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Öğe A Case Report Of Behçet's Disease With Coronary Artery Involvement Cardiac Involvement Due to Behçet's Disease(Sivas Cumhuriyet University, 2022) Karataş, Beliz; Karakaş, Burak; Yalçın, İlker; Çelik, Neşe Çabuk; Sahin, AliWe present a case of coronary artery thrombosis due to Behçet's disease. A 49-year-old female patient, diagnosed with Behçet's disease and followed up by us, applied to the emergency department with sudden onset of pressure-type chest pain, and was evaluated as acute myocardial infarction due to elevated cardiac enzymes and ST segment elevation in the anterior leads on electrocardiography (ECG). Coronary angiography revealed near-total thrombosis in the lumen of the left anterior descending artery (LAD) and in the circumflex (CX) artery,it was intervened with anticoagulant therapy. The patient's cardiac risk was found to be low and differential diagnosis was made in terms of myocardial infarction. Thereupon, the causes of hypercoagulability were investigated in the patient who was consulted to us, and acute phase reactants were found to be high. This was related to the coronary artery involvement of Behçet's disease and in addition to the treatment containing antiaggregant, statin, angiotensin receptor blocker, intravenous (IV) high-dose methylprednisolone and cyclophosphamide-mesna treatment was given for immunosuppressive purposes. It should not be forgotten that there may be vascular involvement due to Behçet's disease and coronary arteries may also be affected.Öğe A national, multicenter, retrospective study evaluating retention rate and efficacy of tocilizumab treatment in patients with active rheumatoid arthritis who had an inadequate response to csDMARDs and/or TNF inhibitors(Tubitak Scientific & Technological Research Council Turkey, 2023) Inanc, Guezide Nevsun; Terzioglu, Mustafa Ender; Karabulut, Yusuf; Yilmaz, Zevcet; Tarhan, Emine Figen; Enecik, Mehmet Emin; Sahin, AliBackground/aim: To describe the disease activity and retention rate in rheumatoid arthritis (RA) patients with inadequate response (IR) to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and/or tumor necrosis factor inhibitors (TNFis) who were prescribed tocilizumab (TCZ) as first-line or second-line biologic treatment in real-world setting.Materials and methods: Data gathered from patients' files was used in a multicenter and retrospective context. Retention rates and the Disease Activity Score in 28 joints with CRP (DAS28-CRP) were evaluated at time points. The relationship of drug efficacy with factors such as smoking, obesity, and previous use of TNFis was also examined.Results: One hundred and twenty-four patients with a median (IQR) RA duration of 3.7 (7.4) years were included. Mean (SD) age was 52.9 (12.9) and 75% of the patients were female. TCZ retention rates in the 6th and 12th months were 94.1% and 86.6%, respectively. In all patients, DAS28-CRP level decreased significantly from baseline to Months 3 and 6. There was an increase in patients with remission and/or low disease activity and a decrease in patients with high disease activity at Month 3 and Month 6 (p < 0.001 for both). Disease activity was similar between subgroups based on body mass index, smoking status, and previous use of TNFis at any time point. Regres-sion analysis showed that absence of concomitant corticosteroid treatment independently was associated with remission/LDA achieve-ment at Month 6 [OR = 0.31, 95% CI (0.14- 0.72), p = 0.006], and Month 12 [OR = 0.35, 95% CI (0.13-0.94), p = 0.037]. Overall, 25 mild adverse events were reported.Conclusion: TCZ was found to be effective and safe in RA patients with IR to csDMARDs and/or TNFis. The drug retention rate was considered satisfactory with more than half of the patients continuing TCZ treatment at Month 12.Öğe Apelin and fetuin-a may be subclinical inflammation biomarker in familial mediterranean fever: A pilot study(DERMAN MEDICAL PUBL, 2017) Sahin, Ali; Demirpence, Ozlem; Sahin, Mehtap; Bagci, Gokhan; Seven, Dogan; Dogan, Halef Okan; Camci, Ayse; Derin, Mehmet Emin; Bagci, BinnurAim: Positive acute-phase reactants generally increase during the attack period (AP) of familial Mediterranean fever (FMF) and return to normal range in the attack-free period (AFP). In some patients, the level of these acute-phase reactants does not decrease during the AFP, suggesting that subclinical vascular inflammation continues during the AFP. In the context of this Information, we tested whether apelin and fetuin-A can be used as inflammatory biomarkers in the AFP of FMF patients. Material and Method: Thirty FMF patients within AFP and thirty healthy subjects were included in this study. Serum apelin and fetuin-a levels were measured using enzyme-linked immunosorbent assay (ELISA) method. Results: The median levels of apelin were 113.07 +/- 15.9 ng/L in FMF and 307.82 +/- 52.76 ng/L in healthy subjects (p = 0.002). The median levels of fewin-A were 1352.2 +/- 127.61 ng/mL in the FMF group and 843.82 +/- 137.66 ng/mL in the control group (p= 0.009). In FMF patients, there was a significant correlation between apelin and fetuin-A levels (r=0.399; p =0.029). Furthermore, a significant inverse correlation was found between age and apelin (r= -0.499; p = 0.005), and a significant positive correlation was found between BMI and apelin (r = 0.769; p = 0.001). Additionally, a significant correlation was found between BMI and fetuin-A (r = 0.397; p = 0.030). Discussion: Lower serum apelin levels and higher fetuin-A levels were observed in FMF patients with AFP than in healthy subjects, suggesting that subclinical vascular inflammation continues during AFP in patients with FMF. Further studies with large study populations and different ethnic groups are necessary to show the role of apelin and fetuin-A in subclinical inflammation resulting from FMF.Öğe Assessment of effectiveness of anakinra and canakinumab in patients with colchicine-resistant/unresponsive familial Mediterranean fever(Bmc, 2020) Sahin, Ali; Derin, Mehmet Emin; Albayrak, Fatih; Karakas, Burak; Karagoz, YalcinIntroduction: Familial Mediterranean fever (FMF) is a hereditary auto-inflammatory disease characterized by recurrent fever and serosal inflammation. Anti-interleukin-1 (Anti-IL-1) treatments are recommended in colchicine resistant and/or intolerant FMF patients. This study aims to evaluate the efficacy of anakinra and canakinumab in FMF patients that are resistant/intolareted to colchicine or complicated with amyloidosis. Methods: Between January 2014 and March 2019, 65 patients following-up at Sivas Cumhuriyet University (Medical Faculty Rheumatology-Internal Medicine Department) who were diagnosed with FMF according to the criteria of Tel-Hashomer were included in the study. The laboratory values and clinical features of patients and disease activities were recorded at least every 3 months, and these data were analyzed. Results: Forty-one (63.1%) patients used anakinra (100 mg/day) and 24 (36.9%) patients used canakinumab (150 mg/8 week). The median duration of anti-IL-1 agents use was 7 months (range, 3-30). Fifteen (23.1%) cases were complicated with amyloidosis. Seven (10.8%) patients had renal transplantation. Overall, the FMF 50 score response was 96.9%. In the group that had a glomerular filtration rate (GFR) >= 60 ml/min/m(2), the median proteinuria decreased from 2390 mg/day (range, 14007200) to 890 mg/day (range, 1202750) (p = 0.008). No serious infections were detected, except in one patient. Conclusions: Anti-IL-1 agents are effective and safe in the treatment of FMF patients. These agents are particularly effective at reducing proteinuria in patients with GFR >= 60 ml/min/m(2), but less effective in cases with FMF associated with arthritis and sacroiliitis. Large and long follow-up studies are now needed to establish the longterm effects of these treatments.Öğe Assessment of the New 2012 EULAR/ACR Clinical Classification Criteria for Polymyalgia Rheumatica: A Prospective Multicenter Study(J RHEUMATOL PUBL CO, 2016) Ozen, Gulsen; Inanc, Nevsun; Unal, Ali Ugur; Bas, Seda; Kimyon, Gezmis; Kisacik, Bunyamin; Onat, Ahmet Mesut; Murat, Sadiye; Keskin, Havva; Can, Meryem; Mengi, Alperen; Cakir, Necati; Balkarli, Ayse; Cobankara, Veli; Yilmaz, Neslihan; Yazici, Ayten; Dogru, Atalay; Sahin, Mehmet; Sahin, Ali; Gok, Kevser; Senel, Soner; Pamuk, Omer Nuri; Yilmaz, Sema; Bayindir, Ozun; Aksu, Kenan; Cagatay, Yonca; Akyol, Lutfi; Sayarlioglu, Mehmet; Yildirim-Cetin, Gozde; Yasar-Bilge, Sule; Yagci, Ilker; Aydin, Sibel Zehra; Alibaz-Oner, Fatma; Atagunduz, Pamir; Direskeneli, HanerObjective. To assess the performance of the new 2012 provisional European League Against Rheumatism (EULAR)/ American College of Rheumatology (ACR) polymyalgia rheumatica (PMR) clinical classification criteria in discriminating PMR from other mimicking conditions compared with the previous 5 diagnostic criteria in a multicenter prospective study. Methods. Patients older than 50 years, presenting with new-onset bilateral shoulder pain with elevated acute-phase reactants (APR), were assessed for the fulfillment of the new and old classification/diagnostic criteria sets for PMR. At the end of the 1-year followup, 133 patients were diagnosed with PMR (expert opinion) and 142 with non-PMR conditions [69 rheumatoid arthritis (RA)]. Discriminating capacity, sensitivity, and specificity of the criteria sets were estimated. Results. Discriminating capacity of the new clinical criteria for PMR from non-PMR conditions and RA as estimated by area under the curve (AUC) were good with AUC of 0.736 and 0.781, respectively. The new criteria had a sensitivity of 89.5% and a specificity of 57.7% when tested against all non-PMR cases. When tested against all RA, seropositive RA, seronegative RA, and non-RA control patients, specificity changed to 66.7%, 100%, 20.7%, and 49.3%, respectively. Except for the Bird criteria, the 4 previous criteria had lower sensitivity and higher specificity (ranging from 83%-93%) compared with the new clinical criteria in discriminating PMR from all other controls. Conclusion. The new 2012 EULAR/ ACR clinical classification criteria for PMR is highly sensitive; however, its ability to discriminate PMR from other inflammatory/noninflammatory shoulder conditions, especially from seronegative RA, is not adequate. Imaging and other modifications such as cutoff values for APR might increase the specificity of the criteria.Öğe Association of Matrix Metalloproteinases and Their Tissue Inhibitor With Disease Activity and Development in Spondyloarthropathy and Inflammatory Bowel Disease(TURKISH LEAGUE AGAINST RHEUMATISM, 2015) Elmas, Dursun; Sahin, Ali; Kucuksahin, Orhan; Turkcapar, Nuran; Toruner, Murat; Cetinkaya, Hulya; Kulahcioglu, Emre; Okoh, Alexis K.; Turgay, MuratObjectives: This study aims to investigate whether clinical measures of disease activity and function in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are associated with matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase -1 (TIMP-1), and if MMPs can be more useful than C-reactive protein and erythrocyte sedimentation rate in predicting disease activity in AS. Patients and methods: MMP-3, MMP-9 and TIMP-1 levels were measured by ELISA in 20 patients with AS, 20 patients with IBD, 20 patients with IBD and AS (35 males, 25 females; mean age 38.1 years; range 19 to 62 years), and 20 healthy volunteers (10 males, 10 females; median age 38.5 years; range 24 to 63 years) as a control group. Bath Ankylosing Spondylitis Disease Activity Index, Truelove-Witts activity criteria for ulcerative colitis, and Crohn's Disease of Activity Index scoring systems were used. Results: Highest MMP-3 level was in IBD group (33.51 59.56 ng/mL, p<0.045). MMP-3 levels were significantly higher in patients with IBD and IBD+AS than in patients with AS (p<0.007 and p<0.035, respectively). Highest MMP-9 levels were in the control group (10.35 +/- 2.61 ng/mL, p<0.48). MMP-9 levels were higher in AS group patients than those in IBD and IBD+AS groups, but the difference was not statistically significant (p<0.494 and p<0.260, respectively). Highest TIMP-1 levels were in the IBD group (8.11 ng/mL, p<0.006).TIMP-1 levels of IBD group were significantly higher than both AS and IBD+AS groups (p<0.033 and p<0.008, respectively). A statistically significant correlation was detected between serum MMP-3 levels and disease activity and Bath Ankylosing Spondylitis Disease Activity Index score in patients with AS (r=0.841, p<0.05). Conclusion: We concluded that serum MMP-3 levels may be a better biomarker than C-reactive protein and erythrocyte sedimentation rate in showing disease activity in AS.Öğe Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?(Korean Acad Medical Sciences, 2020) Asan, Gokmen; Derin, Mehmet Emin; Dogan, Halef Okan; Bayram, Meliha; Sahin, Mehtap; Sahin, AliBackground: Familial Mediterranean fever (FMF) is an autoinflammatory disease that has self-limiting inflammatory attacks during polyserositis. Hepcidin is a protein, and interleukin-6 stimulation increases hepcidin levels. Calprotectin (CLP) is a recently defined cytokine released from monocytes and neutrophils in response to tissue trauma and inflammation. There are studies in the literature showing that it can be used as a biomarker in rheumatic diseases such as ankylosing spondylitis and rheumatoid arthritis. Here, we compared the levels of hepcidin and CLP in healthy individuals and FMF patients during an attack-free period and show its relation to genetic mutations. Methods: This is a cross-sectional study. Between July 2017 and December 2017, 60 patients diagnosed with FMF an admitted to the Cumhuriyet University Faculty of Medicine Department of Internal Medicine Rheumatology as well as 60 healthy volunteers without any rheumatic, systemic, or metabolic diseases were enrolled in this study. Blood was collected from a peripheral vein to measure serum CLP and hepcidin levels. Blood tests were examined by ELISA; the study protocol was approved by the local ethics committee. Results: Median serum hepcidin level was 468.1 (210.3-807.8) pg/mL in FMF group and 890.0 (495.0-1,716.9) pg/mL in the healthy control (HC) group. There was a statistically significant difference between the two groups (P< 0.001). The median serum levels of CLP in the FMF group were measured as 1,331.4 (969.34,584.6 pg/mL and 73.8(45.0-147.9) pg/mL in the HC group. There was a statistically significant difference between the two groups (P < 0.001). Receiver operating characteristic analysis showed that the sensitivity was 66.7% and the specificity was 71.7% at serum hepcidin < 581.25 pg/mL (P< 0.05); the sensitivity was 96.7% and specificity was 100% at CLP > 238 pg/mL (P < 0.05). There was no significant difference between serum hepcidin and CLP levels in FMF patients with M694V homozygous and M694V heterozygous (P> 0.05). There was no significant difference in serum hepcidin levels between FMF patients with and without arthritis, proteinuria, and amyloidosis (P < 0.05). There was no significant correlation between laboratory findings, gender, age, and serum CLP and hepcidin levels (P> 0.05, r< 0.25). Conclusion: Serum CLP levels in FMF patients during an attack-free period are significantly higher than in the HC groups. Serum hepcidin levels in FMF patients are significantly lower than in the HC group. Low levels of hepcidin may be explained by including FMF patients during an attack-free period in the study. CLP may be an important biomarker in FMF. A better understanding of the role of these biomarkers in the diagnosis of FMF is needed to evaluate the results in a more comprehensive way.Öğe Chronic Progressive Neuro-Behcet's Disease: Magnetic Resonance Spectroscopy and Apparent Diffusion Coefficient Findings(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Polat, Selim; Yazgin, Duygu; Sahin, Ali; Yildiz, Bulent…Öğe Comparison of Oxidant and Antioxidant Parameters in Patients with Sjogren's Syndrome and Healthy Subjects(Georg Thieme Verlag Kg, 2020) Dogan, Ismail; Erten, Sukran; Sahin, Ali; Isikoglu, Semra; Neselioglu, Salim; Ergin, Merve; Erel, OzcanObjective Oxidative stress may have an effect on the pathogenesis of diseases, including autoimmune rheumatic diseases. We aimed to investigate the serum paraoxonase activity and other oxidant/antioxidant parameters in patients with Sjogren's syndrome (SS) and healthy controls. Methods 85 patients with SS and 65 healthy subjects were included in the study. Groups were age and gender-matched and had no liver disease. Serum paraoxonase (PON)-1 activity, stimulated paraoxonase (SPON), PON-1 phenotypes that represent polymorphism (Q192R; QQ, QR, RR), arylesterase (ARE), total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), advanced oxidative protein products (AOPP), total thioles (TTL) and ischaemia-modified albumin (IMA) were measured in all study participants. Results Statistically significant differences were found in the QQ and QR + RR phenotype of PON-1 for TAC, TOS and TTL (p < 0.001) between SS and healthy groups. The other parameters were statistically insignificant. Conclusion Antioxidant parameters were lower in SS patients compared with healthy controls. Conversely, oxidant parameters were higher. This imbalance may play a role in SS pathogenesis.Öğe Comparison of Serum Hepcidin and Calprotectin Levels in Patients with Familial Mediterranean Fever (FMF) and Healthy Subjects(WILEY, 2018) Asan, Gokmen; Derin, Mehmet Emin; Dogan, Halef Okan; Bayram, Meliha; Sahin, Mehtap; Sahin, Ali…Öğe Comparison of serum oxidant and antioxidant parameters in familial Mediterranean fever patients with attack free period(PUBLISAUDE-EDICOES MEDICAS LDA, 2014) Sahin, Ali; Erten, Sukran; Altunoglu, Alpaslan; Isikoglu, Semra; Neselioglu, Salim; Ergin, Merve; Atalay, Haci Veil; Erel, OzcanObjective. Familial Mediterranean fever (FMF) is an autoinflammatory, autosomal recessive, inherited disease characterized by recurrent self-limiting attacks of serosal surfaces. The imbalance of oxidants/antioxidants may play a role in such attacks. In this study, we aimed to evaluate the relationship between serum paraoxonase (PON1) activity PON1 phenotype, and other parameters in patients with FMF and healthy controls. Methods: A total of 120 FMF patients with an attack-free period (AFP) and 65 healthy subjects were included in this study The serum PON1 activity, stimulated paraoxonase (SPON) activity, PON1 phenotype (representing Q192R polymorphism; QQ, QR, RR), arylesterase activity, total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), advanced oxidative protein products (AOPP), total thiols (TTL), and ischemia-modified albumin (IMA) and cystatin-c (CYS-C) levels were measured. Results: For the QQ phenotype, the median TTL and AOPP levels of the control group were 264.50 (57.75) mu Amol/L and 21.26 (21.17) mmol/L, respectively, whereas the median TTL, AOPP levels of the patients were 309.00 (47.00) mu mol/L and 12.98 (6.96) mmol/L, respectively There was a statistically significant difference between the patients and controls with the QQ phenotype in terms of TTL and AOPP (p< 0.001 and p= 0.004, respectively). However, there were no statistically significant differences between the QQ and QR+FRR phenotypes with respect to TAC, TOS, OSI, or the other parameters. Conclusions: The FMF patients with AFP had higher TTL and lower AOPP levels than the controls. However, other oxidant and antioxidant parameters were similar among the patients during AFP and the controls.Öğe The Effects of the Jak-Stat Signal Pathway Inhibition on Collagen Biosynthesis in Fibroblast Cell Culture(WILEY, 2018) Sahin, Mehtap; Aydin, Huseyin; Altun, Ahmet; Derin, Mehmet Emin; Sahin, Ali…Öğe Evaluation of ovarian reserve using anti-mullerian hormone and antral follicle count in Sjogren's syndrome: Preliminary study(WILEY, 2017) Karakus, Savas; Sahin, Ali; Durmaz, Yunus; Aydin, Huseyin; Yildiz, Caglar; Akkar, Ozlem; Dogan, Mansur; Cengiz, Ahmet; Cetin, Meral; Cetin, AliAimThe aim of this study was to determine ovarian reserve status using anti-mullerian hormone (AMH) level and antral follicle count (AFC) in patients with Sjogren's syndrome (SS). MethodsTwenty-four women with SS diagnosed according to the classification criteria proposed by the American-European Consensus Group and 25 healthy women as controls were enrolled in this study. Ovarian reserve was assessed on clinical findings, AFC, and serum AMH and reproductive hormone levels. ResultsCompared with the healthy controls, in the SS patients, the duration of menstrual cycle was significantly shorter (P = 0.043); serum AMH (P = 0.001) and AFC (P = 0.001) were significantly lower, and serum luteinizing hormone (LH) was significantly higher (P = 0.019). The right (P = 0.555) and left ovarian (P = 0.386) volumes were also lower but this did not reach statistical significance. Serum follicle-stimulating hormone (P = 0.327), estradiol (P = 0.241), and prolactin (P = 0.55) were similar between the two groups. ConclusionsOvarian reserve may be reduced in SS patients. For the assessment of ovarian reserve, serum AMH and ovarian AFC with serum LH may be useful. Further studies with long-term follow-up are required to determine the course of ovarian reserve abnormalities and best possible biomarkers of reduced ovarian reserve in SS patients.Öğe Evaluation of Ovarian Reserve with Anti-Mullerian Hormone in Familial Mediterranean Fever(HINDAWI LTD, 2015) Sahin, Ali; Karakus, Savag; Durmaz, Yunus; Yildiz, Caglar; Aydin, Huseyin; Cengiz, Ahmet Kivanc; Guler, DuyguObjective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Mullerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters. Methods. Thirty-three AF-FMF patients aging 18-45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd-4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes. Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P = 0.018). There was no statistically significant difference in median AMH levels between E148 Qmutation positive patients and the negative ones (P = 0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P = 0.868). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (P = 0.868). We realized that there was no difference in comparisons between ovarian volumes, number of follicles, and AMH levels ovarian reserves when compared with FMF patients and healthy individuals. Conclusions. Ovarian reserves of FMF pateints were similar to those of healthy subjects according to AMH. However, AMH levels were lower in FMF patients with M694V mutation.Öğe Evaluation of Prolidase and HIF-1 alpha Levels in Patients with Familial Mediterranean Fever (FMF)(WILEY, 2018) Bayram, Meliha; Derin, Mehmet Emin; Dogan, Halef Okan; Asan, Gokmen; Sahin, Mehtap; Sahin, Ali…Öğe EXPERIENCE OF ANAKINRA AND CANAKINUMAB IN PATIENTS WITH COLCHICINE-RESISTANT FAMILIAL MEDITERRANEAN FEVER AND COMPLICATED WITH AMYLOIDOSIS(BMJ PUBLISHING GROUP, 2019) Sahin, Ali; Derin, Mehmet Emin; Albayrak, Fatih; Karakas, Burak…Öğe The Frequency of Spondyloarthropathy in Inflammatory Bowel Diseases(CLINICAL & EXPER RHEUMATOLOGY, 2014) Kucuksahin, Orhan; Ates, Askin; Toruner, Murat; Turkcapar, Nuran; Sahin, Ali; Turgay, Murat; Kinikli, Gulay; Cetinkaya, Hulya; Duzgun, Nursen…Öğe High prolidase levels in patients with Familial Mediterranean Fever (FMF)(Sciendo, 2020) Bayram, Meliha; Derin, Mehmet Emin; Dogan, Halef Okan; Asan, Gokmen; Sahin, Mehtap; Sahin, AliIntroduction. Familial Mediterranean Fever (FMF) is an autoinflammatory disease. Prolidase is a specific imidodipeptidase that plays a role in collagen degradation, and an important role in inflammation and wound healing. Hypoxia-inducible factor-1 alpha (HIF-1) is an important protein in the regulation of immunological response, hemostasis, vascularization. The aim of the study was to compare serum prolidase and HIF-1 alpha levels in patients with FMF in attack-free period and healthy control group. Methods. Between August 2017 and December 2017, sixty patients diagnosed with FMF according to the criteria of the Tel-hashomer and admitted to Sivas Cumhuriyet University Medical Faculty, Internal Medicine Rheumatology Department and sixty healthy volunteers were enrolled in the study. Results. Median serum prolidase levels were 72.1 (25.1-114.9) ng/ml in FMF group and 30.7 (21.3-86.2) ng/mL in healthy control (HC) group (p = 0.018). ROC analysis showed that the sensitivity was 65% and the specificity was 68.3% at serum prolidase levels 54.03 ng/mL (p < 0.05). The median serum levels of HIF-1 alpha in the FMF group was 482.0 (292.0-3967.0) pg/mL and 632.0 (362.0-927.0) pg/mL in the HC group (p > 0.05). There was no significant correlation between laboratory findings, sex, age, and prolidase (p > 0.05). Conclusion. Serum prolidase enzyme levels in FMF patients with attack-free period were significantly higher than in the HC group. However, the role of prolidase and HIF1-alpha in the FMF disease needs to be clarified with more extensive and comprehensive studies.Öğe Idiopathic Presentation of Remitting Seronegative Symmetrical Synovitis with Pitting Edema in an Older Man(WILEY-BLACKWELL, 2015) Yildizgoren, Mustafa Turgut; Sahin, Ali; Osmanoglu, Kasim; Velioglu, Onur…Öğe Interim Analysis of Baseline Characteristics and Preferences of Administration Route of Rheumatoid Arthritis Patients Who Are Bio-Naive or Switched between Advanced RA Treatments; A Multicenter, Prospective, Observational Study(WILEY, 2018) Direskeneli, Haner; Karadag, Omer; Ates, Askin; Tufan, Abdurrahman; Inanc, Nevsun; Koca, Suleyman Serdar; Cetin, Gozde Yildirim; Akar, Servet; Cinar, Muhammet; Yilmaz, Sedat; Yilmaz, Neslihan; Dalkilic, Ediz; Bes, Cemal; Ozbalkan, Zeynep; Yilmazer, Baris; Sahin, Ali; Ersozlu, Emine Duygu; Tezcan, Mehmet Engin; Sen, Nesrin; Keser, Gokhan; Tansoker, Ilkan; Hacibedel, Fatma Basak; Helvacioglu, Kerem; Gunay, Levent Mert…
