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Öğe Additional Therapeutic Effect of Balneotherapy in Low Back Pain(LIPPINCOTT WILLIAMS & WILKINS, 2011) Dogan, Murat; Sahin, Ozlem; Elden, Hasan; Hayta, Emrullah; Kaptanoglu, EceObjectives: Balneotherapy has been widely used for treatment of chronic low back pain recently. However there are only a few clinical controlled trials on balneotherapy. The aim of the present study was to evaluate the effects of balneotherapy in patients with chronic low back pain. Methods: Sixty patients with lumbar spondylosis were included in the study. In Group 1, patients received both balneotherapy and physiotherapy and in Group 2, patients received only physiotherapy for three weeks. The intensity of the pain was evaluated by Visual Analog Scale (VAS) and functional disability was scored according to Revised Oswestry Index (ROI). Spinal mobility was assessed by the Schober and lateral flexion tests. Variables were evaluated before and after the three weeks of treatment. Results: The groups were comparable regarding age (P = 0.970) and sex (P = 0.357). There was no statistically significant difference between the two groups for baseline VAS (P = 0.838), Schober test (P = 0.226), and right (P = 0.642) and left (P = 0.674) lateral flexion measurements, and ROI scores (P = 0.798). At the end of the therapy, all clinical parameters significantly improved in patients in both of the groups (P < 0.05). VAS, Schober test, and ROI scores after the therapy were clearly superior in Group 1 in comparison to Group 2 (P < 0.05). Conclusion: The results of the present study reiterate that besides conventional physiotherapy, balneotherapy may be effective in the treatment of patients with chronic low back pain.Öğe Aquatic Exercise Program for Individuals With Osteoarthritis: Pain, Stiffness, Physical Function, Self-Efficacy(Lippincott Williams & Wilkins, 2019) Fertelli, Tuelay Kars; Mollaoglu, Mukadder; Sahin, OzlemPurpose This research was conducted to determine the effects of an aquatic exercise program on pain, stiffness, physical function, and self-efficacy in individuals with osteoarthritis. Design A randomized controlled trial. Methods Participants in the experimental group participated in the aquatic exercise program three times a week for 8 weeks; participants in the control group did not. Findings The mean scores of the experimental group on the pain, stiffness, and difficulty in carrying out physical functions subscales of the Western Ontario and McMaster Universities Osteoarthritis Index decreased significantly, whereas those of the control group decreased very little. The mean scores of the experimental group on the Arthritis Self-Efficacy Scale and the isokinetic muscle strength measurements increased, but those of the control group did not change in the final measurements. The difference between the groups was statistically significant. Conclusions Through the study, it was determined that the aquatic exercise program decreased pain, stiffness, and difficulty in carrying out physical functions and increased self-efficacy and muscle strength of individuals with osteoarthritis.Öğe Assessment of Effectiveness of Balneotherapy and Physical Agents in Fibromyalgia Syndrome(CLINICAL & EXPER RHEUMATOLOGY, 2014) Ozer, Zafer; Sahin, Ozlem; Ozer, Pinar Kaplan; Tuncay, Mehmet Siddik…Öğe Assessment of Joint Inflammation By Ultrasonography (US) in Patients with Rheumatoid Arthritis (RA) in Clinical Remission(CLINICAL & EXPER RHEUMATOLOGY, 2014) Ozer, Pinar Kaplan; Sahin, Ozlem; Ozer, Zafer; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Kaptanoglu, Ece…Öğe Autoantibodies are not associated with familial mediterranean fever(MEDFARMA-EDICOES MEDICAS, LDA, 2012) Guler, Emel; Kaptanoglu, Ece; Sahin, Ozlem; Candan, Ferhan; Hayta, Emrullah; Elden, HasanObjective: It has been suggested that Mediterranean fever (MEFV) gene mutations are also seen in certain autoimmune diseases and are related to severity of the disease activity. As most of the clinical symptoms of these inflammatory diseases are related to autoantibody positivity, we assessed autoantibody prevalence in patients with Familial Mediterranean fever (FMF) and investigated the relationship between clinical involvement of FMF and the autoantibodies. There are a few studies on this subject with conflicting results. Patients and Methods: Fifty patients with FMF without attack and 27 healthy controls were enrolled to the study Clinical characteristics of the patient group were questioned. Rheumatoid factor (RE), anti-cyclic citrullinated peptide (anti-CCP) values, Fluorescent antinuclear antibody (ANA), extractable nuclear antigen (ENA) profile was studied in both groups. Results: No statistically significant difference was found in ANA, ENA profile, anti-CCP, and RF positivity between the groups (p>0.05). There was no relationship between the autoantibodies and the clinical status in patients with FME MEFV gene mutations were identified in 98% of the FMF patients. Conclusion: In conclusion, autoantibody positivity is similar to the healthy population in FME Although MEFV mutations affect clinical course in other autoantibody mediated diseases, it is not related to autoantibody formation in FMEÖğe Body Composition in Patients with Ankylosing Spondylitis on Anti-Tumor Necrosis Factor Alpha Treatment(KUWAIT MEDICAL ASSOC, 2017) Sahin, Ozlem; Kaptanoglu, Ece; Dinler, Mustafa; Dogan, Sevil Ceyhan; Kurt, Kibar GultekinObjectives: To examine the body composition (BC) of the Ankylosing spondylitis (AS) patients on anti-TNF therapy and to evaluate the clinical parameters in obese AS patients Design: Cross-sectional case-control study Setting: Department of Physical Medicine and Rehabilitation, Cumhuriyet University, Medical Faculty, Sivas, Turkey Subjects: Thirty-four AS patients and 34 healthy subjects as controls were included in the study between November 2014 and May 2015 Main outcome measures: Waist circumference (WC), body mass index (BMI), percent body fat (PBF), fat mass (FM) and fat free mass (FFM) were measured in patients and control group. In AS group, disease activity, functional status, spinal mobility and life quality were examined by standard AS questionnaires. Results: WC, BMI, PBF, FM, and FFM were comparable in AS patients and controls. There was a positive correlation between the duration of the anti-TNF treatment and BMI (p = 0.02, r = 0.409). In obese AS patients, the duration of the anti-TNF treatment was significantly longer than the normal weight AS patients (for BMI p = 0.02, for PBF p = 0.03). Obese and normal weight AS patients were comparable regarding disease duration, disease activity, functional status, spinal mobility and life quality. Conclusions: The BC of AS patients on anti-TNF treatment was similar to healthy controls. Anti-TNF treatment has comparable effects on disease parameters in both the normal weight and obese AS patients. Long-term treatment with anti-TNF drugs may lead to obesity. Prospective controlled studies with more patients to clarify this probable effect of anti-TNF drugs are required.Öğe Bone mineral density in familial Mediterranean fever(SPRINGER HEIDELBERG, 2012) Siverekli, Neslihan Berkdemir; Sahin, Ozlem; Senel, Soner; Hayta, Emrullah; Kaptanoglu, Ece; Elden, HasanThe aim of this study was to evaluate the bone mineral density (BMD) in familial Mediterranean fever (FMF) and to search the effects of genetic factors, family history of FMF and types of clinical attacks on BMD. Forty-four attack-free patients with FMF and 36 healthy voluntary subjects were included in the study. BMD measurements of lumbar spine and left proximal femur were performed by dual energy X-ray absorptiometry (DEXA). There was no statistically significant difference between patient and control groups regarding median values of lumbar BMD (P = 0.06), lumbar T (P = 0.08) and Z (P = 0.12) scores, femoral neck BMD (P = 0.13), femoral T (P = 0.22) and Z (P = 0.16) scores and total femur BMD (P = 0.14), T (P = 0.19) and Z (P = 0.27) scores. Patients with negative FMF family history had significantly lower femoral neck BMD (P = 0.018), femoral neck T (P = 0.009) and Z (P = 0.01) scores and total femur BMD (P = 0.033) than patients with positive FMF family history. There was no significant difference among the groups regarding mutation characteristic and types of attacks in lumbar BMD, T and Z scores, femoral neck BMD, T and Z scores and total femur BMD, T and Z scores (P > 0.05). We found that the bone loss of patients with FMF is not different from that of the controls. The increased bone loss in the patients with negative family history for FMF should be further investigated with larger patient groups taking into consideration of the risk factors related to family history for osteoporosis.Öğe Cutaneous silent period in fibromyalgia(MANEY PUBLISHING, 2011) Sahin, Ozlem; Yildiz, Serpil; Yildiz, NebilObjectives: The pathogenesis of widespread pain and increased tenderness in Fibromyalgia (FM) are still unknown. Recently, the role of central nervous system hyperexcitability is emphasized in pathogenesis of FM. The central sensitization was demonstrated with decrease in nociceptive flexion reflex (NFR) threshold in patients with FM. The NFR and cutaneous silent period (CuSP) are excitatory and inhibitory parts of the same spinal protective reflex, respectively. The aim of this study was to evaluate the changes in CuSP in FM. Patients and methods: Twenty-eight patients with FM and 18 healthy volunteers were subjected to the study. CuSPs on right abductor pollicis brevis muscle evoked by electrical stimulation of the right fifth digit were recorded. Results: The CuSP onset latencies were significantly longer in patients with FM. There was not any significant difference in CuSP duration between patients and controls. Conclusion: The latency elongation of the CuSP shows that there is some delay in the development of the inhibitory part of the spinal protective reflex in patients with FM. The observed changes in CuSP of the patients with FM may suggest some abnormalities in the circuits of sensorimotor integration at spinal and supraspinal levels. The results regarding the changes observed in the CuSP in patients with FM should be confirmed by further studies.Öğe Effect of Treatment on Sleep Quality in Rheumatoid Arthritis(CLINICAL & EXPER RHEUMATOLOGY, 2014) Tuncay, Mehmet Siddik; Sahin, Ozlem; Peksen, Halil; Salihoglu, Salih; Semiz, Esra…Öğe Evaluation of allergic rhinitis with nasal symptoms and nasal mucociliary clearance in patients with fibromyalgia syndrome(IOS PRESS, 2018) Dogan, Sevil Ceyhan; Karadag, Ahmet; Durmus, Kasim; Sahin, Ozlem; Altuntas, Emine ElifBACKROUND: The exact etiopathogenesis of fibromyalgia syndrome (FM) is still unclear but the pathogenesis of FM is associated with neurogenic inflammation. Allergic rhinitis (AR) is a common inflammatory and immunological disease of the nasal mucosa. As a result, it is known that neurogenic inflammation has a role in the pathophysiology of both FM and AR. OBJECTIVE: The aim of this study was to evaluate AR and nasal allergic inflammation using nasal mucociliary clearance time (NMC) in FM patients. METHODS: Forty-five FM patients and fifty healthy controls were included in the study. In both groups, AR was evaluated by total nasal symptom scoring (TNSS) and NMC was measured using saccharine transit time test (STT). RESULTS: TNSS was positive in 9 patients (20%) in the FM group and no positivity in the control group. In FM group, the mean value of TNSS was higher than that of the control group (p = 0.0001). The average value of STT of FM patients was statistically significantly longer when compared to the control group (p = 0.0001). CONCLUSION: The results we obtained suggest that there is a high possibility of coexistence of FM and AR. As a result, the coexistence of AR and FM cannot be denied but we believe that comprehensive clinical studies should be conducted on this subject.Öğe Evaluation of sleep quality in rheumatoid arthritis patients(Bayrakol Medical Publisher, 2024) Tuncay, Mehmet Siddik; Sahin, Ozlem; Semiz, Murat; Semiz, Esra; Alim, Bulent; Peksen, Halil; Salihoglu, SalihAim: The purpose of this study was to evaluate treatment effects on sleep quality and fatigue in patients with RA. Besides, we aim to examine possible effects of disease activity, pain and socio-demographic features on sleep quality and fatigue. Material and Methods: In this study, 78 patients diagnosed with RA according to the American Rheumatism Association (ACR) 1987 revised criteria and European League Against Rheumatism (EULAR) criteria were compared with a parallel healthy control group (n=48). All participants were given a sociodemographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment of Fatigue Scale (MAF), Visual Analog Scale (VAS), Disease Activity Score 28 (DAS28). Results: The mean duration of diagnosis was 9.10 +/- 8.54 years and the mean score of DAS28 was 3.25 +/- 1.04 in patients with RA. In terms of total PSQI, the differences between two groups were found statistically significant (p=0.001; t=8.023). In terms of MAF, The differences between two groups were found statistically significant (p=0.001; t=3.668). The sleep disturbance and daytime functioning scores were found as 1.86 +/- 0.69, 1.40 +/- 0.83 respectively in nonbiological DMARD group and 1.54 +/- 0.66; 0.84 +/- 0.93 in biological + non -biological DMARD group. There were statistically significant differences between groups (p=0.043; t=2.054, p=0.008; t=2.730). According to correlation analysis between DAS28 and disease duration, a positive correlation has been found (r = 0.297; p = 0.008). Discussion: Patients with RA generally experience more fatigue and have worse sleep quality than healthy individuals. High disease activity can lead to longer sleep latency, reduced daytime functionality, and increased fatigue symptoms.Öğe Is There a Clinically Meaningful Change in the Blood Pressure of Osteoarthritis Patients with Comorbid Hypertension During the Course of Balneotherapy?(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2015) Hayta, Emrullah; Yilmaz, Mehmet Birhan; Yayikci, Ilker; Ozer, Zafer; Sahin, OzlemBackground: Balneotherapy (BT) is a treatment modality that uses the physical and chemical effects of water, including thermomineral, acratothermal, and acratopegal waters. It has many effects on cardiovascular system. Aim: The aim of the study is to investigate the effects of 3-week BT on blood pressure of osteoarthritis (OA) patients with no hypertension (HT), and controlled or uncontrolled HT. Materials and Methods: The OA patients (n = 270) were divided into three groups: No HT, controlled HT, and uncontrolled HT. All the groups received BT in the facilities of our university hospital at the same time every day (10: 00-11: 30 AM) for 10 min per day, 5 days per week, for a total duration of 15 days in a 3-week period. Systolic and diastolic blood pressures and pulse rates were measured before and after BT on daily basis. Results: Overall, (1) the pulse rates of study groups measured after BT were significantly increased compared to before BT; (2) the systolic blood pressures of study groups measured before and after BT were found as comparable; and (3) the diastolic blood pressures of no HT and controlled HT groups measured before and after BT were not statistically significant (P > 0.05); however, in the uncontrolled HT group, the diastolic blood pressure showed a decreasing trend after BT (P < 0.05). Conclusions: In patients with OA, BT can be safely used without resulting in any meaningful changes in systolic and diastolic blood pressures in patients with normal and controlled HT but a decrease in diastolic blood pressure of patients with uncontrolled HT. This may be an advantage in OA patients having HT as comorbid disease.Öğe Neuropathic Pain Component in Patients with Ankylosing Spondylitis and the Relationship of Neuropathic Pain and Disease Activity Parameters: A Cross-Sectional Study(Jmni, 2024) Atik, Seda; Sahin, Ozlem; Atik, Irfan; Polat, MusaObjective: It is known that neuropathic pain frequently accompanies rheumatological diseases. In this study, neuropathic pain in Ankylosing Spondylitis(AS) and its relationship with disease activity were investigated. Methods: Forty patients with AS were included. Laboratory data and disease status parameters were recorded. Neuropathic pain questionnaires were administered. Electrophysiological examination was performed on all patients. The relationship between neuropathic pain and disease activity parameters was investigated. Results: According to the Pain Detect and LANSS questionnaire results, the rate of neuropathic pain was 57.5% and 42.5%. ASQoL, BASDAI, and ASDASESH parameters are statistically significantly higher in the group with neuropathic pain according to the PainDetect (p:0.018, p:0.04, p:0.028). MASES, ASQoL, BASDAI, BASFI, and ASDAS-ESH parameters are statistically significantly higher in the group with neuropathic pain according to the LANSS (p:0.004, p:0.005, p: 0.001, p:0.005, p:0.02). Disease activity is higher in patients with neuropathic pain for both scales. Peripheral neuropathy is detected in nine patients. There is a positive correlation between disease activity parameters and neuropathic pain scales. A strong positive correlation was detected between ASQoL and BASDAI parameters and the Pain Detect questionnaire (r:0.533, r:0.606). Conclusions: The majority of patients with AS have a neuropathic pain. This condition is associated with high disease activity and adversely affects the patient's quality of life.Öğe Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report(WILEY, 2017) Kaptanoglu, Ece; Sahin, Ozlem; Tuncer, Tiraje; Hizmetli, Sami; Altan, Lale; Ayhan, Figen; Bal, Ajda; Bilgilisoy, Meral; Bozbas, Gulnur; Cerrahoglu, Lale; Cevik, Remzi; Duruoz, Tuncay; Dulgeroglu, Deniz; Gurer, Gulcan; Gursoy, Savas; Hepguler, Simin; Kacar, Cahit; Kaya, Taciser; Melikoglu, Meltem; Nas, Kemal; Ozcakir, Suheda; Ozdolap, Senay; Saridogan, Merih; Sarikaya, Selda; Sindel, Dilsad; Sendur, Omer F.; Tikiz, Canan; Ugurlu, Hatice…Öğe Routine Assessment Of Patient Index Data 3 In Fibromyalgia: A Rapid and Reliable Instrument For Evaluating Disease Severity?(WILEY-BLACKWELL, 2013) Kaptanoglu, Ece; Sahin, Ozlem; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Hizmetli, Sami…Öğe Subclinical atherosclerosis in fibromyalgia syndrome(Wiley, 2024) Gul, Enes; Yildiz, Bulent; Atik, Irfan; Sahin, OzlemIntroduction: Fibromyalgia syndrome (FMS) is a chronic disease of unknown pathophysiology in which inflammatory markers are not increased. The risk of cardiovascular disease is known to be raised in FMS. Determination of carotid intima-media thickness (CIMT) is essential for the early detection of cardiovascular disease risk. In this study, we aimed to investigate how FMS affects CIMT and its relationship with disease duration.Methods: This study was planned prospectively and included 20 female FMS patients and 20 healthy female controls. Detailed medical histories were obtained. Persons with a known chronic disease (diabetes mellitus, hypertension, thyroid function disorder, rheumatic disease, etc.), known atherosclerotic condition, body mass index >30 and smokers were excluded. Laboratory values of FMS patients and the control group in the last 3 months were recorded. The patients' and control groups' right and left common carotid arteries were imaged with ultrasonography.Results: There was no significant difference in laboratory values (although creatinine was different, it was within the normal range in both groups). The mean right common carotid artery intima-media thickness was 0.5 (+/- 0.07) mm in the patient group and 0.43 (+/- 0.05) mm in the control group (p = .005). The mean left common carotid artery intima-media thickness was 0.5 (+/- 0.06) mm in the patient group and 0.43 (+/- 0.05) mm in the control group (p = .001). Carotid intima-media thickness values were significantly higher in the patient group than in the control group.Conclusions: Although FMS is not an inflammatory disease, it causes endothelial dysfunction and atherosclerosis.Öğe Ultrasound-defined remission for good functional status in rheumatoid arthritis(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2017) Ozer, Pinar Kaplan; Sahin, Ozlem; Ozer, Zafer; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Kaptanoglu, EceBackground & objectives: It has been shown that joint damage due to subclinical synovitis progresses despite apparent clinical remission in rheumatoid arthritis (RA). Hence, finding more objective methods to investigate subclinical synovitis has become a current issue. Ultrasonography (US) has been among the most investigated methods. This study was conducted to detect whether there was subclinical inflammation in RA patients in clinical remission by power Doppler ultrasonography (PDUS) and to evaluate the effects of this inflammation on upper extremity function. Methods: Forty five RA patients fulfilled the remission criteria of disease activity score 28 using erythrocyte sedimentation rate (DAS28-ESR), were enrolled in the study. Bilateral wrist, 2nd and 3th metacarpophalangeal and proximal interphalangeal joints and 2nd and 5th metatarsophalangeal joints were examined by PDUS. Upper extremity function was assessed with Michigan Hand Outcomes Questionnaire (MHQ) and handgrip strength. The pain was evaluated by visual analogue scale (VAS). Results: In 29 of 45 RA patients in clinical remission, synovitis was detected by PDUS at least in one joint. VAS and DAS28-ESR scores were significantly lower and total MHQ, some subgroup scores of MHQ (overall hand function, activity of daily living and work performance) and grip strength of the dominant hand were higher in patients with PD signal negativity. Interpretation & conclusions: PDUS showed a crucial role in determining the subclinical synovitis. Subclinical synovitis negatively affects the upper extremity function. Ultrasound-defined remission may be considered for good functional status and real remission in patients with RA.
