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Öğe Assessment of Mitochondrial Functions and Occurrence of Oxidative Stress at Fibromyalgia Patients(CLINICAL & EXPER RHEUMATOLOGY, 2014) Peksen, Halil; Elden, Hasan; Dogan, Sevil Ceyhan; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Salihoglu, Salih…Öğe Effect of Treatment on Sleep Quality in Rheumatoid Arthritis(CLINICAL & EXPER RHEUMATOLOGY, 2014) Tuncay, Mehmet Siddik; Sahin, Ozlem; Peksen, Halil; Salihoglu, Salih; Semiz, Esra…Öğe Evaluation of sleep quality in rheumatoid arthritis patients(Bayrakol Medical Publisher, 2024) Tuncay, Mehmet Siddik; Sahin, Ozlem; Semiz, Murat; Semiz, Esra; Alim, Bulent; Peksen, Halil; Salihoglu, SalihAim: The purpose of this study was to evaluate treatment effects on sleep quality and fatigue in patients with RA. Besides, we aim to examine possible effects of disease activity, pain and socio-demographic features on sleep quality and fatigue. Material and Methods: In this study, 78 patients diagnosed with RA according to the American Rheumatism Association (ACR) 1987 revised criteria and European League Against Rheumatism (EULAR) criteria were compared with a parallel healthy control group (n=48). All participants were given a sociodemographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment of Fatigue Scale (MAF), Visual Analog Scale (VAS), Disease Activity Score 28 (DAS28). Results: The mean duration of diagnosis was 9.10 +/- 8.54 years and the mean score of DAS28 was 3.25 +/- 1.04 in patients with RA. In terms of total PSQI, the differences between two groups were found statistically significant (p=0.001; t=8.023). In terms of MAF, The differences between two groups were found statistically significant (p=0.001; t=3.668). The sleep disturbance and daytime functioning scores were found as 1.86 +/- 0.69, 1.40 +/- 0.83 respectively in nonbiological DMARD group and 1.54 +/- 0.66; 0.84 +/- 0.93 in biological + non -biological DMARD group. There were statistically significant differences between groups (p=0.043; t=2.054, p=0.008; t=2.730). According to correlation analysis between DAS28 and disease duration, a positive correlation has been found (r = 0.297; p = 0.008). Discussion: Patients with RA generally experience more fatigue and have worse sleep quality than healthy individuals. High disease activity can lead to longer sleep latency, reduced daytime functionality, and increased fatigue symptoms.Öğe Post-Traumatic Stress Disorder, Alexithymia and Somatoform Dissociation in Patients with Fibromyalgia(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2014) Semiz, Murat; Kavakci, Onder; Peksen, Halil; Tuncay, Mehmet Siddik; Ozer, Zafer; Semiz, Esra Aydinkal; Kaptanoglu, EceObjective: We investigated the prevalence of post-traumatic stress disorder, alexithymia, and somatoform dissociative symptoms in patients with fibromyalgia (FM). Material and Methods: Fifty-six consecutive patients with FM admitted to the outpatient department were enrolled in this study after providing informed consent. Forty-six patients with rheumatoid arthritis (RA) were enrolled as controls. Participants completed the Somatoform Dissociation Questionnaire (SDQ), the Post-traumatic Diagnostic Scale (PDS), the Toronto Alexithymia Scale (TAS), and The Childhood Trauma Questionnaire (CTQ). The impact of FM was measured with the Fibromyalgia Impact Questionnaire (FIQ). Results: The number of patients reporting at least one traumatic event was higher in the FM (19, 33.9%) than in the RA (6, 13%) (X2=5.9, p=0.015) group. Post-traumatic stress disorder (PTSD) was found in six (10.7%) of the 56 subjects with FM. In the RA group, no patients met the criteria for PTSD. Current PTSD prevalence was higher in the FM than in the RA group. Among those with FM group and traumatic experiences, FIQ scores were higher in patients with than without PTSD (p=0.02). Additionally, a positive correlation between traumatic experiences and use of analgesics (r=0.415, p=0.002) was also observed. FM patients had significantly higher scores than did RA patients on the CTQ, SDQ and TAS. Conclusion: The results of this study indicate that PTSD, alexithymia, and dissociative symptoms positively influence the levels of pain and FM-related disability in FM patients. Treatment strategies may be developed to manage psychiatric conditions in fibromyalgia.
