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    Does Polyp-Originated Growing have Prognostic Significance for Stage 1 Endometrioid-Type Endometrial Cancer?
    (Springer India, 2020) Kucukyildiz, Irem Alyazici; Gunakan, Emre; Akilli, Huseyin; Haberal, Asuman Nihan; Kuscu, Esra; Haberal, Ali; Ayhan, Ali
    Purpose Endometrioid-type endometrial cancer is usually diagnosed in the early stages and has a good prognosis. Patients with stage 1 disease have survival rates over 95%. Tumor factors affect survival in these patients, but polyp-originated growing has not been sufficiently discussed in the literature. This study aimed to determine the effect of polyp-originated growing in stage 1 endometrioid-type endometrial cancer and to provide a review of the literature. Methods This study includes 318 stage 1 endometrioid-type endometrial cancer patients. The patients were divided into two groups based on the tumor origin. Group I included patients with polyp-originated growing tumors, and Group II included patients with endometrial surface-originated growing tumors. Results Groups I and II included 39 and 279 patients, respectively. The general properties of the patients were similar; there were no significant differences. The univariate survival analyses showed that overall survival for Groups I and II was 65.5 and 83.6 months, respectively; this difference was statistically significant (p = 0.002). The multivariate analysis of age, maximum tumor diameter, tumor origin, lymphovascular space involvement, myometrial invasion depth and tumor grade showed that polyp-originated growing was independently and significantly associated with overall survival (HR 4.05; 95% CI 1.2-13.5; p = 0.023). Conclusion Polyp-originated growing may be a prognostic factor for early stage endometrioid-type endometrial cancer. The prognostic effect of polyp-originated growing is not well known, and further investigation is necessary.
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    Incidence trends of germ cell-gonadal tumors among the pediatric population in Turkey and its importance through the eye of gynecologist
    (IMR Press Limited, 2021) Kucukyildiz, Irem Alyazici; Gultekin, Murat
    Objective: Childhood cancers constitute a major part of childhood diseases and are an important cause of mortality. Germ cell and gonadal tumors are among the top ten cancers in both boys and girls during childhood. Furthermore, the most common locations of germ cell tumors in the female population under the age of 20 are the ovaries. And germ cell tumors are the most common type of ovarian cancer, in these population. The purpose of this study was to explore the incidence trends of chilldhood germ cell and gonadal tumors in Turkey and to compare them with those worldwide. And also emphasizes the importance of the approach to the treatment of this cancer in girls. Methods: This study is based on data from the Turkish National Cancer Statistics Reports and the International Incidence of 10 Childhood Cancer (IICC) collaborative Project. Results: The age specific incidence rates (ASR) of germ cell tumors is 5 per million in Turkey and 4,9 per million across the world. The percentage of germ cell tumors among all childhood cancers in Turkey is 2%-4% in boys and 3,2%-5% in girls. Conclusion: Although germ cell and gonadal tumors are among the top ten cancers observed in childhood, their incidence is low. The survival rates of these cancers are very high if they are diagnosed early and accurately. Thus, knowledge about the trends of these cancers will increase the awareness and success in the diagnosis and treatment of germ cell and gonadal tumors. © 2021 The Authors. Published by IMR Press.
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    Relationship between contraceptive methods and human papillomavirus positivity
    (Springer Heidelberg, 2020) Kayikcioglu, Fulya; Kucukyildiz, Irem Alyazici; Gunes, Muzeyyen; Ozelci, Runa; Dilbaz, Berna; Dilbaz, Serdar
    Purpose Understanding the effect of contraceptive use on high-risk human papillomavirus (HPV) positivity may provide information that is valuable to women in contraceptive decision-making. This study includes women aged 30-65 years who admitted to Family Planing outpatient clinic and have hrHPVDNA positivity. Methods We included a total of 801 women. All participants underwent national cervical cancer screening using HPV screening test conducted by the Cancer Control Department of the Ministry of Health. They completed a questionnaire on demographic information and potential risk factors. Results The HPV DNA positivity rate among all participants was 8.4%. The two most common HPV genotypes were HPV16 and HPV51. Meanwhile, hrHPV infection was associated with age, marital status, smoking status, and contraceptive method. Conclusion HPV is the most common cause of sexually transmitted diseases. Understanding about the reproductive and demographic characteristics affecting HPV persistence is crucial. The effect of contraceptive methods on HPV positivity is important information that is necessary to be relayed to women by healthcare professionals.