Yazar "Ozler, Muhammed Emre" seçeneğine göre listele

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    All-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies
    (Amer Chemical Soc, 2024) Taydas, Dilsad; Ozler, Muhammed Emre; Ergul, Mustafa; Inan, Zeynep Deniz Sahin; Sozmen, Fazli
    A wide variety of methods are being developed to ultimately defeat cancer; while some of these strategies have shown highly positive results, there are serious obstacles to overcome to completely eradicate this disease. So, it is crucial to construct multifunctional nanostructures possessing intelligent capabilities that can be utilized to treat cancer. A possible strategy for producing these multifunctional nanostructures is to combine various cancer treatment techniques. Based on this point of view, we successfully synthesized multifunctional HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids. The peculiarities of these thermosensitive polymer-modified and protoporphyrin IX (PpIX)-loaded hollow nanohybrids are that they combine photodynamic therapy (PDT), sonodynamic therapy (SDT), and photothermal therapy (PTT) with an intelligent design. As an all-in-one nanohybrids, HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids were employed in the SDT-PDT-PTT combination therapy, which proved to have a synergistic therapeutic effect for in vitro tumor treatments against breast tumors.
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    Two-Photon Absorption Response of Functionalized BODIPY Dyes in Near-IR Region by Tuning Conjugation Length and Meso-Substituents
    (Amer Chemical Soc, 2023) Yildiz, Elif Akhuseyin; Unlu, Bekir Asilcan; Karatay, Ahmet; Bozkurt, Yasemin; Ozler, Muhammed Emre; Sozmen, Fazli; Yabas, Ebru
    BODIPY dyes substituted by phenol or -COOMe unitsat themeso-position (C8) with and without a distyryl group including a methoxymoiety at the -C3 and -C5 positions of the BODIPY have been synthesizedto analyze the photophysical properties. To clarify the ground-stateinteraction, absorption and emission features were investigated inthe THF environment. Extending the & pi;-conjugation with the methoxymoiety at -C3 and -C5 positions of BODIPY leads to a spectral shiftingof the absorption maxima toward red by 120 nm. In addition, attachingthe -COOMe unit at the meso-position of the BODIPY structureincreases nonradiative molecular relaxation as compared to compoundspossessing phenol substituents at the same position. We have investigatedthe effect of phenol and a -COOMe group and & pi;-extendedconjugation length with a methoxy moiety on the properties of two-photonabsorption (TPA) and electron transfer dynamics by performing open-aperture(OA) Z-scan and femtosecond transient absorption spectroscopy measurements,respectively. The synthesized BODIPY compounds with the distyryl groupincluding the methoxy unit show TPA character due to the longer conjugationlength and therefore intramolecular charge transfer ability. Basedon the OA Z-scan experiments upon photoexcitation with 800 nm pulsedlaser light, TPA cross-section values were obtained as 74 and 81 GMfor the compounds possessing phenol and -COOMe units at themeso-position of BODIPY treated by distyryl group with methoxy moieties,respectively. Additionally, optical and electronic properties werecalculated theoretically by using the DFT method.