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Öğe Effect of fixed appliances on oral malodor(MOSBY-ELSEVIER, 2011) Babacan, Hasan; Sokucu, Oral; Marakoglu, Ismail; Ozdemir, Hakan; Nalcaci, RuhiIntroduction: The objective of this study was to evaluate the effect of fixed appliances on oral malodor. Methods: Forty-one patients participated in this study. They were randomized into 2 groups: treated with fixed orthodontic appliances and untreated controls. Oral malodor measurements and the gingival and plaque indexes were recorded in each group by same periodontist. Measurements were taken from the study group before bonding, 1 week after bonding, and 4 weeks after bonding. The control group's measurements were made at the same time. Results: Oral malodor and the gingival and plaque indexes were significantly increased 1 week after bonding (P < 0.05). Oral malodor was increased at 4 weeks after bonding (P > 0.05). The comparison of the groups showed differences 1 week and 4 weeks after bonding. Conclusions: The oral malodor reached the critical level during fixed orthodontic treatment. Oral malodor could indicate a need to evaluate oral health and remind patients of the importance of maintaining ideal oral hygiene. (Am J Orthod Dentofacial Orthop 2011;139:351-5)Öğe Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters(SPRINGER HEIDELBERG, 2006) Toker, Hulya; Marakoglu, Ismail; Poyraz, OmerThe aim of the present study was to determine the effects of meloxicam after initial periodontal treatment on interleukin-1beta (IL-1 beta) and IL-1 receptor antagonist (IL-1ra) in gingival crevicular fluid (GCF) and clinical parameters in the chronic periodontitis patients. Data were obtained from 30 patients with chronic periodontitis. Fifteen chronic periodontitis patients received 7.5 mg meloxicam, and 15 patients received placebo tablets in a 1x1 regimen for 1 month. All subjects were nonsmokers and had not received any periodontal therapy. The plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL) were recorded. The GCF was collected using a paper strip: eluted and enzyme-linked immunoabsorbent assays (ELISAs) were performed to determine the cytokine levels. The clinical data and GCF samples were obtained after periodontal therapy and 1 month after periodontal therapy. The PI, GI, PD, and GCF IL-1ra decreased significantly (p < 0.05) in meloxicam group at first month when comparing the initial levels. While decrease of the PI was statistically significant in control group (p < 0.05), statistically significant changes were not determined in the other clinical parameters and GCF cytokine levels (p > 0.05). There were no significant differences between two groups in any of the investigated parameters. Our observations did not reveal any influence of meloxicam on levels of IL-1 beta and IL-1ra in chronic periodontitis. Additional clinical studies are advisable to determine whether COX-2 selective drugs alter periodontal disease outcome with greater safety.Öğe Effects of Debonding on Oral Malodor(Aves Press Ltd, 2009) Sokucu, Oral; Ozdemir, Hakan; Nalcaci, Ruhi; Marakoglu, Ismail; Babacan, HasanThe objective of this study was to evaluate the affect of debonding on oral malodor. This study consists of three groups. The first group (debonding group) included 20 subjects with brackets and would be debonded in a month. The second group ( bracket group) included 20 subjects who still undergone orthodontic treatment with brackets. The last group is a control group who did not receive orthodontic treatment. Oral malodor measurements, Gingival and Plaque Index scores were recorded in each group by same periodontist. Measurements were taken in first study groups before debonding (T1), 1 week after debonding ( T2) and 4 weeks after bonding (T3). At the same time the measurements were applied to the second and control group. Data's were evaluated with three way ANOVA test. Bonferroni test were assessed when significant differences between the measurements were exist. Mann-Whitney U- test was used to compare both groups. Oral malodor, significantly decreased after debonding ( P< 0.05). One month after debonding the parameters were stable on debonding group and bracket group. ( P> 0.05). Control group did not show differences in all measurements. The comparison between groups showed significant differences between groups (P< 0.05). Bonding brackets cause to increase on oral malodor. However, after debonding immediately oral malodor reached to the acceptable scores. Oral malodor could be another indicator to evaluate the oral health as Gingival and Plaque index scores.Öğe Klippel-Trenaunay Syndrome Manifesting as Gingival Overgrowth and Teeth Agenesis(JOURNAL PEDODONTICS INC, 2010) Ozdemir, Hakan; Marakoglu, Ismail; Akyol, Melih; Goze, O. Fahrettin; Gursoy, Ulvi KahramanObjective: Klippel-Trenaunay syndrome (KTS) is characterized by triad of venous varicosity, naevus flammeus, and soft/hard tissue hypertrophy. Manifestations of the syndrome in the head and neck region are rare, but in some cases hemangioma of the lips, tongue, and gums, open bite and cross bite, and early tooth eruption are associated with the disease. Study design: We report a 12-year-old KTS patient with gingival hyperplasia, congenital missing teeth, and increased mucosal vascularization as oral manifestations. Results and conclusion: All manifestations of the KTS were observed on the same side of the head, except bilateral missing teeth. Histological examination showed several vascular enlargements in enlarged gingiva. It is suggested that oral manifestations of the syndrome are generally related to the severity of the disease, but they do not always present in the same pattern.Öğe Periodontal status and cytoplasmic enzyme activities in gingival crevicular fluid of type 2 diabetic and/or obese patients with chronic periodontitis.(2006) Gursoy, Ulvi Kahraman; Marakoglu, Ismail; Ersan, SerpilType 2 diabetes mellitus and obesity are the most common nutritional disorders in developed and developing countries. Increased prevalence of periodontal disease is a well-known complication of type 2 diabetes mellitus (DM). As obesity is generally the first step toward type 2 diabetes mellitus, it is possible to find exacerbated periodontal disease in obese patients, also. The purpose of this cross-sectional study was to investigate the periodontal status and aspartate aminotransferase and lactate dehydrogenase enzyme activities in gingival crevicular fluid (GCF) of type 2 diabetic and/or obese chronic periodontitis patients. A total of 39 chronic periodontitis patients participated in the study. The study population was divided into four groups according to body mass index and type 2 DM status: 1) type 2 DM obese patients, n = 8; 2) type 2 DM patients, n = 12; 3) obese patients, n = 8; 4) systemically healthy control group, n = 11. Enzyme activities in gingival crevicular fluid and periodontal status were evaluated. No significant differences in age, gingival index, plaque index, aspartate aminotransferase and lactate dehydrogenase enzyme activities were observed, but probing depths were significantly higher in the DM groups than in the control group. Obesity did not seem to be a significant factor in any parameters evaluated. The present study showed increased probing depth values for the diabetic groups but failed to show any significant relation between obesity and enzyme activity or periodontal status. However, the slightly increased probing depth values in the obese groups might be a clue to an impaired immune response and predisposition to periodontitis in that patient group.Öğe Periodontitis as a risk factor for preterm low birth weight(YONSEI UNIV COLLEGE MEDICINE, 2008) Marakoglu, Ismail; Gursoy, Ulvi Kahraman; Marakoglu, Kamile; Cakmak, Hulya; Ataoglu, TamerPurpose: There is growing evidence showing that a number of complex human diseases are caused or are at least influenced by periodontal diseases. Such diseases include cardiovascular diseases, respiratory diseases, diabetes mellitus and osteoporosis. The aim of study was to evaluate periodontal diseases as a risk factor for a preterm low birth weight. Materials and Methods: A total of 48 mothers, 20 of who had a preterm low birth weight delivery, were examined in the Clinics of Periodontology, Faculty of Dentistry, Cumhuriyet University. The periodontal exams consisted of a full mouth pocket depth, a Loe and Sillness Gingival index score measurements, and a panoramic radiograph analysis. Information on any other factors that may cause a preterm low birth weight was obtained from the family physician. Results: The study results indicated that periodontitis (OR: 3.6 95% CI: 1.06 - 12.18) together with bacterial vaginosis (OR: 11.57 95% CI: 1.26 - 105.7) were independent risk factors of a preterm low birth weight. According to the data obtained from this study, the paternal age, tobacco use and the mothers' height were not significant risk factors for a preterm low birth weight. Conclusion: Within the limits of this study, it is concluded that a poor periodontal health status of the mother may be a potential risk factor for a preterm low birth weight.Öğe The recurrent aphthous stomatitis frequency in the smoking cessation people(SPRINGER HEIDELBERG, 2007) Marakoglu, Kamile; Sezer, Recep Erol; Toker, Hulya Cakmak; Marakoglu, IsmailThis study was aimed to evaluate the frequency of recurrent aphthous stomatitis ( RAS) within the 6-week period after quitting smoking. The study group consisted of 90 subjects. Oral, medical findings and tobacco habits were recorded for all subjects. Nicotine replacement therapy (NRT) and behavioral treatment were applied to some of the subjects by a family physician. All subjects were evaluated for their RAS and periodontal measurements on baseline, 1, 3, 6 weeks by a periodontist. While the subjects were in this smoking cessation programme, 64 of the 90 smokers successfully quit smoking within the 6 weeks and 26 smokers dropped out during the third week of the study. Point prevalence of RAS among the subjects on the first day of the quitting period and at the end of the first, third and sixth week after smoking cessation was 3.3% (3/ 90), 18.9% (17/ 90), 21.1% (19/ 90) and 17.1 (11/64), respectively. In the following weeks, aphthous ulcer point prevalence was significantly higher than the quitting level ( p < 0.05). As the time after quitting increased, the incidence of aphthous ulcer decreased. Of 64 patients, 35 (54.6%) completed the 6 weeks using NRT and 29 (45.4%) of them did not use any medication. The aphthous ulcer frequency observed in the patients taking NRT [11.4% (4/35)] was lower when compared with the subjects taking no NRT [24.1% (7/29)] ( p > 0.05). The results of this study confirm that RAS is a complication of quitting smoking. Further studies are needed to identify the effects of NRT on RAS.Öğe Relationship between neutrophil functions and severity of periodontitis in obese and/or type 2 diabetic chronic periodontitis patients(QUINTESSENCE PUBLISHING CO INC, 2008) Gursoy, Ulvi Kahraman; Marakoglu, Ismail; Oztop, A. YaseminObjectives: Obesity and diabetes are the most common nutritional and endocrine disorders in developed and developing countries and are related to immune response alterations. Recent studies suggest an association among diabetes, obesity, and periodontitis. The aim of this study was to evaluate the relationship between neutrophil function alterations and periodontal disease severity of type 2 diabetic chronic periodontitis patients with and without obesity. Method and Materials: A total of 39 chronic periodontitis patients participated in the study. The study population was divided into 4 groups according to body mass index and type 2 diabetes status: (1) 8 type 2 diabetic obese patients, (2) 12 type 2 diabetic patients, (3) 8 obese patients, and (4) 11 systemically healthy patients as a control group. Neutrophil chemotaxis and phagocytosis functions and periodontal status were evaluated. Results: No differences in age, Gingival Index, Plaque Index, percentage of phagocytosis, phagocytic efficiency, and intracellular killing were observed among the groups, but chemotaxis was significantly lower in diabetic groups than the control group and probing depth was significantly higher in diabetic groups than the control group. Obesity did not seem to affect the results significantly for all parameters evaluated. Conclusions: Unlike in patients with type 2 diabetes, neither neutrophil functions nor periodontitis severity seemed to change in obese patients. However, in type 2 diabetic patients, neutrophil chemotaxis alterations seem to affect probing depth measurements.Öğe Smoking status and smoke-related gingival melanin pigmentation in army recruitments(OXFORD UNIV PRESS, 2007) Marakoglu, Kamile; Guersoy, U. Kahraman; Toker, Huelya Cakmak; Demirer, Serhat; Sezer, R. Erol; Marakoglu, IsmailThis study aimed to define the smoking status and smoke-related gingival melanin pigmentation in army recruitments and was conducted with army recruitments in Sivas. Nine hundred eight subjects were examined. The oral and dental health of those subjects was checked and recorded. The smoking status of the subjects was self-reported and recorded on questionnaires by researchers. The chi(2) test and Kruskal-Wallis test were used for statistical analysis. More than one-half of the subjects (54.3%) were primary school graduates and the mean age was 20.2 +/- 0.95 years. The response rate regarding smoking was 100%. Of the respondents, 596 (65.7%) were current smokers, 12 (1.3%) were former smokers, and 300 (33.0%) were never smokers. The gingival melanin pigmentation rate was 27.5% in current smokers and 8.6% in those who never smoked (p=0.000). Smoking five to nine cigarettes a day appeared to be sufficient to cause gingival melanin pigmentation. The proportion of smokers who had melanin pigmentation did not change after 10 cigarettes a day. A rehabilitation project on smoking prevention and smoking cessation for army recruitments is urgently needed.
