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Öğe A case with manic delirium(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Mert, Derya Guliz; Kavakci, Onder; Semiz, Murat; Kugu, Nesim; Yonel, EceManic delirium is defined as co-occurrence of mania and delirium. Publications are referred to case reports. In this study, we describe a 63 years old woman with signs and symptoms of delirium and suffering from bipolar disorder. Mania symptoms were not observed during her first evaluation and monitoring. There was no toxic or medical condition that explained the delirium seen. Manic delirium seems to be an acute and severe form of bipolar disorder, which can be treated with (responsive to) antipsychotics and mood stabilizers. Manic delirium should be kept in mind as a diagnosis for the patients who present with delirium and has no organic cause to explain it.Öğe Childhood trauma and general cognitive ability: Roles of minimization/denial and gender(ELSEVIER IRELAND LTD, 2016) Mert, Derya Guliz; Kelleci, Meral; Yildiz, Esengul; Mizrak, Ali; Kugu, NesimThe aim of this study was to investigate the effects of minimization and gender on the interaction between childhood trauma and general cognitive ability. The study included 345 students. The data were obtained via an information form, the Childhood Trauma Questionnaire (CTQ), and Raven's standard progressive matrices (RSPM). The mean CTQ total score and the mean sexual abuse, physical, and emotional neglect subscale scores of the male students were significantly higher than those of the female students (p < 0.05). The mean minimization score of the female students was greater than that of the male students (p < 0.05). However, among the female students with minimization scores of 3, there was a moderate and significant negative correlation between the CTQ and RSPM scores (r=0.533, p < 0.05). This study found that general cognitive ability was influenced by childhood trauma among female students with higher minimization/neglect scores. The results of the current study suggest that ignoring the effects of minimization may be a misleading factor for determining the gender ratio of childhood trauma and evaluating its effect on long-term cognitive functions. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Öğe Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice(TAYLOR & FRANCIS LTD, 2016) Turgut, Nergiz Hacer; Mert, Derya Guliz; Kara, Haki; Egilmez, Hatice Reyhan; Arslanbas, Emre; Tepe, Bektas; Gungor, Huseyin; Yilmaz, Nese; Tuncel, Necati BarisContext: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet. Objective: The objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. Materials and methods: Phenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, d-galactose, d-galactose + M. nigra 50, and d-galactose + M. nigra 100). Mice were administered d-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver. Results: In extract, vanillic (632.093 mu g/g) and chlorogenic acids (555.0 mu g/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H2O2. Morus nigra significantly improved learning dysfunctions (p< 0.01), increased memory retention (p < 0.01), reduced MDA levels (p < 0.05), and elevated SOD, GPx, and CAT activities (p < 0.05) compared with the d-galactose group. Discussion and conclusion: These results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity.Öğe FACTORS ASSOCIATED WITH SUICIDE ATTEMPTS IN PATIENTS WITH BIPOLAR DISORDER TYPE I(MEDICINSKA NAKLADA, 2015) Mert, Derya Guliz; Kelleci, Meral; Mizrak, Ali; Semiz, Murat; Demir, Meral OranBackground: The aim of this study is to identify the risk factors that are associated with suicide attempts in patients with bipolar disorder type I. Subjects and methods: This cross-sectional study was conducted with inpatients and outpatients with BD type I. Patients who met the study inclusion criteria (n=91) were evaluated in terms of sociodemographic variables, history of childhood trauma, comorbidity of adult attention deficit hyperactivity disorder and posttraumatic stress disorder, and the course of the disease. The patients were divided into two groups: those with a history of suicide attempts and those without a history of suicide attempts. The parameters of the study groups were compared with t and chi-square tests as appropriate. Logistic regression was used to identify the predictors of suicide attempt. Results: Logistic regression analysis of the study parameters suggested that the number of major depressive episodes (odds ratio: 7.18; 95% confidence interval: 1.84-28) and history of emotional neglect (odds ratio: 1.83; 95% confidence interval: 1.15-2.90) were significant predictors of suicide attempt in patients with BD. Conclusion: In BD type I patients with a history of suicide attempts, the number of depressive episodes and emotional neglect, a subtype of childhood traumas, were the most remarkable risk factors. Considering the frequency of depressive episodes during the course of the disease and assessing traumas including those in childhood may help predict future suicide attempts in patients with BD.Öğe The influence of quercetin on recognition memory and brain oxidative damage in a ketamine model of schizophrenia(TAYLOR & FRANCIS LTD, 2019) Mert, Derya Guliz; Turgut, Nergiz Hacer; Arslanbas, Emre; Gungor, Huseyin; Kara, HakiOBJECTIVE: The aims of this study were to investigate the protective effect of quercetin on changes in recognition memory as assessed by the novel object recognition (NOR) test, as well as on changes in the oxidative stress levels in the hippocampus and prefrontal cortex, produced in a model of memory impairment in schizophrenia induced by administration of a subanesthetic dose of ketamine. METHODS: A total of 40 Balb-C mice were randomly divided into five groups (Corn oil + Saline, Quercetin 50 + Saline, Corn oil + Ketamine, Quercetin 25 + Ketamine, Quercetin 50 + Ketamine). Corn oil and Quercetin (25 or 50 mg/kg/day) was given by orogastric gavage once daily for 21 days. Corn oil was chosen as the vehicle and administered at the same volume as quercetin. Ketamine was injected at a dose of 25 mg/kg intraperitoneally (i.p.) for a period of 7 days starting from the 15th day. Behavioural responses were evaluated with the NOR test. The activity levels of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in the prefrontal cortex and hippocampus. RESULTS: The time of exploration of the novel object was longer than T-F (time to explore the familiar object) in the Corn oil + Saline and Quercetin 50 + Saline groups in NOR Test-1 (p < .05). The discrimination ratios of the Quercetin 50 + Ketamine and Corn oil + Ketamine groups were significantly lower than that of the Quercetin 50 + Saline group (p < .05). The discrimination ratios of the Quercetin 50 + Ketamine and Corn oil + Saline groups were significantly lower than that of the Quercetin 50 + Saline group (p < .05). The time of exploration of the novel object was longer than T-F in the Corn oil + Saline and Quercetin 50 + Ketamine groups in NOR Test-2 (p < .05). The discrimination ratios of the Corn oil + Ketamine and Quercetin 25 + Ketamine groups were significantly lower than those of the Quercetin 50 + Ketamine group (p < .05). Quercetin at 50 mg/kg reduced the MDA levels and elevated the SOD and GPx activity compared to the Corn oil + Ketamine group. CONCLUSION: These results show that quercetin has the potential to improve cognitive deficits in mice and that quercetin may be useful for treating the symptoms of schizophrenia, partially due to its ability to scavenge free radicals and its high antioxidant capacity.Öğe Mean platelet volume in bipolar disorder: the search for an ideal biomarker(DOVE MEDICAL PRESS LTD, 2016) Mert, Derya Guliz; Terzi, HaticeBackground: The pathophysiology of bipolar disorder (BD) remains a mystery. In this context, interest in the role of the immune and inflammatory systems in BD has been increasing. We aimed to compare the routine hemogram values of BD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups. Mean platelet volume (MPV) can be obtained as routine hemogram parameters and may aid in the detection of systemic inflammation. Subjects and methods: This study was conducted with BD (manic episode) inpatients (n=132) and healthy controls (n= 135). Abnormally distributed variables (ie, neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], neutrophils, lymphocytes, hemoglobin, hematocrit [HCT], mean corpuscular volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC], red cell distribution width [RDW], MPV, and plateletcrit [PCT]) were compared using the Mann-Whitney U-test. Student's t-test was used to compare the mean ages and white blood cell, red blood cell, and platelet counts of the patients with BD against those of the participants in the control group. Results: The comparisons revealed that while the mean WBC and the median NLR, PLR, neutrophil, lymphocyte, MPV, and PCT values were significantly higher in the patients with BD (P<0.05), the median hemoglobin, RBC, HCT, and MCHC values were significantly higher in the control group (P<0.05). Conclusion: Comparisons of hemogram values of patients with BD against those of the healthy control group revealed that inflammatory cells (absolute neutrophil count, platelet count, PCT, and MPV) and ratios (NLR, PLR) seem to be altered during manic episodes. These findings support the hypothesis that inflammatory activation occurs in BD during manic episodes. In addition to NLR and PLR, MPV may be useful in the detection of this activation. The most significant limitation in the study is that smokers were not excluded in both groups. The development of new preventive and therapeutic options can be facilitated through the understanding of this mechanism because through this mechanism, inflammation may pathologically affect brain function, as well as inducing and/or perpetuating BD.Öğe Perspectives on reasons of medication nonadherence in psychiatric patients(DOVE MEDICAL PRESS LTD, 2015) Mert, Derya Guliz; Turgut, Nergiz Hacer; Kelleci, Meral; Semiz, MuratPurpose: This study was carried out to evaluate factors resulting in medication nonadherence within 6 months before admission to the psychiatric service of our hospital for bipolar disorder, schizophrenia/schizoaffective disorder, depression, and other psychiatric diseases. Patients and methods: Two hundred and three patients admitted to the Psychiatry Service of the Medical Faculty were included in this study. Sociodemographic parameters and clinical findings within 6 months before admission and patients' views on reasons of medication nonadherence were examined. Results: Patients were classified into four groups according to their diagnosis: bipolar disorder (n=68, 33.5%), schizophrenia/schizoaffective disorder (n=59, 29.1%), depression (n=39, 19.2%), and others (n=37, 18.2%). The ratio of medication nonadherence was higher in the bipolar disorder group when compared to the groups with schizophrenia/schizoaffective disorder, depression, and other disorders (12.1%, 18.2%, and 24.2% vs 45.5%); however, the ratio of medication nonadherence was similar in schizophrenia/schizoaffective disorder, depression, and the others group. In logistic regression analysis, irregular follow-up (odds ratio [OR]: 5.7; 95% confidence interval [CI]: 2.92-11.31) and diagnosis (OR: 1.5; 95% CI: 1.07-1.95) were determined to be important risk factors for medication nonadherence. The leading factors for medication nonadherence were: "not willing to use medication", "not accepting the disease", and "being disturbed by side effects" in the bipolar disorder group, "not accepting the disease" in the schizophrenia/schizoaffective disorder group, "feeling well" in the depression group, and "being disturbed by side effects" in the other diseases group. Conclusion: Medication nonadherence is an important problem in psychiatric patients and should be dealt with by taking into account the diagnosis, attendance to follow-up appointments, and the patient's attitude. Ensuring regular attendance to follow-up appointments, adjusting the management plan according to the diagnosis, and improving their thoughts about resistance to medication can be beneficial in terms of medication adherence.Öğe Potential Risk Factors Increasing the Severity of Sexual Dysfunction in Women with Fibromyalgia(SPRINGER, 2017) Hayta, Emrullah; Mert, Derya GulizThe purpose of this study is to investigate the effect of clinical features including duration of FM and sexual partnership, and severity of pain, anxiety, and depression on the severity of sexual dysfunction in women with Fibromyalgia (FM). This cross-sectional study was conducted on 130 female patients with FM, who were admitted to Physical Therapy and Rehabilitation Polyclinic in August and September 2015, and 60 healthy controls. The data was collected with Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Women Sexual Function Index (FSFI), Fibromyalgia Impact Questionnaire (FIQ) and Visual Analogue Scale (VAS). Evaluating FM and control group according to the FSFI Score, it was found that 103 (84.4%) and 19 (15.6%) had sexual dysfunction, respectively. The median scores of FSFI scale and subscale, and VAS in the FM patients were significantly higher than those in the control group (p < 0.05). The mean scores of FIQ, BAI, and BDI in the FM patients were significantly higher than those in the control group (p < 0.05). The FSFI score was significantly predicted by FIQ, BAI, duration, and duration of partnership. FSFI score has a negative correlation with BAI score, disease duration and duration of partnership. This study supports that FM may affect all domains of sexual function. In our clinical settings, multiple regression analysis reveals that the duration and severity of FM and duration of sexual partnership, and severity of anxiety but not severity of pain and depression can increase the severity of sexual dysfunction. Knowledge about meaningful contributing factors of duration of FM and sexual partnership, and severity of FM and anxiety may be helpful for physicians for determining correct strategies for prevention and management of sexual dysfunction in FM.Öğe Prospective Evaluation of Psychological Healing in Adults Who Underwent Otoplasty for Prominent Ear(Springer, 2020) Ozkaya, Nese Kurt; Mert, Derya Guliz; Bitgen, Murat; Cepni, MurselBackground Otoplasty is performed to heal the psychological discomfort caused by the appearance of prominent ear by bringing the ear to its anatomical position. However, there have been few studies with limited numbers of patients that have prospectively evaluated psychosocial recovery following otoplasty in adults. The purpose of this prospective study was to evaluate the versatile psychological recovery that can be achieved in adults following otoplasty. Methods In this prospective cohort study, a single-group, pretest-posttest model was used as the experimental research model. Patient satisfaction status was measured, and the Beck Depression Inventory (BDI), State-Trait Anxiety Inventory I-II (STAI I-II), Rosenberg Self-Esteem (RSES), and Body Cathexis Scale (BCS) tests were performed on patients before and after surgery. Results A total of 66 patients with a mean age of 20.7 +/- 3.1 years, 66.7% of whom were women, were included in the study. While 97% of the patients were satisfied with the results of the operation, 3% were undecided. The mean values of the BDI, STAI-I, STAI-II, and BCS before and after surgery were 11.4 +/- 5.7, 40.9 +/- 6.7, 43 +/- 9.4, 74.2 +/- 20.5, and 8.5 +/- 5.5, 38.6 +/- 7.4, 39.5 +/- 9.2, 63.5 +/- 17.6, respectively. While the proportion of patients with a high RSES score before surgery was 42.42%, the proportion after surgery was 96.96%. The differences in the mean scores of all tests before and after surgery were also statistically significant (p < 0.05). Conclusion Our study demonstrated that otoplasty made positive contributions to body perception, self-esteem, anxiety, and depression in adults. Otoplasty is as beneficial in adults as it is in pediatric patients.
