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    Rethinking the Risk: Evalution of the Malignant Potential of Non-16 and 18 HPV Types VIA Colposcopic Results
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Genc, Serife Ozlem; Kurt, Begum; Koç, Tulay; Erdal, Huseyin
    Introduction: The malignancy risks of high-risk HPV types like 16 and 18 are well-known. The oncogenic potential of other HPV types, however, remains unclear. This study reevaluates malignancy risks across HPV types, stressing comprehensive colposcopic evalu ations in cervical cancer screening. Materials and Methods: Conducted at a tertiary care center (January 2021-July 2023), this retrospective study included 138 women divided into two groups: those infected with HPV 16/18 and those with other HPV types. We analyzed and compared colposcopic a nd histopathological outcomes, correlating colposcopic results with biopsy outcomes to assess cervical neoplasia. Statistical analysis was performed using GraphPad Prism 10 (GraphPad Software Inc.; San Diego, CA, USA). Descriptive statisti cs, including means and standard deviations for continuous variables and frequencies and percentages for categorical variables, were calculated. The chi-square test was used to compare categorical variables between the two groups, and an independent t-test was employed to compare continuous variables. A p-value of less than 0.05 was considered statistically significant. Results: Significant differences were noted between groups. While HPV 16 and 18 are linked to higher cervical neoplasia incidences, non-16/18 HPV types were also frequently associated with smear abnormalities. The average age of first sexual intercourse was 20.49 ± 4.2 years. Forty-nine percent of the women were smokers, 8% had only primary school education, and 78% were homemakers. High rates of known risk factors like low educational and socioeconomic status, and smoking were also significant. Conclusion: Our findings suggest that non-16/18 HPV types might have a higher malignancy potential than HPV 16-18, highlighting their importance in cervical cancer screenings and colposcopic evaluations. The study's small sample size limits its conclusions, pointing to the need for larger studies to refine cervical cancer screening strategies globally. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.