuzObjective: The aim of this study was to examine the effect of rectal ozone on the histopathological healing of the colonic mucosa, tissue oxidative stress, and bacterial translocation in the experimental colitis model. Materials and Methods: Three groups of rats were randomly formed
