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    First used of Alkylbenzimidazole-Cobalt(II) complexes as a catalyst for the N -Alkylation of amines with alcohols under solvent -free medium
    (Elsevier Science Sa, 2020) Sahin, Neslihan; Yildirim, Ilkay; Ozdemir, Namik; Gurbuz, Nevin; Ozdemir, Ismail
    [Abstract Not Available]
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    Investigation of the in vitro effects of benzimidazol-2-ylidene-based silver-N-heterocyclic carbene complexes on Microsporidia and Leishmania major promastigotes
    (Elsevier, 2025) Atas, Ahmet Duran; Guelpinar, Derya Guel; Polat, Zuebeyda Akin; Ozdemir, Namik; Sahin, Neslihan
    In this study, chloro[1-methallyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazole-2-ylidene]silver(I) (C24H30AgClN2) (2a), chloro[1-methallyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazole-2ylidene]silver(I) (C25H32AgClN2) (2b), chloro[1-methallyl-3-(naphthylmethyl)benzimidazole-2-ylidene]silver(I) (C24H24AgClN2) (2c) were prepared, and characterized by FT-IR, NMR (1H, 13 C{ 1 H) spectroscopy and elemental analysis. In addition, the structures of 2a and 2b were elucidated by single crystal X-ray diffraction analysis. The study evaluated the cytotoxic potential of benzimidazole-2-ylidene-based silver-NHC complexes in vitro. These complexes were tested for their antimicrosporidial activity using E. intestinalis spores in human renal epithelial cell lines (HEK-293). Similarly, the effect on Leishmania major promastigotes was measured by metabolic activity or cell viability assessed by the tetrazolium reaction. The results of our investigation showed that all the compounds studied exhibited inhibitory effects on the proliferation of both L. major promastigotes and E. intestinalis spores. Complex 2b showed promising potent inhibitory activity to combat microsporidial infections. Complex 2a showed the highest level of activity as a potent anti-Leishmania agent.
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    Synthesis, spectral, X-ray diffraction and DFT studies on 1-(2-methyl-2-propenyl)-3-(2,3,4,5,6-pentamethylbenzyl)benzimidazolium chloride hydrate
    (TAYLOR & FRANCIS LTD, 2018) Sahin, Neslihan; Kilic-Cikla, Isin; Ozdemir, Namik; Gurbuz, Nevin; Ozdemir, Ismail
    A new benzimidazole based N-heterocyclic carbene (NHC) salt (1) was synthesized by the reaction of benzimidazole precursor with alkyl halide. The structure of 1 was determined by elemental analysis, FT-IR, H-1 NMR and C-13 NMR spectroscopy tecniques and X-ray crystallography. The compound crystallized in the triclinic space group P-1 with two molecules in the unit cell. The optimization of 1 was firstly performed at B3LYP/6-311G++(d,p) level, then the theoretical spectral studies performed and compared with the experimental values. Besides the frontier molecular orbital energies and chemical reactivity analysis of 1, together with the electrostatic potential and molecular electrostatic potential analyses were performed at the same level of theory.