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  • Küçük Resim
    Öğe
    Comparison of three different dosages of low-level laser therapy on expression of cell proliferation and inflammatory markers following ovariohysterectomy in rats
    (Eylül 2023) Polat, Bülent; Okur, Damla Tuğçe; Çolak, Armağan; Okur, Sıtkıcan; Özkaraca, Mustafa; Yılmaz, Kader
    The objective of the current study was to evaluate Low-level laser therapy (LLLT) on the healing of incisional wounds following ovariohysterectomy in rats, by means of subjective histopathological and immunohistochemical analysis. A total of 72 female Wistar rats were categorised into four treatment groups (Group I; sacrification 4hours following only one LLLT application, Group II; sacrification 7days following only one LLLT application, Group III; sacrification 4hours after two LLLT applications, and Group IV; sacrification 7days after two LLLT applications). Each group was further divided into four different doses subgroups (Group Control [C, off mode LLLT application], L1 [1 J/ cm2 ], L3 [3 J/cm2 ], and L6 [6 J/cm2 ]), with equal representation in each subgroup. Ovariohysterectomy was employed using two 2-cm-length midline abdominal incisions in the left and right sides of line alba. The Group C was assigned to the left side incision to each rat in the study. After irradiation, the tissue was subjected to histopathological analysis to determine the extent of mononuclear cell infiltration, edoema, and epithelialization. Additionally, immunohistochemical analysis was performed to evaluate the expression of proliferating cell nuclear antigen (pCNA) and inducible nitric oxide synthase (iNOS). Group L1 and L3 significantly decreased mononuclear cell infiltration compared with Group C in all treatment groups (p<0.05). Group L3 significantly decreased edoema compared with Group C in all groups except for treatment Group I (p<0.05). Group L2 and L3 significantly increased epithelization in treatment Group IV (p<0.05). Moreover, Group L2 and L3 significantly increased pCNA in all groups, while L2 and L3 significantly decreased iNOS expression in treatment Group II, III, and IV (p<0.05). However, no statistical difference was found between subgroups of treatment Group I in iNOS expiration (p>0.05). The results of the current examination demonstrated that LLLT can modulate mononuclear cell infiltration and edoema, and improve epithelization, as well as increase pCNA expression, whereas decrease iNOS expression during the wound healing process, therefore enhancing wound healing following ovariohysterectomy in rats
  • Küçük Resim
    Öğe
    The effects of low?level laser therapy on polycystic ovarian syndrome in rats: three diferent dosages
    (Ağustos 2023) Polat, Bülent; Okur, Damla Tuğçe; Çolak, Armağan; Yılmaz, Kader; Özkaraca, Mustafa; Çomaklı, Selim
    The main objective of this in vivo study was to investigate the efect of diferent low-level laser therapy (LLLT) doses on polycystic ovary syndrome (PCOS). In the present experimental study, a single dosage of estradiol valerate (EV) was administered to induce PCOS in female rats. After administration of the EV for induction of PCOS, rats were divided into 5 groups (n = 8/group): C group (animals that were not exposed to any form of procedure), PC group (no treatment following EV induction), L1 group (1 J/cm2 LLLT treatment following EV induction), L2 group (2 J/cm2 LLLT treatment following EV induction), L3 group (6 J/cm2 LLLT treatment following EV induction). The results indicated that no signifcant dif ference was found in the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone (P4) between the C and L2 groups (p < 0.05). Although the serum levels of testosterone (T) were signifcantly higher in the C group compared with other groups (p < 0.05), the L2 group was determined to be the closest to the C group. Additionally, the LH, FSH, and T receptor level of the L2 group was closest to the C group. In conclusion, a 2 J/cm2 dosage of LLLT (L2 group) can be considered the most potentially efective treatment of PCOS in the rat. However, more studies are needed to determine the optimal dose of LLLT for the treatment of PCOS.