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Öğe Comparison of Analgesic Effects Induced by Different Strengths of Extremely Low-Frequency Electromagnetic Fields(AVES PRESS LTD, 2018) Demirkazik, Ayse; Ozdemir, Ercan; Turkay, Yavuz; Pelit, Aykut; Kilinc, Olca; Taskiran, Ahmet Sevki; Arslan, GokhanObjective: Our aim was to compare the results of the most commonly used analgesic measurement techniques and to determine the time and intensity at which the analgesic effects of the magnetic field (MF) are most effective. Methods: This study compared the analgesic effect of MF strengths (1, 5, and 10 mT) in 30 adults, male Wistar albino rats weighing 200-250 g. The analgesic effects were measured using tail-flick (TF) and hot-plate (HP) tests. To determine the optimum MF strength, rats were assigned into four groups: sham group and exposed to 1, 5, and 10 mT MF groups. Rats were placed in a solenoid, and MF of 50 Hz for 165 min was administered daily for 15 days. All four groups were kept in the solenoid for 165 min/15 days and exposed to MF. However, the analgesic effect was measured only on day 0, 4, 7, 11, and 15 using TF and HP tests. The latencies of analgesia were converted to a percentage of maximal antinociceptive effects (% MPE). Results: When the maximum analgesic effect of the 5 mT MF was determined on the seventh day, the% MPEs were 5.37 +/- 0.51, 13.66 +/- 1.27, 25.89 +/- 3.00, and 25.37 +/- 2.41 in the sham, 1 mT, 5 mT, and 10 mT groups, respectively. The optimum effect was observed with 5 mT MF on the seventh day and with 90 min in the solenoid. Conclusion: We didn't find any differences between the analgesic responses to the TF and HP tests.Öğe The effect of modulation magnetic field on Na-KATPase in diaphragm of streptozotocin-induced diabetic rat(Blackwell Publishing, 2006) Demirkazik, Ayse; Yucrbilgic, G.; Emre, Mustafa; Pelit, Aykut[Abstract Not Available]Öğe The effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway(Academic Press Inc Elsevier Science, 2019) Demirkazik, Ayse; Ozdemir, Ercan; Arslan, Gokhan; Taskiran, Ahmet Sevki; Pelit, AykutThere is growing interest in the effects of extremely low-frequency electromagnetic fields on mechanisms in biological organisms. This study's goal is to determine the role of the Nitiric Oxide (NO) pathway for thermal pain by intentionally interfering with it using a pulsed electromagnetic field generated by an extremely low frequency alternating current (ELF-PEMF) in combination with BAY41-2272 (sGC activator), NOS inhibitor L-NAME, and NO donor L-arginine. This study included 72 adult male Wistar albino rats (mean weight of 230 +/- 12 g). The rats were kept at room temperature (22 +/- 2 degrees C) in a 12-h light/dark cycle and in a room with sound insulation. PEMF (50 Hz, 5 mT) were applied four times a day for 30 min and at 15-min intervals for 15 days. Analgesic effects were assessed with tail-flick and hot-plate tests. Before the tests, NO donor L-arginine (300 mg/kg), sGC activator BAY41-2272 (10 mg/kg), and NOS inhibitor L-name (40 mg/kg) were injected intraperitoneally into rats in six randomly-selected groups. The maximum analgesic effect of a 5 mT electromagnetic field was on day 7. PEMF significantly increased the analgesia effect when the functioning of the NO pathway was ensured with L-arginine, which is a NO donor, and BAY41-2271, which is the intracellular receptor and sGC activator. However, there was no difference between rats treated with PEMF and the NOS inhibitor L-NAME as compared to rats only treated with PEMF. In conclusion, PEMF generate analgesia by activating the NO pain pathway.Öğe The Effects of Magnetic Field on the Electrophysiological Parameters of Soleus Muscle in Streptozotocin-Induced Diabetic Rats(Cukurova Univ, Fac Medicine, 2013) Pelit, Aykut; Emre, Mustafa; Demirkazik, Ayse; Gunay, IsmailPurpose: To investigate the effects of magnetic field (MF) on the resting membrane potential and action potential parameters of the Soleus muscle preparations in streptozotocin (STZ) induced diabetic rats. Material and Methods: Forty male wistar rats were used in this study. The rats were divided into four groups; Group I (control), Group II (control with magnetic field), group III (diabetic), group IV (diabetic with magnetic field). The diabetes was induced by a single intravenous injection of STZ (45 mg/kg) in citrate buffer to the jugular vein under the ketamine and xylazine anesthetic combination. Resting membrane potential (RMP), muscle action potential (MAP), depolarization and half-repolarization time, MAP integral, depolarization and repolarization rates were recorded by means of the conventional microelectrode technique. Results: When group III and IV compared to group I, a significant decrease was found in the RMP (p<0.05). When control group compared to the other groups, MAP values found to be significant. When the depolarization time was compared there was a significant increase difference between group I and group III and group IV. Furthermore, half-repolarization time, MAP integral, depolarization and repolarization rates showed significant decrease results as occurred in MAP. Conclusion: MF increased the excitability of the cell membrane in RMP, which revealed that cell membrane had been more depolarized. It was assumed that this increase in depolarization may have been due to the changes in the conductivity of K+ and/or Cl-ion channels.
