Yazar "Kumar, Manoj" seçeneğine göre listele

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    Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig
    (2021) Durna Daştan, Sevgi; Dey, dipta; Quispe, christina; hossain, rajib; jain, divya; Khan, rasel Ahmed; Janmeda, Pracheta; Islam, Muhammed toregul; Suleria, hafız ansar Rasul; Morterell, Miguell; Kumar, Manoj; tahari, yasaman; Petkovska, anka trajkovska; Rad, Javad sharifi
    .e mangrove plants are the potential sources of foods and remedies for people living in the forests and nearby communities. Xylocarpus granatum J. Koenig is traditionally used to treat various diseases including diarrhea, cholera, dysentery, fever, malaria, and viral infections, among others. To summarize critically the taxonomy, ethnomedicinal, phytochemistry, and pharmacological activities of X. granatum, information was collected from different databases. An up-to-date search (till June 2020) was carried out with the help of various scientific web resources from databases such as PubMed, Science Direct, Google Scholar, and various patent offices (e.g., WIPO, CIPO, and USPTO) using the keywords “Xylocarpus granatum” and then paired with ethnomedicinal use and phytochemical, phytochemistry, and pharmacological activity (in vitro, ex vivo, and in vivo studies). Findings revealed that seeds, fruits, stem bark, leaf, and twigs of X. granatum exhibited a wide range of key phytochemicals including limonoids, phragmalin, limonoid-based alkaloids, mexicanolides, protolimonoids, flavonols, and lactones. .e plant possessed potent antioxidant, anticancer, antidiabetic, antimicrobial, antimalarial, antifeedant, and neuroprotective activities. No clinical studies have been reported in the databases. Ethnomedicinal assessment indicated the application of X. granatum in various fields of medical science specially to treat various human ailments, and this was attributed to the presence of enormous alkaloids as confirmed by pharmacological studies. However, to understand the mechanism of action in-depth studies are required. In view of these findings, more research is necessary to explore and characterize the chemical compounds and toxicological aspects of this medicinal mangrove plant. Overall, it can be stated that X. granatum may be one of the hopeful medicinal herbs for the treatment of various diseases in human beings.
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    Green Synthesis of Iron Nanoparticles from Spinach Leaf and Banana Peel Aqueous Extracts and Evaluation of Antibacterial Potential
    (Hindawi Ltd, 2021) Tyagi, Pankaj Kumar; Gupta, Samridhi; Tyagi, Shruti; Kumar, Manoj; Pandiselvam, R.; Dastan, Sevgi Durna; Sharifi-Rad, Javad
    Spinacia oleracea (spinach) and Musa acuminata (banana) were chosen for the study, and aqueous extracts of spinach leaf extract (SLE) and banana peel extract (BPE) were prepared for the synthesis of iron nanoparticles (FeNPs), and their antibacterial potential against pathogenic bacteria Bacillus subtilis (MTTC 1133) and Escherichia coli (MTTC 62) was evaluated. In 10 minutes at 60 & DEG;C, the color of the mixture (FeCl3+SLE) changed from light green to dark blackish-brown, and the color of the mix (FeCl3+BPE) changed from transparent yellow to dark black, confirming the synthesis of FeNPs from SLE and BPE, respectively. The UV-Vis spectra of spinach- and banana-derived FeNPs revealed two peaks ranging from 240 to 430 nm and multiple peaks at 240, 270, and 395 nm, respectively. FTIR spectroscopy was used to show different functional groups on BPE and SLE, and their role in FeNP synthesis was predicted. TEM micrographs showed that the particles were in nanoscale, ranging in size from 20 to 50 nm for BPE-derived FeNPs and 10 to 70 nm for SLE-derived FeNPs. The FeNP (BPE and SLE) XRD analysis revealed amorphism, with a weak iron characteristic peak, indicating noncrystallinity. The antibacterial potential of BPE- and SLE-FeNPs was investigated, and inhibition zones (mm) against B. subtilis (22.70 & PLUSMN;0.4) and E. coli (20.45 & PLUSMN;1.66) were observed, as well as SLE-FeNPs against B. subtilis (23.56 & PLUSMN;1.00) and E. coli (20.33 & PLUSMN;0.58). There were no significant differences in antibacterial activities between BPE-FeNPs and SLE-FeNPs. Positive controls were tetracycline and gentamicin, both standard antibiotics, at 5 mu g/disk. SLE- and BPE-derived green FeNPs were also analysed in vivo of D. melanogaster life history traits, i.e., fecundity, hatchability, viability, and duration of development for toxicity evaluation. SLE- and BPE-derived green FeNPs at a concentration of 10 mg/L were fed flies compared to normal diet-fed flies (control sample), and no significant differences were observed between them. The findings suggest that FeNPs have a high antibacterial potential and could be used as antibacterial agents against pathogenic bacteria while being nontoxic in nature.
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    An Insight into Phytochemical, Pharmacological, and Nutritional Properties of Arbutus unedo L. from Morocco
    (2021) Durna Daştan, Sevgi; ElHaouari, Mohammed; Assem, Najat; Changan, sushil; Kumar, Manoj; Rajkoviç, Jovana; tahari, yasaman; Rad, Javad sharifi
    Arbutus unedo L. (Ericaceae) is an evergreen shrub widely distributed in the Mediterranean region, particularly through the Moroccan forests. It is an important medicinal plant of great scientific interest due to its nutritional, pharmacological, and chemical properties. -e objective of this review is to provide insights into traditional medicinal uses and phytochemical and pharmacological properties of A. unedo from Morocco. In Morocco, the plant has been used as a traditional medicine to treat several pathological conditions. Many phytochemical compounds have been reported in the plant, of which vitamins, carotenoids, flavonoids, polyphenols, tannins, and their derivatives are the most prevalent. Leaves and fruits of A. unedo contain the most significant number of phytochemicals among the species. Furthermore, researchers have demonstrated that A. unedo exhibited antioxidant, anticancer, antibacterial, antidiabetic, antiaggregant, and antihypertensive activities due to the presence of many biochemical compounds with health-promoting properties. According to different toxicity tests, the use of A. unedo is devoid of any significant side effects and/or toxicity. Despite its nutraceutical and health-promoting properties, Moroccan A. unedo remains underexploited mainly, and most of its traditional uses have not yet undergone scientific evidence-based research; therefore, improved knowledge about the potential value of the plant would allow understanding of its biological activity based on its phytochemical compounds that may contribute to the species preservation and valorization.
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    Natural products of relevance in the management of attention deficit hyperactivity disorder
    (Wiley, 2023) Custodio, Luisa; Vizetto-Duarte, Catarina; Cebeci, Fatma; Ozcelik, Beraat; Sharopov, Farukh; Gurer, Eda Sonmez; Kumar, Manoj
    Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.
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    Paving Luteolin Therapeutic Potentialities and Agro-Food- Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits
    (2021) Durna Daştan, Sevgi; tahari, yasaman; Rad, Javad sharifi; antika, gizem; yılmaz, yakup berkay; boyunegmez tumer, tugba; abuhamdah, sawsan; chandra, subhnas; Saklani, sarla; Kılıç, ceyda sibel; sestito, simona; Kumar, Manoj; Al-shehri, Mohammed; rapposelli, simona; Cruz-martins, natalia; Cho, William c
    Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, antiviral, and anti-inflammatory effects, and as a consequence, various clinical trials have been designed to investigate the therapeutic potential of luteolin in humans. However, luteolin has a very limited bioavailability, which consequently affects its biological properties and efficacy. Several drug delivery strategies have been developed to raise its bioavailability, with nanoformulations and lipid carriers, such as liposomes, being the most intensively explored. Pharmacological potential of luteolin in various disorders has also been underlined, but to some of them, the exact mechanism is still poorly understood. Given the great potential of this natural antioxidant in health, this review is aimed at providing an extensive overview on the in vivo pharmacological action of luteolin and at stressing the main features related to its bioavailability, absorption, and metabolism, while essential steps determine its absolute health benefits and safety profiles. In addition, despite the scarcity of studies on luteolin bioavailability, the different drug delivery formulations developed to increase its bioavailability are also listed here.
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    POSSIBLE MUTATION PATHWAYS IN SARS-CoV-2
    (Soc Stiinte Farmaceutice Romania, 2021) Islam, Muhammad Torequl; Quispe, Cristina; Herrera-Bravo, Jesus; Khan, Ishaq N.; Bawazeer, Saud Salem; Kumar, Manoj; Cruz-Martins, Natalia
    Mutations are the best way to generate genetic variation, as they provide the raw material in which evolutionary forces, like natural selection, can act. However, mutations are not always able to change the apparent behaviour of an organism, instead, they are capable of providing normal and abnormal biological functions. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a new and controversial biological scenario. Despite the hundreds of studies performed, to date, there is no specific treatment available. Several genomic and non-genomic mutations have been also reported, and due to its high genome size and mutation capacity, it can acclimatize to variable environments and has become the leading cause of high infection and mortality rates. This review outlines the possible pathways behind SARS-CoV-2 mutations.
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    Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
    (2021) Durna Daştan, Sevgi; Al-shehri, Mohammed; Rad, Javad sharifi; Herrera-Bravo, jesus; Jara, evelyn L.; Salazar, luis A.; Kregiel, dorota; Uprety, yadav; Akram, Muhammad; Iqbal, Mehwish; Morterell, Miguell; Torrens-Mas, Margalida; Pons, daniel gabriel; Cruz-martins, natalia; Ozdemir, fethi Ahmet; Kumar, Manoj; Cho, William c
    analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with Hindawi Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 6331630, 15 pages https://doi.org/10.1155/2021/6331630 estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.