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Öğe Abdominal blockage of iliohypogastric and ilio-inguinal nerves for management of post-caesarean pain: A novel method(SA MEDICAL ASSOC HEALTH & MEDICAL PUBL GROUP, 2012) Boztosun, Abdullah; Duger, Cevdet; Kosar, Mehmet Ilkay; Salk, Ismail; Gursoy, Sinan; Muderris, Iptisam Ipek; Yanik, AliObjective. The aim of this study was to compare pain relief after caesarean section achieved by an intra-abdominal iliohypogastric and ilio-inguinal (IHII) nerve block with levobupivacaine with that in patients given a placebo. Study design. A total of 60 healthy women scheduled for caesarean delivery under general anaesthesia were enrolled in the study. The patients were randomised to an abdominal IHII nerve block with levobupivacaine (levobupivacaine group) or administration of saline (placebo group). Instead of the classic percutaneous method, the block was administered intra-operatively from the peritoneal aspect. Scores on a visual analogue scale (VAS) at 2, 6, 12 and 24 hours, adverse effects, morphine consumption and success of blockage by a pinprick test were recorded. Results. In the levobupivacaine group, the pinprick test showed there to be successful bilateral block in 22 patients and unilateral block in 5, while the block failed in 3. No block was recorded in the placebo group. When morphine consumption at 12 and 24 hours were compared, consumption was found to be significantly low for both time points in the levobupivacaine group. VAS scores 2, 6 and 12 hours after the operation were also significantly lower in the levobupivacaine group. Conclusion. A block of the IHII nerves from inside the abdomen just before abdominal closure appears to be an effective and safe way of relieving pain after caesarean section.Öğe Analysis of Ethmoid Roof and Skull Base With Coronal Section Paranasal Sinus Computed Tomography(LIPPINCOTT WILLIAMS & WILKINS, 2012) Guler, Cemil; Uysal, Ismail Onder; Polat, Kerem; Salk, Ismail; Muderris, Togay; Kosar, Mehmet IlkayChronic paranasal sinus disease is one of the most common causes of application to physicians in pediatric and adult patients. In the surgical treatment of these diseases, endoscopic sinus surgery is an application that is often done to increase the quality of the patient's life. On account of this, the anatomic variations in skull basement must be well known to avoid possible major complications that may occur during the operation. Recent developments in paranasal sinus surgery also enhanced the need for examining exhaustively the anatomy of this region and existing pathology. Superiority of computed tomography (CT) has an unquestionable importance for the evaluation of anatomic structure and pathology compared with conventional radiographs. A likely anatomic knowledge is needed for a safe surgery. Before the surgery, determining the anatomic variations makes the operation safer and increases the prospects, so we can prevent complications that may occur during the surgery. In this study, CT coronal sections of 300 patients who were admitted to the Department of Ear Nose Throat of Medical Faculty of Cumhuriyet University Research and Training Hospital between the dates December 2008 and January 2011 with complaints of nasal flow and postnasal drip were studied. According to coronal section CT examinations, the patients were divided into 2 groups. Group 1, with 156 cases (64%), showed mucosal changes, and in 144 cases (36%), no mucosal changeswere established (group 2). In comparison between the sexes, in groups 1 and 2 females, significant difference was determined for other parameters except the average height of the ethmoid roof. In the comparison between the sexes, in groups 1 and 2 males, significant difference was determined for all parameters. The difference between these 2 rates was statistically significant. Keros types 1 and 2 cases were compared with the control group, and there was no statistically significant difference. Notwithstanding, at the comparison of the Keros type 3 with the control group, there was a statistically significant difference for all the parameters (maximum orbital height, the length of the middle concha, and the nasal wall). It seems to be important for us to know the average length of the peripheral anatomic structures to avoid serious complications that may occur during the operation. Careful preoperative review of paranasal sinus CT scans in patients undergoing sinus surgery seems to be the most important to prevent severe intraoperative complications.Öğe Determination of Lateral Ventricle and Brain Volume in Children with Stereological Method Using MRI(SOC CHILENA ANATOMIA, 2013) Karacan, Keziban; Kosar, Mehmet Ilkay; Cimen, Mehmet; Solak, Orhan; Sahin, BunyaminAlthough brain development is most active during the intrauterina period of life, the processes of myelination and arborization affect the structure of the brain throughout childhood and adolescence. Brain development is also very active in the early years of a child's life, and continues to be so for approximately 15 years after gestation. Volumetric changes in the brain are effected by sex. Understanding the variability of human brain volume during development is important for the interpretation of childhood neuroimaging studies. Hence the aim of this study is to determine the effects of sex difference on brain volume (BV), lateral ventricle volume (LV) and the ratio of brain volume and lateral ventricle volumes as a percentage (RLBV%) of 90 healthy children between the ages of 6-17 according to their sex with MRI. These children were divided into three age groups of 6-9, 10-13 and 14-17 also BV, LV were calculated using the Cavalieri principle, which is classified as a stereological method and than RLBV% were calculated. Results: The BV of age group 6-9 was significantly smaller than the other two age groups (P < 0.05). General average BV of the age group 10-13 was higher than the other two age groups but this difference is insignificant. When the groups were compared according to sex, there was no important difference between girls and boys (P > 0.05). General average LV of the age group 6-9 was higher than the other two age groups but this difference insignificant. Moreover there was no sex difference. This study was presented that BV was continued to increase until the ages 10-13 for both of the genders. While LV was increased until the ages 10-13 for boys, it was had a negative relationship with changes of BV for girls.Öğe Diploe thickness and cranial dimensions in males and females in mid-Anatolian population: An MRI study(ELSEVIER IRELAND LTD, 2012) Sabanciogullari, Vedat; Kosar, Mehmet Ilkay; Salk, Ismail; Erdil, Fatma Hayat; Oztoprak, Ibrahim; Cimen, MehmetBackground: The objective of this study is the classification of the thickness of diploe and dimensions of cranium at different points of cranium in men and women according to age groups. Material and method: In the radiology archive, measurements were made at different points in magnetic resonance (MR) images of 305 (188 females and 117 males) patients, the average ages of whom were 40.98 +/- 20.44 (age range: 4-90) and who had no disorder of the bones. To determine diploe thickness, midfrontal, back and front bregma, lambda, opisthocranion and euryon points were used in the measurement. As for the determination of cranial volume, distances between glabella-opisthocranion, basion-vertex, basion-opisthion, euryon-euryon, nasion-basion, nasion-bregma, bregma-lambda and lambda-opisthocranion were measured. The data were loaded to Statistical Package for the Social Sciences (SPSS) 16.0 program. T-test, Mann-Whitney U, Pearson correlation coefficient and Kruskal-Wallis variance analysis were used in the statistical assessment. Results with a p value smaller than 0.05 were accepted as significant. Results: There was a statistically significant positive correlation between age and diploe thickness in all measurement points. The diploe thickness was also increased with age (p < 0.05). In all points, average diploe thickness was higher in age 61 and over than the other groups (p < 0.001). At the same time, diploe thickness in parietal bones was lower than frontal and occipital bones in both sexes. According to craniometric results cranium in males was bigger (p < 0.001). While the distance between glabella-opisthocranion increased in both sexes aged 61 and over, basion-vertex height decreased in women in the same group (p < 0.05). Interestingly, there was no meaningful statistical difference among age groups in terms of maximum cranial width (p > 0.05). Foramen magnum length decreased related to age in both men and women (p < 0.001). Conclusion: These results related to diploe thickness and cranium dimension may be leading in the determination of sex and age; surgical interventions to the cranium and bone graft choice may increase the reliability of the operation. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Öğe The Efficacy of Bevacizumab, Sorafenib, and Retinoic Acid on Rat Endometriosis Model(SAGE PUBLICATIONS INC, 2013) Ozer, Hatice; Boztosun, Abdullah; Acmaz, Gokhan; Atilgan, Remzi; Akkar, Ozlem Bozoklu; Kosar, Mehmet IlkayBlood vessels are necessary for development and maintenance of the endometriosis and blood flow supplies oxygen and essential nutrient to the disease. Local angiogenesis is regulated by vascular endothelial growth factor (VEGF) and inhibitors of VEGF may be a novel therapeutic approach. We inducted endometriosis in 43 rats and they were randomly allocated into 4 groups. The rats in group I (control n = 11) were given no medication. The rats in group II (n = 11) were given bevacizumab. The rats in group III (n = 11) were given Sorafenib, and the rats in group IV (n = 10) were given retinoic acid (RA). Then groups were compared for microvessel density, VEGF, soluble tyrosine-kinase receptor, ovarian reserve, and treatment effectivity. All these medications were effective on endometriosis and we detected that volume of endometriotic implants were significantly decreased. Ovarian reserve was not affected from the medication, in addition RA have induced reproductive capacity.Öğe Elongated Styloid Process Associated With Nevoid Basal Cell Carcinoma Syndrome(LIPPINCOTT WILLIAMS & WILKINS, 2011) Uysal, Ismail Onder; Atalar, Mehmet H.; Kosar, Mehmet Ilkay; Durmus, KasmThis article presents a case with nevoid basal cell carcinoma syndrome (NBCCS) and an elongated styloid process. Basal cell carcinoma syndrome, also known as Gorlin-Goltz syndrome, is an autosomal dominant inherited syndrome manifested by multiple defects involving the skin, nervous system, eyes, endocrine system, and bones. Elongated styloid process or calcified stylohyoid ligament cause craniofacial or cervical pain. The actual cause of elongation of the styloid process or the calcification of the stylohyoid ligament is unclear. The cause of elongation of styloid process in this case may be the calcification induced by NBCCS. This report is the first case presentation of NBCCS with elongated styloid process. Elongated styloid process might be described as an anomaly of an NBCCS.Öğe Evaluation of the Vertebral Artery by 3D Digital Subtraction Angiography(SOC CHILENA ANATOMIA, 2014) Tetiker, Hasan; Cimen, Mehmet; Kosar, Mehmet IlkayThe objective of the present study is to determine origin, entry level to the transverse foramen and diameter according to sex and side through 3D angiographic images of seventy-nine vertebral arteries obtained using DSA imaging method. During radiological evaluation, axial, coronal and sagittal images of the artery were used. Data of our study was uploaded to SPSS 14.0 program and significance test and Mann Whitney-U test of the difference between two means were used to evaluate the data. While 76 of the vertebral arteries (96.2%) were originating from the subclavian artery, 3 of them (3.8%) were directly originating from aortic arch. In 67 of 76 the vertebral arteries originating from the subclavian artery were entering through C6, 6 through C7, 2 through C5 and one through C4 transverse foramen. It was seen that one of 3 the vertebral artery originating from aortic arch was entering through C6, one through C7 and the other through C4 transverse foramen. While the mean diameter of the vertebral artery was 3.88 +/- 0.71 mm at the right side (3.99 mm in men, 3.66 mm in women), the mean diameter at the left side was 4.15 +/- 1.05 mm (4.23 mm in men, 4.06 mm in women).Öğe MORPHOMETRIC STUDY FOR THE ESTIMATION OF TOTAL HUMERAL LENGTH USING HUMERUS SEGMENTS IN THE ANATOLIAN POPULATION(Romanian Legal Med Soc, 2023) Tetiker, Hasan; Gencer, Ceren Uguz; Kosar, Mehmet Ilkay; Sabanciogullari, VedatThe aim of this study is to estimate the total humeral length (THL) using humerus segment measurementsA total of 124 unknown sexes and ossified humeri (56 right, 68 left) were included in the study. 14 segments, parallel to the long axis of the bone, were formed from 7 landmarks determined as H1-H7. Segment lengths were measured using an osteometric board. In addition, 7 (seven) segments, named C1-C3 in the proximal and W1-W4 in the distal of the bone, wereAll humerus segments and the total humeral length showed a positive correlation. In the regression analyses, C1 in the proximal, W3 and W4 in the distal, and H15, H16, and H27 in the length measures were found to have high explanatoriness for the total humeral length estimation. In multiple regression analyses, it was observed that explanatoriness in the total humeral length estimation increased, particularly when the measurements of the distal end and the diaphyseal length were used together.This study results showed that the total humeral length could be estimated from different segment sizes of the humerus. This information will be a guide for forensic medicine and archaeological research.Öğe Morphometry of corpus callosum related with gender and age: Magnetic resonance imaging study(2012) Kosar, Mehmet Ilkay; Erdil, Fatma Hayat; Sabanciogullari, Vedat; Karacan, Keziban; Cimen, Mehmet; Atalar, MehmetObjective: The corpus callosum (CC) is an important structure of connecting the two cerebral hemispheres. The purpose of this study was to examine the morphometry of the CC of normal cases and its relationship with gender and age. Methodology: Morphometric measurements of the corpus callosum were made on MR imaging in the mid-sagittal plane in 42 male and 48 female total 90 healthy subjects, age range was 6-17 year-old. Age of the cases were divided into three group as 6-9, 10-13 and 14-17 year-old. The length was measured by drawing a straight line at greatest antero-posterior diamater of CC, a perpendicular at its midline, anterior, posterior and medium segments of CC were measured. In addition as a result of these morphometric measurements index of corpus callosum (CCI) was calculated for every cases. Statistical analysis was performed by One-Way ANOVA- Tukey test, Independent Sample t test, Kruskal-Wallis test and Mann - Whitney U test. Results: Without considering sex between the age group, antero-posterior, anterior, posterior and medium segments diamaters of CC was found statistically significance (p<0.05) while analysis of CCI values was not found significant (p>0.05). Conclusions: These datas can be used as morphometric guide, for evaluation of the CC specially in years 6-17 age group.Öğe Morphometry of Corpus Callosum Related with Gender and Age: Magnetic Resonance Imaging Study(PROFESSIONAL MEDICAL PUBLICATIONS, 2012) Kosar, Mehmet Ilkay; Erdil, Fatma Hayat; Sabanciogullari, Vedat; Karacan, Keziban; Cimen, Mehmet; Atalar, MehmetObjective: The corpus callosum (CC) is an important structure of connecting the two cerebral hemispheres. The purpose of this study was to examine the morphometry of the CC of normal cases and its relationship with gender and age. Methodology: Morphometric measurements of the corpus callosum were made on MR imaging in the mid-sagittal plane in 42 male and 48 female total 90 healthy subjects, age range was 6-17 year-old. Age of the cases were divided into three group as 6-9, 10-13 and 14-17 year-old. The length was measured by drawing a straight line at greatest antero-posterior diamater of CC, a perpendicular at its midline, anterior, posterior and medium segments of CC were measured. In addition as a result of these morphometric measurements index of corpus callosum (CCI) was calculated for every cases. Statistical analysis was performed by One-Way ANOVA- Tukey test, Independent Sample t test, Kruskal-Wallis test and Mann - Whitney U test. Results: Without considering sex between the age group, antero-posterior, anterior, posterior and medium segments diamaters of CC was found statistically significance (p<0.05) while analysis of CCI values was not found significant (p>0.05). Conclusions: These datas can be used as morphometric guide, for evaluation of the CC specially in years 6-17 age group.
